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| 1 | The hypothalamic-spinal dopaminergic system:a target for pain modulation显示文摘Nociceptive signals conveyed to the dorsal horn of the spinal cord by primary nociceptors are subject to extensive modulation by local neurons and by supraspinal descending pathways to the spinal cord before being relayed to higher brain centers. Descending modulatory pathways to the spinal cord comprise,among others, noradrenergic, serotonergic, γ-aminobutyric acid(GABA)ergic, and dopaminergic fibers.The contributions of noradrenaline, serotonin, and GABA to pain modulation have been extensively investigated. In contrast, the contributions of dopamine to pain modulation remain poorly understood.The focus of this review is to summarize the current knowledge of the contributions of dopamine to pain modulation. Hypothalamic A11 dopaminergic neurons project to all levels of the spinal cord and provide the main source of spinal dopamine. Dopamine receptors are expressed in primary nociceptors as well as in spinal neurons located in different laminae in the dorsal horn of the spinal cord, suggesting that dopamine can modulate pain signals by acting at both presynaptic and postsynaptic targets. Here, I will review the literature on the effects of dopamine and dopamine receptor agonists/antagonists on the excitability of primary nociceptors, the effects of dopamine on the synaptic transmission between primary nociceptors and dorsal horn neurons, and the effects of dopamine on pain in rodents. Published data support both anti-nociceptive effects of dopamine mediated by D2-like receptors and pro-nociceptive effects mediated by D1-like receptors. | Michelino Puopolo | 2019 | Neural Regeneration Research2019，14，6： | 10 |
| 2 | High performance composite coatings on plastics: UV-curable cy- cloaliphatic expoy resins reinforced by harphene or graphene deriva- tives显示文摘 | Massimiliano Barletta Silvia Vesco Michela Puopolo | 2015 | Surface & Coatings Technology2015，，272： | 1 |
| 3 | p53 over-expression identifies a subset of nodal peripheral T-cell lymphomas with a distinctive biological profile and poor clinical outcome 显示文摘 | Pescarmona E Pignoloni P Puopolo M | 2001 | J Pathol2001，195，3： | 1 |
| 4 | Risk assessment in neonatal early onset sepsis显示文摘 | Mukhopadhyay S Puopolo KM | 2012 | Semin Perinatol2012，36，6： | 1 |
| 5 | Participation of nurses in decision making for seriously ill adults显示文摘 | Kennard M Aperoff T Puopolo A | 1996 | Clin Nurs Res1996，5，2： | 1 |
| 6 | p53 over-expression identifies a subset of nodal peripheral T-cell lymphomas with a distinetive biological profile and poor clinical outcome 显示文摘 | Pescarmona E Pignoloni P Puopolo M | 2001 | J Pathol2001，195，3： | 1 |
| 7 | Assessing soil quality under intensive cultivation and tree orchards in Southern Italy显示文摘 | Bonanomi G D'Ascoli R Antignani V Capodilupo M Cozzolino L Marzaioli R Puopolo G Rutigliano F A Scelza R Scotti R | | 0，，： | 1 |
| 8 | Genetic prion disease:the EUROCJD experience显示文摘 | Kovacs GG Puopolo M Ladogana A | 2005 | Hum Genet2005，118，2： | 1 |
| 9 | Efficacy and safety cefdinir in the treatment of patients with acute bronchitis显示文摘 | Sperling M J Puopolo A Griffin T J | 1996 | Clin Ther1996，18，4： | 1 |
| 10 | Ap- plication and drying at ambient temperature of thick or- ganic-inorganic hybrid coatings on glass显示文摘 | BARLETTA M PUOPOLO M GISARIO A | 2013 | Surf Coat Technol2013，236，： | 1 |
| 11 | No change in the incidence of ampicillin- resistant, neonatal, early- onset sepsis over 18 years 显示文摘 | Puopolo KM Eichenwald EC | 2012 | Pediatrics2012，125，5： | 1 |
| 12 | Is the professional satisfaction of general internists as sociated to patients satisfaction?显示文摘 | Hass JS Cook EF Puopolo RL | 2000 | J Gen Intern Med2000，，15： | 1 |
| 13 | Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314显示文摘 | Puopolo M Binshtok AM Yao GL | 2013 | J Neurophysiol2013，109，7： | 1 |
| 14 | Is the professional satis- faction of general internists associated to patients satisfaction? 显示文摘 | Hass JS Cook EF Puopolo RL | 2000 | Geninter Med2000，，15： | 1 |
| 15 | Is the professional satisfaction of general internists associated with patient satisfaction显示文摘 | Haas JS Cook EF Puopolo AL | | 0，，02： | 1 |
| 16 | High performance composite coatings on plastics: UV-curable cycloaliphatic epoxy resins reinforced by graphene or graphene derivatives 显示文摘 | BARLETTA M VESCO S PUOPOLO M | 2015 | Surface and Coatings Technology2015，272，： | 1 |
| 17 | Genetic prion disease: the EUROCJD experience显示文摘 | Kovacs G G Puopolo M Ladogana A | 2005 | Hum Genet2005，27，： | 1 |
| 18 | Mortality from Creutzfeldt-Jakob disease and related disorders in Europe, Australia, and Canada 显示文摘 | Ladogana A Puopolo M Croes EA | 2005 | Neurology2005，64，9： | 1 |
| 19 | Risk factors for pulmonary candidiasis in preterm infants with a birth weight of less than 1250?g显示文摘 | Simonetta Frezza Luca Maggio Maria Pia Carolis Francesca Gallini Maria Puopolo Valentina Polimeni Simonetta Costa Giovanni Vento Giuseppe Tortorolo | 2005 | European Journal of Pediatrics2005，，2： | 1 |
| 20 | Inhibitory synapses among intemeurons in the glomerular layer of rat and frog olfactory bulbs 显示文摘 | M Puopolo O Belluzzi | 1998 | J Neurophysiol1998，80，1： | 1 |
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