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| 1 | Research Progress in the Use of Drugs for Breast Cancer Targeted Therapy显示文摘In recent years,many significant advances have been made on molecular target therapy to aim directly at epidermal growth factor receptors and vascular endothelial growth factor in breast cancers.Clinical studies of such agents as trastuzumab,lapatinib,erlotinib and bevacituzumab have been widely conducted.This paper will review the recent research progress related to targeted therapy. | Shun 'e Yang Bing Zhao | 2008 | Chinese Journal of Clinical Oncology2008，5，5： | 22 |
| 2 | The Deep Ritz Method: A Deep Learning-Based Numerical Algorithm for Solving Variational Problems显示文摘We propose a deep learning-based method,the Deep Ritz Method,for numerically solving variational problems,particularly the ones that arise from par-tial differential equations.The Deep Ritz Method is naturally nonlinear,naturally adaptive and has the potential to work in rather high dimensions.The framework is quite simple and fits well with the stochastic gradient descent method used in deep learning.We illustrate the method on several problems including some eigenvalue problems. | Weinan E Bing Yu | 2018 | Communications in Mathematics and Statistics2018，6，1： | 22 |
| 3 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 4 | The impact of cleft lip and palate repair on maxillofacial growth显示文摘Surgical correction is central to current team-approached cleft treatment. Cleft surgeons are always concerned about the impact of their surgical maneuver on the growth of the maxilla. Hypoplastic maxilla, concaved mid-face and deformed dental arch have constantly been reported after cleft treatments. It is very hard to completely circumvent these postoperative complications by current surgical protocols. In this paper, we discussed the factors that inhibit the maxillofacial growth on cleft patients. These factors included pre-surgical intervention, the timing of cleft palate and alveolae repair, surgical design and treatment protocol.Also, we made a review about the influence on the maxillary growth in un-operated cleft patients. On the basis of previous researches, we can conclude that most of scholars express identity of views in these aspects: early palatoplasty lead to maxilla growth inhibition in all dimensions; secondary alveolar bone graft had no influence on maxilla sagittal growth; cleft lip repair inhibited maxilla sagittal length in patients with cleft lip and palate; Veau's pushback palatoplasty and Langenbeck's palatoplasty with relaxing incisions were most detrimental to growth; Furlow palatoplasty showed little detrimental effect on maxilla growth;timing of hard palate closure, instead of the sequence of hard or soft palate repair, determined the postoperative growth. Still,scholars hold controversial viewpoints in some issues, for example, un-operated clefts have normal growth potential or not,pre-surgical intervention and pharyngoplasty inhibited maxillofacial growth or not. | Bing Shi Joseph E Losee | 2015 | International Journal of Oral Science2015，7，1： | 16 |
| 5 | A Simplified PCR-SSP Method for HLA-A2 Subtype in a Population of Wuhan,China显示文摘HLA-A2 is the most frequent HLA-A allele in all ethnic populations, and an important restriction element for peptide presentation to T cells in infectious disease and cancer. However, the HLA-A2 supertype consisting of up to 75 subtypes, mutation studies and analyses using cytotoxic T lymphocytes suggest the functional relevance of subtype-specific differences in HLA-A2 molecules for peptide binding and T-cell recognition. Therefore, it is necessary for T-cell response study to discriminate the HLA-A2 subtypes and to understand the profile of HLA-A2 allelic distribution in a given population. In this study, we developed a simple, robust approach based on the nested polymerase chain reaction using sequence-specific primers (PCR-SSP) to discriminate 17 HLA-A2 subtypes which cover the most HLA-A2 alleles (> 99% allele frequency) reported in Chinese, using 15 combinations of 19 allelic specific primers. In the first round of PCR, 3 combinations of 5 primers were used to determine whether the tested sample was