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| 1 | Dimethoate Induced Oxidative Damage and Histopathological Changes in lung of Adult rats:Modulatory Effects of Selenium and/or Vitamin E显示文摘Objective To determine the efficiency of selenium and/or vitamin E to alleviate lung oxidative damage induced by dimethoate,an organophosphorus compound.Methods Adult Wistar rats were exposed during 30 days either to dimethoate (0.2 g/L of drinking water),dimethoate+selenium (0.5 mg/kg of diet),dimethoate+vitamin E (100 mg/kg of diet),or dimethoate+selenium+vitamin E.Results Exposure to dimethoate caused oxidative stress in lung evidenced by an increase of malondialdehyde,protein carbonyl groups and advanced oxidation protein products.An increase in glutathione peroxidase,superoxide dismutase,catalase and a decrease in acetylcholinesterase and butyrylcholinesterase activities,glutathione,non-protein thiols and vitamins C levels were observed.Histopathological changes in lung tissue were noted as emphysema,hemorrhages and hemosiderin deposits.Co-administration of selenium or vitamin E to the diet of dimethoate treated rats ameliorated the biochemical parameters as well as histological impairments.The joint effect of these elements was more powerful in antagonizing dimethoate-induced lung oxidative damage.Conclusion We concluded that selenium and vitamin E ameliorated the toxic effects of this pesticide in lung tissue suggesting their role as potential antioxidants. | Ibtissem Ben AMARA Nejla SOUDANI Afef TROUDI Ahmed HAKIM Khaled Mounir ZEGHAL Tahia BOUDAWARA Najiba ZEGHAL | 2012 | Biomedical and Environmental Sciences2012，25，3： | 2 |
| 2 | Cobalt chloride induces hepatotoxicity in adult rats and their suckling pups显示文摘 | El Mouldi Garoui Hamadi Fetoui Fatma Ayadi Makni Tahia Boudawara Najiba Zeghal | 2009 | Experimental and Toxicologic Pathology2009，，1： | 1 |
| 3 | Protective effects of selenium on methimazole nephrotoxicity in adult rats and their offspring显示文摘 | Ibtissem Ben Amara Afef Troudi Elmouldi Garoui Ahmed Hakim Tahia Boudawara Khaled Mounir Zeghal Najiba Zeghal | 2010 | Experimental and Toxicologic Pathology2010，，6： | 1 |
| 4 | Smoking habits and severity of obstructive sleep apnea hypopnea syn- drome显示文摘 | L Boussoffara N Boudawara M Sakka | 2013 | Revue Des Maladies Respiratoires2013，30，1： | 1 |
| 5 | Oxidative stress in- duced by fluoride in adult mice and their suckling pups 显示文摘 | Bouaziz H Croute F Boudawara T | 2007 | Exp Toxicol Pathol2007，58，5： | 1 |
| 6 | Smoking habits and severity of obstructive sleep apnea hypopnea syndrome 显示文摘 | Boussoffara L Boudawara N Sakka M | 2013 | Rev Mal Respir2013，30，1： | 1 |
| 7 | Smoking habits and sever-ity of obstructive sleep apnea hypopnea syndrome显示文摘 | Boussoffara L Boudawara N Sakka M | | 0，，： | 1 |
| 8 | Protec-tive role of silymarin against manganese-induced nephrotoxicityand oxidative stress in rat显示文摘 | Chtourou Y Mouldi Garoui E Boudawara T | 2014 | Environ Toxicol2014，29，10： | 1 |
| 9 | Oxidative stress induced by fluoride in adult mice and their suckling pups 显示文摘 | Bouaziz H Croute F Boudawara T | 2007 | Exp Toxicol Pathol2007，58，5： | 1 |
| 10 | Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in ω-3 and ω-6 fatty acids in hypercholesterolemic rats显示文摘 | M. Makni H. Fetoui N.K. Gargouri El M. Garoui H. Jaber J. Makni T. Boudawara N. Zeghal | 2008 | Food and Chemical Toxicology2008，，12： | 1 |
| 11 | Oxidative stress induced by fluoride in adult mice and their suckling pups 显示文摘 | BOUAZIZ H CROUTE F BOUDAWARA T | 2007 | Experimental and Toxicologic Pathology2007，58，： | 1 |
| 12 | Cavernous sinus tuberculoma显示文摘 | Rebai R Boudawara MZ Bahioui K | | 0，，06： | 1 |
| 13 | Pure Primary Neuroendocrine Tumor of the Prostate: A Rare Entity显示文摘 | Sabeur Ketata Hafedh Ketata Hamadi Fakhfakh Ahmad Sahnoun Ali Bahloul Tahia Boudawara Mohamed Nabil Mhiri | 2006 | Clinical Genitourinary Cancer2006，，1： | 1 |
| 14 | Type 2 autoimmune hepatitis overlapping with primary sclerosing cholangitis in a 10-year-old boy显示文摘 | L. Gargouri L. Mnif F. Safi F. Turki I. Majdoub B. Maalej I. Bahri H. Mnif T. Boudawara N. Tahri A. Mahfoudh | 2013 | Archives de pédiatrie2013，，12： | 1 |
| 15 | Oxidative stress induced by fluoride in adult mice and their suckling pups显示文摘 | Bouaziz H Croute F Boudawara T ctal | 2007 | Exp Toxicol Pathol2007，58，5： | 1 |
