|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China:A nationwide retrospective study显示文摘Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorable prognosis,but a few patients will also develop complications.Children with severe symptoms will require hospitalization.However,the disease burden of children hospitalized with IM in China has been rarely described.In this study,we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from Jan 1st,2016 to Dec 31st,2020,and medical information such as gender,age,region,time of admission,length of stay and expenditure were extracted.There were 24,120 IM cases,which accounted for 0.42%(24,120/5,693,262)of all hospitalized cases during this period.The ratio of male to female was 1.48:1.Hospitalization for IM in the 4-6 years age group was the highest among inpatients of all age groups.Case numbers increased year by year between 2016 and 2020,and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year.Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients.The median length of stay was 8 days,and the median cost of hospitalization was 970.59 US dollars.This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China. | Mengjia Liu Xinyu Wang Linlin Zhang Guoshuang Feng Yueping Zeng Ran Wang Zhengde Xie | 2022 | Virologica Sinica2022，37，5： | 10 |
| 2 | A brief introduction to the FUTang Updating medical REcords(FUTURE)database显示文摘Introduction Futang Research Center of Pediatric Development(FRCPD),the first nonprofit social service organization engaging in pediatric research in China,was founded in May 2013.Until August 2021,FRCPD has 40 tertiary children’s hospitals,accounting for about 65.6%of all national public children’s hospitals,which was reported to be 61 in China Health Statistical Yearbook(2020).The hospitals are distributed in 30 provinces,autonomous regions,and municipalities(except for Tibet autonomous region),and most of them are in the capital of the province,forming a broad frontline representing the best quality of health care for the diagnosis and treatment of children’s disease in China.Based on the idea of sharing,FRCPD realized the exchange of experts,medical resources,research findings,educational events,preventive strategies,and management experiences among members.In the long run,FRCPD aims to continuously promote the quality of healthcare and medical service capability for children in China. | Xinyu Wang Yueping Zeng Jian Tian Hui Xu Fei Song Yongli Guo Xin Xu Guoshuang Feng Xin Ni | 2021 | Pediatric Investigation2021，5，3： | 6 |
| 3 | Characteristics and prognosis of embryonal rhabdomyosarcoma in children and adolescents:An analysis of 464 cases from the SEER database显示文摘Importance:As the most common subtype of pediatric rhabdomyosarcoma(RMS),the prognosis of embryonal RMS has rarely been investigated solely.Objective:To perform a population-based study to characterize the prognosis of embryonal RMS in children and adolescents.Methods:Demographic and clinical features were retrospectively evaluated in selected patients with embryonal RMS registered in the Surveillance,Epidemiology,and End Results(SEER)program from 1988 to 2016.Survival curves were compared using the log-rank test.A multivariate Cox proportional hazards model was developed to assess the impact of each factor on the overall survival.A nomogram was constructed based on the results of Cox regression model.Results:A total of 464 patients were included in the analysis,among which 64.6%were male and 70.2%were white patients.About 38.6%and 26.3%of the patients were at 1-4 years and 5-9 years,respectively.Cox analysis showed that patients at age group 5-9 years had the lowest risk of mortality(hazard ratio[HR],0.277;95%confidential interval[CI],0.123-0.620),compared with patients diagnosed at less than 1-year-old,and age group 1-4 years had the second-best prognosis.Patients having distant tumors had significantly higher mortality risk(HR,4.842;95%CI,2.804-8.362)than the patients with localized tumor.Compared with receiving no surgery or radiotherapy,receiving any combination of surgery and radiotherapy would lower the risk of mortality significantly(for surgery without radiotherapy:HR,0.418;for radiotherapy without surgery:HR,0.405;and for surgery plus radiotherapy:HR,0.410).Interpretation:Age,stage at diagnosis,and treatment received were found to be the most important predictors of the overall survival of pediatric embryonal RMS. | Xinyu Wang Jun Feng Zhe Li Xin Zhang Jun Chen Guoshuang Feng | 2020 | Pediatric Investigation2020，4，4： | 3 |
