|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Secondary succession of semi-arid mediterranean old-fields in south eastern spain:insights for conservation and restoration of degraded lands显示文摘 | BONET A | 2004 | Journal of Arid Environments2004，56，2： | 1 |
| 3 | The endothelia cell protein C receptor:Its role in thrombosis显示文摘 | Navarro S Bonet E Estelles A | 2011 | Thromb Res2011，128，5： | 1 |
| 4 | Food safety and functional foods in the European Union:Obesity as a paradigmatic example for novel food development显示文摘 | PALOU A PICO C BONET M L | 2004 | Nutrition Reviews2004，62，7： | 1 |
| 5 | FT-IR investigation on char formation during the early stages of coal pyrolysis显示文摘 | IBARRA J V MILINER R BONET A J | 1994 | Fuel1994，73，6： | 1 |
| 6 | Effect of microbial transglutaminase on the rbeological and thermal properties of insect damaged wheat flour 显示文摘 | Caballero P A Bonet A Rosell C M Gomez M | 2005 | Journal of Cereal Science2005，42，1： | 1 |
| 7 | Upper and lower bounds in limit analysis: Adaptive meshing strategies and discontinuous loading显示文摘 | MUNOZ J J BONET J HUERTA A | 2009 | International Journal for Numerical Methods in Engineering2009，77，4： | 1 |
| 8 | FIR investigation on char formation during the early stages of coal pyrolysis 显示文摘 | Ibarra J V Moliner R Bonet A | 1994 | Fuel1994，73，6： | 1 |
| 9 | Lead electrowinning in a fluoborate medium. Use of hydrogen diffusion anodes显示文摘 | E Expósito J González-Garc??a P Bonete V Montiel A Aldaz | 2000 | Journal of Power Sources2000，，1： | 1 |
| 10 | Characterization of the behavior of flavour microcapsules in cotton fabrics 显示文摘 | MONLLOR P BONET M A CASES F | 2007 | European Polymer Journal2007，43，6： | 1 |
| 11 | Effects of 30-yearold Aleppo pine plantations on runoff,soil erosion,and plant diversity in a semi-arid landscape in south eastern Spain 显示文摘 | Chirino E Bonet A Bellot J Sa′nchez JR | 2006 | Catena2006，65，： | 1 |
| 12 | Beta-adrenergic blocking agents in heartfailure:benefits of vasodilating and non-vasodilating agents according to patients′characteristics:a meta-analysis of clinical trails显示文摘 | Bonet S Agusti A Arnau JM | 2000 | Arch Intern Med2000，160，： | 1 |
| 13 | Risk factors for lower airway bacterial colonization in chronic bronchitis 显示文摘 | Monso E Rosell A Bonet G | 1999 | Eur Respir J1999，13，： | 1 |
| 14 | Obesity:molecular bases of a multifactorial problem显示文摘 | PALOU A SERRA F BONET ML | 2000 | Eur J Nutr2000，39，： | 1 |
| 15 | Solid neuroendocrine breast carcinomas: Incidence, clinico - pathological features and immunohistoehemical profiling显示文摘 | LOPEZ - BONET E ALONSO - RUANO M BARRAZA G A | 2008 | Oncol Rep2008，20，6： | 1 |
| 16 | The formation of wrinkles in single-layer graphene sheets under nanoindentation显示文摘 | A J Gil S Adhikari F Scarpa J Bonet | 2010 | Journal of Physics: Condensed Matter2010，，14： | 1 |
| 17 | Secondary succession of semi-arid Me diterranean old-fields in south-eastern Spain:insights for conservation and restoration of degraded lands显示文摘 | Bonet A | 2004 | Journal of Arid Environments2004，56，： | 1 |
| 18 | NADP-dependent isocitrate dehydrogenase from the halophilic archaeon Halolferax volcanii: cloning, sequence determination and overexpression in Escherichia coli显示文摘 | Camacho M Rodriguez-Arhedo A Bonete MJ | 2002 | FEMS Microbiol Lett2002，209，： | 1 |
| 19 | Microbial transglutaminase as a tool to restore the functionality of gluten from insect - damaged wheat 显示文摘 | Bonet A Caballero P A Go'mez M | 2005 | Cereal Chemistry2005，82，4： | 1 |
| 20 | Effects of 30-year-old Aleppo pine plantations on runoff,soil erosion,and plant diversity in a semi-arid landscape in south eastern Spain显示文摘 | Chirino E Bonet A Bellot J | 2006 | Catena2006，65，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员