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| 1 | Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies显示文摘AIM: To evaluate the long-term efficacy adefovir(ADV)-based combination therapies in entecavir(ETV)-resistant chronic hepatitis B(CHB) patients. METHODS: F i fty CHB pat ient s wi t h genotypic resistance to ETV at 13 medical centers in South Korea were included for the analysis. All the patients received rescue therapy with the combination of ADV plus ETV(ADV/ETV,n = 23) or ADV plus lamivudine(LMV)(ADV/LMV,n = 27) for more than 12 mo. Patients were monitored at least every 3-4 mo during ADV-based combination therapy by clinical examination as well as biochemical and virological assessments. Hepatitis B virus(HBV) DNA levels were measured by realtime PCR and logarithmically transformed for analysis. Cumulative rates of virologic response(VR; HBV DNA < 20 IU/m L) were calculated using the Kaplan-Meier method,and the difference was determined by a logrank test. Multivariate logistic regression and Cox proportional hazards models were used to identify independent risk factors significantly associated with short-term and long-term VR,respectively.RESULTS: Baseline median HBV DNA levels were 5.53(2.81-7.63) log10 IU/m L. The most commonly observed ETV genotypic mutation sites were rt184 and rt202. Patients were treated for a median of 27(12-45) mo. Overall,cumulative VR rates at 6,12,24,and 36 mo were 26%,36%,45%,and 68%,respectively. Patients treated with the ADV/ETV combination showed higher cumulative VR rates(35%,43%,65%,and 76%,respectively) than those with the ADV/LAM combination(18%,30%,30%,and 62%,respectively; P = 0.048). In the multivariate analysis,low baseline HBV DNA levels(< 5.2 log10 IU/m L) and initial virologic response at 3 mo(IVR-3; HBV DNA < 3.3 log10 IU/m L after 3 mo) were independent predictive factors for VR. Patients with favorable predictors achieved cumulative VR rates up to 90% at 36 mo. During the same period,the cumulative incidence of virologic breakthrough was as low as 6% in patients with the both favorable predictors.CONCLUSION: If tenofovir is not available,ADV/ETV combination could be considered in ETV-resistant patients with low HBV DNA titers,and may becontinued if IVR-3 is achieved. | Hyoung Su Kim Hyung Joon Yim Myoung Kuk Jang Ji Won Park Sang Jun Suh Yeon Seok Seo Ji Hoon Kim Bo Hyun Kim Sang Jong Park Sae Hwan Lee Sang Gyune Kim Young Seok Kim Jung Il Lee Jin-Woo Lee In Hee Kim Tae Yeob Kim Jin-Wook Kim Sook-Hyang Jeong Young Kul Jung Hana Park Seong Gyu Hwang | 2015 | World Journal of Gastroenterology2015，21，38： | 13 |
| 2 | Histological improvement following administration of autologous bone marrow‐derived mesenchymal stem cells for alcoholic cirrhosis: a pilot study显示文摘 | Yoon Ok Jang Young Ju Kim Soon Koo Baik Moon Young Kim Young Woo Eom Mee Yon Cho Hong Jun Park So Yeon Park Bo Ra Kim Jae Woo Kim Hyun Soo Kim Sang Ok Kwon Eun Hee Choi Yong Man Kim | 2014 | Liver Int2014，，1： | 2 |
| 3 | Association of kinase insert domain-containing receptor ( KDR ) gene polymorphisms with idiopathic recurrent spontaneous abortion in Korean women显示文摘 | HyungChul Rah Young Joo Jeon Bo Eun Lee Dong Hee Choi Tae Ki Yoon Woo Sik Lee Nam Keun Kim | 2012 | Fertility and Sterility2012，，： | 2 |
