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| 1 | The status of Nrf2-based therapeutics: current perspectives and future prospects显示文摘This mini-review presents the authors' vision on the current status and future trends in the development of neuroprotective agents working via activation of nuclear factor erythroid 2-related factor 2(Nrf2),and in particular,via disruption of Nrf2-Keapl interaction.There are two opposite 'chemical' mechanisms underlying such activation:the first one is a non-specific covalent modification of Keap1 thiols,resulting in side effects of varied severity,and the second one is the shift of the Nrf2-Kelch-like ECH associated protein-1(Keap1) binding equilibrium in the presence of a competitive and chemically benign displacement agent.At this point,no displacement activators exhibit sufficient biological activity in comparison with common Nrf2 activators working via Keapl thiol modification.Hence,the hope in therapeutics is now linked to the FDA approved dimethylfumarate,whose derivative,monomethylfumarate,as we demonstrated recently,is much less toxic but equally biologically potent and an ideal candidate for clinical trials right now.A newly emerging player is a nuclear inhibitor of Nrf2,BTB domain and CNC homolog 1(Bach1).The commercially developed Bachl inhibitors are currently under investigation in our laboratory showing promising results.In our viewpoint,the perfect future drug will present the combination of a displacement activator and Bachl inhibitor to insure safety and efficiency of Nrf2 activation. | Irina G. Gazaryan Bobby Thomas | 2016 | Neural Regeneration Research2016，11，11： | 6 |
| 2 | Sister Mary Joseph's nodule as the first sign of pregnancy-associated gastric cancer:A case report显示文摘Sister Mary Joseph's nodule is an inconspicuous and uncommon clinical sign of advanced malignant disease, especially gastric cancer. Pregnancy-associated gastric cancer is an extremely rare condition and can be difficult to diagnose, due to the absence or misinterpretation of symptoms as pregnancy-related. Diagnostic aids, such as a basic chemistry panel and imaging techniques, may not show any abnormalities. We present a case of a 37-year-old pregnant patient whose umbilical nodule was the first presenting physical sign of gastric cancer, which had metastasized throughout the abdominal and pelvic regions. | Sara Fill Andrei Taran Hans-Ulrich Schulz Stefan Kahl Thomas Kalinski Bobbie Smith Serban-Dan Costa | 2008 | World Journal of Gastroenterology2008，14，6： | 3 |
| 3 | Managing liver transplantation during the COVID-19 pandemic:A survey among transplant centers in the Southeast United States显示文摘BACKGROUND The coronavirus disease-2019(COVID-19)pandemic has had a profound worldwide impact.Indeed,it has led to a vast decrease in organ transplantation,including liver transplants(LT).There is little data regarding adjustments made by LT centers as a response to the COVID-19 pandemic.AIM To assess the experience of LT centers in the United States during the pandemic.METHODS We performed an observational survey study from May 11,2020 to June 5,2020.We sent out a 13 question survey to 15 LT centers across the southeastern United States.RESULTS Eleven LT centers responded to the survey.We found that(11/11)100%of transplant centers made adjustments because of the COVID-19 pandemic.At least 50%of transplant centers had at least one transplant recipient infected with COVID-19.To adjust,greater than 50%of centers performed fewer LT,100%of patients were tested for COVID-19,and most centers implemented a virtual platform.CONCLUSION The COVID-19 pandemic greatly affected liver transplantation in the southeastern United States.It was evident that a concerted effort was made by LT centers to protect their patients and employees from COVID-19 but also to continue the lifesaving procedure of LT in this sick patient population.Further studies are needed to assess how LT centers around the world managed the pandemic in order to learn strategies to continue life-saving procedures in this patient population. | Adalberto Jose Gonzalez Nikhil Kapila Emmanuel Thomas Antonio Pinna Andreas Tzakis Xaralambos Bobby Zervos | 2021 | World Journal of Hepatology2021，13，12： | 1 |
