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| 1 | Methane and nitrous oxide concentration and emission flux of Yangtze Delta plain river net显示文摘Methane (CH4) and nitrous oxide (N2O) saturation concentration and gas-water interface emission flux in surface water of the Yangtze Delta plain river net were investigated in summer at representative sites including the upper reaches of the Huangpu River and the rivers in the Chongming Island. The results show that the CH4 concentration in river water ranged from 0.30±0.03 to 6.66±0.14 μmol.L-1, and N2O concentration ranged from 13.8±2.33 to 435±116 nmol.L-1. River surface water had a very high satura- tion level of CH4 (from 468±49.0% to 11560±235%) and that of N2O (from 175±29.5% to 4914±1304%). Dissolved oxygen (DO) was the primary factor controlling the CH4 concentration in water. N2O concentration had significant negative correlation with salinity and a significant positive correlation with nitrate (NO3-), nitrite (NO2-), chemical oxygen demand (CODcr) concentration and pH of river water. CH4 and N2O of river water were brought about mainly by methanogenesis and denitrification in river bottom sediment that diffused through sediment-water interface into the water body and then into atmosphere through the gas-water interface. The emission flux of CH4 and N2O at river gas-water interface reached 778±59.8 and 236±63.6 μmol.m-2.h-1, respectively in summer. The river net was a potential source of atmospheric CH4 and N2O because of eutrophication of the water body. | WANG DongQi CHEN ZhenLou SUN WeiWei HU BeiBei XU ShiYuan | 2009 | Science China Chemistry2009，52，5： | 19 |
| 2 | Photonic circuits written by femtosecond laser in glass:improved fabrication and recent progress in photonic devices显示文摘Integrated photonics is attracting considerable attention and has found many applications in both classical and quantum optics,fulfilling the requirements for the ever-growing complexity in modern optical experiments and big data communication.Femtosecond(fs)laser direct writing(FLDW)is an acknowledged technique for producing waveguides(WGs)in transparent glass that have been used to construct complex integrated photonic devices.FLDW possesses unique features,such as three-dimensional fabrication geometry,rapid prototyping,and single step fabrication,which are important for integrated communication devices and quantum photonic and astrophotonic technologies.To fully take advantage of FLDW,considerable efforts have been made to produce WGs over a large depth with low propagation loss,coupling loss,bend loss,and highly symmetrical mode field.We summarize the improved techniques as well as the mechanisms for writing high-performance WGs with controllable morphology of cross-section,highly symmetrical mode field,low loss,and high processing uniformity and efficiency,and discuss the recent progress of WGs in photonic integrated devices for communication,topological physics,quantum information processing,and astrophotonics.Prospective challenges and future research directions in this field are also pointed out. | Dezhi Tan Zhuo Wang Beibei Xu Jianrong Qiu | 2021 | Advanced Photonics2021，3，2： | 19 |
| 3 | Spectral tomographic imaging with aplanatic metalens显示文摘Tomography is an informative imaging modality that is usually implemented by mechanical scanning,owing to the limited depth-of-field(DOF)in conventional systems.However,recent imaging systems are working towards more compact and stable architectures;therefore,developing nonmotion tomography is highly desirable.Here,we propose a metalens-based spectral imaging system with an aplanatic GaN metalens(NA=0.78),in which large chromatic dispersion is used to access spectral focus tuning and optical zooming in the visible spectrum.After the function of wavelength-switched tomography was confirmed on cascaded samples,this aplanatic metalens is utilized to image microscopic frog egg cells and shows excellent tomographic images with distinct DOF features of the cell membrane and nucleus.Our approach makes good use of the large diffractive dispersion of the metalens and develops a new imaging technique that advances recent informative optical devices. | Chen Chen Wange Song Jia-Wern Chen Jung-Hsi Wang Yu Han Chen Beibei Xu Mu-Ku Chen Hanmeng Li Bin Fang Ji Chen Hsin Yu Kuo Shuming Wang Din Ping Tsai Shining Zhu Tao Li | 2019 | Light(Science & Applications)2019，8，1： | 12 |
