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| 1 | Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer显示文摘胰腺的癌症是有导致世界范围的高死亡率的一个高变形的潜力的好攻击的恶意。尽管巨噬细胞有潜力杀死肿瘤房间并且对肿瘤得到有免疫力的回答,有证据,联系肿瘤的巨噬细胞(TAM ) 支持肿瘤前进并且压制 T 房间回答。CC-chemokine ligand 20 (CCL20 ) 并且它的唯一的受体 CC-chemokine 受体(CCR6 ) 6 被癌症房间为移植和转移利用并且在癌症的发展和前进起重要作用。最近的研究证明了 CCL20 的表示是在胰腺的癌症的 upregulated;然而, CCL20 的行动的机制尚待充分被阐明。在这研究,包括变形胰腺的癌症织物,在胰腺的癌症织物的 TAM 的 CCL20 的异常表示被检测。CCL20 表示比在胰腺的癌症房间排队的在巨噬细胞是更加更高的,特别地在 interleukin-4-treated (M2 ) 巨噬细胞。用胰腺的癌症房间的 Boyden 房间试金,我们发现 M2 巨噬细胞分泌的 CCL20 支持了胰腺的癌症房间的迁居,上皮间充质的转变,和侵略。RNA 干扰结果证明 CCR6 是为在胰腺的癌症房间的 CCL20 的受体,调停这些房间的增加的侵略性质由 CCL20 支持了。用一个老鼠模型,我们在在 vivo 支持胰腺的癌症生长和肝转移证实了 CCR6/CCL20 的角色。我们的调查结果在胰腺的癌症提供卓见进藏匿巨噬细胞的 CCL20 的重要角色并且含有 CCR6/CCL20 同样潜在的治疗学的目标。 | Bingyan Liu Yiping Jia Jun Ma Shaoqiu Wu Haosheng Jiang Yan Cao Xianjun Sun Xiang Yin Shuo Yan Mingyi Shang Aiwu Mao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 13 |
| 2 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 3 | Features of colorectal cancer in China stratified by anatomic sites:A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018显示文摘Objective:The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer.However,for Chinese patients,there is limited information on the proportion of cases at each site and the related features.In this study,we explored the location,distribution and other features of colorectal cancers at each anatomic site in Chinese patients.Methods:We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018;the reports covered a total of 2,097,347 hospitalizations.Incident cases were chosen as the study population,and their epidemiological features were further analyzed.Results:A total of 20,739 colorectal cancer patients were identified.Rectum was the most common location(48.3%)of the cancer,whereas the proportions of patients with distal and proximal colon cancer were 24.5%and18.6%,respectively.Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites(each P<0.001).The highest proportion of emergency admissions,the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer(each P<0.001).The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy,cholecystolithiasis and/or gallbladder polyps and appendectomy(P=0.009,P<0.001 and P<0.001,respectively).The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension(P<0.001,respectively).Conclusions:The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer.Different epidemiological features were also found based on anatomic sites.Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment. | Ruize Qu Yanpeng Ma Liyuan Tao Xiaoyuan Bao Xin Zhou Bingyan Wang Fei Li Siyi Lu Lin Tuo Siyan Zhan Zhipeng Zhang Wei Fu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 10 |
| 4 | Active catalysts based on cobalt oxide@cobalt/N-C nanocomposites for oxygen reduction reaction in alkaline solutions显示文摘 | Dekang Huang Yanping Luo Shaohui Li Bingyan Zhang Yan Shen Mingkui Wang | 2014 | Nano Research2014，7，7： | 8 |
| 5 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 6 | Maximum entropy based probabilistic load flow calculation for power system integrated with wind power generation显示文摘Distributed generation including wind turbine(WT) and photovoltaic panel increases very fast in recent years around the world, challenging the conventional way of probabilistic load flow(PLF) calculation. Reliable and efficient PLF method is required to take this chage into account.This paper studies the maximum entropy probabilistic density function reconstruction method based on cumulant arithmetic