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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 3 | Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study显示文摘 | Martina Goffredo Sonia Caprio Ariel E. Feldstein Ebe D’Adamo Melissa M. Shaw Bridget Pierpont Mary Savoye Hongyu Zhao Allen E. Bale Nicola Santoro | 2016 | Hepatology2016，，1： | 1 |
| 4 | Cadmium,Lead,and Other Metals in Relation to Semen Quality:Human Evidence forMolybdenum as a Male Reproductive Toxicant显示文摘 | John D M Mary G R Bridget P | 2008 | Environ Health Perspect2008，116，11： | 1 |
| 5 | Postoperative Complications After Primary Adult Optical Penetrating Keratoplasty: Prevalence and Impact on Graft Survival显示文摘 | Michael D Wagoner Rola Ba-Abbad Mansour Al-Mohaimeed Samar Al-Swailem M Bridget Zimmerman | 2009 | Cornea2009，，4： | 1 |
| 6 | Both actin and polypro- line interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothe- lial cells 显示文摘 | Zhijie D David G Bridget D | 2009 | Experimental Cell Research2009，315，17： | 1 |
| 7 | Effects of participation in a martial arts-based antibullying program in elementary schools 显示文摘 | Stuart W T Bridget K B Timothy D N Eric M V Peter F Stephen W T | 2008 | Psychology in the School2008，45，10： | 1 |
| 8 | Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral(salen)Co Ⅲ complexes,practical synthesis of enantioenriched terminal epoxides and 1,2-diols显示文摘 | Scott E Schaus Bridget D | 2002 | American Chemical Society2002，124，： | 1 |
| 9 | Almond flower development: floral initiation and organogenesis显示文摘 | BRIDGET M L JOSEPH H C ROGER A D | 2001 | Journal of the American Society for Horticultural Science2001，126，6： | 1 |
| 10 | Conserved cysteine residues within the attachment G glycoprotein of respiratory syncytial virus play a critical role in the enhancement of cytotoxic T-lymphocyte responses 显示文摘 | Melendi GA Bridget D Monsalvo AC | 2011 | Virus Genes2011，42，1： | 1 |
| 11 | Wetland management: an analysis of past practice and recent policy changes in ontario显示文摘 | BRIDGET S- H ALTERS D W | 2007 | Journal of Environment Management2007，82，： | 1 |
| 12 | Diversity of avian Pasteurella multocida strains based on capsular PCR typing and variation of the OmpA and OmpH outer membrane proteins显示文摘 | Robert L D Roslyn M Bridget C | 2003 | Vet Microbiol2003，91，： | 1 |
| 13 | Impact of Donor Age and Year of Transplantation on Graft and Patient Survival Following Liver Transplantation for Hepatitis C Virus显示文摘 | David J. Mutimer Bridget Gunson John Chen J Berenguer Peter Neuhaus D Castaing J C. Garcia-Valdecasas M Salizzoni Gonzalez E. Moreno Darius Mirza | 2006 | Transplantation2006，，1： | 1 |
| 14 | The Importance of Course Design, Feed- back,and Facilitation: Student Perceptions of the Relationship Be- tween Teaching Presence and Cognitive Presence显示文摘 | Hoslera K A Bridget D A | 2012 | Educational Me- dia International2012，49，3： | 1 |
| 15 | Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral(salen)Co^Ⅲ complexes显示文摘 | SCOTT E S BRIDGET D B JAY F L | 2002 | J Am Chem Soc2002，124，7： | 1 |
| 16 | Vaccination of cattle with Mycobacterium bovines culture Filtrate Proteins andinterleukin-2 for protection against Bovine Tuberculosis显示文摘 | Neil W D Bridget V M A Skinner | 2000 | Infection and Immunity2000，68，： | 1 |
| 17 | Cadmium,Lead,and other metals in relation to semen quality:Human evidence for molybdenum as a male reproductive toxicant显示文摘 | John D M Mary G R Bridget P | 2008 | Environmental Health Perspectives2008，116，11： | 1 |
| 18 | The conditional probability of survival of patients with primary malignant brain tumors:surveillance, epidemiolgy, and end results(SEER) data显示文摘 | Faith G D Bridget J M Sally F | 1999 | Cancer1999，85，2： | 1 |
| 19 | Diversity of avian Pasteurella muhocida strains based on capsular PCR typing and variation of the OmpA and OmpH outer membrane proteins显示文摘 | Robert L D Roslyn M C Bridget C | 2003 | Vet Microbiol2003，91，23： | 1 |
| 20 | The Release of Nanosilver from Consumer Products Used in the Home显示文摘 | Benn Troy Cavanagh Bridget Hristovski Kiril Posner Jonathan D Westerhoff Paul | 2010 | EN2010，，6： | 1 |
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