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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Recombination between sequences of hepatitis B virus from different genotypes显示文摘 | Bollyky PL Rambaut A Harvey PH Holmes EC | 1996 | J Med Evol1996，42，： | 1 |
| 3 | Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4 CD25 regulatory T- cells of type 1 diabetic subjects 显示文摘 | LONG S A CEROSALET'FI K BOLLYKY P L | 2010 | Diabetes2010，59，2： | 1 |
| 4 | Review of the application of ozone for increasing storage time of perishable foods显示文摘 | Rice R G Farquhar W Bollyky L J | 1982 | Ozone Science and Engineering1982，4，： | 1 |
| 5 | Developing symptoms:noncommunicable diseases go global显示文摘 | Bollyky T | 2012 | Foreign Affairs2012，56，： | 1 |
| 6 | Review of the application of ozone for increasing storage time of perishable food显示文摘 | Rice R G Farquhar W Bollyky L J | 1982 | Ozone Science and Engineering1982，，14： | 1 |
| 7 | Review of the application of ozone for increasing storage time of perishable foods显示文摘 | Rice R G Farquhar W Bollyky L J | 1982 | Ozone Science and Engineering1982，，4： | 1 |
| 8 | Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+CD25+regulatory T-cells of type 1 diabetic subjects显示文摘 | Long SA Cerosaletti K Bollyky PL | 2010 | Diabetes2010，59，2： | 1 |
| 9 | CDld-restricted T-cell subsets and dendritic cell function in autoimmunity显示文摘 | Bollyky P L Wilson S B | 2004 | Immunol Cell Bi- ol2004，82，3： | 1 |
| 10 | Assessment of seasonal influenza A virus- specific CD4 T- cell responses to 2009 pandemic HlNl swine-origin influenza A virus显示文摘 | Ge X Tan V Bollyky PL | 2010 | J Virol2010，847，： | 1 |
| 11 | Recombination between sequences of hepatitis B virus from different genotypes显示文摘 | Bollyky P L Rambaut A Harvey P H | 1996 | J Mol Evol1996，42，2： | 1 |
| 12 | Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function显示文摘 | S. Alice Long Mary Rieck Srinath Sanda Jennifer B. Bollyky Peter L. Samuels Robin Goland Andrew Ahmann Alex Rabinovitch Sudeepta Aggarwal Deborah Phippard Laurence A. Turka Mario R. Ehlers Peter J. Bianchine Karen D. Boyle Steven A. Adah Jeffrey A. Bluest | 2012 | Diabetes2012，，9： | 1 |
| 13 | Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing and induces angiogenesis显示文摘 | Swathi Balaji Maria LeSaint Sukanta S. Bhattacharya Chad Moles Yashu Dhamija Mykia Kidd Louis D. Le Alice King Aimen Shaaban Timothy M. Crombleholme Paul Bollyky Sundeep G. Keswani | 2014 | Journal of Surgical Research2014，，： | 1 |
| 14 | Short - term IL - 1 beta blockade reduces monocyte CDllb integrin expression in an IL -8 dependent fas- hion in patients with type 1 diabetes 显示文摘 | Sanda S Bollyky J Standifer N | 2010 | Clin Immunol2010，136，2： | 1 |
| 15 | Recombination between sequences of hepatitis B virus from different genotypes显示文摘 | Paul L. Bollyky Andrew Rambaut Paul H. Harvey Edward C. Holmes | 1996 | Journal of Molecular Evolution1996，，2： | 1 |
| 16 | Review of the application of ozone for increasing storage times for perishable foods显示文摘 | Rice R G Farquhar W Bollyky L J | 1982 | Ozone Science and Engineering1982，，4： | 1 |
| 17 | Chemiluminescence from reactions of electronegatively substituted aryl oxalates with hydrogen peroxide and fluorescent compounds显示文摘 | RAUHUT M M BOLLYKY L J ROBERTS B G | 1967 | J Am Chem Soc1967，89，： | 1 |
| 18 | Obama and the Promotion of International Science显示文摘 | Bollyky T J Bollyky P L | 2012 | Science2012，328，6107： | 1 |
| 19 | Reconstructing the complex evolutionary history of hepatitis B virus 显示文摘 | Bollyky PL Holmes EC | 1999 | J Mol Evol1999，49，1： | 1 |
| 20 | The toll-like receptor signaling molecule Myd88 contributes to pancre- atic beta-cell homeostasis in response to injury 显示文摘 | BOLLYKY P L BICE J B SWEET I R | 2009 | PLoS One2009，4，4： | 1 |
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