HLA-A2 positive, meanwhile the subtypes of HLA-A*0209 and HLA-A*0215N were determined for the variant position of these two subtypes is in exon 4 instead of exon 2, 3. Samples of HLA-A2 positive were subtyped in the second round of PCR, using PCR products of the first round as templates. This strategy was applied to test the samples of 78 random HLA-A2 positive individuals for their HLA-A2 subtypes. Those samples were screened for HLA-A2 positive by the first round PCR-SSP from 154 healthy blood donors in Wuhan, China. The subtyping results were verified by using flow cytometric analysis (FCM) with HLA-A2 specific monoclonal antibody BB7.2 and DNA sequencing. The typing results of the samples show 50.7% random individuals in the population carry HLA-A2, HLA-A*0201 ranks the first (allele frequency = 15.5%), followed by A*0207 (5.8%), A*0206 (4.7%), A*0203 (2.6%), A*0210 (0.7%), and these 5 alleles account for 99.0% HLA-A2 subtypes of allele frequency. Our study indicates that the developed typing method is simple and reliable for HLA-A2 subtyping in Chinese, and the profile of allelic distribution of HLA-A2 subtypes is revealed in the population of Wuhan, China. | Bing Liang Lijun Zhu Zhihui Liang Xiufang Weng Xiaoling Lu Cai'e Zhang Hui Li Xiongwen Wu | 2006 | Cellular & Molecular Immunology2006，3，6： | 9 |
| 6 | Induction of the apoptosis of cancer cell by sonodynamic therapy:a review显示文摘Ultrasound can be used not only in examination,but also in therapy,especially in the therapy of cancer.Sonodynamic therapy is an experimental cancer therapy method which uses ultrasound to enhance the cytotoxic effects of agents known as sonosensitizers.It has been tested in vitro and in vivo.The ultrasound could penetrate the tissue and cell under some of conditions which directly changes cell membrane permeability,thereby allowing the delivery of exogenous molecules into the cells in some degree.Ultrasound could inhibit the proliferation or induce the apoptosis of cancer cells in vitro or in vivo.Recent researches indicated low-frequency and low-intensity ultrasound could induce cell apoptosis,which could be strengthened by sonodynamic sensitivity,microbubbles,chemotherapeutic drugs and so on.Most kinds of ultrasound suppressed the proliferation of cancer cells through inducing the apoptosis of cancer cells.The mechanism of apoptosis is not clear.In this review,we will focus on and discuss the mechanisms of the induction of cancer cell apoptosis by ultrasound. | Wen-Kun Bai E Shen Bing Hu | 2012 | Chinese Journal of Cancer Research2012，24，4： | 9 |
| 7 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 8 | Tick-borne Pathogens in Shanxi Province, China显示文摘Ticks are recognized as one of the most important vectors that cause diseases in animals and humans,and have significant public health impacts worldwide[1].They have a wide range of hosts among terrestrial vertebrates,including mammals,birds,amphibians.The numerous zoonotic pathogens transmitted by ticks are the causative agents of Lyme disease,rickettsiosis,ehrlichioses,relapsing fever,Q fever,and tularemia.Cases of tick-borne diseases are increasing around the world and some emerging or re-emerging pathogens are being discovered,which pose great challenges for prevention and control. | YANG Xiao Na YANG Hui Jun ZHANG Lin HOU Xue Xia MIAO Guang Qing CAO Hong Bing HAO Rui E HAO Qin | 2021 | Biomedical and Environmental Sciences2021，34，5： | 4 |
| 9 | Antifouling Technology Trends in Marine Environmental Protection显示文摘Marine fouling is a worldwide problem,which is harmful to the global marine ecological environment and economic benefits.The traditional antifouling strategy usually uses toxic antifouling agents,which gradually exposes a serious environmental problem.Therefore,green,long-term,broad-spectrum and eco-friendly antifouling technologies have been the main target of engineers and researchers.In recent years,many eco-friendly antifouling technologies with broad application prospects have been developed based on the low toxicity and non-toxicity antifouling agents and materials.In this review,contemporary eco-friendly antifouling technologies and materials are summarized into bionic antifouling and non-bionic antifouling