| 4 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘POU 抄写因素 OCT4 不仅在维持 pluripotent 和房间而且幕作为通过基因剂量的一个房间命运决定因素完成的胚胎的茎(ES ) 的自我更新的状态起一个必要作用。然而,控制细胞内部的 OCT4 蛋白质水平的分子的机制留下逃犯。这里,我们报导那人的 WWP2, E3 ubiquitin (Ub ) 蛋白质 ligase,通过它的 WW 领域明确地与 OCT4 交往并且在 vitro 并且在 vivo 提高 OCT4 的 Ub 修正。我们首先证明在人的 ES 房间的内长的 OCT4 能被 Ub post-translationally 修改。而且,我们发现 WWP2 以一种剂量依赖者方式,和 WWP2 的活跃地点半胱氨酸残余通过 26S proteasome 支持了 OCT4 的降级在 OCT4 上为它的酶的活动和解朊的效果被要求。显著地,我们当 WWP2 表示是由特定的 RNA 干扰(RNAi ) 的 downregulated 时,内长的 OCT4 蛋白质水平显著地被提高的数据表演,建议那 WWP2 是为在人的 ES 房间维持合适的 OCT4 蛋白质水平的一个重要管理者。而且,北污点分析证明 WWP2 抄本在多样的人的织物 / 器官是广泛地在场的并且高度在无差别的人的 ES 房间表示了。然而,它的表示水平快速在区分的人的 ES 房间以后被减少,显示 WWP2 表示力量发展地被调整。我们的调查结果证明 WWP2 是在人的 ES 房间的 OCT4 蛋白质水平的一个重要管理者。 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，5： | 8 |
| 5 | sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator显示文摘Objective: Mucin 1(MUC1/EMA) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe^(x) and to assess their diagnostic and prognostic value in patients with IMPC.Methods: The expression of sLe^(x) and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence analysis.Results: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/EMA in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/EMA, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/EMA-expression patterns, and 8 patients had sLe^(x)-/EMA+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/EMA and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS cells.Conclusions: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnostic indicator to avoid missed IMPC diagnosis. | Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang Feng Gu Yongjie Ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu | 2021 | Cancer Biology & Medicine2021，18，2： | 7 |
| 6 | Metalens-integrated compact imaging devices for wide-field microscopy显示文摘Metasurfaces have demonstrated unprecedented capabilities in manipulating light with ultrathin and flat architectures.Although great progress has been made in the metasurface designs and function demonstrations,most metalenses still only work as a substitution of conventional lenses in optical settings,whose integration advantage is rarely manifested.We propose a highly integrated imaging device with silicon metalenses directly mounted on a complementary metal oxide semiconductor image sensor,whose working distance is in hundreds of micrometers.The imaging performances including resolution,signal-to-noise ratio,and field of view(FOV)are investigated.Moreover,we develop a metalens array with polarization-multiplexed dual-phase design for a wide-field microscopic imaging.This approach remarkably expands the FOV without reducing the resolution,which promises a non-limited space-bandwidth product imaging for wide-field microscopy.As a result,we demonstrate a centimeter-scale prototype for microscopic imaging,showing uniqueness of meta-design for compact integration. | Beibei Xu Hanmeng Li Shenglun Gao Xia Hu Cheng Yang Chen Chen Feng Yan Shining Zhu Tao Li | 2020 | Advanced Photonics2020，2，6： | 6 |
