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| 1 | Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis显示文摘Ulcerative colitis(UC)is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and rectum.The hallmark clinical symptom of UC is bloody diarrhea.The clinical course is marked by exacerbations and remissions,which may occur spontaneously or in response to treatment changes or intercurrent illnesses.UC is most commonly diagnosed in late adolescence or early adulthood,but it can occur at any age.The incidence of UC has increased worldwide over recent decades,especially in developing nations.In contrast,during this period,therapeutic advances have improved the life expectancy of patients,and there has been a decrease in the mortality rate over time.It is important to emphasize that there is considerable variability in the phenotypic presentation of UC.Within this context,certain clinical and demographic characteristics are useful in identifying patients who tend to have more severe evolution of the disease and a poor prognosis.In this group of patients,better clinical surveillance and more intensive therapy may change the natural course of the disease.The aim of this article was to review the epidemiology and demographic characteristics of UC and the factors that may be associated with its clinical prognosis. | Bruno César da Silva Andre Castro Lyra Raquel Rocha Genoile Oliveira Santana | 2014 | World Journal of Gastroenterology2014，20，28： | 48 |
| 2 | Nutrient availability and leaching in an archaeological Anthrosol and a Ferralsol of the Central Amazon basin: fertilizer, manure and charcoal amendments显示文摘 | Johannes Lehmann Jose Pereira da Silva Christoph Steiner Thomas Nehls Wolfgang Zech Bruno Glaser | 2003 | Plant and Soil2003，，2： | 8 |
| 3 | Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions显示文摘Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal function.Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ductus.Conclusions: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ineffective.However, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol. | Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames Ciomar Aparecida Bersani-Amado Roberto Kenji Nakamura Cuman | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 4 |
| 4 | Endoscopic management and prevention of migrated esophageal stents显示文摘The use of self-expandable metallic stents has increased recently to palliate inoperable esophageal neoplasia and also in the management of benign strictures. Migration is one of the most common complications after stent placement and the endoscopist should be able to recognize and manage this situation. Several techniques for managing migrated stents have been described, as well as new techniques for preventing stent migration. Most stents have a 'lasso' at the upper flange which facilitates stent repositioning or removal. An overtube, endoloop and large polypectomy snare may be useful for the retrieval of stents migrated into the stomach. External fixation of the stent with Shim's technique is efficient in preventing stent migration. Suturing the stent to the esophageal wall, new stent designs with larger flanges and double-layered stents are promising techniques to prevent stent migration but they warrant validation in a larger cohort of patients. | Bruno da Costa Martins Felipe Alves Retes Bruno Frederico Medrado Marcelo Simas de Lima Caterina Maria Pia Simione Pennacchi Fabio Shiguehissa Kawaguti Adriana Vaz Safatle-Ribeiro Ricardo Sato Uemura Fauze Maluf-Filho | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 3 |
| 5 | Migrasomes: a new organelle of migrating cells显示文摘 | Bruno da Rocha-Azevedo Sandra L Schmid | 2015 | Cell Research2015，25，1： | 3 |
| 6 | Taxing Digital Economy:A Critical View around the GloBE(Pillar Two)显示文摘The Organisation for Economic Co-operation and Development(OECD)proposal for taxation of digital economy constitutes one of the most ambitious projects in the field of taxation and may lead to the most significant reform to international tax rules in the 20th century.Based on a two-pillar approach,Pillar Two of the proposal suggests the adoption of Global Anti-Base Erosion(GloBE)provisions that are aimed at introducing a worldwide minimum tax.In this article,a critical analysis is based that the GloBE proposal suggests that it represents a shift in the OECD policy.As compared to base erosion and profit shifting(BEPS),it jeopardizes the tax sovereignty of jurisdictions and it raises fundamental challenges of implementation,both in terms of amendments to domestic law and conflicts with tax treaties. | Bruno da Silva | 2020 | Frontiers of Law in China-Selected Publications from Chinese Universities2020，15，2： | 3 |
