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| 1 | Tacrolimus for children with refractory nephrotic syndrome:a one-year prospective,multicenter,and open-label study of Tacrobell®,a generic formula显示文摘Background:Cyclosporine A and tacrolimus(TAC)are often used as a second-line treatment for children with refractory nephrotic syndrome(NS).This study was undertaken to investigate the efficacy and safety of Tacrobell®,a locally produced generic form of TAC.Methods:This study was a one-year prospective,open-label,single-arm,multicenter trial.Fourty-four children with steroid-dependent NS(SDNS)and 33 children with steroid-resistant NS(SRNS)were enrolled.The primary endpoints were defined as the remission rates,whereas the secondary endpoints were recognized as the duration of remission and adverse effects of TAC.Results:After one-year treatment,34(77.3%)of the 44 patients with SDNS were in complete remission,and 6(13.6%)were in partial remission.Nineteen(43.2%)patients did not relapse during the study;for those who did relapse,the mean duration of remission was 4.6±2.9 months.The number of relapse episodes during the study period(0.90 per patient-year)was significantly lower than that in the preceding year(2.8 per patientyear).After treatment for 3 and 6 months,12(36.4%)of the 33 patients with SRNS were in remission,and after treatment for 12 months,the number of patients had increased to 13(39.4%).The mean time to achieve remission was 4.0±3.2 months.After remission(duration,3.7±2.7 months),12(54.5%)of 22 patients relapsed.The fasting blood glucose and blood pressure levels during the therapy were similar to those at the time of study entry.Conclusions:Treatment with Tacrobell®was effective and safe for children with refractory NS.The efficacy of this generic form of TAC was better than that of the original TAC formula. | Eun Mi Yang Sang Taek Lee Hyun Jin Choi Hee Yeon Cho Joo Hoon Lee Hee Gyung Kang Young Seo Park Hae Il Cheong Il-Soo Ha | 2016 | World Journal of Pediatrics2016，12，1： | 4 |
| 2 | Bile acid increases expression of the histamine-producing enzyme,histidine decarboxylase,in gastric cells显示文摘AIM:To investigate the effect of bile acid on the expression of histidine decarboxylase(HDC),which is a major enzyme involved in histamine production,and gene expression of gastric transcription factors upon cooperative activation.METHODS:HDC expression was examined by immunohistochemistry,reverse transcriptase polymerase chain reaction,and promoter assay in human gastric precancerous tissues,normal stomach tissue,and gastric cancer cell lines.The relationship between gastric precancerous state and HDC expression induced by bile acid was determined.The association between the expression of HDC and various specific transcription factors in gastric cells was also evaluated.MKN45 and AGS human gastric carcinoma cell lines were transfected with farnesoid X receptor(FXR),small heterodimer partner(SHP),and caudal-type homeodomain transcription factor(CDX)1 expression plasmids.The effects of various transcription factors on HDC expression were monitored by luciferase-reporter promoter assay.RESULTS:Histamine production and secretion in the stomach play critical roles in gastric acid secretion and in the pathogenesis of gastric diseases.Here,we show that bile acid increased the expression of HDC,which is a rate-limiting enzyme of the histamine production pathway.FXR was found to be a primary regulatory transcription factor for bile acid-induced HDC expression.In addition,the transcription factors CDX1 and SHP synergistically enhanced bile acid-induced elevation of HDC gene expression.We confirmed similar expression patterns for HDC,CDX1,and SHP in patient tissues.CONCLUSION:HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR,SHP,and CDX1. | Hye Jin Ku Hye Young Kim Hyeong Hoe Kim Hee Ju Park Jae Hun Cheong | 2014 | World Journal of Gastroenterology2014，20，1： | 3 |
| 3 | Risk Factors for Progression from Cytomegalovirus Viremia to Cytomegalovirus Disease after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘 | Ji Eun Jang Shin Young Hyun Yun Deok Kim Sul Hee Yoon Doh Yu Hwang Soo Jeong Kim Yuri Kim Jin Seok Kim June-Won Cheong Yoo Hong Min | 2012 | Biology of Blood and Marrow Transplantation2012，，6： | 2 |
| 4 | Oleanolic acid attenuates MK-801-induced schizophrenia-like behaviors in mice显示文摘 | Se Jin Park Younghwa Lee Hee Kyong Oh Hyung Eun Lee Younghwan Lee Sang Yoon Ko Boseong Kim Jae Hoon Cheong Chan Young Shin Jong Hoon Ryu | 2014 | Neuropharmacology2014，，： | 2 |
| 5 | Variable phenotype of Pierson syndrome显示文摘 | Hyun Jin Choi Beom Hee Lee Ju Hyung Kang Hyoen Joo Jeong Kyung Chul Moon Il Soo Ha Young Suk Yu Verena Matejas Martin Zenker Yong Choi Hae Il Cheong | 2008 | Pediatric Nephrology2008，，6： | 1 |
| 6 | Hospital‐based influenza surveillance in Korea: Hospital‐based influenza morbidity and mortality study group显示文摘 | Joon Young Song Hee Jin Cheong Sung Hyuk Choi Ji Hyeon Baek Seung Baik Han Seong‐Heon Wie Byung Hak So Hyo Youl Kim Young Keun Kim Won Suk Choi Sung Woo Moon Jacob Lee Gu Hyun Kang Hye Won Jeong Jung Soo Park Woo Joo Kim | 2013 | J Med Virol2013，，5： | 1 |
