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| 1 | Carcinoma in situ in a 7 mm gallbladder polyp: Time to change current practice?显示文摘Detection of polypoid lesions of the gallbladder is increasing in conjunction with better imaging modalities. Accepted management of these lesions depends on their size and symptomatology. Polyps that are symptomatic and/or greater than 10 mm are generally removed, while smaller, asymptomatic polyps simply monitored. Here, a case of carcinoma-in-situ is presented in a 7 mm gallbladder polyp. A 25-year-old woman, who had undergone a routine cholecystectomy, was found to have an incidental 7 mm polyp containing carcinoma in situ. She had few to no risk factors to alert to her condition. There are few reported cases of cancer transformation in gallbladder polyps smaller than 10 mm reported in the literature. The overwhelming consensus, barring significant risk factors for cancer being present, is that such lesions should be monitored until they become symptomatic or develop signs suspicious for malignancy. In our patient's case this could have led to the possibility of missing a neoplastic lesion, which could then have gone on to develop invasive cancer. As gallbladder carcinoma is an aggressive cancer, this may have led to a tragic outcome. | David Kasle Amir A Rahnemai-Azar Shahida Bibi Vinaya Gaduputi Brian F Gilchrist Daniel T Farkas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 8 |
| 2 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 3 | A synoptic survey of nitrogen and phosphorus in tributary streams, and great rivers of the upper mississippi, Missouri, and Ohio River Basins 显示文摘 | Brian H Hill David W Bolgrien Alan T Herlihy | 2011 | Water Air Soil Pollution2011，216，： | 1 |
| 4 | Prevalence of Raynaud's phenomenon in Great Britain and its relation to hand transmitted vibration:a national postal survey显示文摘 | Keith T Palmer Michael J Griffin Holly Syddall Brian Pannett Cyrus Cooper David Coggon | 2000 | Occup Environ Med2000，57，： | 1 |
| 5 | Comparison of four Acti- graph GT3X accelerometers during walking and running 显示文摘 | DINESH J Brian T DAVID R | 2010 | Med Sci Sports Exerc2010，42，2： | 1 |
| 6 | Evaluation of the Cd/hemoglobin affinity assays for the rapid determination of metallothionein in biological tissues 显示文摘 | David L E Brian F T | 1982 | Toxical Appl Pharmacol1982，66，： | 1 |
| 7 | Use of non-timber forest products from invasive alien Prosopis species(mesquite) and native trees in South Africa: implications for management显示文摘Background: Prosopis species have been introduced to many areas outside their native range to provide benefits to local communities. Several Prosopis species and their hybrids(hereafter 'mesquite') have, however, become naturalised and invasive and now generate substantial costs. Management options are limited because of the complex conflicts of interest regarding benefits and costs. Management policies and strategies must take account of such conflicts, but further insights are needed on the dimensions of uses and impacts before such information can be usefully applied. Current policy in South Africa allows for the growth and use of mesquite in one province,but not in others where its control is mandatory. We report on a study to quantify the direct use and perceptions of non-timber forest products(NTFPs) from mesquite and native trees in South Africa.Methods: Semi-structures household interviews were conducted with various stakeholder groups to identify what tree products are used, to ascertain amounts used as well as to gauge perceptions of natural resource use between different tree species and use over time.Results: The direct household use value of native trees was higher than that of mesquite, and local stakeholders attached greater value to products from native trees than from mesquite. Therefore, native trees are and will still be preferentially harvested, and mesquite is unlikely to offer protection to native species by providing an alternative