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| 1 | Role of nanotopography in the development of tissue engineered 3D organs and tissues using mesenchymal stem cells显示文摘Recent regenerative medicine and tissue engineering strategies(using cells, scaffolds, medical devices and gene therapy) have led to fascinating progress of translation of basic research towards clinical applications. In the past decade, great deal of research has focused on developing various three dimensional(3D) organs, such as bone, skin, liver, kidney and ear,using such strategies in order to replace or regenerate damaged organs for the purpose of maintaining or restoring organs' functions that may have been lost due to aging, accident or disease. The surface properties of a material or a device are key aspects in determining the success of the implant in biomedicine, as the majority of biological reactions in human body occur on surfaces or interfaces. Furthermore, it has been established in the literature that cell adhesion and proliferation are, to a great extent, influenced by the micro- and nanosurface characteristics of biomaterials and devices. In addition, it has been shown that the functions of stem cells, mesenchymal stem cells in particular, could be regulated through physical interaction with specific nanotopographical cues. Therefore, guided stem cell proliferation, differentiation and function are of great importance in the regeneration of 3D tissues and organs using tissue engineering strategies. This review will provide an update on the impact of nanotopography on mesenchymal stem cells for the purpose of developing laboratory-based 3D organs and tissues, as well as the most recent research and case studies on this topic. | Shima Salmasi Deepak M Kalaskar Wai-Weng Yoon Gordon W Blunn Alexander M Seifalian | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 2 | Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading:A mechanistic study显示文摘The successful application of magnesium(Mg)alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical integrity.This study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating Hanks’Balanced Salt Solution(HBSS)with and without in situ cyclic compression(30 N/1 Hz).The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume correlation.Although in situ cyclic compression induced acceleration of the corrosion rate,probably due to local disruption of the coating layer where fatigue microcracks were formed,no critical failures in the overall scaffold were observed,indicating that the mechanical integrity of the Mg scaffolds was preserved.Structural changes,due to the accumulation of corrosion debris between the scaffold fibres,resulted in a significant increase(p<0.05)in the material volume fraction from 0.52±0.07 to 0.47±0.03 after 14 days of corrosion.However,despite an increase in fibre material loss,the accumulated corrosion products appear to have led to an increase in Young’s modulus after 14 days as well as lower third principal strain(εp3)accumulation(-91000±6361μεand-60093±2414μεafter 2 and 14 days,respectively).Therefore,this innovative Mg scaffold design and composition provide a bone replacement,capable of sustaining mechanical loads in situ during the postoperative phase allowing new bone formation to be initially supported as the scaffold resorbs. | Roxane Bonithon Colin Lupton Marta Roldo Joseph Nicholas Dunlop Gordon William Blunn Frank Witte Gianluca Tozzi | 2023 | Bioactive Materials2023，，1： | 2 |
| 3 | In vivo evaluation of additively manufacturedmulti-layered scaffold for the repair of large osteochondral defects显示文摘The repair of osteochondral defects is one of the major clinical challenges in orthopaedics.Well-established osteochondral tissue engineering methods have shown promising results for the early treatment of small defects.However,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the tissue.In this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion techniques.The developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite system.The microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle model.The 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage formation.The histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control group.Chondrogenic genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control group.The findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects. | Maryam Tamaddon Gordon Blunn Rongwei Tan Pan Yang Xiaodan Sun Shen-Mao Chen Jiajun Luo Ziyu Liu Ling Wang Dichen Li Ricardo Donate Mario Monzón Chaozong Liu | 2022 | Bio-Design and Manufacturing2022，5，3： | 2 |
| 4 | Three-dimensional collagen architctrue in bovine articular cardlage 显示文摘 | Jefery AK Blunn CW Archer CW | 1991 | Bone Joint Surg Br1991，73，5： | 1 |
| 5 | Cementless fixation for primary segmental bone tumor endoprostheses 显示文摘 | Blunn GW Briggs TW Cannon SR | 2000 | Clin Orthop RelatRes2000，372，： | 1 |
| 6 | Evaluation of a testing method for the fatigue performance of total knee tibial trays显示文摘 | Ahir P Blunn G Haider H | 1999 | J Biomech1999，32，10： | 1 |
| 7 | A knee simulating machine for performance evaluation of total knee replacements 显示文摘 | Walker P S Blunn G W Broome D R | 1997 | Journal of Biomechanics1997，30，1： | 1 |
| 8 | Role of hydroxyapatite coating in resisting wear particle migration and osteolysis around acetabular components显示文摘 | Melanie Jean Coathup James Blackburn Allen E. Goodship James L. Cunningham Tracey Smith Gordon W. Blunn | 2004 | Biomaterials2004，，19： | 1 |
| 9 | Cementless fixation for primary segmental bone turnout endoprostheses 显示文摘 | Blunn GW Briggs TW Cannon SR | 2000 | Clin Orthop Relat Res2000，372，： | 1 |
| 10 | Three-dimensional collagenarchitecture in hovine articular cardlage显示文摘 | Jefery AK Blunn GW Archer CW | 1991 | J Bone Joint Surg Br1991，73，5： | 1 |
| 11 | Ultra high molecular-weight polyethylene(UHMWPE)in total knee replacement:fabrica-tion,sterilisation and wear显示文摘 | Blunn G Brach del Prever EM Costa L | 2002 | J Bone Joint Surg Br2002，7，： | 1 |
| 12 | Development of a soft tissue seal around bone-anchored transcutaneous amputation prostheses 显示文摘 | Pendegrass CJ Goodship AE Blunn GW | 2006 | Biomaterials2006，27，23： | 1 |
| 13 | Tendon bone healing can be enhanced by demineralized bone matrix: a functional and histological study 显示文摘 | Sundar S Pendegrass C J Blunn GW | 2009 | J Biomed Mater Res B Appl Biomater2009，1，： | 1 |
| 14 | Wear in retrieved condylar knee arthroplasties: A comparison of wear in different designs of 280 retrieved condylar knee prostheses 显示文摘 | BLUNN G W JOSHI A B MINNS R J | 1997 | The Journal of Arthroplasty1997，12，3： | 1 |
| 15 | Can mesenchymal stem cells survive under normal impaction force in revision total hip replacements显示文摘 | Korda M Blunn G Phipps K | | 0，，03： | 1 |
| 16 | Influence of psychiatric diagnosis on treatment uptake and interferon side effects in patients with hepatitis C显示文摘 | Jing Yuan J Wu Bruce Shadbolt Narci Teoh Anne Blunn Caroline To Ilys Rodriguez‐Morales Shivakumar Chitturi Graham Kaye Kalyana Rodrigo Geoff Farrell | 2014 | J Gastroenterol Hepatol2014，，6： | 1 |
| 17 | Prevention of strain-related osteopenia in aseptic loosening of hip prostheses using perioperative bisphosphonate显示文摘 | Goodship AE Blunn GW Green J | 2008 | J Orthop Res2008，26，5： | 1 |
| 18 | Prevention of strain-related osteopenia in aseptic loosening of hip prostheses u- sing perioperative bisphosphonate 显示文摘 | Goodship A E Blunn G W Green J | 2008 | J Orthop Res2008，26，5： | 1 |
| 19 | Os- teoinduction of bone grafting materials for bone repair and re- generation显示文摘 | GARCIA-GARETA E COATHUP M J BLUNN G W | 2015 | Bone2015，81，2015： | 1 |
| 20 | Three dimensional collagen architecture in bovine articular carti lage显示文摘 | Jeffery AK Blunn GW Arecher CW | | 0，，05： | 1 |
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