of linearized load flow formulation,and then develops a maximum entropy based PLF(MEPLF) calculation algorithm for power system integrated with wind power generation(WPG). Compared with traditional Gram–Charlier expansion based PLF(GC-PLF)calculation method, the proposed ME-PLF calculation algorithm can obtain more reliable and accurate probabilistic density functions(PDFs) of bus voltages and branch flows in various WT parameter scenarios. It can solve thelimitation of GC-PLF calculation method that mistakenly gains negative values in tail regions of PDFs. Linear dependence between active and reactive power injections of WPG can also be effectively considered by the modified cumulant calculation framework. Accuracy and efficiency of the proposed approach are validated with some test systems. Uncertainties yielded by the wind speed variations, WT locations, power factor fluctuations are considered. | Bingyan SUI Kai HOU Hongjie JIA Yunfei MU Xiaodan YU | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，5： | 8 |
| 7 | Effect of miniscalpel-needle on relieving the pain of myofascial pain syndrome: a systematic review显示文摘OBJECTIVE: To evaluate the effect and safety of miniscalpel-needle(MSN) on reducing the pain of myofascial pain syndrome(MPS).METHODS: We reviewed the available literatures inception up to February 2014 using Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure Database, Chinese Biomedical Database and Wanfang Database.RESULTS: Eight randomized controlled trials were finally identified. The main controls involved acupuncture, medications, injection, massage and cupping. We found that all of the studies agreed on the potential benefit of MSN as a strategy for MPS and the superiority compared to the controls, however,randomized methods applied in most of the trials could be criticized for their high or unclear risk of bias. Further research is also needed to clarify questions around the appropriate frequency and number of treatment sessions of MSN.CONCLUSION: This review shows that MSN might have the effect on MPS, even though there were some limitations in the studies included in the review. Studies with robust methodology are warranted to further test its pain-relieving effect on MPS. | Liu Tong Peng Yuanyuan Zhu Shipeng Chen Huan Li Fuyun Hong Peixin Cao Bingyan Peng Bo Fan Yifan Chen Yupei Zhang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 6 |
| 8 | Performance projections for ballistic carbon nanotube FinFET at circuit level显示文摘为碳 nanotube (CNT ) 的新奇三维的设备结构鳍地效果晶体管(FinFET ) 被建议并且评估。我们包括繁殖延期,全部的力量驱散,和精力延期产品(电子数据处理) 用三个表演度量标准在电路水平在一个 22-nm 节点与 Si FinFET 相比评估了 CNT FinFET 的潜力。与 Si FinFET 相比, CNT FinFET 处于在更高全部的功率驱散从它的几乎更大的当前的密度而且结果产生的速度和电子数据处理介绍明显的优点,特别在低阀值电压(V th = 1/3V dd ) 。在 V th 能有效地贡献漏电流和力量驱散的重要抑制,然后明显的优化处于速度与可接受的牺牲在 EDP 被获得。特别地,有优化阀值电压的 CNT FinFETs 能在低供应电压下面在 Si FinFETs 上提供约 50 次的一个电子数据处理优点(V dd = 0.4 V ) ,为 CNT 基于 FinFET 的集成电路建议大潜力。 | Panpan Zhang Chenguang Qiu Zhiyong Zhang Li Ding Bingyan Chen Lianmao Peng | 2016 | Nano Research2016，9，6： | 6 |
| 9 | Realization of low contact resistance close to theoretical limit in graphene transistors显示文摘认识到在 graphene 和金属电极之间的低接触抵抗为造高效的 graphene 设备仍然是著名挑战。在这个工作,我们试图在 graphene 晶体管减少接触抵抗并且进一步探索在 graphene 和金属接触之间的抵抗限制。在房间温度的 Pd/graphene 接触抵抗在 100 ?? 下面被减少 ? ?? 汣獡 ? 愢瀭畬 ? 汰獵?? 猯'T ￣慮潮慰瑲捩敬 ? 敤潣慲整 ? 湯吠佩猼'T 挠慬獳∽ ? 汰獵瀭畬 ? 资 ? ?? 渠湡景扩牥 ? 湥 'L 敬 ? 桴 ? ?捣獥晳汵椠瑮来慲楴湯漠 ? 桴 ? 楢慮祲挠浯潰楳整椠瑮 ? 慢瑴牥敩 ? 潴愠摤敲獳猠牴 ' 壮霊 `? 瑳 'L 汩瑩 ? 湡 ? 潬 ? 慣慰楣吗? | Hua Zhong Zhiyong Zhang Bingyan Chen Haitao Xu Dangming Yu Le Huang Lianmao Peng | 2015 | Nano Research2015，8，5： | 5 |