| 7 | Plasmonic biosensors and nanoprobes based on gold nanoshells显示文摘Gold nanoshells (GNSs), consisting of a dielectric core coated with gold, have gained extensive attention as they show readily tunable optical properties and good biocompatibility. As highly sensitive and label-free optical biosensors with wide applications, GNSs have been investigated in many fields including drug delivery, immunoassay, cancer treatment, biological sensing and imaging. Taking advantage of the adjustability of the local surface plasmon resonance (LSPR) and the sensitivity of the surfaceenhanced Raman scattering (SERS) signal of GNSs, we have developed diverse applications including plasmonic biosensors and nanoprobes based on GNSs. In this review we introduce plasmonic and electromagnetic properties and fabrication methods of GNSs. We describe research progress in recent years, and highlight several applications of GNSs developed by our group. Finally we provide a brief assessment of future development of GNSs as plasmonic materials that can be integrated with complementary analytical techniques. | XU BeiBei MA XiaoYuan RAO YanYing DONG Jian QIAN WeiPing | 2011 | Chinese Science Bulletin2011，56，31： | 6 |
| 8 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020，13，1： | 5 |
| 9 | Cluster-formula-embedded machine learning for design of multicomponent β-Ti alloys with low Young’s modulus显示文摘The present work formulated a materials design approach,a cluster-formula-embedded machine learning(ML)model,to search for body-centered-cubic(BCC)β-Ti alloys with low Young’s modulus(E)in the Ti–Mo–Nb–Zr–Sn–Ta system.The characteristic parameters,including the Mo equivalence and the cluster-formula approach,are implemented into the ML to ensure the accuracy of prediction,in which the former parameter represents the BCC-βstructural stability,and the latter reflects the interactions among elements expressed with a composition formula.Both auxiliary gradient-boosting regression tree and genetic algorithm methods were adopted to deal with the optimization problem in the ML model. | Fei Yang Zhen Li Qing Wang Beibei Jiang Biaojie Yan Pengcheng Zhang Wei Xu Chuang Dong Peter K.Liaw | 2020 | npj Computational Materials2020，，1： | 5 |
| 10 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 11 | Sulfonated carbon catalyzed oxidation of aldehydes to carboxylic acids by hydrogen peroxide显示文摘Sulfonated carbon as a strong and stable solid acid catalyst exhibited excellent catalytic performance in various acid-catalyzed reactions. Here, sulfonated carbon, as catalyst for oxidation reaction, was prepared via the carbonization of starch followed by sulfonation with concentrated sulfuric acid. N2 physisorption, X-ray diffraction, Fourier transform infrared spectroscopy, X-ray fluorescence and acid-base titration were used to characterize the obtained materials. The catalytic activity of sulfonated carbon was studied in the oxidation of aldehydes to carboxylic acids using 30 wt% H2O2 as oxidant. This oxidation protocol works well for various aldehydes including aromatic and aliphatic aldehydes. The sulfonated carbon can be recycled for three times without obvious loss of activity. | Lipeng Zhou Beibei Dong Si Tang Hong Ma Chen Chen Jie Xu Xiaomei Yang Jie Xu | 2013 | Journal of Energy Chemistry2013，22，4： | 4 |
| 12 | Synthesis of high-purity silver nanorods with tunable plasmonic properties and sensor behavior显示文摘Through anisotropic Ag overgrowth on the surface of Au nanobipyramids(Au NBPs), high-purity and sizecontrolled Ag nanorods(Au/Ag NRs) are obtained by a simplified purification process. The diameters of the Au/Ag NRs are determined by the size of the as-prepared Au NBPs, and the lengths of the Au/Ag NRs are tunable using different amounts of Ag precursor in the growth solution. Surface-enhanced Raman scattering(SERS) studies using Rhodamine-6G(R6G) as a test molecule indicate that the Au/Ag NRs have excellent sensing potential. The tunable optical properties and strong electromagnetic effect of the Au/Ag NRs, along with their superior SERS signal enhancement, show that Au/Ag NRs are promising for further applications in plasmon sensing and biomolecular detection. | Haiying Xu Caixia Kan Changzong Miao Changshun Wang Jingjing Wei Yuan Ni Beibei Lu Daning Shi | 2017 | Photonics Research2017，5，1： | 4 |