| 4 | Endoscopic stenting is not as effective for palliation of colorectal obstruction in patients with advanced gastric cancer as emergency surgery显示文摘 | Bo Kyung Kim Sung Pil Hong Hyun Mi Heo Jin Young Kim Hyuk Hur Kang Young Lee Jae Hee Cheon Tae Il Kim Won Ho Kim | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 5 | Endoscopic stenting is not as effective for palliation of colorectal obstruction in patients with advanced gastric cancer as emergency surgery显示文摘 | Bo Kyung Kim Sung Pil Hong Hyun Mi Heo Jin Young Kim Hyuk Hur Kang Young Lee Jae Hee Cheon Tae Il Kim Won Ho Kim | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 6 | Unilateral spontaneous lens absorption and dislocation of the empty capsular bag into the anterior chamber显示文摘Dear Editor,C ases involving spontaneous aphakic change in the visual axis are rare in Outpatient Clinics.However,we can often ascertain the past events affecting the patient’s eye by examining its current status.The placement of the | Bo Hee Kim Deoksun Cha Sunmin Yim Ji-Won Kwon Won Ryang Wee Young Keun Han | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 1 |
| 7 | Volumetric fluid analysis of fixed monthly anti-VEGF treatment in patients with neovascular age-related macular degeneration显示文摘·AIM:To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor(VEGF)injections to treat neovascular agerelated macular degeneration(n AMD)with subretinal fluid(SRF)and pigment epithelial detachment(PED).·METHODS:This prospective study included eyes with n AMD previously treated with as-needed anti-VEGF injections.The patients were treated with six monthly intravitreal injections of ranibizumab.Quantitative volumetric segmentation analyses of the SRF and PED were performed.The main outcome measures included best-corrected visual acuity(BCVA),and SRF and PED volumes.·RESULTS:Twenty eyes of 20 patients were included in this study.At the 6-month follow-up,BCVA and PED volume did not change significantly(P=0.110 and 0.999,respectively)but the mean SRF volume decreased from 0.53±0.82 mm3 at baseline to 0.08±0.23 mm3(P=0.002).The absorption rate of the SRF volume was negatively correlated with the duration of previous antiVEGF treatment(P=0.029).Seven of the 20 eyes(35%)showed a fluid-free macula and significant improvement in BCVA(P=0.036)by month 6.·CONCLUSION:Quantifying the SRF can precisely determine the patient’s responsiveness to anti-VEGF treatment of n AMD. | Bo Hee Kim In Boem Chang Hyeong Gon Yu In Hwan Hong | 2023 | International Journal of Ophthalmology(English edition)2023，16，6： | 1 |
| 8 | Resting-state regional homogeneity as a biological marker for patients with Internet gaming disorder: A comparison with patients with alcohol use disorder and healthy controls显示文摘 | Heejung Kim Yu Kyeong Kim Ah Reum Gwak Jae-A Lim Jun-Young Lee Hee Yeon Jung Bo Kyung Sohn Sam-Wook Choi Dai Jin Kim Jung-Seok Choi | 2015 | Progress in Neuropsychopharmacology & Biological2015，，： | 1 |
| 9 | Air-oil Cooling Method for Turning of Hardened Material显示文摘 | KO Tae Jo KIM Hee Sool CHUNG Bo Gu | | 0，，07： | 1 |
| 10 | Prevention of traumatic brain injury-induced neuronal death by inhibition of NADPH oxidase activation显示文摘 | Bo Yong Choi Bong Geom Jang Jin Hee Kim Bo Eun Lee Min Sohn Hong Ki Song Sang Won Suh | 2012 | Brain Research2012，，： | 1 |
| 11 | Clinical significance of the BRAF V600E mutation in multifocal papillary thyroid carcinoma in Korea显示文摘 | Hwa Young Ahn Yun Jae Chung Byung Seup Kim Kyung Ho Kang Ju Won Seok Hee Sung Kim Sung Jun Park Bo Youn Cho | 2013 | Surgery2013，，： | 1 |
| 12 | Atypical basal ganglia germinoma presenting as cerebral hemiatrophy: diagnosis and follow-up with 11 C-methionine positron emission tomography显示文摘 | Jeehun Lee Bo Lyun Lee Keon Hee Yoo Ki Woong Sung Hong Hoe Koo Su Jin Lee Joon Young Choi Kyung-Han Lee Jung Il Lee Hyung-Jin Shin Ji Hye Kim Yeon Lim Suh Ke Hyang Lee Munhyang Lee | 2009 | Child’s Nervous System2009，，1： | 1 |
