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| 1 | Role of hydroxyapatite coating in resisting wear particle migration and osteolysis around acetabular components显示文摘 | Melanie Jean Coathup James Blackburn Allen E. Goodship James L. Cunningham Tracey Smith Gordon W. Blunn | 2004 | Biomaterials2004，，19： | 1 |
| 2 | A Gram-Charlier series method of calculating the probability of error in lightwave transmission systems显示文摘 | COATHUP L W | 1986 | J Lightwave Technol1986，4，5： | 1 |
| 3 | Use of mesenchymal stem cells to facilitate bone regeneration in normal and chemotherapy treated rats显示文摘 | Lee OK Coathup MJ Goodship AE | 2005 | Tissue Eng2005，11，1112： | 1 |
| 4 | The effects ofmicroporosity on osteoinduction of calcium pho-sphate bone graft substitute biomaterials显示文摘 | Chan O Coathup MJ Nesbitt A | 2012 | ActaBiomater2012，8，7： | 1 |
| 5 | The osteoinductivity of silicate-substituted calcium phosphate显示文摘 | Coathup MJ Samizadeh S Fang YS | | 0，，23： | 1 |
| 6 | Os- teoinduction of bone grafting materials for bone repair and re- generation显示文摘 | GARCIA-GARETA E COATHUP M J BLUNN G W | 2015 | Bone2015，81，2015： | 1 |
| 7 | The effects of microporosity on osteoinduction of calcium phosphate bone graft substitute biomaterials显示文摘 | Chan O Coathup MJ Nesbitt A | | 0，，07： | 1 |
| 8 | Effect of increased strut porosity of calcium phosphate bone graft substitute biomaterials on osteoinduction显示文摘 | Coathup MJ Hing KA Samizadeh S | | 0，，06： | 1 |
| 9 | Role of hydroxyapatite coating in resisting wear particle migration and osteolysis around acetabular components显示文摘 | Coathup MJ Blackburn J Goodship AE | | 0，，： | 1 |
| 10 | Development of a hydroxyapatite coating containing silver for the prevention of peri-prosthetic infection 显示文摘 | Ghani Y Coathup M J Hing KA | 2012 | J Orthop Res2012，30，3： | 1 |
| 11 | Role of hydroxyapatite coating in resisting wear particle migration and osteolysis around acetabular components显示文摘 | Coathup MJ Blackbum J Goodship AE | | 0，，19： | 1 |
| 12 | Structural and electrical properties of carbon-ion-implanted ultrananocrystalline diamond films显示文摘We investigate the structural and electrical properties of carbon-ion-implanted ultrananocrystalline diamond(UNCD)films. Impedance spectroscopy measurements show that the impedance of diamond grains is relatively stable, while that of grain boundaries(GBs)(R_b) significantly increases after the C^+ implantation, and decreases with the increase in the annealing temperature(T_a) from 650℃ to 1000℃. This implies that the C^+ implantation has a more significant impact on the conductivity of GBs. Conductive atomic force microscopy demonstrates that the number of conductive sites increases in GB regions at T_a above 900℃, owing to the formation of a nanographitic phase confirmed by high-resolution transmission electronic microscopy. Visible-light Raman spectra show that resistive trans-polyacetylene oligomers desorb from GBs at T_a above 900℃, which leads to lower R_b of samples annealed at 900 and 1000℃. With the increase in T_a to 1000℃, diamond grains become smaller with longer GBs modified by a more ordered nanographitic phase, supplying more conductive sites and leading to a lower R_b. | 徐辉 刘建军 叶海涛 D J Coathup A V Khomich 胡晓君 | 2018 | Chinese Physics B2018，27，9： | 1 |
| 13 | A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss显示文摘Radiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in surrounding and otherwise healthy bone.Presently,no effective countermeasure exists,and ionizing radiation-induced bone damage continues to be a substantial source of pain and morbidity.The purpose of this study was to investigate a small molecule aminopropyl carbazole named P7C3 as a novel radioprotective strategy.Our studies revealed that P7C3 repressed ionizing radiation(IR)-induced osteoclastic activity,inhibited adipogenesis,and promoted osteoblastogenesis and mineral deposition in vitro.We also demonstrated that rodents exposed to clinically equivalent hypofractionated levels of IR in vivo develop weakened,osteoporotic bone.However,the administration of P7C3 significantly inhibited osteoclastic activity,lipid formation and bone marrow adiposity and mitigated tissue loss such that bone maintained its area,architecture,and mechanical strength.Our findings revealed significant enhancement of cellular macromolecule metabolic processes,myeloid cell differentiation,and the proteins LRP-4,TAGLN,ILK,and Tollip,with downregulation of GDF-3,SH2B1,and CD200.These proteins are key in favoring osteoblast over adipogenic progenitor differentiation,cell matrix interactions,and shape and motility,facilitating inflammatory resolution,and suppressing osteoclastogenesis,potentially via Wnt/β-catenin signaling.A concern was whether P7C3 afforded similar protection to cancer cells.Preliminarily,and remarkably,at the same protective P7C3 dose,a significant reduction in triple-negative breast cancer and osteosarcoma cell metabolic activity was found in vitro.Together,these results indicate that P7C3 is a previously undiscovered key regulator of adipo-osteogenic progenitor lineage commitment and may serve as a novel multifunctional therapeutic strategy,leaving IR an effective clinical tool while diminishing the risk of adverse post-IR complications.Our data uncover a new approach for the prevention of radiation-induced bone damage,and further work is needed to investigate its ability to selectively drive cancer cell death. | Fei Wei Zewen Kelvin Tuong Mahmoud Omer Christopher Ngo Jackson Asiatico Michael Kinzel Abinaya Sindu Pugazhendhi Annette R.Khaled Ranajay Ghosh Melanie Coathup | 2023 | Bone Research2023，11，3： | 0 |
| 14 | A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme显示文摘The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy exists.Ionizing radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing osteoclast.We demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic bone.At reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic activities.These properties make cerium oxide nanomaterials fascinating.We show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and strength.These investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in vivo.Further,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in vitro.These findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials. | Fei Wei Craig J.Neal Tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward Khoa Minh Ta Samuel Moxon Marco Molinari Jackson Asiatico Michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup | 2023 | Bioactive Materials2023，，3： | 0 |
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