|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Calcium-Dependent Protein Kinase CPK21 Functions in Abiotic Stress Response in Arabidopsis thaliana显示文摘钙依赖者蛋白质 kinases (CDPK ) 包括察觉到领域和 kinase 受动器领域的钙在一个分子以内在被联合的植物 serine/threonine 蛋白质 kinases 的一个家庭。到目前为止,在不能生活的应力发信号的生物功能仅仅为很少 CDPK isoforms 被报导了,而为这些 CDPK 的内在的生物化学的机制主要仍然是未知的。这里,我们证明从 Arabidopsis thaliana 的 CPK21 生物化学地响应 hyperosmotic 应力在 vivo 被激活。cpk21 的 Loss-of-function 幼苗对 hyperosmotic 应力更容忍,变异的植物关于标记基因表示和代谢物累积显示出增加的压力回答。在互补在 cpk21 异种背景衬里的转基因的 Arabidopsis,在哪个任何一个 CPK21 野类型,或带氨基酸的替换的全身的酶变体稳定地被表示,压力 responsitivity 被 CPK21 然而并非与 kinase 恢复不活跃的变体。生物化学的描述在 planta,综合并且净化的 CPK21 蛋白质表明在钙绑定领域以内,与 C 终端 EF3 主题和 EF4 主题相比的 N 终端 EF1 主题和 EF2 主题在他们对调整钙的 kinase 活动的贡献不同,为 N 终端 EF 手对建议一个关键角色。我们的数据为在不能生活的应力发信号作出贡献的 CPK21 提供证据并且建议 N 终端 EF 手对是控制 CPK21 的特性的一个察觉到钙的决定因素函数。 | Sandra Franz Britta Ehlert Anja Liese Joachim Kurth Anne-Claire Cazale Tina Romeis | 2011 | Molecular Plant2011，4，1： | 27 |
| 2 | Innate and adaptive immunity in inflammatory bowel disease显示文摘Inflammatory bowel diseases are the consequence of a dysregulated mucosal immune system. The mucosal immune system consists of two arms, innate and adaptive immunity, that have been studied separately for a long time. Functional studies from in vivo models of intestinal inflammation as well as results from genome-wide association studies strongly suggest a crossregulation of both arms. The present review will illustrate this interaction by selecting examples from innate immunity and adaptive immunity, and their direct impact on each other. Broadening our view by focusing on the cross-regulated areas of the mucosal immune system will not only facilitate our understanding of disease, but furthermore will allow identification of future therapeutic targets. | Britta Siegmund Martin Zeitz | 2011 | World Journal of Gastroenterology2011，17，27： | 9 |
| 3 | Enhanced electrochemical performance in lithium ion batteries of a hollow spherical lithium-rich cathode material synthesized by a molten salt method显示文摘高电压有空球形的结构的分层的 Li1.2Ni0.16Co0.08Mn0.56O2 阴极材料被熔融盐的方法在 NaCl 流动综合了。由 X 光检查衍射和扫描电子显微镜学的描述证实了它的结构并且证明同样准备的粉末由小、同质地大小的空范围(11.5 m ) 组成。展出的材料首先提高了率能力和高度周期效率由于第二等的粒子的好分散。Galvanostatic 在不同温度骑车(20, 40,和 60 ?瑬湩 ? 湩猠汥' 虡 N 敶攠捴楨杮漠 ? 桴 ? 湚 ? 剎挠牯獥舀 ? 销吗?? | Xin He Jun Wang Richard Kloepsch Steffen Krueger Haiping Jia Haidong Liu Britta Vortmann Jie Li | 2014 | Nano Research2014，7，1： | 9 |
| 4 | 金属标准物质中杂质的辉光放电质谱法溯源分析显示文摘标准物质定值分析的溯源性要求比常规分析高很多。在常规分析中,有证标准物质(CRM)可用于校准以及建立可溯源性。尽管与标准物质生产和认定相关的ISO导则并没有十分明确地提到校准,但众多标准物质生产者在定值分析时却不接受基准标准物质用于校准。这些要求制约了标准物质定值方法的使用,因为这些方法可以采用已知高纯度的标准物质、化学计量法及已知高纯度标准物质的混合物进行校准。有效的固体取样技术,例如通常使用的块状标准物质进行校准的辉光放电质谱法(GD-MS)或火花源发射光谱法(spark-OES),似乎不太适合定值分析。尤其是固体样品中痕量元素分析测定的有力工具辉光放电质谱法,除金属杂质外,使用特定气体混合物,这种方法也可以分析相关的非金属杂质如硫和磷。我们开发了一种可以使用已知高纯度的标准物质混合物和化学计量法的校准方法,这种校准方法同样可用于辉光放电质谱法。与溶液中基体匹配技术类似,此校准方法基于掺杂的粉末压片。本文还结合铜和钢标准物质的定值分析结果进行了陈述。 | RECKNAGEL Sebastian KIPPHARDT Heinrich LANGE Britta HOPPE Marion | 2012 | 冶金分析2012，32，2： | 6 |
