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| 1 | 子二代中华鲟分枝杆菌感染及血液生理生化指标的变化显示文摘鱼类分枝杆菌病是由分枝杆菌属的非结核分枝杆菌造成的长期性感染疾病。本研究发现,养殖中华鲟(Acipenser sinensis)子二代可感染该病,典型病理特征是腹水、腹膜肉芽肿、肾脏水肿、肝脏呈灰白色等。采集腹水,通过细菌分离培养获得一株缓慢生长型的抗酸杆菌,进一步通过16S r DNA和IS2404重复序列进行分子生物学鉴定,发现该菌与Mycobacterium liflandii相似性最高。将10尾健康子二代中华鲟3次体检的血液参数与4尾分枝杆菌感染子二代中华鲟12次检查的血液参数进行比较,发现在26项生理生化指标中,有9项指标差异显著(P<0.05),即中性粒细胞、淋巴细胞、钠、氯、钙、总蛋白、球蛋白、外周血白细胞总数(TWBC)和谷丙转氨酶(ALT),其中TWBC、中性粒细胞和ALT这3项指标显著升高,其他指标显著下降,说明分枝杆菌感染对鱼体肝脏和肾脏的损伤较大。采用盐酸卡纳霉素、红霉素和利福平三种抗生素联合用药进行治疗,给药时间75 d,治疗后腹水明显减少,RBC、血红蛋白、PCV、MCV和球蛋白这5项血液理化指标均有显著性升高(P<0.05),说明药物治疗初期具有一定的效果,但随着病程的加剧,该尾鱼最终未能治愈。以上结果表明,分枝杆菌在中华鲟广泛流行,对中华鲟的危害较大,目前尚未见有效的疫苗和药物,因此对该病的预防、早期诊断和治疗极其重要。 | 张书环 聂品 舒少武 杜浩 Foo Khong Lee 杨月梅 邵纯 邸军 黄君 曾令兵 危起伟 | 2017 | 中国水产科学2017，24，1： | 16 |
| 2 | Energy-efficient adaptive sensor scheduling for target tracking in wireless sensor networks显示文摘Sensor scheduling is essential to collaborative target tracking in wireless sensor networks(WSNs).In the existing works for target tracking in WSNs,such as the information-driven sensor query(IDSQ),the tasking sensors are scheduled to maximize the information gain while minimizing the resource cost based on the uniform sampling intervals,ignoring the changing of the target dynamics and the specific desirable tracking goals.This paper proposes a novel energyefficient adaptive sensor scheduling approach that jointly selects tasking sensors and determines their associated sampling intervals according to the predicted tracking accuracy and tracking energy cost.At each time step,the sensors are scheduled in alternative tracking mode,namely,the fast tracking mode with smallest sampling interval or the tracking maintenance mode with larger sampling interval,according to a specified tracking error threshold.The approach employs an extended Kalman filter(EKF)-based estimation technique to predict the tracking accuracy and adopts an energy consumption model to predict the energy cost.Simulation results demonstrate that,compared to a non-adaptive sensor scheduling approach,the proposed approach can save energy cost significantly without degrading the tracking accuracy. | Wendong XIAO Sen ZHANG Jianyong LIN Chen Khong THAM | 2010 | 控制理论与应用(英文版)2010，8，1： | 9 |
| 3 | Comparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injury显示文摘 | Wang, YX Cheung, PT Shen, GX Bhatia, I Wu, EX Qiu, DQ Khong, PL | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 4 | Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy显示文摘 | Francesco S. Loffredo Matthew L. Steinhauser Steven M. Jay Joseph Gannon James R. Pancoast Pratyusha Yalamanchi Manisha Sinha Claudia Dall’Osso Danika Khong Jennifer L. Shadrach Christine M. Miller Britta S. Singer Alex Stewart Nikolaos Psychogios Robert | 2013 | Cell2013，，4： | 2 |
| 5 | Efficient solvent extraction of antioxidant-rich extract from a tropical diatom,Chaetoceros calcitrans (Paulsen) Takano 1968显示文摘Objective: To compare the in vitro antioxidant capacity of a diatom, Chaetoceros calcitrans(C. calcitrans) extracted using six types of solvents.Methods: Each extract was evaluated in terms of extraction yield, total carotenoid,fucoxanthin content, total phenolic and antioxidant capacities(DPPH and ABTS +scavenging activity and iron chelating activity).Results: The methanol extract exhibited the highest yield [(22.71 ± 0.96) g/100 g dry weight(DW)], total carotenoid [(4.46 ± 0.36) mg/g DW], total phenolic [(2.49 ± 0.08) mg gallic acid equivalents/g DW] and second highest fucoxanthin content [(2.08 ± 0.03) mg fucoxanthin/g DW] as compared to other solvent extracts. Methanolic extract also exhibited significantly higher(P < 0.05) scavenging(DPPH, ABTS +) and iron chelating activities.Conclusions: Methanol was the recommended solvent for the production of antioxidant rich extract from C. calcitrans. Both carotenoids and phenolic acids were found to be positively correlated to the antioxidant capacities of C. calcitrans. Lead bioactives confirmed by subsequent high performance liquid chromatography studies were fucoxanthin, gallic acid and protocatechuic acid. | Su Chern Foo Fatimah Md.Yusoff Maznah Ismail Mahiran Basri Nicholas Mun Hoe Khong Kim Wei Chan Sook Kun Yau | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，10： | 2 |