| 13 | In-situ surface decoration of RuO_(2) nanoparticles by laser ablation for improved oxygen evolution reaction activity in both acid and alkali solutions显示文摘Improving the OER activity of noble metal-based materials is of profound importance to minimize the usage of noble metals and lower the cost.Here,we report considerable improvement on the catalytic activity of RuO_(2) particles for OER in both alkali and acid environments.The RuO_(2) nanoparticles were treated with a method of pulse laser ablation.Numerous Ru and RuO_(2) clusters were generated at the surface of RuO_(2) nanoparticles after the laser ablation,forming a lychee-shaped morphology.The larger pulse energy RuO_(2) nanoparticles are treated with,the better the OER activity can be.DFT calculations shows that the surface tension induced by the lychee-shaped morphology benefits the OER performance.Our best sample gives an overpotential of 172 mV(at 10 mA cm^(-2))and a Tafel slope of 53.5 mV dec^(-1) in KOH,while an overpotential of 219 mV and a Tafel slope of 44.9 mV dec^(-1) in H_(2)SO_(4),which are of topclass results.This work may inspire a new way to develop high-performance electrocatalysts for OER. | Zongpeng Wang Beibei Xiao Zhiping Lin Shijie Shen Aijiao Xu Zexin Du Yuchao Chen Wenwu Zhong | 2021 | Journal of Energy Chemistry2021，30，3： | 4 |
| 14 | TAA family contributes to auxin production during de novo regeneration of adventitious roots from Arabidopsis leaf explants显示文摘Many differentiated plant organs have the ability to regenerate into a new plant after detachment via de novo organogenesis. During de novo root organogenesis from Arabidopsis thaliana leaf explants, wounding first induces endogenous auxin production in mesophyll cells. Auxin is then polar transported to, and accumulates in, regenerationcompetent cells near the wound to trigger the cell-fate transition. The TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS(TAA) family proteins and the YUCCA(YUC) family proteins catalyze two successive biochemical steps in auxin biogenesis, and YUCs have been shown to be involved in auxin production in mesophyll cells during de novo root organogenesis. In thisstudy, we show that the TAA family is also required for adventitious rooting. Inhibition of TAA blocked adventitious root formation from leaf explants. Intriguingly,whereas YUC1 and YUC4 have been shown to be highly induced by wounding, TAA genes retained consistent expression levels before and after leaf detachment.Therefore, we suggest that TAAs and YUCs are both required for auxin biogenesis in leaf explants, but they play different roles in regeneration. While YUC1 and YUC4 function in response to wounding to catalyze the ratelimiting step in auxin biosynthesis, TAAs probably serve as abiding and basal enzymes during de novo root organogenesis from leaf explants. | Beibei Sun Lyuqin Chen Jingchun Liu Xuening Zhang Zhongnan Yang Wu Liu Lin Xu | 2016 | Science Bulletin2016，61，22： | 4 |
| 15 | Design of near-α Ti alloys via a cluster formula approach and their high-temperature oxidation resistance显示文摘The multi-component composition characteristics of high-temperature near-α Ti alloys were investigated in the present work by means of a cluster formula approach. The uniform cluster formula [CN12 cluster](glue atom)3 for the hexagonal close-packed α solid solution was first obtained based on the Friedel oscillation theory, with a total atom number in the formula of Z = 16. Then it was analyzed that the Z values in the cluster composition formulas of typical near-α Ti alloys are within the range of Z = 16.0016.30, being perfectly consistent with the ideal Z = 16. Based on it, a series of new alloys with Z = 16 and with Nb/Ta substitution for Mo in Ti1100 