source of products. Mesquite pods do, however, provide valuable additional resources(fodder and medicinal products). The use of both native trees and mesquite is decreasing as the incomes of poorer households rise and as alternative energy sources become available. The benefits and reliance on mesquite are not as high as previously assumed and the impacts from mesquite invasions create large problems for local communities.Conclusion: This study provides further evidence that the impacts of mesquite exceed the benefits, lending support for a policy to reduce negative impacts. | Ross T Shackleton David C Le Maitre Brian W van Wilgen David M Richardson | 2015 | Forest Ecosystems2015，2，3： | 1 |
| 8 | The perspectives of adults living with peritoneal dialysis: thematic synthesis of qualitative studies 显示文摘 | Allison T Brian L David WJ | 2013 | Am J Kidney Dis2013，61，6： | 1 |
| 9 | Haloacetic acids in Canadian lake waters and precipitation显示文摘 | Brian F S David M T Christine S | 2000 | Environ Sci Technol2000，34，20： | 1 |
| 10 | Fatty acid flux in adipocytes: The in's and our's of fat cell lipid trafficking 显示文摘 | Brian R T Sandra L David A B | 2010 | Molecular and Cellular Endocrinology2010，318，： | 1 |
| 11 | Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases显示文摘 | Pamela T Soliman Brian M Slomovitz Russell R Broaddus Charlotte C Sun Jonathan C Oh Patricia J Eifel David M Gershenson Karen H Lu | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 12 | The mediat- ing role of psychological empowerment on the relationships between P-0 fit, job satisfaction, and in-role perfor- mance 显示文摘 | Brian T Gregory M David Albritton | 2010 | Journal of Business and Psychology2010，25，4： | 1 |
| 13 | The Mediating Role of Psychological Empowermeni on itle Rela- tionships between P - O Fit, Job Satisfaction,and In-role Per- formanee 显示文摘 | Brian T Gregory M David Albritton Talai Osmonbekov | 2010 | Journal of Bussiniss Psychology2010，25，： | 1 |
| 14 | Measurement and Modeling of Heat Transfer Across Interfacial Mold Flux Layers 显示文摘 | David T Stone Brian G Thomas | 1999 | Canadian Metallurgical Quarterly1999，38，5： | 1 |
| 15 | Genome sequence of the palaeopolyp|oid soybean 显示文摘 | Jeremy S Steven B C Jessica S Ma J X Therese M William N David L H Qijian S Jay J T Cheng J L Xu D Uffe H Gregory D M Yeisoo Y Tetsuya S Taishi U Madan K B Devinder S Babu V Erika L Myron P David G Shu S Q David G Kerrie B Montona F Brian A Du J C Tian Z Zhu L Navdeep G Trupti J Marc L Anand S Zhang X C Kazuo S Henry T N Rod A Perry C James S Jane G Dan R Gary S Randy C S Scott A J | 2010 | Nature2010，463，： | 1 |
| 16 | The Mediating Role of Psycho- logical Empowerment on the Relationships between P - O Fit, Job Satisfaction, and In - role Performance 显示文摘 | BRIAN T GREGORY M DAVID A | 2010 | Journal of Business & Psychology2010，25，： | 1 |
| 17 | 通过预处理短暂诱导缺氧适应不能提高脊髓损伤后雪旺细胞移植的存活率显示文摘缺氧预处理在多种损伤和疾病模型中具有保护作用,但它是否对移植到脊髓损伤(SCI)部位的细胞有益在很大程度上尚待探索。本研究分析了缺氧相关的预处理是否能保护移植到挫伤的大鼠胸髓中的雪旺细胞(SC)。雪旺细胞在移植前通过暴露于低氧(1%O2)或药物制剂(去铁胺或adaptaquin)诱导缺氧预处理。所有预处理方法均诱导缺氧适应,包括HIF-1α及其靶基因的表达增加。然而这些适应是短暂的,并在移植后24 h内消失。药理学预处理减弱了脊髓氧化应激,并增强了移植血管形成,但它并没有改善移植细胞的存活或感觉/运动功能的恢复。总之,这些实验结果表明,与缺氧相关的预处理在改善脊髓损伤后移植雪旺细胞的细胞存活或功能方面是无效的。本研究还揭示了在细胞移植疗法中由预处理引起的缺氧相关适应的益处并不普遍。 | Brian T David Jessica J Curtin Jennifer L Brown Kerri Scorpio Veena Kandaswamy David J C Coutts Ana Vivinetto Paola Bianchimano Saravanan S Karuppagounder Mariajose Metcalfe JohnWCave Caitlin E Hill 杜一星(编译) | 2023 | 神经损伤与功能重建2023，18，1： | 0 |
| 18 | 因地制宜:落实非传染性疾病的防控措施显示文摘众所周知,非传染性疾病(NCDs)是人类健康和发展所面临的最大挑战之一,全球出台了很多有关防控的政治承诺、这其中最知名的当属《联合国可持续发展目标》(SDGs),明确提出了“到2030年将NCDs导致的过早死亡减少三分之一”的奋斗目标2。但从当前的全球降低速率来看,理想和现实之间还有很大差距3。而更令人揪心的“国际共识”是,世界卫生组织(WHO)推广的“最划算措施”等循证干预并未落实到位,有相当大比例的NCDs导致的过早死亡案例原本可以避免3-5。 | Joao Breda Kremlin Wickramasinghe David H Peters Ivo Rakovac Brian Oldenburg Bente Mikkelsen Ruitai Shao Cherian Varghese Téa Collins Kristen Wall Jill Farrington Nick Townsend 李丹麑(译) | 2020 | 英国医学杂志中文版2020，23，5： | 0 |
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