| 6 | 在胃的恶意的阶段 laparoscopy 的角色 - 我们的机构的经验显示文摘 AIM: To investigate the value of staging laparoscopy with laparoscopic ultrasound (LUS) and peritoneal lavage cytology in patients with newly-diagnosed gastric tumours in our department.METHODS: Retrospective review of prospectively-collected data was conducted in all patients with newly-diagnosed gastric tumours on oesophagogastroduode-noscopy between December 2003 and July 2008. All the patients had a pretreatment histological diagnosis and were discussed at the hospital multidisciplinary tumour board meeting for their definitive management. Computed tomography scan was performed in all patients as a part of standard preoperative staging work up. Staging laparoscopy was subsequently performed in selected patients and staging by both modalities was compared.RESULTS: Twenty seven patients were included. Majority of patients had cardio-oesophageal junction adenocarcinoma. Thirteen patients (48%) were up-staged following staging laparoscopy and one patient was downstaged (3.7%). None of the patients had procedure-related complications. None of the patients with metastasis detected at laparoscopy underwent laparotomy. Gastrectomy after staging laparoscopy was performed in 13 patients (9R0 resections, 3 R1 resections and 1 R2 resection). Only one patient did not have gastrectomy at laparotomy because of extensive local invasion. Three patients were subjected to neoadjuvant therapy following laparoscopy but only one patient subsequently underwent gastrectomy. CONCLUSION: In this small series reflecting our institutional experience, staging laparoscopy appears to be safe and more accurate in detecting peritoneal and omental metastases as compared to conventional imaging. Peritoneal cytology provided additional prognostic information although there appeared to be a high false negative rate. | Vishal G Shelat Juin Fong Thong Melanie Seah Khong Hee Lim | 2012 | World Journal of Gastrointestinal Surgery2012，4，9： | 2 |
| 7 | Quantitative determination of four nitrofuran metabolites in meat by isotope dilution liquid chromatography–electrospray ionisation–tandem mass spectrometry显示文摘 | Pascal Mottier Seu-Ping Khong Eric Gremaud Janique Richoz Thierry Delatour Till Goldmann Philippe A. Guy | 2004 | Journal of Chromatography A2004，，1： | 2 |
| 8 | Imaging of peripheral PNET:common and uncommon locations显示文摘 | Khong PL Chan GCF Shek TWH | 2002 | Clin Radiol2002，57，4： | 1 |
| 9 | Severe acute respiratory syndrome:radiographic and CT findings显示文摘 | Müller NL Ooi GC Khong PL | 2003 | Am J Roentgenol2003，181，1： | 1 |
| 10 | New Triterpenoid Extractives from Lemaireocereus chichipe显示文摘 | Khong P W Lewis K G | 1975 | Aust J Chem1975，28，： | 1 |
| 11 | Postbuckling Formulation for Symmetric Laminated Panels with Various Edge Support Conditions 显示文摘 | Chai Gin Boay Khong Poh Wah | 2001 | Mechanics of Composite Materials and Struc-tures2001，8，： | 1 |
| 12 | Characterization of an isotype-dependent monoclonal antibody against linear neutralizing epitope effective for prophylaxis of enterovirus 71 infection显示文摘 | Lim XF Jia Q Khong WX | 2012 | PLo S One2012，7，29： | 1 |
| 13 | Quantitative determination of four nitrofuran metabolites in meat by isotope dilution liquid ehromatography-electrospray ionisation tandem mass speetrometry显示文摘 | Mottier P Khong S P Gremaud E | 2005 | J Chromatogr A2005，1067，： | 1 |
| 14 | Transduction of an HLA-DP4-restricted NY-ESO-1-specific TCR into primary human CD4+ lymphocytes显示文摘 | Zhao Y Zheng Z Khong HT | 2006 | J Immunother2006，29，4： | 1 |
| 15 | A unified plasticity model for cyclic behavior of clay and sand显示文摘 | YU H S KHONG C WANG J | 2007 | Mechanics Research Communications2007，34，： | 1 |
| 16 | Sinks,suppressors and antigen presenters:How lymphodepletion enhances T cell-mediated tumor immunotherapy显示文摘 | Klebanoff CA Khong HT Antony PA | 2005 | Trends Immunol2005，26，2： | 1 |
| 17 | Non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection 显示文摘 | Khong W X Yah B Yeo H | 2012 | J Virol2012，86，4： | 1 |
| 18 | Quantitative assessment of diffusion-weighted MR imaging in patients with primary rectal cancer: correlation with FDG-PET/CT显示文摘 | Gu J Khong PL Wang S Chan Q Law W Zhang J | 2011 | Mol Imaging Biol2011，13，： | 1 |
| 19 | Placenta creta and placenta praevia creta显示文摘 | Khong TY Robertson WB | 1987 | Placenta1987，8，4： | 1 |
| 20 | Targeting HSP 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma 显示文摘 | Khong T Spencer A | 2011 | Mol Cancer Ther2011，10，10： | 1 |
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