| 10 | Effect on glycemia in rats with type 2 diabetes induced by streptozotocin: low-frequency electro-pulse needling stimulated Weiwanxiashu(EX-B 3) and Zusanli(ST 36)显示文摘OBJECTIVE: To investigate the effect of low frequency electro-pulse acupuncture(EA) on blood glucose in rats with streptozotocin-induced type 2diabetes, and the possible mechanism underlying the action.METHODS: Rat models were established with high fat feeding and intraperitoneal injection of streptozotocin(STZ)(30 mg/kg). Rats with a random blood glucose > 16.7 mmol/L and blood glucose at 2 h-point of oral glucose tolerance test(OGTT) > 11.1 mmol/L were included as diabetic rats, and randomly divided into model group, EA Weiwanxiashu(EX-B 3) group, EA Zusanli(ST 36)group, glimepiride group, and EA non-acupoint group(n = 12). EA(2 Hz continuous wave, 2 m A,20 min/day, 6 days/week, 4 weeks) and intra-gastric administration of glimepiride were applied as interventions. With fasting blood glucose and OGTT tested at the end of the intervention, thestudy observed the patterns of hypoglycemic effects. For mechanism study, it observes hematoxylin and eosin staining and Masson staining of pancreas paraffin sections, protein expression of glucagon-like peptide 1 receptor(GLP-1R) in the pancreas and skeletal muscle, glucose transporter 4(GLUT4) protein expression in skeletal muscle membrane, to detect whether EA controls blood glucose via regulation of GLP-1R.RESULTS: EA Weiwanxiashu(EX-B 3) significantly increased model rats' pancreas GLP-1R, and GLUT4 of skeletal muscle membrane; the therapy significantly decreased model rats' skeletal muscle GLP-1R, restored pancreas morphology, and reduced fasting blood glucose and insulin resistance indices.CONCLUSION: EA Weiwanxiashu(EX-B 3) alone has significant effect on glycemia. EA Weiwanxiashu(EX-B 3) plus glimepiride further strengthen the effect. The regulation of the GLP-1R in pancreas and skeletal muscle might be mechanism underpinning the effect. | Cao Bingyan Li Rui Tian Huanhuan Ma Yanjia Hu Xiaogang Jia Ning Wang Yueying | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 4 |
| 11 | Preparation and characteristics of indium tin oxide (ITO) thin films at low temperature by r.f. magnetron sputtering显示文摘Low resistivity and highly transparent ITO conducting films for solar cell applications were fabricated at low temperature by r.f. magnetron sputtering. ITO films were deposited on glass and silicon substrate. Electrical, optical, structural and morphological properties of the ITO films were investigated in terms of the preparation conditions. The annealing treatment has improved the properties of the ITO films at different degree. The maximum transmittance of the obtained ITO films in the visible range is over 92%, and the low resistivity for the ITO films are about 3.85×10-4 Ω·cm at 80 ℃, 80 W after annealing. | REN Bingyan LIU Xiaoping WANG Minhua XU Ying | 2006 | Rare Metals2006，25，z1： | 4 |
| 12 | Dynamically measuring the holo-information of light fields in three-dimensional space using a periodic polarization-structured light显示文摘Spatially structured light field has attracted great attention due to its novel properties and application potential in numerous fields.Among them,the most striking one is the polarization-structured light,known as the vector beam.Here,using a periodic polarization-structured light,we propose a method to dynamically measure the holo-information of light fields,including the amplitude,phase,and polarization