| 5 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 6 | Extraluminal factors contributing to inflammatory bowel disease显示文摘Many identified and yet unknown factors contribute to the pathogenesis of inflammatory bowel disease(IBD).The genome-wide association studies clearly support the earlier developed concept that IBD occurs in genetically predisposed individuals who are exposed to distinct environmental factors,which together result in dysregulation of the mucosal immune system.Thus,the majority of previous studies have focused on the immune response within the intestinal wall.The present review aims to emphasize the contribution of three extraluminal structures to this inflammatory process,namely the mesenteric fat tissue,the lymphatics and the microvasculature.Broadening our view across the intestinal wall will not only facilitate our understanding of the disease,but will also us to identify future therapeutic targets. | Arvind Batra Thorsten Stroh Britta Siegmund | 2011 | World Journal of Gastroenterology2011，17，5： | 3 |
| 7 | hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma显示文摘AIM To screen clinically relevant micro RNAs (mi RNAs) silenced by DNA methylation in human hepatocellular carcinoma(HCC).METHODS Knockdown of DNA methyltransferases (DNMTs) using si RNAs and mi RNA profiling in HCC cell lines were performed to identify DNA hypermethylation-mediated mi RNA downregulation. Confirmation using individual quantitative real-time PCR (qR T-PCR) assays was thenperformed followed by DNA methylation quantification at the promoter of the mi RNA genes. Quantification of DNA methylation and mi RNA expression was then performed in primary HCC tumor samples and related with clinicopathological variables.RESULTS mi RNA profiling after DNMT knockdown in HCC cell lines revealed upregulation of mi R-23, mi R-25 and mi R-183. After q RT-PCR confirmation and Cp G island methylation quantification of these miR NAs in cell lines, further analysis in primary HCC specimens showed that hsa-mi R-183 is hypermethylated in 30% of HCC (n = 40). Expression of mature miR-183 showed an inverse correlation with DNA methylation levels. In HCC cells, DNMT knockdown and 5-aza-2'-deoxycytidine treatment reduced methylation and stimulated expression of mi R-183. In HCC patients, hypermethylation at hsami R-183 promoter significantly correlates with poor survival (log-rank test P = 0.03). DNA methylation analysis in healthy liver, benign liver tumors (hepatocellular adenoma and focal nodular hyperplasia) and their corresponding adjacent tissues showed absence of hypermethylation supporting the notion that aberrant methylation at hsa-miR-183 is specific for the malignant transformation of hepatocytes.CONCLUSION Our data indicate that hypermethylation of hsa-miR-183 is a frequent event in HCC and potentially useful as a novel surrogate diagnostic and prognostic marker. | Sumadi Lukman Anwar Till Krech Britta Hasemeier Elisa Schipper Nora Schweitzer Arndt Vogel Hans Kreipe Reena Buurman Britta Skawran Ulrich Lehmann | 2017 | World Journal of Gastroenterology2017，23，9： | 3 |
| 8 | Interventional treatment of the left subclavian in 2 patients with coronary steal syndrome显示文摘In patients with history of coronary artery disease angina pectoris is usually attributed to the progression of atherosclerotic lesions. However,in patients with previous coronary artery bypass graft operation(CABG) using internal mammary artery grafts,great vessel disease should also be considered. Herein we present two patients with history of CABG whose symptoms were suspicious for coronary ischemia. During cardiac catheterization reverse blood flow was observed from the left artery disease to the left internal mammary artery(LIMA) graft in both cases. After angioplasty and stent implantation of the left subclavian artery antegrade flow was restored in the LIMA grafts and both patients had complete resolution of symptoms. | Julia Heid Britta Vogel Arnt Kristen Wanda Kloos Benedikt Kohler Hugo A Katus Grigorios Korosoglou | 2017 | World Journal of Cardiology2017，9，1： | 3 |