| 4 | Lack of correlation between aristolochic acid exposure and hepatocellular carcinoma显示文摘Besides upper tract urothelial cell carcinoma(UTUCs),a recent study published in Science Translational Medicine has indicated that liver cancer may be associated with the exposure of aristolochic acids and similar derivatives(collectively,AA).However,according to our research,this study needs more number of samples for further verification which should be sampled from a wider range of people. | Xiangjun Ji Guoshuang Feng Geng Chen Tieliu Shi | 2018 | Science China(Life Sciences)2018，61，6： | 3 |
| 5 | Pediatric cancer surveillance in China:A hospital-based introduction显示文摘Background In recent years,increasing numbers of families have been affected by childhood cancer.According to data from the International Agency for Research on Cancer(IARC)of the World Health Organization,approximately 279000 new cases of cancer were predicted in children and adolescents aged 0–19 years worldwide in 2020.The global incidence of childhood cancer is 10.9 per 100000(global standard rate)and the mortality rate is 4.2 per 100000.1 According to data from the China National Cancer Center,the incidences of cancer in 2017 were 9.9 per 100000 in children aged 0–14 years and 11.5 per 100000 in adolescents aged 15–19 years.2 There are estimated to be approximately 22000 new cases of childhood cancer in China each year,and the incidence of malignant tumors in children aged 0–14 years has increased by 2.5%annually in the past decade. | Zhe Li Rongshou Zheng Xin Xu Yuanhu Liu Chenguang Jia Guoshuang Feng Xiao Zhang Xinping Li Guoliang Bai Xin Ni | 2021 | Pediatric Investigation2021，5，2： | 3 |
| 6 | Hormonal changes throughout puberty in boys:an observational study on the treatment outcome of congenital hypogonadotropic hypogonadism显示文摘To the Editor:It is difficult to capture the exact time of initiation of puberty in normal children,such as when breasts in girls and testicles in boys begin to grow,especially in boys.As a result,research on the detailed patterns of physical development during puberty and the cut-off values and changes of hormones at the initiation of puberty and developmental maturation is rare.It is generally believed that hormonal changes during puberty are a direct result of the stimulating effect of luteinizing hormone(LH)on initiation of puberty;[1]thus,LH is widely accepted as an indicator to evaluate initiation of puberty.However,researchers have not yet reached an agreement on the cut-off value of LH,especially in boys. | Xiaoya Ren Yuanyuan Tian Guoshuang Feng Yi Wang Beibei Zhang Bingyan Cao Jiajia Chen Chunxiu Gong | 2022 | Chinese Medical Journal2022，，3： | 2 |
| 7 | Common Statistical Methods and Reporting of Results in Medical Research显示文摘Statistical analysis is critical in medical research.The objective of this article is to summarize the appropriate use and reporting of commonly used statistical methods in medical research,on the basis of existing statistical guidelines and the authors’experience in reviewing manuscripts,to provide recommendations for statistical applications and reporting. | Guoshuang Feng Guoyou Qin Tao Zhang Zheng Chen Yang Zhao | 2022 | Cardiovascular Innovations and Applications2022，，1： | 1 |
| 8 | Pericryptal Fibroblast Sheath in Intestinal Metaplasia,Dysplasia and Carcinoma of the Stomach显示文摘在正常胃的 mucosa 调查 pericryptal 成纤维细胞鞘( PCFS )的存在的目的,肠的组织变形( IM ),为发育异常( I-Dys )不定,低等级发育异常( L-Dys ),高等级发育异常( H-Dys )和胃的癌症( GC ),并且它有胃的 carcinogenesis 的协会。在这的方法学习,我们在正常检验了 PCFS 的存在胃的 mucosa ( N=10 ), IM ( N=26 ), I-Dys ( N=16 ), L-Dys ( N=13 ), H-Dys ( N=21 )和用免疫的 GC ( N=145 )为二个光滑的肌肉标记的组织化学的染色,高山哈光滑的肌肉肌动朊( α-SMA )和高分子的重量 caldesmon ( hCD )。PCFS 的意义被讨论,特别与胃的 carcinogenesis 联合。结果 PCFS 在 65.4% 被认出(17/26 ) IM, 62.5%(10/16 ) I-Dys 并且 23.1%(3/13 ) L-Dys 分别地。没有 PCFS 在 H-Dys 和 GC 被检测。PCFS 逐渐地在顺序(P<0.0001 ) 在 IM, Dys 和 GC 被减少。PCFS 与上皮的区别被联系并且经由上皮间充质的相互作用在胃的 carcinogenesis 包含了的结论。 | Lu-ying Liu Yu Sun Zhong-wu Li Guoshuang Feng Wei-cheng You Ji-you Li | 2009 | Chinese Journal of Cancer Research2009，21，4： | 1 |