| 16 | Association of genetic variations in TCF7L2, SLC30A8, HHEX, LOC387761, and EXT2 with Type 2 diabetes mellitus in Tunisia显示文摘 | Kifagi C Makni K Boudawara M | 2011 | Genet Test Mol Bio-markers2011，15，6： | 1 |
| 17 | Oxidative stress induced by fluoride in adult mice and their suckling pups 显示文摘 | Bouaziz H Croute F Boudawara T | 2007 | Exp Toxicol Pathol2007，58，： | 1 |
| 18 | Smoking hab- its and severity of obstructive sleep apnea hypopnea syn- drome 显示文摘 | Boussoffara L Boudawara N Sakka M | 2013 | Revue Des Maladies Respiratoires2013，30，1： | 1 |
| 19 | Histopathological findings in cholecystectomies specimens:A single institution study of 20 584 cases显示文摘Background: The histopathological examination of cholecystectomy specimens has not been standardized with a debate concerning the routine and the selective approach. The aim of this study was to assess the information obtained from routine histopathological examination of cholecystectomy specimens.Methods: All histopathological reports of cholecystectomy specimens between January 2003 and December 2016 were analyzed, including a clinical diagnosis of benign gallstone disease or cholecystitis.Results: A total of 20,584 reports were examined. The mean age of patients was 54.2 years. Patients aged more than 60 years represent 37.6% of the study population. Of all patients, 15,973(77.6%) were females.Incidental gallbladder cancers(GBC) were present in 155 cholecystectomies specimens(0.8%). 67.1% of GBC are at T2 and T3 stage. Granulomatous cholecystitis was diagnosed in only 19 cases(0.1%). GBC were more prevalent in older patients(P < 10^(-6)) and cholesterolosis was more prevalent in young patients(P < 10^(-6)). There was no gender predilection for GBC(P = 0.739).Conclusions: The rate of incidental gallbladder carcinoma in our study is low, yet, we found a higher proportion of T2 and T3 carcinomas stage. Granulomatous cholecystitis may need further investigations and treatments. When a selective approch of histopathological examination of cholecystectomy specimens is used, it is important to take into account that clinical parameters are significantly associated with gallbladder cancer. | Slim Charfi Naourez Gouiaa Hela Mnif Lassaad Chtourou Nabil Tahri Bassem Abid Rafik Mzali Tahya Sellami Boudawara | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 0 |
| 20 | Nitrate-induced Biochemical and Histopathological Changes in the Liver of Rats:Ameliorative Effect of Hyparrhenia hirta显示文摘Objective The present study investigated the protective role of Hyparrhenia hirta(H. hirta) against sodium nitrate(NaNO3)-induced hepatoxicity. Methods Male Wistar rats were randomly divided into three groups: a control group and two treated groups during 50 d with NaNO3 administered either alone in drinking water or co-administered with H. hirta. Results NaNO3 treatment induced a significant increase in serum levels of glucose, total cholesterol and triglyceride while serum total protein level decreased significantly. Transaminases and lactate deshydrogenase activities in serum were elevated indicating hepatic cells' damage after treatment with NaNO3. The hyperbilirubinemia and the increased serum gamma glutamyl transferase activities suggested the presence of cholestasis in NaNO3 exposed rats. In parallel, a significant increase in malondialdehyde level along with a concomitant decrease in total glutathione content and superoxide dismutase, catalase and glutathione peroxidase activities were observed in the liver after NaNO3 treatment. Furthermore, nitrate caused a significant induction of DNA fragmentation. These modifications in NaNO3-treated rats corresponded histologically with hepatocellular necrosis and mononuclear cells infiltration. H. hirta supplementation showed a remarkable amelioration of the abnormalities cited above. Conclusion The results concluded that the treatment with H. hirta had a significant role in protecting the animals from nitrate-induced liver dysfunction. | Hanen BOUAZIZ-KETATA Ghada BEN SALAH Hichem BEN SALAH Rim MARREKCHI Kamel JAMOUSSI Tahia BOUDAWARA Faiza FAKHFEKH Najiba ZEGHAL | 2014 | Biomedical and Environmental Sciences2014，27，9： | 0 |
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