| 9 | 原发性恶性甲状腺淋巴瘤的诊断与治疗(英文)显示文摘原发性恶性甲状腺淋巴瘤是一种罕见病,约占甲状腺恶性疾病的1%-3%,甚至不到非何杰金氏淋巴瘤的1%。根据改良的Ann-Arhor分类法对原发性甲状腺淋巴瘤所下的定义,此类淋巴瘤或局限于甲状腺(ⅠE期),或累及甲状腺与其邻近的膈上淋巴结(ⅡE期)。原发性甲状腺淋巴瘤是一种异源性疾病,它包括许多淋巴瘤的特性。本文的重点在于原发性甲状腺淋巴瘤的诊断和治疗。 | Peter Meusers Britta Elo Andrea Wittig | 2003 | The Chinese-German Journal of Clinical Oncology2003，2，4： | 3 |
| 10 | Neuroendocrine differentiation:The mysterious fellow of colorectal cancer显示文摘Neuroendocrine differentiation in sporadic colorectal cancer has been recognized since decades, but its clinical impact is still controversially discussed. Detailed parameter analyses hint at the possibility that probablynot neuroendocrine differentiation itself, but its association with poor grade of tumor differentiation, lymph node metastases, distant metastases and other unfavorable features contribute to worse clinical outcome. However, other studies deny a relationship between neuroendocrine differentiation and prognosis of colorectal cancer. This review elucidates, whether new insights into the origin of neuroendocrine differentiation in the intestinal epithelium, its regulation by m TOR pathway components and its possible link to the intestinal stem cell compartment could determine a role of neuroendocrine cells as prognostic marker and putative therapeutic target in sporadic colorectal cancer. | Britta Kleist Micaela Poetsch | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 11 | 作为发展中国家热带环境毒理学生物测定的浮萍(Lemna aequinoctialis)显示文摘在泰国和菲律宾采集了热带浮萍Lemna aequinoctialis Wel-witsch(Lemnaceae),以便发展一种有效的热带环境毒理学生物测定法。调查了生态毒理学生长试验的最佳条件,并且采用结果试验手册检验了重金属(Cd^(2+)、Cr^(6+)、Cu^(2+)、Hg^(2+)、Zn^(2+))、ClO^(3-)、3,5-二氯苯酚及苯酚对两种浮萍生长的影响。对生长的影响通过单位面积生物量和产生的叶片数量(类叶过程)96小时EC50值来检测。两种浮萍对所检验化合物的敏感性非常相似。Cd^(2+)、Cu^(2+)和Hg^(2+)的毒性最大,ClO^(3-)和苯酚的毒性最弱,Cr^(6+)和Zn^(2+)具有中等毒性。 | Bengt-Erik Bengtsson Britta Eklund Juvy P.Bongo 王宏 | 1999 | 人类环境杂志1999，28，2： | 2 |
| 12 | Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy显示文摘 | Francesco S. Loffredo Matthew L. Steinhauser Steven M. Jay Joseph Gannon James R. Pancoast Pratyusha Yalamanchi Manisha Sinha Claudia Dall’Osso Danika Khong Jennifer L. Shadrach Christine M. Miller Britta S. Singer Alex Stewart Nikolaos Psychogios Robert | 2013 | Cell2013，，4： | 2 |
| 13 | Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential显示文摘 | Ananta Paine Britta Eiz-Vesper Rainer Blasczyk Stephan Immenschuh | 2010 | Biochemical Pharmacology2010，，： | 2 |
| 14 | Rapid Identification of Nine Microorganisms Causing Acute Respiratory Tract Infections by Single-Tube Multiplex Reverse Transcription-PCR: Feasibility Study 显示文摘 | Britta GN Wolfram P Andrea H | 1999 | Journal of Clinical Microbiology1999，37，1： | 2 |
| 15 | Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure显示文摘 | Britta Vogel Andreas Keller Karen S. Frese Petra Leidinger Farbod Sedaghat-Hamedani Elham Kayvanpour Wanda Kloos Christina Backe Ann Thanaraj Thomas Brefort Markus Beier Stefan Hardt Eckart Meese Hugo A. Katus Benjamin Meder | 2013 | European Heart Journal2013，，： | 2 |
