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| 1 | Robotic rectal surgery: State of the art显示文摘Laparoscopic rectal surgery has demonstrated its superiority over the open approach, however it still has some technical limitations that lead to the development of robotic platforms. Nevertheless the literature on this topic is rapidly expanding there is still no consensus about benefits of robotic rectal cancer surgery over the laparoscopic one. For this reason a review of all the literature examining robotic surgery for rectal cancer was performed. Two reviewers independently conducted a search of electronic databases(Pub Med and EMBASE) using the key words 'rectum', 'rectal', 'cancer', 'laparoscopy', 'robot'. After the initial screen of 266 articles, 43 papers were selected for review. A total of 3013 patients were included in the review. The most commonly performed intervention was low anterior resection(1450 patients, 48.1%), followed by anterior resections(997 patients, 33%), ultra-low anterior resections(393 patients, 13%) and abdominoperineal resections(173 patients, 5.7%). Robotic rectal surgery seems to offer potential advantages especially in low anterior resections with lower conversions rates and better preservation of the autonomic function. Quality of mesorectum and status of and circumferential resection margins are similar to those obtained with conventional laparoscopy even if robotic rectal surgery is undoubtedly associated with longer operative times. This review demonstrated that robotic rectal surgery is both safe and feasible but there is no evidence of its superiority over laparoscopy in terms of postoperative, clinical outcomes and incidence of complications. In conclusion robotic rectal surgery seems to overcome some of technical limitations of conventional laparoscopic surgery especially for tumors requiring low and ultralow anterior resections but this technical improvement seems not to provide, until now, any significant clinical advantages to the patients. | Fabio Staderini Caterina Foppa Alessio Minuzzo Benedetta Badii Etleva Qirici Giacomo Trallori Beatrice Mallardi Gabriele Lami Giuseppe Macrì Andrea Bonanomi Siro Bagnoli Giuliano Perigli Fabio Cianchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，11： | 7 |
| 2 | Coagulopathy and transfusion therapy in pediatric livertransplantation显示文摘Bleeding and coagulopathy are critical issues complicating pediatric liver transplantation and contributing to morbidity and mortality in the cirrhotic child. The complexity of coagulopathy in the pediatric patient is illustrated by the interaction between three basic models. The first model, 'developmental hemostasis', demonstrates how a different balance between pro- and anticoagulation factors leads to a normal hemostatic capacity in the pediatric patient at various ages. The second, the 'cell based model of coagulation', takes into account the interaction between plasma proteins and cells. In the last, the concept of 'rebalanced coagulation' highlights how the reduction of both pro- and anticoagulation factors leads to a normal, although unstable, coagulation profile. This new concept has led to the development of novel techniques used to analyze the coagulation capacity of whole blood for all patients. For example, viscoelastic methodologies are increasingly used on adult patients to test hemostatic capacity and to guide transfusion protocols. However, results are often confounding or have limited impact on morbidity and mortality. Moreover, data from pediatric patients remain inadequate. In addition, several interventions have been proposed to limit blood loss during transplantation, including the use of antifibrinolytic drugs and surgical techniques, such as the piggyback and lowering the central venous pressure during the hepatic dissection phase. The rationale for the use of these interventions is quite solid and has led to their incorporation into clinical practice; yet few of them have been rigorously tested in adults, let alone in children. Finally, the postoperative period in pediatric cohorts of patients has been characterized by an enhanced risk of hepatic vessel thrombosis. Thrombosis in fact remains the primary cause of early graft failure and re-transplantation within the first 30 d following surgery, and it occurs despite prolongation of standard coagulation assays. Data, however, are currently lacking regarding the use of anti-aggregation/anticoagulation therapies and how to best monitor for thrombosis in the early postoperative period in pediatric patients. Therefore, further studies are necessary to elucidate the interaction between the development of the coagulation system and cirrhosis in children. Moreover, strategies to optimize blood transfusion and anticoagulation must be tested specifically in pediatric patients. In conclusion, data from the adult world can be translated with difficulty into the pediatric field as indication for transplantation, baseline pathologies and levels of pro- and anticoagulation factors are not comparable between the two populations. | Mirco Nacoti Davide Corbella Francesco Fazzi Francesca Rapido Ezio Bonanomi | 2016 | World Journal of Gastroenterology2016，22，6： | 5 |