| 7 | Preparation of Polycarbonate/Clay Nanocomposite and Characterization by X-Ray, Thermal Analyzes and Low-Field Nuclear Magnetic Resonance显示文摘 | Pedro Paulo Merat Maria Ines Bruno Tavares Emerson Oliveira da Silva | 2011 | 材料科学与工程(中英文A版)2011，1，5X： | 2 |
| 8 | Influence of Sugarcane Bagasse Fiber Size on Biodegradable Composites of Thermoplastic Starch显示文摘Although thermoplastic starch(TPS)is biodegradable,its low mechanical resistance limits its wide application.Sugarcane bagasse(SB)fibers can be used as reinforcement in TPS matrix composites,but the influence of fiber size on the properties of the composite is still unknown.In this study,TPS composites reinforced with SB short fibers of four sizes were processed and characterized in order to analyze the influence of fiber size on the mechanical properties of the TPS/SB composite.It was observed that the interaction between fiber and matrix was good and optimized when the fibers are sifted in sieves between 30 and 50 mesh,obtaining fibers with average length of 1569±640μm and average diameter of 646±166μm.For these composites,increases of more than 660%in the modulus and more than 100%in the maximum tension were verified when compared to the pure TPS. | Bruno Henrique dos Santos Karen de Souza do Prado Asaph Armando Jacinto Marcia Aparecida da Silva Spinace | 2018 | Journal of Renewable Materials2018，6，2： | 2 |
| 9 | Nutrient availability and leaching in an archaeological Anthrosol and a Ferralsol of the Central Amazon basin: fertilizer, manure and charcoal amendments显示文摘 | Johannes Lehmann Jose Pereira da Silva Christoph Steiner Thomas Nehls Wolfgang Zech Bruno Glaser | 2003 | Plant and Soil2003，，2： | 2 |
| 10 | Joannesia princeps: Evaluation of Aqueous Extracts Genotoxicity Utilizing Allium cepa Assay and Micronucleus Test显示文摘 | Viviane Moreira de Lima Jessica Tamara dos Santos Teixeira Jennifer Vieira Gomes Lelio Kallut Almeida Netto Leonardo Oliveira Bastos Hataanderson Luiz Cabral dos Santos Lenicio Gongalves Francisco de Assis da Silva Bruno Pereira Berto Helcio Resende Borba | 2013 | Journal of Life Sciences2013，7，12： | 1 |
| 11 | Fatigue Strength Evaluation of Resin-Injected Bolted Connections Using Statistical Analysis显示文摘在对老旧的螺栓和铆接金属桥进行修补和加固时可以使用不同的方案。由于铆接链接技术目前并不常用,连接它需要特定的设备和熟练的工人。另一种解决方案是使用焊接。但是,老旧钢材的可焊性较差。螺栓是一种非常可行的替代解决方案,并且常用于修复旧金属桥。装配螺栓的解决方案成本高昂,另一种方法是使用树脂灌注式螺栓。带有预紧力的树脂灌注式老旧螺栓连接的受力性能已经用准静态和蠕变试验进行了研究,然而,关于这些连接节点的滑移和疲劳行为的文献很少。本文概述了几位研究者的实验项目,旨在评估单侧受剪和双侧受剪的树脂灌注式螺栓连接的疲劳行为。对有预紧力的标准螺栓和有预紧力的树脂灌注式螺栓的连接节点的实验数据进行比较分析,显示后者的疲劳强度较低。但欧洲规范3(EC3)对树脂灌注式螺栓和标准螺栓的连接节点提出的疲劳强度曲线大致相同,这应得到足够的重视。此外,本研究还展示了使用黏结螺栓连接的可行性研究。最后的研究是用高强度低合金结构钢板和用于金属黏结的丙烯酸结构黏结剂进行的。针对两个实际工程案例,使用线性化边界及Castillo和Fernández-Canteli模型对疲劳实验数据进行统计分析。最终提出疲劳设计曲线,并与欧洲和北美规范中的几个设计建议进行比较。 | Jose Antonio Fonseca de Oliveira Correia Bruno Alexandre Silva Pedrosa Patricia Cordeiro Raposo Abilio Manuel Pinho De Jesus Helena Maria dos Santos Gervisio Grzegorz Stanislaw Lesiukc Carlos Alberto da Silva Rebelo Rui Artur Bartolo Calcada Luis Alberto Proenca Simoes da Silva | 2017 | Engineering2017，3，6： | 1 |
| 12 | The Last C-Terminal Residue of VP3,Glutamic Acid 257,Controls Capsid Assembly of Infectious Bursal Disease Virus显示文摘 | Christophe Chevalier Jean Lepault Bruno Da Costa | 2004 | J Virol2004，78，： | 1 |
| 13 | Movement behaviors and their association with depressive symptoms in Brazilian adolescents:A cross-sectional study显示文摘Background:Physical activity,sleep,and sedentary behaviors compose 24-h movement behaviors and have been independently associated with depressive symptoms.However,it is not clear whether it is the movement behavior itself or other contextual factors that are related to depressive symptoms.The objective of the present study was to examine the associations between self-reported and accelerometer-measured movement behaviors and depressive symptoms in adolescents.Methods:Cross-sectional data from 610 adolescents(14-18 years old)were used.Adolescents answered questions from the Center for Epidemiological Studies Depression scale and reported time spent watching videos,playing videogames,using social media,time spent in various physical activities,and daytime sleepiness.Wrist-worn accelerometers were used to measure sleep duration,sleep efficiency,sedentary time,and physical activity.Mixed-effects logistic regressions were used.Results:Almost half of the adolescents(48%)were classified as being at high risk for depression(score≥20).No significant associations were found between depressive symptoms and accelerometer-measured movement behaviors,self-reported