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	题名	作者	年代	出处	被引量
1	Juvenile polyposis syndrome显示文摘Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer.The cumulative life-time risk of colorectal cancer is 39% and the relative risk is 34.Juvenile polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive changes.Clinically,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis.In about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is found.Both genes play a role in the BMP/TGF-beta signalling pathway.It has been suggested that cancer in juvenile polyposis may develop through the socalled 'landscaper mechanism' where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive carcinoma.Recognition of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk individuals.Each clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis syndrome.In addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of cancer.This review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome.	Lodewijk AA Brosens Danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus	2011	World Journal of Gastroenterology2011，17，44：	7
2	Diagnosis of endometriosis 显示文摘	Brosens I	1997	Semin Repord Endocrinol1997，15，：	2
3	Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study 显示文摘	Pedersen RS Damkier P Brosen K	2005	Clin Pharmacol Ther2005，77，：	1
4	Bowel injury in gynecologic laparoscopy显示文摘	Brosens I Gordon A Campo R	2003	J Am Assoc Gynecol Laparosc2003，10，1：	1
5	The myometrial junctional zone spiral arteries in normal and abnormal pregnancies显示文摘	Brosens JJ Pijnenborg R Brosens IA	2002	Am J Obstel Gynecol2002，187，5：	1
6	Thesparteine/debrisoquine(CYP2D6)polymorphism and the risk of lung cancer:a meta-analysis显示文摘	P C Gotzsche K Brosen	1997	Eur J Clin Pharmacol1997，51，：	1
7	Bowel injury in gynecologic laparoecopy显示文摘	Brosens I Gordon A Campe R	2003	J Am Assoc Gynecol Laparoec2003，10，1：	1
8	The hypoalgesic effect oftramadol in relation to CYP2D6显示文摘	Poulsen L Arendt-Nielsen L Brosen K	1996	Clin Pharmacol Ther1996，60，6：	1
9	Monoclonal origin of primary unilateral multifocal pleomorphic adenoma of the parotid gland显示文摘	Sylvia L. van Egmond Wendy W.J. de Leng Folkert H.M. Morsink G.Johan A. Offerhaus Lodewijk A.A. Brosens	2012	Human Pathology2012，，：	1
10	The endometrium in adenomyosis显示文摘	Benagiano G Brosens I	2012	Womens Health(Lond Engl)2012，8，3：	1
11	The great obstetrical syndromes are associated with disorders of deep placentation显示文摘	Brosens I Pijnenborg R Vercruysse L	2011	Am J Obstet Gynecol2011，20，3：	1
12	Noninvasive diagnosis of endometfiosis:the role of imaging and markers显示文摘	Brosens J Timmerman D Starzinaki-Powitz	2003	Obstet Gynecol Clin North Am2003，30，1：	1
13	How the role of the spiral arteries in the pathogenesis of preeclampsia was discovered显示文摘		1996	Hypertensive Pregnancy1996，15，1：	1
14	Endometriosis,a modern syndrome显示文摘	Brosens I Benagiano G		0，，06：	1
15	Evolution of the revised American fertility society claasification of endometriosis显示文摘	Brosens IA Cornillie F Koninckx P		0，，05：	1
16	Non-genomic progesterone actions in female reproduction显示文摘	Gellersen B Fernandes MS Brosens JJ		0，，01：	1
17	Large genomic deletions of SMAIM, BMPRIA and PTEN in juvenile polyposis 显示文摘	van Hattem WA Brosens LA de Leng WW	2008	Gut2008，57，5：	1
18	Some aspects of genetic polymorphism in the biotransformation of antidepressants显示文摘	Brosen K	2004	Therapie2004，59，：	1
19	Increased cyclooxygenase -2 expression in juvenile polyposis syndrome 显示文摘	van Hattem WA Brosens LA Marks SY	2009	Clin Gastroenterol Hepatol2009，7，1：	1
20	Pharmacokinetics of cita- lopram in relation to the sparteine and the mephenytoin oxidation pol- ymorphisms 显示文摘	Sindrup SH Brosen K Hansen MG	1993	Ther Drug Monit1993，15，：	1

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