| 13 | Usefulness of magnifying endoscopy for iodine-unstained lesions in a high-risk esophageal cancer population显示文摘AIM: To investigate the usefulness of magnified observations of iodine-unstained esophageal lesions in the histological diagnosis of esophageal mucosa abnormalities, in high-risk esophageal cancer groups. METHODS: The subjects included 38 patients who had at least one of the four criteria known to be highrisk factors for esophageal cancer. Following endoscopic observation, magnified observations were performed on iodine-unstained lesions of the esophagus. The total number of lesions was 43. These lesions were classified as type A (clear papilla), type B (fused papilla), and type C (non-visible papilla) according to the findings. Tissue biopsy was then carried out. Finally the histological findings were graded in terms of histological factors, and their relationships were compared. RESULTS: Of the 43 lesions, 11 were type A, 17 were type B, and 15 were type C under magnifying endoscopy. Histological findings such as inflammatory cell infiltration and basal cell hyperplasia were significantly increased in type B and type C lesions compared with type A lesions (P < 0.05). Low-grade esophageal dysplasia was apparent in 1 (9%) of 11 type A lesions, in 3 (18%) of 17 type B lesions, and in 6 (40%) of 15 type C lesions, with the highest rate in type C. CONCLUSION: Magnified observations of the esophagus, classified by papillary aspects using magnifying endoscopy of iodine-unstained lesions in high-risk esophageal cancer groups, are considered useful in estimating dysplasia and inflammation of esophageal mucosa. | Ik Seong Choi Jae Young Jang Won Young Cho Tae Hee Lee Hyun Gun Kim Bo Young Lee Soung Won Jeong Joo Young Cho Joon Seong Lee So Young Jin | 2010 | World Journal of Gastroenterology2010，16，37： | 1 |
| 14 | Air–Oil Cooling Method for Turning of Hardened Material显示文摘 | Tae Jo Ko Hee Sool Kim Bo Gu Chung | 1999 | International Journal of Advanced Manufacturing Technology1999，，7： | 1 |
| 15 | Ail-oil cooling method for turning of hardened material显示文摘 | Tae Jo Ko Hee Sool Kim Bo Gu Chung | 1999 | International Journal of Advanced Manufacturing Technology1999，15，： | 1 |
| 16 | Fabrication of the hybrid ZnO LED structure grown on p-type GaN by metal organic chemical vapor deposition显示文摘 | Dong Chan Kim Won Suk Han Bo Hyun Kong Hyung Koun Cho Chang Hee Hong | 2007 | Physica B: Physics of Condensed Matter2007，，： | 1 |
| 17 | Endoscopic stenting is not as effective for palliation of colorectal obstruction in patients with advanced gastric cancer as emergency surgery显示文摘 | Bo Kyung Kim Sung Pil Hong Hyun Mi Heo Jin Young Kim Hyuk Hur Kang Young Lee Jae Hee Cheon Tae Il Kim Won Ho Kim | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 18 | Effects of Aerobic Exercise Training on C1q Tumor Necrosis Factor α-Related Protein Isoform 5 (Myonectin): Association with Insulin Resistance and Mitochondrial DNA Density in Women显示文摘 | Soo Lim Sung Hee Choi Bo Kyung Koo Seon Mee Kang Ji Won Yoon Hak Chul Jang Soon Mi Choi Man Gyoon Lee Wan Lee Hayley Shin Young-Bum Kim Hong Kyu Lee Kyong Soo Park | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，1： | 1 |
| 19 | Expression of transforming growth factor-β–inducible gene-h3 in normal and cyclosporine-treated rat kidney显示文摘 | Bo Kyung Sun Can Li Sun Woo Lim Ju Young Jung Suk Hee Lee In San Kim Yong Soo Kim Jin Kim Byung Kee Bang Chul Woo Yang | 2004 | The Journal of Laboratory and Clinical Medicine2004，，3： | 1 |
| 20 | Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a novel respiratory infectious disease,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which led to a global pandemic.Although vaccination is the best measure to overcome a pandemic,the immunogenicity of vaccines can be influenced by diverse factors,including intrinsic(age,sex,genetics,and comorbidities),extrinsic(diet,nutrition,and behavior),and vaccine-associated characteristics. | Hye Seong Bo Kyu Choi Young-Hee Han Jun Hyoung Kim Jeong-An Gim Sooyeon Lim Ji Yun Noh Hee Jin Cheong Woo Joo Kim Joon Young Song | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
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