| 4 | Impaired vasodilation in the pathogenesis of hypertension: focus on nitric oxide, endothelial-dirved hyperpolarizing factors, and prostaglandins 显示文摘 | Thomas D Giles Gary E Sander Bobby D Nossaman | 2012 | J Clin Hypertens2012，14，4： | 1 |
| 5 | A bridge for accelerating materials by design显示文摘Recent technical advances in the area of nanoscale imaging,spectroscopy and scattering/diffraction have led to unprecedented capabilities for investigating materials structural,dynamical and functional characteristics.In addition,recent advances in computational algorithms and computer capacities that are orders of magnitude larger/faster have enabled large-scale simulations of materials properties starting with nothing but the identity of the atomic species and the basic principles of quantum and statistical mechanics and thermodynamics.Along with these advances,an explosion of high-resolution data has emerged.This confluence of capabilities and rise of big data offer grand opportunities for advancing materials sciences but also introduce several challenges.In this perspective,we identify challenges impeding progress towards advancing materials by design(e.g.,the design/discovery of materials with improved properties/performance),possible solutions and provide examples of scientific issues that can be addressed using a tightly integrated approach where theory and experiments are linked through big-deep data. | Bobby G Sumpter Rama K Vasudevan Thomas Potok Sergei V Kalinin | 2015 | npj Computational Materials2015，，1： | 1 |
| 6 | Lipoic acid effects on established atherosclerosis显示文摘 | Zhekang Ying Nisharahmed Kherada Britten Farrar Thomas Kampfrath Yiucho Chung Orlando Simonetti Jeffrey Deiuliis Rajagopal Desikan Bobby Khan Frederick Villamena Qinghua Sun Sampath Parthasarathy Sanjay Rajagopalan | 2009 | Life Sciences2009，，3： | 1 |
| 7 | Digital repeat photography for phenological research in forest ecosystems显示文摘 | Oliver Sonnentag Koen Hufkens Cory Teshera-Sterne Adam M. Young Mark Friedl Bobby H. Braswell Thomas Milliman John O’Keefe Andrew D. Richardson | 2011 | Agricultural and Forest Meteorology2011，，： | 1 |
| 8 | 欧文·佩恩的影像人生显示文摘20世纪最高产、最具影响力的时尚摄影师之一欧文·佩恩于星期三(10月7日)在曼哈顿的家中去世,享年92岁。这位名人将古典的优雅和绝妙的简约主义相结合的标志性风格得到了杂志读者们和全世界经常去博物馆的人们的认可。 | Bobbie Thomas 汤桥(翻译) | 2009 | 英语沙龙(初级版)2009，，12： | 0 |
| 9 | KMAP-O framework for care management research of patients with type 2 diabetes显示文摘AIM To review impacts of interventions involving self-management education, health coaching, and motivational interviewing for type 2 diabetes. METHODS A thorough review of the scientific literature on diabetes care and management was executed by a research team. RESULTS This article summarizes important findings in regard to the validity of developing a comprehensive behavioral system as a framework for empirical investigation. The behavioral system framework consists of patients' knowledge(K), motivation(M), attitude(A), and practice(P) as predictor variables for diabetes care outcomes(O). Care management strategies or health education programs serve as the intervention variable that directly influences K, M, A, and P and then indirectly affects the variability in patient care outcomes of patients with type 2 diabetes. CONCLUSION This review contributes to the understanding of the KMAP-O framework and how it can guide the care management of patients with type 2 diabetes. It will allow the tailoring of interventions to be more effective through knowledge enhancement, increased motivation, attitudinal changes, and improved preventive practice to reduce the progression of type 2 diabetes and comorbidities. Furthermore, the use of health information technology for enhancing changes in KMAP and communications is advocated in health promotion and development. | Thomas T H Wan Amanda Terry Bobbie McKee Waleed Kattan | 2017 | World Journal of Diabetes2017，8，4： | 0 |
| 10 | 帕金森氏症基因显示文摘具有遗传根源的极少数帕金森氏症病例能帮助研究人员更深入地了解疾病的细胞机理,并找出病因,且最终开发出有效的疗法。 | Bobby Thomas M.Flint Beal 周林文 | 2011 | 生物技术世界2011，，2： | 0 |
| 11 | 百味来意面的自豪感来自哪里显示文摘2013年9月一个天气温暖的傍晚,克劳迪奧·科尔扎尼(Claudio Colzani)开着他的奥迪(Audi)车跑了160多公里,从米兰来到帕尔马,后者近两百年来都是世界最大的意大利面帝国所在地。不到一年前,他加入百味来(Barilla SpA)担任首席执行官,这天要去跟公司董事长圭多.巴里拉(Guido Barilla)共进晚餐。 | Thomas Buckley Bobby Doherty(摄影) | 2019 | 商业周刊(中文版)2019，0，11： | 0 |
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