| 3 | New endoscopic imaging techniques in surveillance of inflammatory bowel disease显示文摘Endoscopy plays a crucial role in the management of inflammatory bowel disease(IBD). Advancesimaging techniques allow visualization of mucosal details, tissue characteristics and cellular alteration. In particular chromoendoscopy, magnification endoscopy, confocal laser endomicroscopy and endocytoscopy seem to have the possibility to radically modify the approach to surveillance and decision making. Dyebased chromoendoscopy(DBC) and magnification chromoendoscopy improve detection of dysplasia, and evaluation of inflammatory activity and extension of ulcerative colitis and are thus considered the standard of care. Dye-less chromoendoscopy could probably replace conventional DBC for surveillance. Narrow band imaging and i-scan have shown to improve activity and extent assessment in comparison to white-light endoscopy. Confocal laser endomicroscopy(CLE) can detect more dysplastic lesions in surveillance colonoscopy and predict neoplastic and inflammatory changes with high accuracy compared to histology. This technology is best used in conjunction with chromoendoscopy, narrow-band imaging, or autofluorescence because of its minute scanning area. This combination is useful for appropriate tissue classification of mucosal lesions already detected by standard or optically enhanced endoscopy. The best combination for IBD surveillance appear to be chromoendoscopy for identification of areas of suspicion, with further examination with CLE to detect intraepithelial neoplasia. However cost, availability, and experience are still an issue. | Tommaso Gabbani Natalia Manetti Andrea Giovanni Bonanomi Antonio Luca Annese Vito Annese | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 3 |
| 4 | Thrombosis prophylaxis in pediatric liver transplantation: A systematic review显示文摘AIM To review current literature of thrombosis prophylaxis in pediatric liver transplantation(PLT) as thrombosis remains a critical complication.METHODS Studies were identified by electronic search of MEDLINE, EMBASE and Cochrane Library(CENTRAL) databases until March 2018. The search was supplemented by manually reviewing the references of included studies and the references of the main published systematic reviews on thrombosis and PLT. We excluded from this review case report, small case series, commentaries, conference abstracts, papers which describing less than 10 pediatric liver transplants/year and articles published before 1990. Two reviewers performed study selection independently, with disagreements solved through discussion and by the opinion of a third reviewer when necessary.RESULTS Nine retrospective studies were included in this review. The overall quality of studies was poor. A pooled analysis of results from studies was not possible due to the retrospective design and heterogeneity of included studies. We found an incidence of portal vein thrombosis(PVT) ranging from 2% to 10% in pediatric living donorliver transplantation(LDLT) and from 4% to 33% in pediatric deceased donor liver transplantation(DDLT). Hepatic artery thrombosis(HAT) was observed mostly in mixed LDLT and DDLT pediatric population with an incidence ranging from 0% to 29%. In most of the studies Doppler ultrasonography was used as a first line diagnostic screening for thrombosis. Four different surgical techniques for portal vein anastomosis were reported with similar efficacy in terms of PVT reduction. Reduced size liver transplant was associated with a low risk of both PVT(incidence 4%) and HAT(incidence 0%, P < 0.05). Similarly, aortic arterial anastomosis without graft interposition and microsurgical hepatic arterial reconstruction were associated with a significant reduced HAT incidence(6% and 0%, respectively). According to our inclusion and exclusion criteria, we did not find eligible studies that evaluated pharmacological prevention of thrombosis. CONCLUSION Poor quality retrospective studies show the use of tailored surgical strategies might be useful to reduce HAT and PVT after PLT; prospective studies are urgently needed. | Mirco Nacoti Giulia Maria Ruggeri Giovanna Colombo Ezio Bonanomi Federico Lussana | 2018 | World Journal of Hepatology2018，10，10： | 3 |
| 5 | Suppressive effect of 1, 25-dihydroxyvitamin D3 and its anlogues EB1089 and KH1060 on T lymphocyte proliferation in active ulcerative colitis 显示文摘 | Stio M Bonanomi AG d' Albasio G | 2001 | Biochem Pharmaeol2001，61，： | 1 |