alloy were designed, suction-cast into φ 6 mm rods, and then heat-treated with solid solution and aging. It was found that the alloy with co-addition of Mo, Ta and Nb has a high strength and good ductility at both room and high temperatures. More importantly, the additions of Nb and Ta can contribute to the formation of continuous and compact Al2O3 scales, resulting in an obvious improvement of oxidation resistances at both 923 K and 1073 K. The effects of Mo, Ta and Nb on the oxidation behaviors of the designed alloys at 1073 K were further discussed. | Beibei Jiang Donghui Wen Qing Wang Jinda Che Chuang Dong Peter K. Liaw Fen Xu Lixian Sun | 2019 | Journal of Materials Science & Technology2019，35，6： | 4 |
| 16 | Self-organized phase-transition lithography for all-inorganic photonic textures显示文摘Realizing general processing applicable to various materials by one basic tool has long been considered a distant dream.Fortunately,ultrafast laser-matter interaction has emerged as a highly universal platform with unprecedented optical phenomena and provided implementation paths for advanced manufacturing with novel functionalities.Here,we report the establishment of a three-dimensional(3D)focal-area interference field actively induced by a single ultrafast laser in transparent dielectrics.Relying on this,we demonstrate a radically new approach of self-organized phase-transition lithography(SOPTL)to achieve super-resolution construction of embedded all-inorganic photonic textures with extremely high efficiency.The generated textures exhibit a tunable photonic bandgap(PBG)in a wide range from〜1.3 to〜2 pm.More complicated interlaced textures with adjustable structural features can be fabricated within a few seconds,which is not attainable with any other conventional techniques.Evidenee suggests that the SOPTL is extendable to more than one material system.This study augments light-matter interaction physics,offers a promising approach for constructing robust photonic devices,and opens up a new research direction in advaneed lithography. | Bo Zhang Dezhi Tan Zhuo Wang Xiaofeng Liu Beibei Xu Min Gu Limin Tong Jianrong Qiu | 2021 | Light(Science & Applications)2021，10，6： | 3 |
| 17 | Honeycomb-patterned films of polystyrene/poly(ethylene glycol): Preparation, surface aggregation and protein adsorption显示文摘Highly ordered honeycomb-patterned polystyrene (PS)/poly(ethylene glycol) (PEG) films were prepared by a water-assisted method using an improved setup, which facilitated the formation of films with higher regularity, better reproducibility, and larger area of honeycomb structures. Surface aggregation of hydrophilic PEG and adsorption of bovine serum albumin (BSA) on the honeycomb-patterned films were investigated. Field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) were used to observe the surface morphologies of the films before and after being rinsed with water. As confirmed by the FESEM images and the AFM phase images, PEG was enriched in the pores and could be gradually removed by water. The adsorption of fluorescence-labeled BSA on the films was studied in visual form using laser scanning confocal microscopy. Results clearly demonstrated that the protein-resistant PEG was selectively enriched in the pores. This water-assisted method may be a latent tool to prepare honeycomb-patterned biofunctional surfaces. | WAN LingShu KE BeiBei LI XiaoKai MENG XiangLin ZHANG LuYao XU ZhiKang | 2009 | Science China Chemistry2009，52，7： | 3 |