| 16 | Postoperative pain after transvaginal cholecystectomy: single-center, double-blind, randomized controlled trial显示文摘 | Dietmar H. Borchert Matthias Federlein Frauke Fritze-Büttner Jens Burghardt Britta Liersch-L?hn Yüksel Atas Verena Müller Oskar Rückbeil Stefan Wagenpfeil Stefan Gr?ber Klaus Gellert | 2014 | Surgical Endoscopy2014，，6： | 2 |
| 17 | Separation and Characterization of Surfactin Isoforms Produced by Bacillus subtilis OKB 105显示文摘 | Martin Kowall Joachim Vater Britta Kluge Torsten Stein Peter Franke Dieter Ziessow | 1998 | Journal of Colloid And Interface Science1998，，1： | 2 |
| 18 | Loss of Aβ-nerve endings associated with the Merkel cell-neurite complex in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis显示文摘The Merkel cell-neurite complex initiates the perception of touch and mediates Ab slowly adapting type I responses.Lichen planus is a chronic inflammatory autoimmune disease with T-cell-mediated inflammation,whereas hyperkeratosis is characterized with or without epithelial dysplasia in the oral mucosa.To determine the effects of lichen planus and hyperkeratosis on the Merkel cell-neurite complex,healthy oral mucosal epithelium and lesional oral mucosal epithelium of lichen planus and hyperkeratosis patients were stained by immunohistochemistry(the avidin-biotin-peroxidase complex and double immunofluorescence methods)using pan cytokeratin,20(K20,a Merkel cell marker),and neurofilament 200(NF200,a myelinated Ab-and Ad-nerve fibre marker)antibodies.NF200-immunoreactive(ir)nerve fibres in healthy tissues and in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis were counted and statistically analysed.In the healthy oral mucosa,K20-positive Merkel cells with and without close association to the intraepithelial NF200-ir nerve fibres were detected.In the lesional oral mucosa of lichen planus and hyperkeratosis patients,extremely rare NF200-ir nerve fibres were detected only in the lamina propria.Compared with healthy tissues,lichen planus and hyperkeratosis tissues had significantly decreased numbers of NF200-ir nerve fibres in the oral mucosal epithelium.Lichen planus and hyperkeratosis were associated with the absence of Ab-nerve endings in the oral mucosal epithelium.Thus,we conclude that mechanosensation mediated by the Merkel cell-neurite complex in the oral mucosal epithelium is impaired in lichen planus and hyperkeratosis. | Daniela Calderon Carrion Yiiksel Korkmaz Britta Cho Marion Kopp Wilhelm Bloch Klaus Addicks Wilhelm Niedermeier | 2016 | International Journal of Oral Science2016，8，1： | 2 |
| 19 | Selenium Regulation of Selenium-dependent Glutathione Peroxidases in Animals and Transfected CHO Cells显示文摘Glutathione peroxidase (GPX1) was the first identified selenium-dependent enzyme, and this enzyme has been most useful as a biochemical indicator of selenium (Se) status and the parameter of choice for determining Se requirements. We have continued to study Se regulation of GPX1 to better understand the underlying mechanism and to gain insight into how cells themselves regulate nutrient status. In progressive Se deficiency in rats, GPX1 activity,protein and mRNA all decrease in a dramatic, coordinated and exponential fashion such that Se-deficient GPX1 mRNA levels are 6-15% of Sexadequate levels. mRNA levels for other Sedependent proteins are far less