|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | Leaf trajectory verification during dynamic intensity modulated radiotherapy using an amorphous silicon flat panel imager显示文摘 | Ploeger LS Brand B | 2004 | Med Phy2004，31，2： | 1 |
| 4 | J AlloyComp显示文摘 | Bogdanovi'c B Brand R A Marjanovi'c A | 2000 | 302: 362000，302，： | 1 |
| 5 | Stress -restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus 显示文摘 | Harvey B H Oosthuizen F Brand L | 2004 | Psychopharmacology ( Berl )2004，175，4： | 1 |
| 6 | Insights into neural stem cell biology in flies显示文摘 | Egger B Chell J M Brand A | 2008 | Phil Trans R Soe B2008，363，1489： | 1 |
| 7 | Does minimally invasive lumbar disc surgery result in less muscle injury than conventional surgery? A randomized controlled trial显示文摘 | Arts M Brand R van der Kallen B | 2011 | Eur Spine J2011，20，1： | 1 |
| 8 | Gammadelta T cells:an altemative type of professional APC显示文摘 | Brandes M | 2006 | Trends Immunol2006，27，2： | 1 |
| 9 | Black death,a disease syendrome of penaeid shrimp related to a dietary deficiency of ascorbic acid显示文摘 | LIGHTNER D V COLVIN L B BRAND C | 1977 | Proceedings of the Annual Meeting:World Mariculture Society1977，8，1234： | 1 |
| 10 | Does minimally inva- sive lumbar disc surgery result in less muscle injury than conven- tional surgery? A randomized controlled trial显示文摘 | Arts M Brand R van der Kallen B | 2011 | Eur Spine J2011，20，1： | 1 |
| 11 | Analog peptides of type Ⅱ collagen can suppress arthritis in HLA- DR4(DRB1 * 0401)transgenic mice显示文摘 | Sakurai Y Brand D D Tang B | 2006 | Arthritis Res Ther2006，8，5： | 1 |
| 12 | Ultrastructural and cytochemical changes in cuhured human lung cells显示文摘 | Brandes D Murphy D G Anton E B et ol | 1972 | J Ultrastruct Res1972，39，5： | 1 |
| 13 | Laser ablation-combustion-GC-IRMS — a new method for online analysis of intra-annual variation of δ13C in tree rings显示文摘 | Schulze B Wirth C Linke P Brand WA Kuhlmann I Horna V Schulze ED | | 0，，： | 1 |
| 14 | Major depressive disorder and patient satisfaction in relation to methadone pharmacokinetics and pharmacodynamics in stabilized methadone maintenance patients显示文摘 | Elkader AK Brands B Dunn E | 2009 | J Clin Psychopharmacol2009，29，1： | 1 |
| 15 | Smithells metals reference book 7th ed 显示文摘 | Brandes E A Brook G B | 1992 | Butterworth-Heinemann Ltd1992，，： | 1 |
| 16 | The synthesis of peptides related to gramicidin显示文摘 | Erlanger B F Sachs H Brand E J | 1954 | J Am Chem Soc1954，76，4： | 1 |
| 17 | Nitric oxide may prevent hypertension early in diabetes by counteracting renal actions of superoxide显示文摘 | Brands MW Bell TD Gibson B | 2004 | Hypertension2004，43，1： | 1 |
| 18 | Aneurysm of the splenic vein显示文摘 | Heeren M Op - de - Beeck B Van - den - Brande P | 2004 | Acta Chir Belg2004，104，3： | 1 |
| 19 | Crosspresenting human gamma delta T cells induce robust CD8+alpha beta T cell responses显示文摘 | Brandes M Willimann K Bioley G Lévy N Eberl M Luo M TampéR Lévy F Romero P Moser B | 2009 | Proc Natl Acad Sci USA2009，106，7： | 1 |
| 20 | Prospective evaluation of morpholo- gy, function, and quality of life after extracorporeal shockwave litho- tripsy and endoscopic treatment of chronic calcific panereatitis 显示文摘 | Brand B Kahl M Sidhu S | 2000 | Am J Gastroenterol2000，95，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员