| 9 | Different Percentile Regression of Blood Glucose Among Adolescents Aged 12−20-United States,1999−2018显示文摘What is already known on this topic?The incidence of diabetes is on the rise in the world,and it is increasingly affecting young people.The American Diabetes Association(ADA)has published the 2020 Diabetes Medical Standard,but there is no blood glucose standard for teenagers by age and sex.What is added by this report?In this study,quantile regression was used to analyze the data of National Health and Nutrition Examination Survey(NHANES)and found that blood glucose varied significantly based on demographics.What are the implications for public health practice?This study provides reference for formulating the normal ranges of adolescent blood glucose and helping to screen out high-risk groups at an early stage for key interventions.The quantile regression method can give a set of curves,which could better describe the situation. | Yuehua Hu Junting Liu Hongyan Yao Dapeng Yin Jian Zhang Guoshuang Feng | 2021 | China CDC weekly2021，3，3： | 0 |
| 10 | Clinical epidemiology and disease burden of adenoviral encephalitis in hospitalized children in China:A nationwide cross-sectional study显示文摘Importance:Adenovirus encephalitis is a significant infectious disease of the central nervous system that commonly affects children under the age of 5 and has a profound impact on the health of infants and young children throughout China.National multicenter epidemiological studies have significant public health implications.Objective:This study aims to report the epidemiology of adenovirus encephalitis in hospitalized children in China,providing valuable guidance for clinicians.Methods:The data utilized in this study were extracted from the comprehensive Futang Update Medical Records database,which comprises discharge medical records collected by 27 tertiary children’s hospitals between January 2016 and December 2018 in China.Specifically,the face sheet of discharge medical records encompassed critical sociodemographic variables and basic medical care details.Results:In this database,a total of 544 children were hospitalized due to adenoviral encephalitis.The male-to-female ratio was 1.62:1,with more boys being affected across different age groups and places of residence.Of the children hospitalized,the highest number of hospitalizations occurred in the 1–3-year age group and the number of hospitalizations decreased each year from 2016 to 2018.The disease exhibits seasonal characteristics with a pronounced peak in the summer months of June and July.While most children(58%)did not have any significant complications,one-third of them developed respiratory complications,including pneumonia and acute bronchitis.The median length of stay for adenoviral encephalitis was 7 days,and the median cost of hospitalization was 2145.56 US dollars.Interpretation:This study highlights the prevalence of adenovirus encephalitis in hospitalized children in China.Children aged 1–3 years were found to be the main demographic hospitalized due to this condition,with boys being significantly more affected than girls.The seasonal variations of adenovirus encephalitis were also found to be significant.Fortunately,the fatality rate associated with this condition was low,and the prognosis was generally favorable. | Jiao Tian Xinyu Wang Linlin Zhang Qi Li Guoshuang Feng Yueping Zeng Ran Wang Zhengde Xie | 2023 | Pediatric Investigation2023，7，4： | 0 |
| 11 | POvaStim:An online tool for directing individualized FSH doses in ovarian stimulation显示文摘Individualized controlled ovarian stimulation(COS)is a milestone for treatment of infertility.^(1)The two acknowledged time points for individualized ovarian stim-ulation are,one,the beginning of each new treatment cycle when the starting dose is selected and,two,during a given COS cycle when dose adjustment is performed.A few algorithms for directing the follicle-stimulating hormone(FSH)dose have been developed.The number of oocytes retrieved(NOR)during ovarian stimulation was used as the outcome variable,and then the outcome variable and independent variables are stratified and a dose suggested by considering their experience. | Huiyu Xu Guoshuang Feng Yong Han Antonio La Marca Rong Li Jie Qiao | 2023 | The Innovation2023，4，2： | 0 |
| 12 | PCOSt:A non-invasive and cost-effective screening tool for polycystic ovary syndrome显示文摘Dear Editor,Polycystic ovary syndrome(PCOS)affects more than 1 in 10 women worldwide.^(1)Despite its high prevalence,PCOS and its accompanying morbidities are likely underdiagnosed.^(2)To induce a PCOS-like phenotype in animals,testosterone and dihydrotestosterone are usually used,indicating that androgen excess is a major contributor to PCOS.^(3)Anti-M€ullerian hormone(AMH)is an upstream regulator of androgen and is well correlated with the androgens. | Huiyu Xu Guoshuang Feng Li Shi Yong Han Qin Huang Rong Li | 2023 | The Innovation2023，4，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员