| 6 | Synaptophysin : leading actor or walk-on role in synaptic vesicle exocytosis? 显示文摘 | Valtorta F Pennuto M Bonanomi D | 2004 | Bioessays2004，26，4： | 1 |
| 7 | Male fertility: core chemical structure in pharmacological research显示文摘 | BONANOMI M LUCENTE G SILVESTRINI B | 2002 | Contra- ception2002，65，4： | 1 |
| 8 | Building up an electrocatalytic activity scale of cathode mate- rials for organic halide reduetions显示文摘 | BELLOMUNNO C BONANOMI D FALCIOLA L | 2005 | Electroehimica Acta2005，50，11： | 1 |
| 9 | Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis显示文摘 | Valtorta F Pennuto M Bonanomi D | 2004 | Bioessays2004，26，4： | 1 |
| 10 | Measuring patient engagement: development and psychometric properties of the Patient Health Engagement (PHE) Scale 显示文摘 | GRAFFIGNA G BARELLO S BONANOMI A | 2015 | Front Psychol2015，6，： | 1 |
| 11 | Biochemical effects of KH 1060 and anti-TNF monoclonal antibody on human peripheral blood mononuclear cells显示文摘 | Maria Stio Cristina Treves Maria Martinesi Andrea G. Bonanomi | 2004 | International Immunopharmacology2004，，4： | 1 |
| 12 | Assessing soil quality under intensive cultivation and tree orchards in Southern Italy显示文摘 | Bonanomi G D'Ascoli R Antignani V Capodilupo M Cozzolino L Marzaioli R Puopolo G Rutigliano F A Scelza R Scotti R | | 0，，： | 1 |
| 13 | Phytotoxicity dynamics of decaying plant materials显示文摘 | BONANOMI G SICUREZZA M G CAPORASO S | 2006 | New Phytologist2006，169，3： | 1 |
| 14 | CT colonography after incomplete colonoscopy in subjects with positive faecal occult blood test显示文摘AIM: To report our experience with computed tomog- raphy colonography (CTC) systematically performed in subjects with positive faecal occult blood test (FOBT) and an incomplete colonoscopy in the setting of a population-based screening for colorectal cancer (CRC). METHODS: From April 2006 to April 2007, 43 290 indi- viduals (age range 50-70) who adhered to the regional screening program for the prevention of CRC under-went immunochemical FOBT. FOBT was positive in 1882 subjects (4.3%). 1463 (77.7%) of these subjects underwent colonoscopy, 903 performed in a single center. Of 903 colonoscopies 65 (7.2%) were incom- plete. Forty-two of these subjects underwent CTC. CTC was performed with a 16-MDCT scanner after standard bowel prep (polyethyleneglycole) in both supine and prone position. Subjects whose CTC showed polyps or masses were referred to the endoscopist for repeat colonoscopy under sedation or underwent surgery. Per-lesion and per-segment positive predictive values (PPV) were calculated. RESULTS: Twenty-one (50%) of 42 CTCs showed pol-yps or masses. Fifty-five of these subjects underwent a repeat colonoscopy, whereas 2 subjects underwentsurgery for colonic masses of indeterminate nature. Four subjects refused further examinations. CTC cor- rectly identified 2 colonic masses and 20 polyps. PPV for masses or polyps greater than 9 mm was of 87.5%. Per-lesion and per-segment PPV were, respectively, 83.3% and 83.3% for polyps greater or equal to 10 mm, and 77.8% and 85.7% for polyps of 6-9 mm. CONCLUSION: In the context of a screening program for CRC based on FOBT, CTC shows high per-segment and per-lesion PPV for colonic masses and polyps greater than 9 mm. Therefore, CTC has the potential to become a useful technique for evaluation of the non visualized part of the colon after incomplete colonos-copy. | Lapo Sali Massimo Falchini Andrea Giovanni Bonanomi Guido Castiglione Stefano Ciatto Paola Mantellini Francesco Mungai Ilario Menchi Natale Villari Mario Mascalchi | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 15 | Decomposition and nutrient dynamics in mixed litter of Mediterranean species显示文摘 | Giuliano Bonanomi Guido Incerti Vincenzo Antignani Manuela Capodilupo Stefano Mazzoleni | 2010 | Plant and Soil (-)2010，，1： | 1 |
| 16 | Differential expression of eight chitinase genes in Medicago truncatula roots during mycorrhiza formation, nodulation, and pathogen infection 显示文摘 | SALZER P BONANOMI A BEYER K | 2000 | Molecular Plant Microbe Interactions2000，13，7： | 1 |
| 17 | Spiral CT virtual endoscopy of abdominal arteries; Clinical applications显示文摘 | Neri E Bonanomi G Vignali C | 2000 | Abdom Imaging2000，25，1： | 1 |
| 18 | Differential expression of eightchitinase genes in Medicago truncatula roots during mycorrhiza formation,nodulation,and pathogen infection显示文摘 | Salzer P Bonanomi A Beyer K | | 0，，07： | 1 |
| 19 | What makes A Ilium species el-fective against pathogenic microbes? 显示文摘 | Lanzotti V Bonanomi G Scala F | 2013 | Phytochemistry Reviews2013，12，4： | 1 |
| 20 | Decomposition and nutrient dynamics in mixed litter of Mediterranean species显示文摘 | Bonanomi G Incerti G Antignani V | 2010 | Plant and Soil2010，331，12： | 1 |
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