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| 1 | Pancreaticβ-cell dysfunction in type 2 diabetes:Implications of inflammation and oxidative stress显示文摘Insulin resistance and pancreaticβ-cell dysfunction are major pathological mechanisms implicated in the development and progression of type 2 diabetes(T2D).Beyond the detrimental effects of insulin resistance,inflammation and oxidative stress have emerged as critical features of T2D that defineβ-cell dysfunction.Predominant markers of inflammation such as C-reactive protein,tumor necrosis factor alpha,and interleukin-1βare consistently associated withβ-cell failure in preclinical models and in people with T2D.Similarly,important markers of oxidative stress,such as increased reactive oxygen species and depleted intracellular antioxidants,are consistent with pancreaticβ-cell damage in conditions of T2D.Such effects illustrate a pathological relationship between an abnormal inflammatory response and generation of oxidative stress during the progression of T2D.The current review explores preclinical and clinical research on the pathological implications of inflammation and oxidative stress during the development ofβ-cell dysfunction in T2D.Moreover,important molecular mechanisms and relevant biomarkers involved in this process are discussed to divulge a pathological link between inflammation and oxidative stress duringβ-cell failure in T2D.Underpinning the clinical relevance of the review,a systematic analysis of evidence from randomized controlled trials is covered,on the potential therapeutic effects of some commonly used antidiabetic agents in modulating inflammatory makers to improveβ-cell function. | Phiwayinkosi V Dludla Sihle E Mabhida Khanyisani Ziqubu Bongani B Nkambule Sithandiwe E Mazibuko-Mbeje Sidney Hanser Albert Kotze Basson Carmen Pheiffer Andre Pascal Kengne | 2023 | World Journal of Diabetes2023，14，3： | 2 |
| 2 | Hydroch|orina tion of acetylene using carbon-supported gold cata- lysts:A study of catalyst reactivation显示文摘 | Bongani N Adams M D Neil ] C | 1991 | Journal of Catalysis1991，，37： | 1 |
| 3 | Hydrochlori- nation of acetylene using gold catalysts = A study of cat- alyst deactivation 显示文摘 | Bongani N Neil J C Hutchigs G J | 1991 | Journal of Catalysis1991，，128： | 1 |
| 4 | Hydrochlorination of acetylene using gold catalysts: A study of catalyst deactivation 显示文摘 | Bongani Nkosi Neil J Coville Graham Hutchings Mike D Adams | 1991 | Joumal of Catalysts1991，128，： | 1 |
| 5 | How teachers perceive the new curriculum reform: Lessons from a school district in the Eastern Cape Province, South Africa显示文摘 | Bongani Bantwini D | 2010 | International Journal of Educational Development2010，30，： | 1 |
| 6 | Identification of Arabidopsis salt and osmotic stress responsive proteins using two-dimensional difference gel electrophoresis and mass spectrometry显示文摘 | Bongani KN Stephen C William JS | | 0，，05： | 1 |
| 7 | Hydrochlorination of acetylene using gold catalysts: A study of catalyst deactivation 显示文摘 | Bongani Nkosi Neil J Coville Graham J Hutchings | 1991 | Journal of Catalysis1991，128，9： | 1 |
| 8 | Hydrochlorination of acetylene using carbon-supported gold catalysts: A study of catalyatreactivation 显示文摘 | Bongani Nkosi Mike D Adams Neff J Coville | 1991 | Journal of Catalysis1991，128，： | 1 |
| 9 | Recent advances in the epidemiology, pathogenesis and prognosis of acute heart failure and cardiomyopathy in Africa显示文摘 | Karen Sliwa Bongani M Mayosi | 2013 | Heart2013，，18： | 1 |
| 10 | Hydrochlorination of acetylene using carbon-supported gold catalysts: A study of catalyst reactivation显示文摘 | Bongani Nkosi Mike D Adams Neil J Coville | 1991 | Journal of Catalysts1991，128，： | 1 |
| 11 | Hydrochlorination of acetylene using gold catalysts: A study of catalyst deactivation 显示文摘 | Nkosi Bongani Coville Neil J Hutchings Graham J | 1991 | Journal of Catalysis1991，128，9： | 1 |
| 12 | Triage and management of perlcardial effusion 显示文摘 | Massimo I Bongani M Mayosib | 2010 | Journal of Cardiovascular Medicine2010，11，： | 1 |
| 13 | Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension显示文摘 | Bongani MM Peter JA Martin F | 2008 | European Heart Journal2008，29，： | 1 |
| 14 | Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis显示文摘 | Kerryn Matthews Katalin A. Wilkinson Barbara Kalsdorf Teri Roberts Andreas Diacon Gerhard Walzl Janine Wolske Mpiko Ntsekhe Faisal Syed James Russell Bongani M. Mayosi Rodney Dawson Keertan Dheda Robert J. Wilkinson Willem A. Hanekom Thomas J. Scriba | 2011 | Tuberculosis2011，，6： | 1 |
