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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | A comparison of eleven static heuristics for mapping a class of independent tasks onto heterogeneous distributed computing systems显示文摘 | Braun T D Siegel H S Beck N | 2001 | Journal of Parallel and Distributed Computing2001，61，6： | 1 |
| 3 | A comparison of eleven static heuristics for mapping a class of independent tasks onto heterogeneous distributed computing systems显示文摘 | BRAUN TD SIEGEL HI BECK N | 2001 | Journal of Parallel and Distributed Computing2001，61，6： | 1 |
| 4 | Oxidized low densi- ty lipoproteins, statin therapy and severity of coronary artery dis- ease显示文摘 | Ndrepepa G Braun S von Beckerath N | 2005 | Clin Chim Acta2005，360，12： | 1 |
| 5 | Corrosion of experimental magnesium alloys in blood and PBS: A gravimetric and microscopic evaluation 显示文摘 | SCHILLE C BRAUN M WENDEL H P SCHEIDELER L HORT N REICHEL H P SCHWEIZER E GEIS-GERSTORFER J | 2011 | Materials Science and Engineering B2011，176，20： | 1 |
| 6 | Strategies for reducting radiation dose in CT 显示文摘 | McCollough CH Primak AN Braun N | 2009 | Radiol Clin North Am2009，47，： | 1 |
| 7 | A comparison of eleven static heuristics for mapping a class of independent tasks onto heterogeneous distributed computing systems显示文摘 | BRAUN T D SIEGEL H J BECJ N | 2001 | Journal of Parallel and Distributed Computing2001，61，6： | 1 |
| 8 | Advantages of soft X-ray absorption over TEM-EELS for solid carbon studies-a comparative study on diesel soot with EELS and NEXAFS 显示文摘 | Braun A Huggins F E Shah N | 2005 | Physital Review B Condensed Matter2005，43，1： | 1 |
| 9 | Immunoadsorption onto protein A induces remission in severe systemic lupus erythematosus显示文摘 | Braun N Erley C Klein R | 2000 | Nephrol Dial Transplant2000，15，9： | 1 |
| 10 | Semiconducting polymer- buck- minsterfullerene heterojunctions : Diodes, Photodiodes, and Photovoltaic cells显示文摘 | Sariciftci N S Braun D Zhang C | 1993 | Appl Phys Lett1993，62，： | 1 |
| 11 | Stress in Pimelodus maculatus(Siluriformes:Pimelodidae)at different densities andtimes in a simulated transport显示文摘 | Braun N Nuer A P O | 2014 | Zoologia(Curitiba)2014，31，1： | 1 |
| 12 | A study of die- sel PM with X-ray microspectroscopy 显示文摘 | Braun A Shan N Huggins F E | 2004 | Fuel2004，83，78： | 1 |
| 13 | Semiconducting polymer-buckminsterfullerene heterojunctions: Diodes, photodiodes, and photovoltaic cell显示文摘 | Sariciftei N D Braun D Zhang C | 1993 | Appl Phys Lett1993，62，6： | 1 |
| 14 | A comparison of eleven static heuristics for mapping a class of independent tasks onto heterogeneous distributed computing systems显示文摘 | BRAUN T D SIEGEL H J BECK N | 2001 | Journal of Parallel and Distributed Computing2001，61，6： | 1 |
| 15 | Strate- gies for reducing radiation dose in CT显示文摘 | McCollough C H Primak A N Braun N | 2009 | Radiologic Clinics of North America2009，47，1： | 1 |
| 16 | Association of the Ecto-ATPase NTPDase2 with glial cells of the peripheral nervoussystem显示文摘 | Robson SC Hammer K | 2004 | Glia2004，45，2： | 1 |
| 17 | Proteinase inhibitors as drugs 显示文摘 | Schnebli H P Braun N J | 1986 | Research Monographs in Cell and Tissue Physiolo- gy1986，12，3： | 1 |
| 18 | Cytoreductive surgery and hyperthermic intrathoracic chemotherapy perfusion for malignant pleural tumours : perioperative management and clinical experience 显示文摘 | Ried M Potzger T Braune N | 2013 | Eur Cardiothorac Surg2013，43，4： | 1 |
| 19 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 20 | Prevalence and functioning of children with cerebral palsy in four areas of the United States in 2006: a report from the Autism and Developmental Disabilities Monitoring Network 显示文摘 | Kirby R S Wingate M S Braun K V N | 2011 | Research in developmental disabilities2011，32，2： | 1 |
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