strategies(2000-2020).Non-bionic antifouling technologies mainly include protein resistant polymers,antifoulant releasing coatings,foul release coatings,conductive antifouling coatings and photodynamic antifouling technology.Bionic antifouling technologies mainly include the simulated shark skin,whale skin,dolphin skin,coral tentacles,lotus leaves and other biology structures.Brief future research directions and challenges are also discussed in the end,and we expect that this review would boost the development of marine antifouling technologies. | Limei Tian Yue Yin Wei Bing E Jin | 2021 | Journal of Bionic Engineering2021，18，2： | 3 |
| 10 | Treatment of PC-3 cells with ultrasound combined with microbubbles induces distinct alterations in the expression of Bcl-2 and Bax显示文摘The objective of the present study was to investigate whether ultrasound combined with microbubbles induces apoptotic cell death in androgen-independent prostate cancer cells and to identify the probable mechanism.We used ultrasound in continuous wave mode with a frequency of 21 kHz and a spatial-average temporal-average intensity of 46 mW/cm2.Ultrasound combined with microbubbles(200μL SonoVue)was used to treat androgen-independent human prostate cancer PC-3 cells for 30 s.PC-3 cells were divided into three groups:the control group,the ultrasound group and the ultrasound combined with microbubbles group.Immediately after treatment,trypan blue exclusion was used to assess cell viability.Cell apoptosis at 24 h after treatment was measured using transmission electron microscopy and flow cytometry.Western blotting was used to evaluate the expression of the apoptosis-related proteins,Bcl-2 and Bax.Ultrasound combined with microbubbles had a minimal effect on the viability of PC-3cells and induced minimal levels of cell lysis.The level of apoptosis in PC-3 cells induced by this modality was significantly higher than in controls(12.77±0.31%vs.2.56±0.22%,P<0.01).Treatment with ultrasound combined with microbubbles increased the expression of Bax,a pro-apoptotic protein,and decreased the expression of Bcl-2,an anti-apoptotic protein.It was concluded that ultrasound combined with microbubbles induces apoptotic cell death in human prostate cancer PC-3 cells through down-regulation of Bcl-2 and up-regulation of Bax. | BAI WenKun YANG ShaoLing SHEN E ZHANG JiZhen SHEN ZhiYong HU Bing | 2013 | Chinese Science Bulletin2013，58，28： | 2 |
| 11 | Neuronal differentiation of adipose-derived stem cells and their transplantation for cerebral ischemia显示文摘OBJECTIVE:To review published data on the biological characteristics,differentiation and applications of adipose-derived stem cells in ischemic diseases.DATA RETRIEVAL:A computer-based online search of reports published from January 2005 to June 2012 related to the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia was performed in Web of Science using the key words 'adipose-derived stem cells','neural-like cells','transplantation','stroke',and 'cerebral ischemia'.SELECTION CRITERIA:The documents associated with the development of adipose-derived stem cells and their transplantation for treatment of cerebral ischemia were selected,and those published in the last 3-5 years or in authoritative journals were preferred in the same field.Totally 89 articles were obtained in the initial retrieval,of which 53 were chosen based on the inclusion criteria.MAIN OUTCOME MEASURES:Biological characteristics and induced differentiation of adipose-derived stem cells and cell transplantation for disease treatment as well as the underlying mechanism of clinical application.RESULTS:The advantages of adipose-derived stem cells include their ease of procurement,wide availability,rapid expansion,low tumorigenesis,low immunogenicity,and absence of ethical constraints.Preclinical experiments have demonstrated that transplanted adipose-derived stem cells can improve neurological functions,reduce small regions of cerebral infarction,promote angiogenesis,and express neuron-specific markers.The improvement of neurological functions was demonstrated in experiments using different methods and time courses of adipose-derived stem cell transplantation,but the mechanisms remain unclear.CONCLUSION:Further research into the treatment of ischemic disease by adipose-derived stem cell transplantation is needed to determine their mechanism of action. | Guoping Tian Jin Zhou Jing'e Wang Bing Xu Li Li Feng Zhu Jian Han Jianping Li Siyang Zhang Xiaoguang Luo | 2012 | Neural Regeneration Research2012，7，25： | 2 |