| 15 | How strong is the evidence for use of beta-blockers as first-line therapy for hypertension? Systematic review and meta-analysis显示文摘 | Hazel A Bradley Charles Shey Wiysonge Jimmy A Volmink Bongani M Mayosi Lionel H Opie | 2006 | Journal of Hypertension2006，，11： | 1 |
| 16 | Established and novel pathophysiological mechanisms of pericardial injury and constrictive pericarditis显示文摘This review article aims to:(1) discern from the literature the immune and inflammatory processes occurring in the pericardium following injury; and(2) to delve into the molecular mechanisms which may play a role in the progression to constrictive pericarditis. Pericarditis arises as a result of a wide spectrum of pathologies of both infectious and non-infectious aetiology, which lead to various degrees of fibrogenesis. Current understanding of the sequence of molecular events leading to pathological manifestations of constrictive pericarditis is poor. The identification of key mechanisms and pathways common to most fibrotic events in the pericardium can aid in the design and development of novel interventions for the prevention and management of constriction. We have identified through this review various cellular events and signalling cascades which are likely to contribute to the pathological fibrotic phenotype. An initial classical pattern of inflammation arises as a result of insult to the pericardium and can exacerbate into an exaggerated or prolonged inflammatory state. Whilst the implication of major drivers of inflammation and fibrosis such as tumour necrosis factor and transforming growth factor β were foreseeable, the identification of pericardial deregulation of other mediators(basic fibroblast growth factor, galectin-3 and the tetrapeptide Ac-SDKP) provides important avenues for further research. | Vinasha Ramasamy Bongani M Mayosi Edward D Sturrock Mpiko Ntsekhe | 2018 | World Journal of Cardiology2018，10，9： | 1 |
| 17 | Effect of faulting on coal burst——A numerical modelling study显示文摘Coal burst occurrence on roadways has always been a major concern in deep underground coal mines,especially under complex geological conditions. To evaluate the effect of faulting on coal burst, the stress concentration in the vicinity a reverse fault was analysed considering the geological history of the fault formation where high horizontal stresses led to the initiation and propagation of the reverse fault.Various in situ stresses and mechanical parameters of the fault, including the ratio of horizontal stress to vertical stress were used to analyse the state of fault. Numerical modelling was conducted using two and three dimensional distinct element models(UDEC and 3 DEC) based on a geotechnical conditions of an Australian underground coal mine. The formation process of reverse fault was simulated to evaluate the stress characteristics in the coal seam and the immediate roof and floor near the fault. The results show that, both the horizontal and vertical stress in footwall were higher than those in hanging wall after the formation of the reverse fault. The stress condition near fault was complicated due to complex geology in the coal measures, and the vertical stress peaked in the footwall at a distance of about 160 m from the fault. When a roadway was excavated, stress concentration occurred at both the roadway face and ribs, which reached as high as 38 MPa in the ribs at a depth of 500 m. This will significantly elevate the risk of dynamic instability of the roadway such as coal burst. The stress concentration zone in the footwall can be considered as a hazardous zone near the reverse fault. This study provides a general reference for analysis of roadway stability affected by faults. | Lu Chen Baotang Shen Bongani Dlamini | 2018 | International Journal of Mining Science and Technology2018，28，5： | 1 |
| 18 | Hydrochlorination of cetylene using gold catalysts: a study of catalyst deactivation显示文摘 | Bongani Nkosi Neil J Coville Graham J Hutchings | 1991 | Journal of Catalysts1991，，128： | 1 |
| 19 | Hydrochlorination of acetylene using gold catalysts: A study of catalyst deactivation显示文摘 | Bongani N Neil J C Hutchigs G J | 1991 | Joumal of Catalysis1991，128，： | 1 |
| 20 | Hydrochlorination of acetylene using gold catalysts: a study of catalyst reactivation显示文摘 | Bongani Nkosi Mike D Adams Neil J Coville | 1991 | Journal of Catalysts1991，，128： | 1 |
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