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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | DNA polymorphism of HLA class II genes in primary biliary cirrhosis显示文摘 | Niels Morling Kim Dalhoff Lars Fugger J?rgen Georgsen Bodil Jakobsen Leo Ranek Niels ?dum Arne Svejgaard | 1992 | Immunogenetics1992，，2： | 2 |
| 3 | Biophysical consequences of remodeling the neutral side chains of rhamnogalacturonan?I in tubers of transgenic potatoes显示文摘 | Peter Ulvskov Helle Wium David Bruce Bodil J?rgensen Karsten Bruun Qvist Michael Skj?t David Hepworth Bernhard Borkhardt Susanne Oxenb?ll S?rensen | 2005 | Planta2005，，4： | 1 |
| 4 | Mucosa-associated bacteria in two middle-aged women diagnosed with collagenous colitis显示文摘AIM:To characterize the colon microbiota in two women histologically diagnosed with collagenous colitis using a culture-independent method.METHODS:Biopsies were taken from the ascending colon and the total DNA was extracted.Universal bacterial primers were used to amplify the bacterial 16S rRNA genes.The amplicons were then cloned into competent Escherichia coli cells.The clones were sequenced and identified by comparison to known sequences.RESULTS:The clones could be divided into 44 different phylotypes.The microbiota was dominated by Firmicutes and Bacteroidetes.Seven phylotypes werefound in both patients and constituted 47.5% of the total number of clones.Of these,the most dominating were clones similar to Bacteroides cellulosilyticus,Bacteroides caccae,Bacteroides thetaiotaomicron,Bacteroides uniformis and Bacteroides dorei within Bacteroidetes.Sequences similar to Faecalibacterium prausnitzii and Clostridium citroniae were also found in both patients.CONCLUSION:A predominance of potentially pathogenic Bacteroides spp.,and the presence of clones showing similarity to Clostridium clostridioforme were found but the overall colon microbiota showed similarities to a healthy one.Etiologies for collagenous colitis other than an adverse bacterial flora must also be considered. | Rita J Gustafsson Bodil Ohlsson Cecilia Benoni Bengt Jeppsson Crister Olsson | 2012 | World Journal of Gastroenterology2012，18，14： | 1 |
| 5 | 注意力缺陷/多动症和儿童期自闭症与产前暴露于全氟烷基物质之间的关联:丹麦全国出生队列的一项巢式病例对照研究显示文摘[背景]全氟烷基物质(PFASs)是持久性污染物,动物实验中具有内分泌干扰性和神经毒性。一些横断面数据显示PFASs与儿童神经行为的问题之间存在正向关联,但是来自前瞻性研究的结果仍然有限。[目的]研究产前暴露于PFASs是否与儿童中的注意力缺陷/多动障碍(ADHD)或儿童期自闭症之间有关联。[方法]在1996—2002年丹麦全国出生队列的83 389对母子中,根据丹麦国家医院登记和丹麦精神病中心登记,确定了890名ADHD病例和301名儿童自闭症病例。从这个队列中,随机各选择220例多动症和自闭症病例,并随机选择550例性别相匹配的对照儿童。测量在妊娠早期或中期采集的母体血浆中16种PFASs,使用广义线性模型计算风险比(RRs),模型中考虑到了抽样权重。[结果]在所有样品中均检测到全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA),在≥90%的样本中可以定量其他4种PFASs。没有发现母亲PFAS血浆水平和ADHD之间关联的一致性证据[浓度(ng/m L)的自然对数值每增加一个单位,PFOS对应的RR=0.87(95%CI:0.74,1.02),PFOA对应的RR=0.98(95%CI:0.82,1.16)],对于自闭症也是如此[浓度(ng/m L)的自然对数每增加一个单位,PFOS对应的RR=0.92(95%CI:0.69,1.22),PFOA对应的RR=0.98(95%CI:0.73,1.31)]。在同时校正所有PFASs的模型中,较高的PFAS分位数和ADHD之间既有阳性关联也有阴性关联,但是这些关联的估计值并不精确。[结论]在这项研究中,没有发现一致性的证据能够提示产前PFAS暴露增加儿童中ADHD或儿童期自闭症儿的风险。 | Zeyan Liew Beate Ritz Ondine S.von Ehrenstein Bodil Hammer Bech Ellen Aagaard Nohr Chunyuan Fei Rossana Bossi Tine Brink Henriksen Eva Cecilie Bonefeld-Jφrgensen Jφrn Olsen | 2015 | 环境与职业医学2015，32，10： | 1 |
| 6 | Lessons learned from metabolic engineering of cyanogenic glucosides显示文摘 | Anne V M Kirsten J Bodil J | 2007 | Metabolo mics2007，3，3： | 1 |
| 7 | The effect of 4-nonylphenol on the synthesis of vitellogenin in the flounder Platichthys flesus显示文摘 | Lene J C Bodil K Poul B | 1999 | Aquatic Toxicology1999，46，： | 1 |
| 8 | Ca2+ and Na+ binding to high affinity sites of calcium-containing proteins measured by capillary electrophoresis显示文摘 | Bodil W Rasmussen Morten J Bjerrum | 2003 | Journal of Inorganic Biochemistry2003，95，： | 1 |
| 9 | Subclinical atherosclerosis in systemic lupus erythematosus(SLE):the raltive contribution of classic risk factors and the lupus phenotype显示文摘 | Ahmad Y Shelmerdine J Bodill H | 2007 | Rheumatol2007，46，6： | 1 |
| 10 | The surface lipids of non-tuberculous mycobacteria suppress production of phagocyte activating cytokines in human peripheral blood mononuclear cells 显示文摘 | Bodil J Malin R Agnes EW | 2012 | Microbes and Infection2012，14，9： | 1 |
| 11 | 流域养分减排的综合模拟:不同情景的效果、潜力和措施成本显示文摘对瑞典南部的伦讷(Rnnea)河流域(1900km^2)应用水力模型HBV-NP分析了目前养分负荷情况的详细特征和改善处理措施或减少土壤淋溶的可能性。对几种不同的情景进行了模拟,以求找到实现瑞典环境目标的策略,其目标为将人类产生的氮的输送量减少30%,磷的输送量减少20%。可以通过不同的方法达到目标,这些方法将会影响不同的污染者和社会部门。然而,没有任何一种单一措施是足够的。相反,为了达到预期的目标,采取综合措施是必要的。氮的减排目标最难以实现。为了更达到更为经济的目的,这些措施应该应用于对于减少净的海洋负荷影响最大的地区。与在整个流域采取措施相比,这一策略能够使成本减少70%~80%。综合流域模型对于减少环境控制项目的成本来说是有用的工具。 | Berit Arheimer Marianne Lwgren Bodil Charlotta Pers Jrgen Rosberg 徐学华 | 2005 | AMBIO-人类环境杂志2005，34，B11： | 0 |
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