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| 1 | Metabolic Engineering of Plant-derived (E)-β-farnesene Synthase Genes for a Novel Type of Aphid-resistant Genetically Modified Crop Plants显示文摘Aphids are major agricultural pests that cause significant yield losses of crop plants each year.Excessive dependence on insec-ticides for long-term aphid control is undesirable because of the development of insecticide resistance,the potential negative effects on non-target organisms and environmental pollution.Transgenic crops engineered for resistance to aphids via a non-toxic mode of action could be an efficient alternative strategy.(E)-β-Farnesene (EβF) synthases catalyze the formation of EβF,which for many pest aphids is the main component of the alarm pheromone involved in the chemical communication within these species.EβF can also be synthesized by certain plants but is then normally contaminated with inhibitory compounds.Engineering of crop plants capable of synthesizing and emitting EβF could cause repulsion of aphids and also the attraction of natural enemies that use EβF as a foraging cue,thus minimizing aphid infestation.In this review,the effects of aphids on host plants,plants' defenses against aphid herbivory and the recruitment of natural enemies for aphid control in an agricultural setting are briefly introduced.Furthermore,the plant-derived EβF synthase genes cloned to date along with their potential roles in generating novel aphid resistance via genetically modified approaches are discussed. | Xiu-Dao Yu John Pickett You-Zhi Ma Toby Bruce Johnathan Napier Huw D.Jones Lan-Qin Xia | 2012 | Journal of Integrative Plant Biology2012，54，5： | 10 |
| 2 | Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China显示文摘它通常被相信细胞毒素的 T 淋巴细胞(CTL ) 玩的那 CD8 + 在限制人的免疫不全病毒类型 1 的复制(HIV-1 ) 并且在决定感染的结果,和这效果可以部分优先地取决于产品是哪个 HIV 的一个关键角色指向了。在以前的血浆施主(FPD ) 的一个队探讨在 HIV-1-specific CTL 回答和病毒复制之间的关联,天真的 FPD 与 HIV-1 clade B' 紧张感染了的 143 antiretroviral 治疗与 IFN-γ 为 HIV-1-specific CTL 回答被估计;在由使用盖住整个一致 clade B proteome 的重叠的肽(OLP ) 的单个肽水平的 Elispot 试金。由使用一个枪兵的等级关联分析,当是断然相关到 CD4 计数时,我们发现在全部的病毒特定的 CTL 活动之中的作呕特定的 CTL 回答的比例相反地与病毒的负担被相关,与与增加的病毒的负担被联系并且减少的Pol特定、Env特定的回答对比, CD4 数。另外, Vpr-specifc CTL 回答显示出类似的保护的效果与作呕回答,但是与识别的低得多的频率。显著地,我们也观察了在 HLA 之间的一个协会 --*30/B*13/Cw*06 haplotype 和可能由于的更低的病毒的负担限制了作呕特定的 CTL 回答。因此,我们的数据在疾病控制表明作呕特定的 CTL 回答的突出的角色。HLA 的优点 -- 在病毒的控制的 *30/B*13/Cw*06 haplotype 可以在学习个人与作呕特定的 CTL 回答的贡献被联系。 | Mingming Jia Kunxue Hong Jianping Chen Yuhua Ruan Zhe Wang Bing Su Guoliang Ren Xiaoqing Zhang Zhen Liu Quanbi Zhao Dan Li Hong Peng Marcus Altfeld Bruce D Walker Xu G Yu Yiming Shao | 2012 | Cell Research2012，22，5： | 3 |
| 3 | 加氢裂化预处理催化剂的发展(英文)显示文摘讨论了雪佛龙技术转让部的加氢裂化预处理催化剂的发展历史. 用'更多的类型 II 活性位导致更好的 HDN/HDS 催化性能'理论解释了我们最近研发的加氢裂化预处理催化剂 HDN 催化性能好的原因. | 贾继飞 Bruce YU Theo MAESEN Cecelia RADLOWSKI Art DAHLBERG John CREIGHTON Dave KRENZKE Dan TORCHIA Woody SHIFLETT | 2009 | 催化学报2009，30，8： | 3 |
| 4 | The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor显示文摘 | Anne E. Powell Yang Wang Yina Li Emily J. Poulin Anna L. Means Mary K. Washington James N. Higginbotham Alwin Juchheim Nripesh Prasad Shawn E. Levy Yan Guo Yu Shyr Bruce J. Aronow Kevin M. Haigis Jeffrey L. Franklin Robert J. Coffey | 2012 | Cell2012，，1： | 2 |