| 18 | Designing Textile Architectures for High Energy-Efficiency Human Body Sweat-and Cooling-Management显示文摘Thermal management of textiles requires local microclimate control over heat and wet dissipation to create a comfortable thermal-wet environment at the interface of the human body and clothing.Herein,we design a fabric capable of both sweat-and cooling-management using a knitted fabric featuring a bilayer structure consisting of hydrophobic polyethylene terephthalate and hydrophilic cellulose fibers to simultaneously achieve high infrared(IR)transmittance and good thermal-wet comfort.The IR transmission of this cooling textile increased by~twofold in the dry state and~eightfold in the wet state compared to conventional cotton fabric.When the porosity changes from 10 to 47%with the comparison of conventional cotton fabric and our cooling textile,the heat flux is increased from 74.4 to 152.3 W/cm^(2).The cooling effect of the cooling fabric is 105%greater than that of commercial cotton fabric,which displays a better thermal management capacity for personal cooling.This bilayer design controls fast moisture transfer from inside out and provides thermal management,demonstrating high impact not only for garments,but also for other systems requiring heat regulation,such as buildings,which could mitigate energy demand and ultimately contribute to the relief of global energy and climate issues. | Kun Fu Zhi Yang Yong Pei Yongxin Wang Beibei Xu YuHuang Wang Bao Yang Liangbing Hu | 2019 | Advanced Fiber Materials2019，1，1： | 3 |
| 19 | Light weight, mechanically strong and biocompatible α-chitin aerogels from different aqueous alkali hydroxide/urea solutions显示文摘Light weight and mechanically strong α-chitin aerogels were fabricated using the sol-gel/self-assembly method from α-chitin in different aqueous alkali hydroxide(KOH, Na OH and Li OH)/urea solutions. All of the α-chitin solutions exhibited temperature-induced rapid gelation behavior. 13 C nuclear magnetic resonance(NMR) spectra revealed that the aqueous alkali hydroxide/urea solutions are non-derivatizing solvents for α-chitin. Fourier transform infrared(FT-IR), X-ray diffraction(XRD) and cross-polarization magic angle spinning(CP/MAS) 13 C NMR confirmed that α-chitin has a stable aggregate structure after undergoing dissolution and regeneration. Subsequently, nanostructured α-chitin aerogels were fabricated by regeneration from the chitin solutions in ethanol and then freeze-drying from t-Bu OH. These α-chitin aerogels exhibited high porosity(87% to 94%), low density(0.09 to 0.19 g/cm^3), high specific surface area(419 to 535 m^2/g) and large pore volume(2.7 to 3.8 cm^3/g). Moreover, the α-chitin aerogels exhibited good mechanical properties under compression and tension models. In vitro studies showed that m BMSCs cultured on chitin hydrogels have good biocompatibility. These nanostructured α-chitin aerogels may be useful for various applications, such as catalyst supports, carbon aerogel precursors and biomedical materials. | Beibei Ding Dan Zhao Jianhui Song Huichang Gao Duoduo Xu Min Xu Xiaodong Cao Lina Zhang Jie Cai | 2016 | Science China Chemistry2016，59，11： | 2 |
| 20 | Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis显示文摘环境暗示和细胞内部的 bioenergetic 状态深刻地影响细胞内部的 pH (pHi ) 。一个房间怎么对 pHi 变化作出回应维持 bioenergetic 动态平衡,留下逃犯。这里,我们显示出那 Smad5,发信号的形态基因的蛋白质(BMP ) 回答到 pHi 的骨头的一个描绘得好的下游的部件变化。冷、基本或张力亢进的条件增加 pHi,它接着在 Smad5 的 MH1 域以内声言不赞成控告的氨基酸簇,推动它到细胞质的从原子核的重定位。在另一方面,加热,酸或张力减退的条件减少 pHi,堵住 Smad5 的原子出口,并且因此引起它的原子累积。环境变化和 pHi 变化导致的 Smad5 的活跃 nucleocytoplasmic shuttling 独立于 BMP 发信号, carboxyl 终点 phosphorylation 和 Smad4。另外, Smad5 的脱离引起在区别识别了的神经发展过程人的 pluripotent 干细胞建模的细胞的 bioenergetic 动态平衡和破坏正常的长期、不可逆的 dysregulation。重要地,在 Smad5 缺乏的房间的这些新陈代谢、发展的赤字能仅仅由细胞质的 Smad5 被救。细胞质的 Smad5 身体上与 hexokinase 交往 1 并且加速 glycolysis。一起,我们的调查结果显示 Smad5 充当一个 pHi 送信人并且由调整细胞质的新陈代谢的机械维持房间的 bioenergetic 动态平衡。 | Yujiang Fang Zhongliang Liu Zhenyu Chen Xiangjie Xu Mengtao Xiao Yanyan Yu Yuanyuan Zhang Xiaobai Zhang Yanhua Du Cizhong Jiang Yuzheng Zhao Yiran Wang Beibei Fan Daniel Terheyden-Keighley Yang Liu Lei Shi Yi Hui Xin Zhang Bowen Zhang Hexi Feng Lin Ma Quanbin Zhang Guohua Jin Yi Yang Bin Xiang Ling Liu Xiaoqing Zhang | 2017 | Cell Research2017，27，9： | 2 |
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