| 7 | Renal manifestations of Dent disease and Lowe syndrome显示文摘 | Hee Yeon Cho Bum Hee Lee Hyun Jin Choi Il Soo Ha Yong Choi Hae Il Cheong | 2008 | Pediatric Nephrology2008，，2： | 1 |
| 8 | Variable phenotype of Pierson syndrome显示文摘 | Hyun Jin Choi Beom Hee Lee Ju Hyung Kang Hyoen Joo Jeong Kyung Chul Moon Il Soo Ha Young Suk Yu Verena Matejas Martin Zenker Yong Choi Hae Il Cheong | 2008 | Pediatric Nephrology2008，，6： | 1 |
| 9 | Renal manifestations of Dent disease and Lowe syndrome显示文摘 | Hee Yeon Cho Bum Hee Lee Hyun Jin Choi Il Soo Ha Yong Choi Hae Il Cheong | 2008 | Pediatric Nephrology2008，，2： | 1 |
| 10 | Changes in serum histologic surrogate markers and procollagen III N-terminal peptide as independent predictors of HBeAg loss in patients with chronic hepatitis B during entecavir therapy显示文摘 | Jee Hoon Koo Myoung Hee Lee Soon Sun Kim Dong Hoon Kim In Sung Kim Kee Myung Lee Byung Moo Yoo Kwang Jae Lee Jin Hong Kim Sung Won Cho Jae Youn Cheong | 2011 | Clinical Biochemistry2011，，1： | 1 |
| 11 | WT1 and NPHS2 mutations in Korean children with steroid-resistant nephrotic syndrome显示文摘 | Hee Yeon Cho Joo Hoon Lee Hyun Jin Choi Bum Hee Lee Il Soo Ha Yong Choi Hae Il Cheong | 2008 | Pediatric Nephrology2008，，1： | 1 |
| 12 | Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a novel respiratory infectious disease,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which led to a global pandemic.Although vaccination is the best measure to overcome a pandemic,the immunogenicity of vaccines can be influenced by diverse factors,including intrinsic(age,sex,genetics,and comorbidities),extrinsic(diet,nutrition,and behavior),and vaccine-associated characteristics. | Hye Seong Bo Kyu Choi Young-Hee Han Jun Hyoung Kim Jeong-An Gim Sooyeon Lim Ji Yun Noh Hee Jin Cheong Woo Joo Kim Joon Young Song | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 13 | Development of annulus fibrosus tissue construct with hydrogel coils containing pre-conditioned mesenchymal stem cell显示文摘Low back pain associated with degenerative disc diseases has been a major health concern that brings suffering to the patients physically and economically.Many existing therapeutic strategies provide shortterm relief of symptoms rather than treatment of the underlying cause.Development of an engineered tissue for disc regeneration is still in its infancy due to the limited autologous healthy disc cell source from the patients.It is also challenging to mimic the complexity of micro-architecture in the native disc tissue that determine their unique structural properties.To date,simple tissue models that mimic the annulus fibrosus(AF)micro-environment for understanding the potential of mesenchymal stem cells(MSCs)in AF tissue engineering are still lacking.In this study,the assembly of a coiled hydrogel microfiber has shown its capability to encapsulate MSCs and create an engineered tissue model that mimics the multiple lamellae of native AF.Using this model,we investigated the potential of MSCs that were previously induced by ascorbic acid(AA).Compared to non-induced MSCs,AA-induced MSCs exhibited significant increase in AF-associated biomarkers during later development in the engineered AF tissue model and also encouraged collagen accumulation through the down-regulated catabolic gene MMP1 and upregulated anti-catabolic gene TIMP1.Furthermore,AA-induced MSCs exhibited a Col2/Col1 ratio closer to that of a native AF tissue.These results suggested that AA-induced MSCs could be a potential cell source for AF tissue engineering and this established tissue model may provide a simple tool for successful AF tissue engineering strategies in the future. | Yon Jin Chuah Yingnan Wu Mei Ling Shirlynn Cheong Yan Qing Chia Ching Ann Tee Hwan Tak Hee Chenjie Xu Yuejun Kang Dong-An Wang | 2021 | Journal of Materials Science & Technology2021，，4： | 0 |
| 14 | Two distinct stem cell-like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials显示文摘Dear Editor Hepatocellular carcinoma(HCC)is among the most com-mon cancers worldwide,causing about 600,000 deaths annully[1].In HCC,stem cell-like characteristics,which drive early recurrence and therapy resistance,are major contributors to poor prognosis[2].In this current study,we integrated and analyzed gene expression data from human fetal liver cells and primary HCC tumors(n=1231)and.uncovered two clinically and biologically distinct hepatic stem cell(HS)subtypes,potential biomarkers associated with these subtypes,and a potential new therapeutic inter-vention for these subtypes. | Sung Hwan Lee Yun Seong Jeong Sunyoung Lee Bo Hwa Sohn Ho Kyoung Hwang Gi Hong Choi Chang Moo Kang Jin Sub Choi Woo Jung Lee Jae-Ho Cheong Hee Jin Jang Ahmed Kaseb Lewis Roberts Sun Young Yim Yun Shin Chun Ju-Seog Lee | 2022 | Cancer Communications2022，42，2： | 0 |
| 15 | 基于辣椒基因组测序探究辣味在种群中的进化显示文摘辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。 | Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun Lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰 张西露 | 2014 | 辣椒杂志2014，0，2： | 0 |
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