| 12 | MODELING OF SEDIMENT AND NONPOINT SOURCE POLLUTANT YIELD显示文摘For water and soil conservation and water pollution control, it is very important to simulate and predict the load of sediment and pollutant during storm-runoff. On the basis of analyzing the simultaneous measurements of flow, sediment and pollutants observed at watershed outlet, a practical sediment yield model is developed by standardizing the load rate. The results show that the standardized pollutant yield equals effective rainfall and the process of effective load yield is the same as effective rainfall hyetograph. Comparison with measured data show that this model is applicable to various pollutants. | Huai’en LI, Xiaokang Hong and Bing SHEN Professor, Institute of Environmental Sciences, Xi’an University of Technology, Xi’an 710048, Shaanxi Province, P.R.China. Ph.D. studdent in Hydrology and Water Resources, Xi’an University of Techology, and Senior E | 2001 | International Journal of Sediment Research2001，16，3： | 2 |
| 13 | Novel Anti-fouling Strategies of Live and Dead Soft Corals(Sarcophyton trocheliophorum):Combined Physical and Chemical Mechanisms显示文摘At present,biomimetic antifouling research objects are mostly concentrated on the fast-moving marine organism,but the anti-fouling effect of the low-speed or static marine equipment is not obvious.This paper describes the anti-fouling mechanism of soft coral(Sarcophyton trocheliophorum),including the physical defense mechanism and the bactericidal ability of mucus and coral powder.As a sessile organisms,soft coral lacks escape mechanism.Therefore,the study on its antibacterial strategy is significant because it can provide theoretical guidance for static antifouling.Results showed that the live soft coral would molt in unfriendly environment,and the secreted mucus could defend themselves against fouling microorganism.Then,Liquid Chromatography-Mass Spectrometry(LC-MS)analysis was conducted to identify the bioactive compounds of the coral powder and mucus.Results revealed that both powder and mucus contained a wide variety of toxic components,which had bactericidal effects.Moreover,at the same concentration,the inhibitory effect of the main components on Gram-negative bacteria was stronger than that on positive bacteria.These findings enhance the understanding about the antifouling mechanism of soft coral and provide new ideas for design and prepare novel antifouling strategy to combat biofouling under static condition. | Limei Tian E Jin Benli Yu Hang Sun Yangeng Shang Wei Bing | 2020 | Journal of Bionic Engineering2020，17，4： | 2 |
| 14 | Estimating saturated hydraulic conductivity in spatially variable fields using neural network ensembles 显示文摘 | KAMBAN P AMIN E BING C S | 2006 | Soil Science Society of America Journal2006，70，6： | 1 |
| 15 | Long-term effect of chemical fertilizer, straw, and manure on soil chemical and biological properties in northwest China显示文摘 | Liu E Yan C Mei X He W Bing SH Ding L Liu Q Liu S Fan T | 2010 | Geoderrna2010，158，： | 1 |
| 16 | Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice显示文摘 | Bing C Russell S Becket E | 2006 | Br J Cancer2006，95，8： | 1 |
| 17 | Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice 显示文摘 | Shin E J Jeong J H Bing G | 2008 | Cell Signal2008，20，4： | 1 |
| 18 | Applying support vector machines to predict building energy consumption in tropical region显示文摘 | ING Bing CAO Cheng LEE S E | 2005 | Energy and Buildings2005，37，5： | 1 |
| 19 | Psychiatric Disorders and Drug Use among Human Immunodeficiency Virusinfected Adults in the United States显示文摘 | Bing E G Burnam M A Longshore D | 2001 | Arch Gen Psychiatry2001，58，8： | 1 |
| 20 | Psychiatric disorders,and drug use among human immunodeciency virus infected adults in the United States显示文摘 | Bing E urnam A B ongshore D L | 2001 | Arch Gen Psychiatry2001，58，： | 1 |
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