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| 1 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006,12,29: | 8 |
| 2 | 高纤维膳食和补充乙酸盐改变肠道菌群,预防醋酸脱氧皮质酮-盐型高血压小鼠高血压和心力衰竭的发展显示文摘水果和蔬菜的膳食摄入与高血压的发生率较低有关,但所涉及的机制尚未阐明。该研究评估了高纤维膳食和短链脂肪酸(short-chain fatty acid,SCFA)(乙酸盐)对肠道微生物群和预防心血管病的影响。方法:用盐皮质激素诱发小鼠高血压模型,观测正常喂食组、高纤维喂食组和补充乙酸盐组的肠道微生物、心脏结构/功能和血压水平。 | 刘莉 叶鹏 Marques FZ Nelson EM Chu PY Horlock D Fiedler A Ziemann M Tan JK Kuruppu S Rajapakse NW El-Osta A Mackay CR Kaye DM | 2016 | 中华高血压杂志2016,24,12: | 8 |
| 3 | 吸湿对单向亚麻纤维复合材料力学性能的影响显示文摘为探明亚麻纤维增强树脂复合材料(FFRPs)在长期潮湿环境中的力学性能变化规律,基于真空辅助树脂模塑传递成型(VARTM)手段制备了的干燥状态的单向FFRPs(纤维体积分数为40vol%)。试验研究了FFRPs在30°C、80%相对湿度(RH)环境中放置5天、35天、86天后拉伸力学性能变化。结果表明,FFRPs在湿热环境中吸水量近似符合一维情况下的Fickian第二定律,饱和吸水量为5.3%左右。FFRPs在垂直于纤维方向上的拉伸强度和模量随吸湿度增加递减,断口微观分析表明吸湿降低了纤维基体界面结合性能。然而,FFRPs在纤维方向上的拉伸强度并未因吸湿降低,反而在吸湿过程呈现出先减小后增加的趋势,此变化规律文献中尚未报道:相比干燥状态,放置5天后拉伸强度下降5.7%;放置35天后拉伸强度增加18.7%;放置86天时样品已处在饱和吸湿状态,拉伸强度略微减小,但仍比干燥状态增加13.7%。FFRPs在纤维取向上拉伸强度变化可解释为多因素共同作用的结果。 | 贾云龙 FIEDLER Bodo | 2022 | 复合材料学报2022,39,2: | 5 |
| 4 | MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure显示文摘 | Thomas Thum Paolo Galuppo Christian Wolf Jan Fiedler Susanne Kneitz Linda W. van Laake Pieter A. Doevendans Christine L. Mummery Jürgen Borlak Axel Haverich Carina Gross Stefan Engelhardt Georg Ertl Johann Bauersachs | 2007 | Circulation2007,,3: | 3 |
| 5 | Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes. | Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer | 2006 | World Journal of Gastroenterology2006,12,37: | 2 |
| 6 | DMT/PTA工艺的技术改进显示文摘改进的DMT/PTA工艺技术是由苏尔寿化工有限公司和H&G Hegmanns公司联合开发的。该技术对Witten-Katzschmann工艺进行了大量改进,并结合了苏尔寿公司的环境友好熔融结晶技术。改进的工艺包括:氧化反应部分(有效回收了副产品和能量);粗酯和副产品蒸馏;采用熔融结晶技术精制DMT。 | Manfred Stepanski Klaus Fiedler Anton Schoengen | 2003 | 石油化工设计2003,20,2: | 2 |
| 7 | Laser in situ keratomileusis for hyperopia and hyperopic astigmatism using the meditec MEL 70 spot scanner显示文摘 | DITZEN K FIEDLER J PIEGER S | 2002 | Journal of Refractive Surgery2002,18,4: | 2 |
| 8 | Angio-poietin-2 sensitizes endothelial cells to TNF-alpha and has a cr-ucial role in the induction ofinflammation显示文摘 | Fiedler U Reiss Y Scharpfenecker M | 2006 | Nat Med2006,12,2: | 1 |
| 9 | On the anisotropy of adhesively bonded metallic hollow sphere structures显示文摘 | Thomas Fiedler Andeas Ochsner | 2008 | Scripta Materialia2008,58,: | 1 |
| 10 | Algebraic connectivity of graphs显示文摘 | Fiedler M | 1973 | Czechoslovak Mathematical Journal1973,23,98: | 1 |
| 11 | Autoimmune hemolytic anumia associated with postirradiatiom mailigmant stromal tumor (leimyosarcoma) of the ejunum 显示文摘 | Fiedler P Passarelli J | 2000 | Am Diagn Pathol2000,4,6: | 1 |
| 12 | Vascular endothelial growth factor and its receptors in normal human testicular tissue显示文摘 | Kilic N Fiedler W | 1997 | Mol Cell Endocrinol1997,131,1: | 1 |
| 13 | Facts about the FAG bearing on the Hughes glomar explorer 显示文摘 | H Fiedler H Hofmann G Markfelder | 1975 | Ball and Roller Bearing Engineering1975,14,2: | 1 |
| 14 | Vascular endothelial growthfactor, a possible paracrine growth factor in human acute myeloidleukemia显示文摘 | Fiedler W Graven U Ergun S | 1997 | Blood1997,89,6: | 1 |
| 15 | Vascular endothelial growth factor and its receptors in normal human testicular tissue显示文摘 | Ergun S Kilic N Fiedler W | 1997 | Mol Cell Endocrinol1997,131,1: | 1 |
| 16 | Minor head injury as cause and co-factor in the aetiology of stroke in childhood:a report of eight cases显示文摘 | Kieslich M Fiedler A Heller C | 2002 | J Neurol Neurosurg Psychiatry2002,73,1: | 1 |
| 17 | Standardized approachto proteome profiling of human serum based on magnetic beadseparation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry显示文摘 | Baumann S Ceglarek U Fiedler GM | 2005 | Clin Chem2005,51,6: | 1 |
| 18 | Dolphin prey abundance de- termined from acoustic backscatter data in eastern Pacific surveys 显示文摘 | Fiedler P C Barlow J Gerrodctte T | 1998 | Fishery Bulletin1998,96,: | 1 |
| 19 | Plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis 显示文摘 | MORALES P FIEDLER J L ANDRES S | 2008 | J Neurosci Res2008,86,12: | 1 |
| 20 | Genomic profile of copy number variants on the short arm of human chromosome 8显示文摘 | Yu S Fiedler S Stegner A | 2010 | Eur J Hum Genet2010,18,: | 1 |