维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

6篇 您的检索式：作者名="Boateng SY"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Exploring quercetin and luteolin derivatives as antiangiogenic agents显示文摘	Ravishankar D Watson KA Boateng SY	2015	EurJ Med Chem2015，97，：	1
	2	GRGDSP peptide-bound silicone membranes withstand mechanicai flexing in vitro and display enhanced fibroblast adhesion显示文摘	Samuel Boateng Thomas J Hartman	2002	Biomaterials2002，23，：	1
	3	Low-dose ramipril treatmentimproves relaxation and calcium cycling after established cardiac hyper-trophy 显示文摘	Boateng SY Naqvi RU Koban MU	2001	Am J Physiol2001，280，3：	1
	4	Kinetics of induction and protective effect of heat-shock proteins after cardioplegic arrest显示文摘	Amrani M Corbett J Boateng SY	1996	Ann Thorac Surg1996，61，：	1
	5	Kinetics of induetion and protective effect of heat-shock proteins after cardioplegic arrest显示文摘	Amrani M Corbett J Boateng SY	1996	Ann Thorac Surg1996，，5：	1
	6	Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data显示文摘BACKGROUND Hepatitis B virus(HBV) is a cause of hepatocellular carcinoma(HCC). Interestingly, this process is not necessarily mediated through cirrhosis and may in fact involve oncogenic processes. Prior studies have suggested specific oncogenic gene expression pathways were affected by viral regulatory proteins. Thus, identifying these genes and associated pathways could highlight predictive factors for HCC transformation and has implications in early diagnosis and treatment.AIM To elucidate HBV oncogenesis in HCC and identify potential therapeutic targets.METHODS We employed our Search, Tag, Analyze, Resource platform to conduct a meta-analysis of public data from National Center for Biotechnology Information’s Gene Expression Omnibus. We performed meta-analysis consisting of 155 tumor samples compared against 185 adjacent nontumor samples and analyzed results with ingenuity pathway analysis.RESULTS Our analysis revealed liver X receptors/retinoid X receptor(RXR) activation and farnesoid X receptor/RXR activation as top canonical pathways amongst others. Top upstream regulators identified included the Ras family gene rab-like protein 6(RABL6). The role of RABL6 in oncogenesis is beginning to unfold but its specific role in HBV-related HCC remains undefined. Our causal analysis suggests RABL6 mediates pathogenesis of HBV-related HCC through promotion of genes related to cell division, epigenetic regulation, and Akt signaling. We conducted survival analysis that demonstrated increased mortality with higher RABL6 expression. Additionally, homeobox A10(HOXA10) was a top upstream regulator and was strongly upregulated in our analysis. HOXA10 has recently been demonstrated to contribute to HCC pathogenesis in vitro. Our causal analysis suggests an in vivo role through downregulation of tumor suppressors and other mechanisms.CONCLUSION This meta-analysis describes possible roles of RABL6 and HOXA10 in the pathogenesis of HBV-related HCC. RABL6 and HOXA10 represent potential therapeutic targets and warrant further investigation.	Jihad Aljabban Michael Rohr Saad Syed Eli Cohen Naima Hashi Sharjeel Syed Kamal Khorfan Hisham Aljabban Vincent Borkowski Michael Segal Mohamed Mukhtar Mohammed Mohammed Emmanuel Boateng Mary Nemer Maryam Panahiazar Dexter Hadley Sajid Jalil Khalid Mumtaz	2022	World Journal of Gastrointestinal Oncology2022，14，9：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费