distributions,in three-dimensional(3D)space.The measurement system is composed of a Mach-Zender interferometer involving a liquid crystal polarized grating in the reference arm,which is simple,stable,and easy to operate.Featuring the single-shot measurement,this method supports observing the dynamic variation of object light fields.The accuracy,3D polarimetry,and dynamic observation of this method are validated by measuring a calibrated quarter-wave plate,a vector vortex beam,a Poincarébeam,and a stressed polymethyl methacrylate sample. | ShuXia Qi Sheng Liu Lei Han BingYan Wei Peng Li JinZhan Zhong XuYue Guo JianLin Zhao | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，6： | 3 |
| 13 | Effects of argon gas flow rate and guide shell on oxygen concentration in Czochralski silicon growth显示文摘φ 2 00 公里硅单身者晶体在φ 4 被种 50 公里 aCzochralski (CZ ) 的热地区炉子。由修改模式和氩流动的速度,有不同的氧集中的硅壁炉晶体被获得。通过数字模拟,氩气体流动的速度第一次被阴谋。实验结果被分析,有最低的氧集中的氩流动的最佳条件被获得。 | REN Bingyan ZHAO Long ZHAO Xiuling WANG Huixian CAO Zhongqian ZHU Huimin FU Hongbo | 2006 | Rare Metals2006，25，1： | 3 |
| 14 | Clinical features and predictors of remission in children under the age of 7 years with Graves’disease显示文摘Importance:Graves’disease(GD)is rare in children under the age of 7 years.Children with this disease exhibit greater thyrotoxicity at diagnosis and require a longer course of medical therapy,compared with pubertal and postpubertal children and adults.Objective:To investigate the clinical features and identify predictors of remission in children under the age of 7 years with GD.Methods:This retrospective study included 77 children who were diagnosed with GD under the age of 7 years and were treated in the Department of Endocrinology,Beijing Children’s Hospital from 2010 to 2018.Clinical manifestations,laboratory data,and follow-up records were collected for all patients.Children who achieved remission of treatment with methimazole were compared with those who had persistent disease to identify which variables were associated with remission;multiple logistic regression and Cox regression analyses were used to evaluate interactions among predictive variables.Results:Sixty-three boys and 14 girls were included;the median age at diagnosis was 4.2 years(interquartile range:3.2-5.3 years).Forty-six(56.7%)patients had no family history of thyroid disease,17 patients had family history of thyroid disease and 14 patients with unknown family history.Of the 77 patients,18(23.4%)patients achieved remission of treatment with methimazole and 59 patients did not;moreover,51(66.2%)had Graves’ophthalmopathy.Univariate analyses revealed no significant differences between the remission group and non-remission group in terms of age at diagnosis,sex,initial goiter size,or initial thyroid hormone concentration.However,there were a trend of correlation between the initial level of thyroid peroxidase antibody(TPOAb)and remission status(univariate analysis OR 1.002,P=0.038;multivariate analysis OR 1.004,P=0.019).Similar results were observed in univariate analysis of the initial thyrotropin receptor antibody(TRAb)level,but this association was not significant in multivariate analysis.Cox regression analyses revealed that children with high TRAb level required longer duration of remission,compared with low TRAb level(OR 0.950,95%CI 0.904-0.997,P=0.037).Interpretation:Initial TRAb level was an independent predictor of remission outcome in young children under the age of 7 years with GD.Initial TRAb level may predict the likelihood of remission in patients with young-age-of-onset GD. | Yi Gu Xuejun Liang Ming Liu Di Wu Wenjing Li Bingyan Cao Yuchuan Li Chang Su Jiajia Chen Chunxiu Gong | 2020 | Pediatric Investigation2020，4，3： | 3 |
