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| 1 | Negundoside,an irridiod glycoside from leaves of Vitex negundo,protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride显示文摘AIM:To evaluate the protective effect of 2'-p-hydroxy benzoylmussaenosidic acid [negundoside(NG) ,against carbon tetrachloride(CCl4) -induced toxicity in HuH-7 cells. METHODS:CCl4 is a well characterized hepatotoxin,and inducer of cytochrome P450 2E1(CYP2E1) -mediated oxidative stress. In addition,lipid peroxidation and accumulation of intracellular calcium are important steps in the pathway involved in CCl4 toxicity. Liver cells(HuH-7) were treated with CCl4,and the mechanism of the cytoprotective effect of NG was assessed. Silymarin,a known hepatoprotective drug,was used as control. RESULTS:NG protected HuH-7 cells against CCl4 toxicity and loss of viability without modulating CYP2E1 activity. Prevention of CCl4 toxicity was associated with a reduction in oxidative damage as reflected by decreased generation of reactive oxygen species(ROS) ,a decrease in lipid peroxidation and accumulation of intracellular Ca2+ levels and maintenance of intracellular glutathione homeostasis. Decreased mitochondrial membranepotential(MMP) ,induction of caspases mediated DNA fragmentation and cell cycle arrest,as a result of CCl4 treatment,were also blocked by NG. The protection afforded by NG seemed to be mediated by activation of cyclic adenosine monophosphate(cAMP) synthesis and inhibition of phospholipases(cPLA2) . CONCLUSION:NG exerts a protective effect on CYP2E1-dependent CCl4 toxicity via inhibition of lipid peroxidation,followed by an improved intracellular calcium homeostasis and inhibition of Ca2+-dependent proteases. | Sheikh A Tasduq Peerzada J Kaiser Bishan D Gupta Vijay K Gupta Rakesh K Johri | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 2 | MBA:A market-based approach to data allocation and dynamic migration for cloud database显示文摘With the coming shift to cloud computing,cloud database is emerging to provide database service over the Internet.In the cloud-based environment,data are distributed at Internet scale and the system needs to handle a huge number of user queries simultaneously without delay.How data are distributed among the servers has a crucial impact on the query load distribution and the system response time.In this paper,we propose a market-based control method,called MBA,to achieve query load balance via reasonable data distribution.In MBA,database nodes are treated as traders in a market,and certain market rules are used to intelligently decide data allocation and migration.We built a prototype system and conducted extensive experiments.Experimental results show that the MBA method significantly improves system performance in terms of average query response time and fairness. | WANG TengJiao LIN ZiYu YANG BiShan GAO Jun HUANG Allena YANG DongQing ZHANG Qi TANG ShiWei NIU JinZhong | 2012 | Science China(Information Sciences)2012，55，9： | 2 |
| 3 | Impaired mitochondrial energy metabolism and neuronal apoptotic cell death after chronic dichlorvos (OP) exposure in rat brain显示文摘 | Pushpinder Kaur Bishan Radotra Ranjana W. Minz K.D. Gill | 2007 | Neurotoxicology2007，，6： | 1 |
| 4 | An iterative criterion for H-Matrices显示文摘 | Li Bishan | 1998 | Linear Algebra and Its Applications1998，，1： | 1 |
| 5 | An Iterative Criterion for H-Matrices显示文摘 | Li Bishan Li Lei | 1998 | Linear Algebra Appl1998，271，： | 1 |
| 6 | Doubly diagonally dominant matrices显示文摘 | Li Bishan Tsatsomeros M J | 1997 | Linear Algebra Appl1997，261，： | 1 |
| 7 | A Canadian multicenter,double-blind study of paroxetine and flu- oxetine in major depressive disorder显示文摘 | Guy Chouinarda Bishan Saxenab Marie-Claire Be'langera | 1999 | Journal of Affective Dis- orders1999，54，12： | 1 |
| 8 | Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines显示文摘 | Anjali Pandey Sarang Bani Naresh Satti Bishan Gupta Krishan Suri | 2012 | Inflammation Research2012，，4： | 1 |
