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| 1 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 2 | Synthesis,in vivo activity of novel 9-deoxo-9a-aza-homoerythromycin A derivatives; A new class of macrolide antibiotics,the azalides显示文摘 | Nagel A A Bordnor J | 1988 | J Antibiot1988，41，8： | 1 |
| 3 | American Academy of Audiology Childhood Hearing Screening Guidelines显示文摘 | Bright K Eichwald J Loveland CO | 2011 | 2011，，： | 1 |
| 4 | AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure显示文摘 | Thornton C Bright N J Sastre M | 2011 | Biochem J2011，434，3： | 1 |
| 5 | Induction of heterosubtypic immunity to influenza A virus using a DNA vaccine expressing hemagglutinin-C3d fusion proteins显示文摘 | Mitchell J A Green T D Bright R A | 2003 | Vaccine2003，21，910： | 1 |
| 6 | 3-Nitropropionate, the toxic substance of indigofera, is a suicide inactivator of succinate dehydrogenase 显示文摘 | Alston T A Mela L Bright H J | 1997 | Proc Nat Acad Sci USA1997，74，37： | 1 |
| 7 | Incidence of adamantine resistance among influenza A (H3N2 ) viruses isolated worldwide from 1994 to 2005:a cause for concern 显示文摘 | Bright R A Mcdina M J Xu X Y | 2005 | Lancet2005，366，： | 1 |
| 8 | Cognitive therapy for bipolar illness-a pilot study of relapse prevention显示文摘 | Dominic H Bright J Steve J | 2000 | Cognitive Therapy and Research2000，24，5： | 1 |
| 9 | The NBS large-area alpha- particle counting systems显示文摘 | Hutchinson J M R Bright S J | 1987 | J Res NBS1987，92，5： | 1 |
| 10 | Recovery of trace DNA and its application to DNA profiling of shoe insoles 显示文摘 | Bright J A Petricevic S F | 2004 | Forensic Sci Int2004，145，1： | 1 |
| 11 | Determination of the deposition order of overlapping latent fingerprints and inks using secondary ion mass spectrometry显示文摘 | Bright N J Webb R P Bleay S | 2012 | Anal Chem2012，84，9： | 1 |
| 12 | Prehospital recognition of acute myocardial infarction显示文摘 | Bright H Pocock J | 2002 | CJEM2002，4，3： | 1 |
| 13 | AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid beta-peptide exposure显示文摘 | Thornton C Bright N J Sastre M | 2011 | Biochem J2011，434，3： | 1 |
| 14 | ABA, hydrogen peroxide and nitric oxide signaling in stomatal guard cells 显示文摘 | Desikan R Cheung M K Bright J | 2004 | J Exp Bot2004，55，395： | 1 |
| 15 | Improvement of protein quality in cereals显示文摘 | BRIGHT S W J SHEWRY P R | 1983 | Crit Rev Plant Sci1983，，1： | 1 |
| 16 | Protozoan size influences algal pigment degradation during grazing显示文摘 | Strom S L Morello T A Bright K J | 1998 | Mar Ecol Prog Ser1998，164，： | 1 |
| 17 | Metabonomics with ^1H- NMR spectroscopy and liquid chromatographymass spectrometry applied to the investigation of metabolic changes caused by gentamicin - induced nephrotoxicity in the rat显示文摘 | Lenz EM Bright J Knight R | 2005 | Biomarkers2005，10，23： | 1 |
| 18 | ABA-induced NO Generation and Stomatal Closure in Arabidopsis are Dependent on H2O2 Synthesis显示文摘 | BRIGHT J DESIKAN R HANCOCK J T | 2006 | Plant J2006，45，： | 1 |
| 19 | Nitric oxide, stomatal closure, and abiotic stress 显示文摘 | Neill S Barros R Bright J | 2008 | Journal of experimental botany2008，59，2： | 1 |
| 20 | Sweep methods for parallel computational geometry显示文摘 | Goodrich M T Ghouse M R Bright J | 1996 | Algorithmica1996，15，2： | 1 |
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