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| 1 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | 围孕期补充叶酸和/或多种维生素预防神经管缺陷显示文摘1背景
神经管缺陷(NTDs)是在脑和脊索发育过程中形成的先天性畸形,包括无脑儿(颅骨、表面皮肤和脑组织全部或部分缺失)、脊柱裂(脊柱未闭合造成的脊索、脊膜分别或同时突出或暴露;有些病例合并脑积水)和脑膨出(脑膜疝,脑组织位于颅骨外,表面被正常或萎缩皮肤覆盖). | Lumnley J Watson L Watson M Bower C 陈晓军 丰有吉 | 2005 | 生殖与避孕2005，25，7： | 3 |
| 3 | Dramatically stabilized phosphotriesterase - polymers for nerve agent degradation显示文摘 | LeJeune KE Mesiano A J Bower SB | 1997 | Biotechnol Bioeng1997，54，2： | 1 |
| 4 | Diseases of cultured Japanese scallops (Patinopecten yessoensis ) in British Columbia, Canada 显示文摘 | Bower S M Blackbourn J Meyer G R | 1992 | Aquaculture1992，107，： | 1 |
| 5 | Germination inhibitor from Eucalyptus pulverulenta显示文摘 | Bolte M L Bowers J Crow W D | 2003 | Agric Biol Chem2003，48，2： | 1 |
| 6 | Cephalopod paralarvae assemblages in Hawaiian Islands waters 显示文摘 | BOWER J R PSEKI M YOUNG R E | 1999 | Marine Ecology Progress Series1999，185，2： | 1 |
| 7 | Enhanced strain-rate sensitivity in fcc nanocrystals due to grain boundary diffusion and sliding 显示文摘 | Wei Y J Bower A F Gao H J | 2008 | Acta Materialia2008，56，： | 1 |
| 8 | Customer power, strate- gic investment, and the failure of leading firms 显示文摘 | Christensen C M Bower J L | 1996 | Strategic Management Journal1996，17，3： | 1 |
| 9 | Aircraft route op- timization for formation flight 显示文摘 | Xu J S Ning S A Bower G C Kroo I M | 2014 | Journal of Aircraft2014，51，2： | 1 |
| 10 | Lymph nodes involved by multicentric Castleman disease among HIV-positive individuals are often involved by Kaposi sarcoma显示文摘 | Naresh KN Rice A J Bower M | 2008 | Am J Surg Pathol2008，32，7： | 1 |
| 11 | Cholesteryl ester transfer protein expression prevents dietinduced atherosclerotic lesions in male db/db mice显示文摘 | MACLEAN P S BOWER J F VADLAMUDI S | 2003 | Arterioscler Thromb Vasc Biol2003，23，8： | 1 |
| 12 | Disruptive Technologies:Catching the Wave显示文摘 | C M Christensen | 1995 | Harvard Business Review1995，，12： | 1 |
| 13 | Modeling sucrose hydrolysis in dilute sulfuric acid solutions at pretreatment conditions for lignocellulosic biomass显示文摘 | Bower S Wickramasinghe R Nagle N J | 2008 | Bioresource Technology2008，99，15： | 1 |
| 14 | Model based comparisons of pool and bilateral markets for electricity显示文摘 | Bower J Bunn D W | 2000 | The Energy Journal2000，21，3： | 1 |
| 15 | Aggregation Behavior of Aqueous Solutions of Ionic Liquid显示文摘 | Bowers James Butts C P Martin P J | 2004 | Langmuir2004，20，： | 1 |
| 16 | The first experimental observation of stable H4+ ions显示文摘 | Kirchner N J Gilbert J R Bowers M T | | 0，，1： | 1 |
| 17 | Design and analysis of ultra-high-speed near-ballistic uni-traveling-carrier photodiodes under a 50 g load for high- power performance显示文摘 | Shi J W Kuo F M Bowers J E | 2012 | IEEE Photonics Technology Letters2012，24，7： | 1 |
| 18 | SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia显示文摘 | Bowers A J Scully S Boylan JF | 2003 | Oncogene2003，22，18： | 1 |
| 19 | Experimental analysis of the efficiency of uniform-price versus discriminatory auctions in the England and Wales electricity market显示文摘 | BOWER J BUNN D | 2001 | Journal of Economic Dynamics & Control2001，25，4： | 1 |
| 20 | Serf- consistent analysis of high-temperature effect on strained layer multiple quantum-well InGaAsP-InP lasers显示文摘 | PIPREK J ABRAHAM P BOWERS J E | 2000 | IEEE J Quant Electron2000，36，3： | 1 |
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