decreased in the same animals. The mRNA levels for a second Se-dependent peroxidase, phospholipid hydroperoxide glutathione peroxidase (GPX4 ), are little affected by Se deficiency, demonstrating that Se regulation of GPX1 is unique. Se regulation of GPX1 activity in growing male and female rats shows that the Se requirernent is 100 ng/g diet, based on liver GPX1 activity; use of GPX1 mRNA as the parameter indicates that the Se requirement is nearer to 50 ng Se/g diet in both male and female rats. This approach will readily detect an altered dietary Se requirement, as shown by the incremental increases in dietary Se requirement by 150, 100 or 50 ng Se/g diet in Seudeficient rat pups repleted with Se for 3, 7 or 14 d, respectively. Studies with CHO cells stably transfected with recombinant GPX1 also show that overexpression of GPX1 does not alter the minimum level of media Se necessary for Se-adequate levels of GPX1 activity or mRNA. We hypothesize that classical GPX1 has an integral biological role in the mechanism used by cells to regulate Se status,making GPX1 an especially useful and effective parameter for determining Se requirements in | ROGER A. SUNDE BRITTA M. THOMPSON MELANIE D. PALM SHERRI L.WEISS KEVIN M. THOMPSON AND JACQUELINE K. EVENSON(Nutritional Sciences Program and Department of Biochemistry,University of Missouri, Columbia MO 65211 USA) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 2 |
| 20 | Multiphase-field modelling of concurrent grain growth and coarsening in complex multicomponent systems显示文摘Phase-field modelling of microstructural evolution in polycrystalline systems with phase-associated grains has largely been confined to continuum-field models.In this study,a multiphase-field approach,with a provision for introducing grain boundary and interphase diffusion,is extended to analyse concurrent grain growth and coarsening in multicomponent polycrystalline microstructures with chemically-distinct grains.The effect of the number of phases and components on the kinetics of evolution is investigated by considering binary and ternary systems of duplex and triplex microstructures,along with a single phase system.It is realised that the mere increase in the number of phases minimises the rate of concurrent grain growth and coarsening.However,the effect of components is substantially dependent on the respective kinetic coefficients.This work unravels that the disparity in the influence of phases and components is primarily due to the corresponding change introduced in the transformation mechanism.While the raise in number of phases convolutes the diffusion paths,the increase in number of component effects the rate of evolution through the interdiffusion,which introduces interdependency in the diffusing chemical-species.Additionally,the role of phase-fractions on the transformation rate of triplex microstructure is studied,and correspondingly,the interplay of interface-and diffusion-governed evolution is elucidated.A representative evolution of three-dimensional triplex microstructure with equal phase-fraction is comparatively analysed with the evolution of corresponding two-dimensional setup. | P.G.Kubendran Amos Ramanathan Perumal Michael Selzer Britta Nestler | 2020 | Journal of Materials Science & Technology2020，42，10： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员