| 9 | Doubly diagonally dominant matrices 显示文摘 | Bishan Li Tsatsomeros M J | 1997 | Linear Algebra Appl1997，261，： | 1 |
| 10 | Evaluation of the Test-mate ChE (Cholinesterase) Field Kit in Acute Organophosphorus Poisoning显示文摘 | Bishan N. Rajapakse Horst Thiermann Peter Eyer Franz Worek Steven J. Bowe Andrew H. Dawson Nicholas A. Buckley | 2011 | Annals of Emergency Medicine2011，，6： | 1 |
| 11 | Doubly Diagonally Dominant Matrices显示文摘 | Li Bishan Tsatsomeros M J | 1997 | Linear Algebra and Its Applications1997，261，123： | 1 |
| 12 | An iterative criterion for H-matrices显示文摘 | Lei Li Masunori Harada | 1998 | Linear Algebra and Its Applications1998，271，： | 1 |
| 13 | Impaired mitochondrial energy metabolism and neuronal apoptotic cell death after chronic dichlorvos exposure in rat brain 显示文摘 | Pushinder K Bishan R Ranjana W M | 2007 | Neurotoxicology2007，28，12： | 1 |
| 14 | Double diagonally dominant matrices显示文摘 | Li Bishan Tsatsonmeros M J | 1997 | Linear Algrbra Appl1997，261，13： | 1 |
| 15 | Impaired mitochondrial energy metabolism and neuronal apoptotic cell death after chronic dichlorvos exposure in rat brain显示文摘 | PUSHINDER K BISHAN R RANJANA W M | 2007 | Neurotoxicology2007，28，12： | 1 |
| 16 | Robust H∞ Fuzzy Output-feedback Control With Both General Multiple Probabilistic Delays and Multiple Missing Measurements and Random Missing Control显示文摘 | Bishan Zhang Zhongjun Ma Meixiang Yang | 2017 | 自动化学报2017，43，9： | 0 |
| 17 | Glutamine metabolic microenvironment drives M2 macrophage polarization tomediate trastuzumab resistance in HER2-positive gastric cancer显示文摘Background:Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2(HER2)-positive gastric cancer.However,the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit,and there is currently no effective reversal measure.Existing researches on the mechanism of trastuzumab resistance mainly focused on tumor cells themselves,while the understanding of the mechanisms of environment-mediated drug resistance is relatively lacking.This study aimed to further explore the mechanisms of trastuzumab resistance to identify strategies to promote survival in these patients.Methods:Trastuzumab-sensitive and trastuzumab-resistant HER2-positive tumor tissues and cells were collected for transcriptome sequencing.Bioinformatics were used to analyze cell subtypes,metabolic pathways,and molecular signaling pathways.Changes in microenvironmental indicators(such as macrophage,angiogenesis,and metabolism)were verified by immunofluorescence(IF)and immunohistochemical(IHC)analyses.Finally,a multi-scale agent-based model(ABM)was constructed.The effects of combination treatment were further validated in nude mice to verify these effects predicted by the ABM.Results:Based on transcriptome sequencing,molecular biology,and in vivo experiments,we found that the level of glutamine metabolism in trastuzumabresistant HER2-positive cells was increased,and glutaminase 1(GLS1)was significantly overexpressed.Meanwhile,tumor-derived GLS1 microvesicles drove M2macrophage polarization.Furthermore,angiogenesis promoted trastuzumab resistance.IHC showed high glutamine metabolism,M2 macrophage polarization,and angiogenesis in trastuzumab-resistant HER2-positive tumor tissues from patients and nudemice.Mechanistically,the cell division cycle 42(CDC42)promoted GLS1 expression in tumor cells by activating nuclear factor kappa-B(NF-κB)p65 and drove GLS1microvesicle secretion through IQmotif-containing GTPase-activating protein 1(IQGAP1).Based on the ABM and in vivo experiments,we confirmed that the combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy had the best effect in reversing trastuzumab resistance in HER2-positive gastric cancer.Conclusions:This study revealed that tumor cells secrete GLS1 microvesicles via CDC42 to promote glutamine metabolism,M2 macrophage polarization,and pro-angiogenic function of macrophages,leading to acquired trastuzumab resistance in HER2-positive gastric cancer.A combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy may provide a new insight into reversing trastuzumab resistance. | Xingbin Hu Zhenfeng Ma Beibei Xu Shulong Li Zhiqi Yao Bishan Liang Jiao Wang Wangjun Liao Li Lin Chunling Wang Siting Zheng Qijing Wu Qiong Huang Le Yu Fenghua Wang Min Shi | 2023 | Cancer Communications2023，43，8： | 0 |