| 15 | Hormonal changes throughout puberty in boys:an observational study on the treatment outcome of congenital hypogonadotropic hypogonadism显示文摘To the Editor:It is difficult to capture the exact time of initiation of puberty in normal children,such as when breasts in girls and testicles in boys begin to grow,especially in boys.As a result,research on the detailed patterns of physical development during puberty and the cut-off values and changes of hormones at the initiation of puberty and developmental maturation is rare.It is generally believed that hormonal changes during puberty are a direct result of the stimulating effect of luteinizing hormone(LH)on initiation of puberty;[1]thus,LH is widely accepted as an indicator to evaluate initiation of puberty.However,researchers have not yet reached an agreement on the cut-off value of LH,especially in boys. | Xiaoya Ren Yuanyuan Tian Guoshuang Feng Yi Wang Beibei Zhang Bingyan Cao Jiajia Chen Chunxiu Gong | 2022 | Chinese Medical Journal2022，，3： | 2 |
| 16 | QTL mapping of quality traits in peanut using whole-genome resequencing显示文摘Oil and protein content and fatty acid composition are quality traits in peanut.Elucidating the genetic mechanisms underlying these traits may help researchers to obtain improved cultivars by molecular breeding.Whole-genome resequencing of a recombinant inbred population of 318 lines was performed to construct a high-density linkage map and identify QTL for peanut quality.The map,containing 4561 bin markers,covered 2032 c M with a mean marker density of 0.45 c M.A total of 110 QTL for oil and protein content,and fatty acid composition were mapped on the 18 peanut chromosomes.The QTL q A05.1 was detected in four environments and showed a major phenotypic effect on the contents of oil,protein,and six fatty acids.The genomic region spanned by q A05.1,corresponding to a physical interval of approximately 1.5 Mb,contains two SNPs polymorphic between the parents that could cause missense mutations.The two SNP sites were employed as KASP markers and validated using lines with extremely high and low oil contents.These sites may be useful in the marker-assisted breeding of peanut cultivars with high oil contents. | Ziqi Sun Feiyan Qi Hua Liu Li Qin Jing Xu Lei Shi Zhongxin Zhang Lijuan Miao Bingyan Huang Wenzhao Dong Xiao Wang Mengdi Tian Jingjing Feng Ruifang Zhao Xinyou Zhang Zheng Zheng | 2022 | The Crop Journal2022，10，1： | 2 |
| 17 | Enhancing the perm selectivity of thin-film com- posite poly (vinyl alcohol) (PVA) Nano filtration membrane by incorporating poly (sodium p-styrene- suffocate) 显示文摘 | LIU Meihong ZHOU Choumou DONG Bingyan | 2014 | Journal of Membrane Science2014，463，17： | 1 |
| 18 | Generation of CD8^+ suppression T cells by protoscoleces of Echinococcus multilocularis in vitro显示文摘 | Kizaki T Ishige M Bingyan W | 1993 | Immunol1993，79，3： | 1 |
| 19 | Dispersion and rheological properties of ceramic suspensions using linear polyacrylate copolymers with carboxylic groups as superplasticizer 显示文摘 | JIANG Bingyan ZHOU Shoufa JI Hongguo | 2012 | Colloids Surf A Physicochem Eng Asp2012，396，7： | 1 |
| 20 | Catalytic ozonation of p-chlorobenzoic acid in aqueous solution using Fe-MCM-41 ascatalyst显示文摘 | Lan Bingyan Huang Ruihuan Li Laisheng | 2013 | Chemical Engineering Journal2013，219，： | 1 |
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