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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Effects of osthole on apoptosis and TGF-bl of hypertrophic scar fibroblasts 显示文摘 | Xiaohua H Bo C Hongqi L | 2009 | J Asian Natural Products Res2009，11，7： | 1 |
| 4 | Intracortical multiplesclerosis lesions are not associatecd with increased lymphocyteinfiltration显示文摘 | Bo L Vedeler C A Nyland H | 2003 | Mult Scler2003，9，4： | 1 |
| 5 | Expression of inflammationrelated genes in endothelial cells is not directly affected by microparticles from preeclamptic patients显示文摘 | Lok C A Boing A N Reitsma P H | 2006 | J Lab Clin Med2006，147，6： | 1 |
| 6 | Isolation of a strain of Acidithiobacillus caldus and its role in bioleaching of chalcopyrite显示文摘 | ZHOU Q G BO F BO Z H XI L JIAN G FEI L F HUA C X | 2007 | World Journal of Microbiology and Biotechnology2007，23，9： | 1 |
| 7 | Evidence-based review of lasers,light sources and photodynamie therapy in the treatment of acne vulgaris显示文摘 | HAEDERADAL M TOGSVERD BO K WUIF H C | 2008 | J Eur Acad Dermatol Venereol2008，22，3： | 1 |
| 8 | Optimum design and analysis based on independent reaction amount for distillation column with side reactors: production of benzyl chloride 显示文摘 | Ding L H Tang J H Cui M F Bo C M Chen X Qiao X | 2011 | Industrial & Engineering Chemistry Research2011，50，11： | 1 |
| 9 | Anisotropy in the wetting of rough surfaces 显示文摘 | Yong C Bo H Lee J H | 2005 | J Colloid Interf Sci2005，281，： | 1 |
| 10 | Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups显示文摘 | Scherag A Dina C Hinney A Vatin V Scherag S Vogel C I Muller T D Grallert H Wichmann H E Balkau B Heude B Jarvelin M R Hartikainen A L Levy-Marchal C Weill J Delplanque J Korner A Kiess W Kovacs P Rayner N W Prokopenko I McCarthy M I Schafer H Jarick I Bo | | 0，，04： | 1 |
| 11 | A novel droop method for converter parallel operation 显示文摘 | Jung W K Hang S C Bo H C | 2002 | IEEE Transactionon Power Electronics2002，17，1： | 1 |
| 12 | Pelvic floor muscle training for urinary incontinence in women显示文摘 | Hay-Smith E J Bo Berghmans L C Hendriks H J | 2001 | Cochrane Database Syst Rev2001，20，00： | 1 |
| 13 | 显示文摘 | Ye S H Bo J K Li C Z | 2010 | Electrochimica Acta2010，55，： | 1 |
| 14 | Incorporation of a computerized human patient simulator in critical care training: Apreliminary report显示文摘 | Jeffrey H Mordechai B Bo C | 2002 | Journal of Trauma - Infection & Critical Care2002，53，6： | 1 |
| 15 | Building information modelling experts'views on standardisation and industry deployment 显示文摘 | Rob H Bo C B | 2008 | Advanced Engineering Informatics2008，，22： | 1 |
| 16 | Use of standards for CAD layers in building 显示文摘 | Rob H Bo C B | 2007 | Au- tomation in Construction2007，，16： | 1 |
| 17 | Supramolecular self-assembly of polypseudorotaxanes in ionic liquid显示文摘 | Bo J Xiao C Qiu H Y | 2007 | Colloids and Surfaces A:2007，292，： | 1 |
| 18 | Cellular microRNA let-7cinhibits M1protein expression of the H1N1influenza A virus in infected human lung epithelial cells显示文摘 | Ma Y J Yang J Fan X L Zhao H B Hu W Li Z P Yu G C Ding X R Wang J Z Bo X C Zheng X F Zhou Z Wang S Q | 2012 | J Cell Mol Med2012，16，10： | 1 |
| 19 | Reliable Mixed H2/ H1 Control for Stochastic Time-Varying Systems Against Actuator Failures显示文摘 | WU Y C MA L F BO Y M LIU X H | 2014 | Proceedings of the 33rd Chinese Con- trol Conference2014，1，： | 1 |
| 20 | A Novel Method for As- sessing the Segmentation Quality of High-spatial Resolution Remote-sensing Images显示文摘 | Cheng J H Bo Y C Zhu Y X | 2014 | International Journal of Remote Sensing2014，，： | 1 |
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