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| 1 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 2 | An analysis of multiple staging management strategies for carcinoma of the esophagus: computed tomography, endoscopic ultrasound, positron emission tomography, and thoracoscopy/laparoscopy显示文摘 | Michael B Wallace Paul J Nietert Craig Earle Mark J Krasna Robert H Hawes Brenda J Hoffman Carolyn E Reed | 2002 | The Annals of Thoracic Surgery2002，，4： | 2 |
| 3 | Predictors of survival for esophageal cancer patients with and without celiac axis lymphadenopathy: impact of staging endosonography显示文摘 | Mohamad A Eloubeidi Michael B Wallace Brenda J Hoffman Margaret B Leveen Annette Van Velse Robert H Hawes Carolyn E Reed | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 4 | Viral load of human papillomavirus and risk of CIN3 or cervical cancer显示文摘 | Attila T Lorincz Philip E Castle Mark E Sherman David R Scott Andrew G Glass Sholom Wacholder Brenda B Rush Patti E Gravitt John E Schussler Mark Schiffman | 2002 | The Lancet . 2002 (9328)2002，，9328： | 1 |
| 5 | Isolation and identification of rhizoxin analogs from Pseudomonas fluorescens Pf- 5 by using a genomic mining strategy显示文摘 | Joyce E L Marcella D H Brenda T S | 2008 | Appl Environ Microbiol2008，74，10： | 1 |
| 6 | Costs associated with delirium in mechanically ventilated patients显示文摘 | Eric B. Milbrandt Stephen Deppen Patricia L. Harrison Ayumi K. Shintani Theodore Speroff Renée A. Stiles Brenda Truman Gordon R. Bernard Robert S. Dittus E. Wesley Ely | 2004 | Critical Care Medicine2004，，4： | 1 |
| 7 | Clinical human papilloma- virus detection forecasts cervical cancer risk in Women over 18 years of follow-up显示文摘 | Philip E Andtew G Brenda B | 2012 | J Clin Oncol2012，30，25： | 1 |
| 8 | Costs associated with delirium in mechanically ventilated patients显示文摘 | Eric B. Milbrandt Stephen Deppen Patricia L. Harrison Ayumi K. Shintani Theodore Speroff Renée A. Stiles Brenda Truman Gordon R. Bernard Robert S. Dittus E. Wesley Ely | 2004 | Critical Care Medicine2004，，4： | 1 |
| 9 | The costs of caring : Gender identi- fication increases threat following exposure to sexism显示文摘 | Dina E Brenda M Wendy BM | 2010 | J Exp Soe Psychol2010，36，1： | 1 |
| 10 | Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children显示文摘 | Brenda E Amy R M Asa B | 2007 | Environmental Health Perspectives2007，115，5： | 1 |
| 11 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 12 | SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity outcome.Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral replication.We found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis.In addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)patients.The rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung tissue.These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host. | Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda | 2022 | Journal of Molecular Cell Biology2022，14，4： | 1 |
| 13 | Use of Traceback Methods To Confirm the Source of a Multistate Escherichia coli O157:H7 Outbreak Due to In-Shell Hazelnuts显示文摘 | Miller Benjamin D Rigdon Carrie E Ball Jill Rounds Joshua M Klos Rachel F Brennan Brenda M Arends Katherine D Kennelly Patrick Hedberg Craig Smith Kirk E | 2012 | EN2012，，2： | 1 |
| 14 | Autologous fat grafts: a quantitative and morphometric study in rabbits显示文摘 | MARQUES A BRENDA E SALDIVA P H | 1994 | Scand J Plast Reeonstr Surg Hand Surg1994，28，4： | 1 |
| 15 | Evolution and Implementation:A Study of Values, Business Ethics and Corporate Social Responsibility 显示文摘 | Brenda E joyner Dinah Payne | 2002 | Journal of Business Ethics2002，41，4： | 1 |
| 16 | Enzyme entrapment in liposomes 显示文摘 | G Gregoriadis P D Leathwood Brenda E Ryman | 1971 | FEBS Letters1971，14，2： | 1 |
| 17 | Interim clinical outcomes in the collaborative initial glaucoma treatment study comparing initial treatment randomized to medications or surgery显示文摘 | Paul R Lichter David C Musch Brenda W Gillespie Kenneth E Guire Nancy K Janz Patricia A Wren M.P.H.Richard P Mills | 2001 | Ophthalmology2001，，11： | 1 |
| 18 | Immunogenicity and Safety Testing of a Group B Intranasal Meningoeoccal Native Outer Membrane Vesicle Vaccine显示文摘 | Rohit K K Brenda L B Ellen E M | 2002 | Infect Immun2002，70，2： | 1 |
| 19 | Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders 1 1 This study was registered with ClinicalTrials.gov (trial registry no. NCT00006157).显示文摘 | Douglas A Drossman Brenda B Toner William E Whitehead Nicholas E Diamant Chris B Dalton Susan Duncan Shelagh Emmott Valerie Proffitt Donna Akman Karen Frusciante Terry Le Kim Meyer Barbara Bradshaw Kristi Mikula Carolyn B Morris Carlar J Blackman Yuming H | 2003 | Gastroenterology2003，，1： | 1 |
| 20 | A framework for analysis of transboundary institutions for air pollution policy in the United States显示文摘 | Brenda J N William H L Michelle E B | 1998 | Environmental Science & Policy 11998，，： | 1 |
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