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| 1 | Genetic epidemiology of primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known. A more than 80-fold increased risk of PSC among first-degree relatives emphasizes the importance of genetic factors. Genetic associations within the human leukocyte antigen (HLA) complex on chromosome 6p21 were detected in PSC 25 years ago. Subsequent studies have substantiated beyond doubt that one or more genetic variants located within this genetic region are important. The true identities of these variants,however,remain to be identified. Several candidate genes at other chromosomal loci have also been investigated. However,according to strict criteria for what may be denominated a susceptibility gene in complex diseases,no such gene exists for PSC today. This review summarises present knowledge on the genetic susceptibility to PSC,as well as genetic associations with disease progression and clinical subsets of particular interest (inflammatory bowel disease and cholangiocarcinoma). | Tom H Karlsen Erik Schrumpf Kirsten Muri Boberg | 2007 | World Journal of Gastroenterology2007，13，41： | 7 |
| 2 | Autoantibodies in primary sclerosing cholangitis显示文摘The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients,but the specifi city of these antibodies is generally low,and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecifi c dysregulation of the immune system,but the literature in PSC points to the possible presence of specifi c antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC,with a particular emphasis on the prevalence,clinical relevance and possible pathogenetic importance of each individual marker. | Johannes Roksund Hov Kirsten Muri Boberg Tom H Karlsen | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 3 | Liver Transplantation for Nonresectable Liver Metastases From Colorectal Cancer显示文摘 | Morten Hagness Aksel Foss P?l-Dag Line Tim Scholz P?l Foyn J?rgensen Bjarte Fosby Kirsten Muri Boberg ?ystein Mathisen Ivar P. Gladhaug Tor Skatvedt Egge Steinar Solberg John Hausken Svein Dueland | 2013 | Annals of Surgery2013，，5： | 4 |
| 4 | Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue显示文摘 | Kirsten Muri Boberg Roger W. Chapman Gideon M. Hirschfield Ansgar W. Lohse Michael P. Manns Erik Schrumpf | 2010 | Journal of Hepatology2010，，2： | 4 |
| 5 | Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis显示文摘 | T. H. Karlsen M. Vesterhus K. M. Boberg | 2014 | Aliment Pharmacol Ther2014，，3： | 2 |
| 6 | Impact of a pa- tient - centered, computer - based health information/sup- port system显示文摘 | Gustafson DH Hawkins R Boberg E | 1999 | Am J Prey Med1999，16，1： | 1 |
| 7 | Patients with small duct primary sclerosing cholangitis have a favourable long term prognosis 显示文摘 | Bjornsson E Boberg KM Cullen S | 2002 | Gut2002，51，5： | 1 |
| 8 | Low-dose perinatal exposure to di(2-ethylhexyl)phthalate induces anti-androgenic effects in male rats显示文摘 | Christiansen S Boberg J Axelstad M | | 0，，02： | 1 |
| 9 | Diagnosis and treatment of cholangiocarcinoma显示文摘 | Boberg KM Schrumpf E | 2004 | Curr Gastroenterol Rep2004，6，1： | 1 |
| 10 | Diagnosis treatment of cholangiocareino ma显示文摘 | Boberg KM Schrumpf E | 2004 | Curt Castronenterol Rep2004，6，1： | 1 |
| 11 | CHESS : 10 years of research and development in consumer health informatics for broad populations, including the underserved 显示文摘 | Gustafson DH Hawkins RP Boberg EW | 2002 | Int Med Inform2002，65，3： | 1 |
| 12 | Low-dose perinatal exposure to di ( 2-ethylhexyl ) phthalate induces anti-androgenic effects in male rats显示文摘 | Christiansen S Boberg J Axelstad M | 2010 | Reprod Toxieol2010，30，2： | 1 |
| 13 | Hospital cost of dislocation after primary total hip arthroplasty显示文摘 | Sanchez-Sotelo J Haidukewych GJ Boberg CJ | 2006 | J Bone Joint Surg Am2006，88，2： | 1 |
| 14 | ABO-incompatible deceased donor liver transplantation with the use of antigen-specific immunoadsorption and anti-CD20 monoclonal antibody 显示文摘 | BOBERG K M FOSS A MIDTVEDT K | 2006 | Clin Transplant2006，20，2： | 1 |
| 15 | CREME96: A Revision of the Cosmic Ray Effects on Micro-Electronics Code显示文摘 | Tylka AJ AdamsJ H Boberg P R | 1997 | IEEE Trans1997，44，6： | 1 |
| 16 | Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes显示文摘 | Wiencke K Karlsen TH Boberg KM | 2007 | Tissue antigens2007，69，2： | 1 |
| 17 | Hypertension is related to cognitive impairment:a 20-year follow-up of 999 men显示文摘 | Kilander L Nyman H Boberg M | | 0，，03： | 1 |
| 18 | Development, implementation and pilot evaluation of a web - based virtual patient case simulation environment Web - SP显示文摘 | Zary N Johnson G Boberg J | 2006 | BMC Med Educ2006，6，： | 1 |
| 19 | Modelling solid-convective flash pyrolysis of straw and wood in the pyrolysis centrifuge reactor 显示文摘 | Niels Bech Morten Boberg Larsen Peter Arendt Jensen | 2009 | Biomass and Bioenergy2009，33，： | 1 |
| 20 | Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis显示文摘 | Karlsen T H Boberg K M Olsson M | 2007 | J Hepatol2007，46，： | 1 |
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