| 5 | Precision Phenotyping Reveals Novel Loci for Quantitative Resistance to Septoria Tritici Blotch显示文摘Accurate,high-throughput phenotyping for quantitative traits is a limiting factor for progress in plant breeding.We developed an automated image analysis to measure quantitative resistance to septoria tritici blotch(STB),a globally important wheat disease,enabling identification of small chromosome intervals containing plausible candidate genes for STB resistance.335 winter wheat cultivars were included in a replicated field experiment that experienced natural epidemic development by a highly diverse but fungicide-resistant pathogen population.More than 5.4 million automatically generated phenotypes were associated with 13,648 SNP markers to perform the GWAS.We identified 26 chromosome intervals explaining 1.9-10.6%of the variance associated with four independent resistance traits.Sixteen of the intervals overlapped with known STB resistance intervals,suggesting that our phenotyping approach can identify simultaneously(i.e.,in a single experiment)many previously defined STB resistance intervals.Seventeen of the intervals were less than 5 Mbp in size and encoded only 173 genes,including many genes associated with disease resistance.Five intervals contained four or fewer genes,providing high priority targets for functional validation.Ten chromosome intervals were not previously associated with STB resistance,perhaps representing resistance to pathogen strains that had not been tested in earlier experiments.The SNP markers associated with these chromosome intervals can be used to recombine different forms of quantitative STB resistance that are likely to be more durable than pyramids of major resistance genes.Our experiment illustrates how high-throughput automated phenotyping can accelerate breeding for quantitative disease resistance. | Steven Yates Alexey Mikaberidze Simon GKrattinger Michael Abrouk Andreas Hund Kang Yu Bruno Studer Simone Fouche Lukas Meile Danilo Pereira Petteri Karisto Bruce A.McDonald | 2019 | Plant Phenomics2019，1，1： | 2 |
| 6 | Long-term Prognosis of Patients Presenting With ST-Segment Elevation Myocardial Infarction With No Significant Coronary Artery Disease (from The HORIZONS-AMI Trial)显示文摘 | Alf Inge Larsen Dennis W.T. Nilsen Jennifer Yu Roxana Mehran Eugenia Nikolsky Alexandra J. Lansky Adriano Caixeta Helen Parise Martin Fahy Ecaterina Cristea Bernhard Witzenbichler Giulio Guagliumi Jan Z. Peruga Bruce R. Brodie Dariusz Dudek Gregg W. Stone | 2013 | The American Journal of Cardiology2013，，： | 2 |
| 7 | Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy显示文摘Chimeric antigen receptor-based T-cell immunotherapy is a promising strategy for treatment of hematological malignant tumors;however,its efficacy towards solid cancer remains challenging.We therefore focused on developing nanobody-based CAR-T cells that treat the solid tumor.CD105 expression is upregulated on neoangiogenic endothelial and cancer cells.CD105 has been developed as a drug target.Here we show the generation of a CD105-specific nanobody,an anti-human CD105 CAR-T cells,by inserting the sequences for anti-CD105 nanobody-linked standard cassette genes into AAVS1 site using CRISPR/Cas9 technology.Co-culture with CD105+target cells led to the activation of anti-CD105 CAR-T cells that displayed the typically activated cytotoxic T-cell characters,ability to proliferate,the production of pro-inflammatory cytokines,and the specific killing efficacy against CD105+target cells in vitro.The in vivo treatment with anti-CD105 CAR-T cells significantly inhibited the growth of implanted CD105+tumors,reduced tumor weight,and prolonged the survival time of tumor-bearing NOD/SCID mice.Nanobody-based