| 18 | Surgical Cooperation during Implantation of a Boston type-Ⅰ Keratoprosthesis显示文摘This study was designed to summarize the key points of surgical cooperation involving penetrating corneal transplantation combined with implantation of keratoprosthesis. Preoperative preparation and intraoperative procedures were fully implemented to ensure cooperation with the physicians,.to observe the the severity of the disease, and to guarantee the success of the surgery. | Bishan Tian Sufen Lu Hairong Zhang Feipeng Wang Jiaqi Chen Jiajie Zhai Lijin Su | 2014 | Eye Science2014，29，4： | 0 |
| 19 | Molecular basis and mechanism of action of Albizia julibrissin in depression treatment and clinical application of its formulae显示文摘Albizzia julibrissin is empirically used as an antidepressant in clinical practice.Preclinical studies have indicated that its total extracts or bioactive constituents exerted antidepressant-like responses in animal models,providing the molecular basis to reveal its underlying mechanism of action.While attempts have been made to understand the antidepressant effect of A.julibrissin,many fundamental questions regarding its mechanism of action remain to be addressed at the molecular and systems levels.In this review,we conclusively discussed the mechanism of action of A.julibrissin and A.julibrissin formulae by reviewing recent preclinical and clinical studies conducted by using depressive animal models and depressive patients.Several representative bioactive constituents and formulae were highlighted as examples,and their mechanisms of action were discussed.In addition,some representative A.julibrissin formulae that have been shown to be compatible with conventional antidepressants in clinical practice were also reviewed.Furthermore,we discussed the future research directions to reveal the underlying mechanism of A.julibrissin at the molecular and systems levels in depression treatment.The integrated study using both the molecular and systematic approaches is required not only for improving our understanding of its molecular basis and mechanisms of action,but also for providing a way to discover novel agents or approaches for the effective and systematic treatment of depression. | Bishan Huang Yingyao Wu Chan Li Qingfa Tang Yuanwei Zhang | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
| 20 | Giant pyogenic granuloma on the glans penis显示文摘A middle aged uncircumcised man presented with a painless growth on the glans penis which started 6 months back as a pinhead sized papule and rapidly progressed in size.The patient reported occasional bleeding from the lesion on minimal trauma.The patient was unable to perform sexual intercourse owing to the size of lesion and concern of bleeding.The patient was in monogamous relationship with his wife and denied any high risk sexual behaviour.On examination,there was a non-tender,oval,dark red,smooth,shiny,exophytic pedunculated growth of size 2.5 cm2 cm0.5 cm on the glans with a small but broad pedicle at the base of the lesion(Fig.1).Histopathological examination of the mucosal biopsy from the lesion revealed lobular proliferation of capillaries with thinned out epithelium(Fig.2).The diagnosis of penile pyogenic granuloma(PG)was reached on the basis of above findings.The lesion was referred to urology services and the lesion was surgically excised. | Sheetanshu Kumar Tarun Narang Bishan Dass Radotra Dipankar De | 2020 | Asian Journal of Urology2020，7，4： | 0 |
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