CAR-T cells can therefore function as an antitumor agent in human tumor xenograft models.Our findings determined that the strategy of nanobody-based CAR-T cells engineered by CRISPR/Cas9 system has a certain potential to treat solid tumor through targeting CD105 antigen. | Fengzhen Mo Siliang Duan Xiaobing Jiang Xiaomei Yang Xiaoqiong Hou Wei Shi Cueva Jumbo Juan Carlos Aiqun Liu Shihua Yin Wu Wang Hua Yao Zihang Yu Zhuoran Tang Shenxia Xie Ziqiang Ding Xinyue Zhao Bruce D.Hammock Xiaoling Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 8 | Absence of porcine circovirus type 1 (PCV1) and high prevalence of PCV 2 exposure and infection in swine finisher herds显示文摘 | Sumathy Puvanendiran Suzanne Stone Wanqin Yu Craig R. Johnson Juan Abrahante Liza Garcia Jimenez Theodor Griggs Charles Haley Bruce Wagner Michael P. Murtaugh | 2011 | Virus Research2011，，1： | 2 |
| 9 | Write back-aware partitioning and replacement for last-level caches in phase change main memory systems显示文摘 | Miao Zhou Yu Du Bruce C el al | 2012 | ACM Transactions on Architecture and Code Optimi- zation2012，8，4： | 1 |
| 10 | Electrochemical reduction of oxygen with iron phthalocyanine in neutral media显示文摘 | Eileen Hao Yu Shaoan Cheng Bruce E. Logan Keith Scott | 2009 | Journal of Applied Electrochemistry2009，，5： | 1 |
| 11 | Polybrominated diphenyl ethers (PBDEs) in sediments and mussel tissues from Hong Kong marine waters显示文摘 | Ying Liu Gene J. Zheng Hongxia Yu Michael Martin Bruce J. Richardson Michael H.W. Lam Paul K.S. Lam | 2005 | Marine Pollution Bulletin2005，，11： | 1 |
| 12 | PPARγ suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cells显示文摘 | Wei-Hua Yu Fu-Gui Li Xiao-Yong Chen Jian-Tao Li Yan-Heng Wu Li-Hua Huang Zhen Wang Panlong Li Tao Wang Bruce T. Lahn Andy Peng Xiang | 2011 | International Journal of Biochemistry and Cell Biology2011，，2： | 1 |
| 13 | Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo 显示文摘 | Yu ZF Bruce - Keller AJ Goodman Y | 1998 | J Neurosci Res1998，53，5： | 1 |
| 14 | Nanoparticulate TiO2 (B): an anode for lithium-ion batteries 显示文摘 | Yu Ren Liu Zheng Pourpoint Frederique Armstrong A Robert Grey Clare P Bruce Peter G | 2012 | Angewandte Chemie International Edition2012，51，9： | 1 |
| 15 | Design, analysis and simulation for development of the first clinical micro-CT scanner 1显示文摘 | Ge Wang Shiying Zhao Hengyong Yu Charles A. Miller Paul J. Abbas Bruce J. Gantz Seung Wook Lee Jay T. Rubinstein | 2005 | Academic Radiology2005，，4： | 1 |
| 16 | Mesoporous LiFePO4 as a cathode material for rechargeable lithium ion batteries显示文摘 | Ren Yu Bruce Peter G | 2012 | Electrochemistry Communications2012，17，1： | 1 |
| 17 | Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo 显示文摘 | Yu ZF Bruce - Keller A J Goodman Y | 1998 | J Neurosci Res1998，53，5： | 1 |
| 18 | Lack of the p50 subunit of NF - κB increases the vulnerability of hippocampal neurons to exeito- toxic injury 显示文摘 | Yu ZF Zhou D Bruce - Keller A J | 1999 | J Neurosei1999，19，20： | 1 |
| 19 | Subclinical infection with the nematode Trichostrongylus colubriformis increases gastrointestinal tract leucine metabolism and reduces availability of leucine for other tissues显示文摘 | Yu F Bruce L A Calder A G | 2000 | J Anim Sci2000，78，2： | 1 |
| 20 | Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphoeytes, and inflammation in the gut of vitamin D receptor KO mice显示文摘 | Yu S Bruce D Froicu M | 2008 | Proc Natl Acad Sci USA2008，105，20： | 1 |
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