non-sport physical activity,watching videos,and playing videogames.However,higher levels of self-reported total physical activity(odd ratio(OR)=0.92,95%confidence interval(95%CI):0.86-0.98)and volume of sports(OR=0.88,95%CI:0.79-0.97),in minutes,were associated with a lower risk of depression,while using social media for either 2.0-3.9 h/day(OR=1.77,95%CI:1.58-2.70)or>3.9 h/day(OR=1.67,95%CI:1.10-2.54),as well as higher levels of daytime sleepiness(OR=1.17,95%CI:1.12-1.22),were associated with a higher risk of depression.Conclusion:What adolescents do when they are active or sedentary may be more important than the time spent in the movement behaviors because it relates to depressive symptoms.Targeting daytime sleepiness,promoting sports,and limiting social media use may benefit adolescents. | Bruno Goncalves Galdino da Costa Jean-Philippe Chaput Marcus Vinicius Veber Lopes Luis Eduardo Argenta Malheiros Kelly Samara Silva | 2022 | Journal of Sport and Health Science2022，11，2： | 1 |
| 14 | Mechanistic aspects of COX-2 expression in colorectal neoplasia 显示文摘 | Dixon DA Blanco FF Bruno A | 2013 | Recent Results Cancer Res2013，191，： | 1 |
| 15 | Effect of linezolid compared with glycopeptides in methicillin-resistant Staphylococcus aureus severe pneumonia in piglets 显示文摘 | Luna CM Bruno DA Morato JG | 2009 | Chest2009，135，15： | 1 |
| 16 | Atualiza??o em pneumonia comunitária viral显示文摘 | Ozéas Galeno da Rocha Neto Ricardo Ferreira Leite Bruno Guedes Baldi | 2013 | Revista da Associa??o Médica Brasileira2013，，1： | 1 |
| 17 | Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity:a review显示文摘Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B,paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment.However, adverse effects, long-term treatment and the emergence of parasite resistance have led to the search for alternative treatments. Natural products used in traditional medicine provide an unlimited source of molecules for the identification of new drugs, and the Amazon region has abundant biodiversity that includes several species of plants and animals, providing a rich source of new products and compounds. Although the literature describes numerous promising compounds and extracts for combating Leishmania protozoans, the results of such research have not been embraced by the pharmaceutical industry for the development of new drugs. Therefore, this review focused on the antileishmanial activity of extracts, isolated compounds and essential oils commonly used by the local population in the Brazilian Amazonian region to treat several illnesses and described in the literature as promising compounds for combating leishmaniasis. | Bruno Jose Martins Da Silva Amanda Anastacia Pinto Hage Edilene Oliveira Silva Ana Paula Drummond Rodrigues | 2018 | Journal of Integrative Medicine2018，16，4： | 1 |
| 18 | Mechanistic aspects of COX-2expression in colorectal neoplasia显示文摘 | Dixon DA Blanco FF Bruno A | 2013 | Recent Results Cancer Res2013，191，： | 1 |
| 19 | Effect of Graphene Nanoplatelets Presence on the Thermal and Mechanical Properties of Polypropylene Fibers Produced by Melt Spinning显示文摘In aiming to obtain fibers with enhanced thermal and mechanical properties,graphene based textile fibers with 144 filaments were developed using an approach in which the PP/GnP(polypropylene/graphene nanoplatelets)nanocomposite was employed as conductive material in a fiber with circular cross-section geometry.The kinetics of thermal degradation was evaluated by the Broido method using thermogravimetric analysis(TGA).Activation energy was enhanced from 260.6 kJ·mol^-1 to 337.4 kJ·mol^-1 compared to the neat PP.GnP increased the thermal stability of the PP,slowing its degradation by thermal depolymerization.Furthermore,the degree of crystallization declined as the GnP content increased,reducing the tenacity of the yarn,but improving its elastic modulus from 91.9 to 95.9 cN/tex,being a promising alternative to produce smart textiles.In conclusion,it has been confirmed that GnP loading up to 1%(w/w)can be incorporated into polypropylene by melt spinning and that the resulting nanocomposite fibers are suitable for several applications in the textile industry. | Ricardo Rodrigo Ramos Cecci Adriano Alves Passos Nathan Riany Valério Albino Daniel da Silva Vicente Ademir Severino Duarte Maria Inês Bruno Tavares | 2020 | 材料科学与工程(中英文B版)2020，10，2： | 1 |
| 20 | Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism显示文摘 | Rafael Deminice Gabriela Salim Ferreira de Castro Lucas Vieira Francisco Lilian Eslaine Costa Mendes da Silva Jo?o Felipe Rito Cardoso Fernando Tadeu Trevisan Frajacomo Bruno Gonzaga Teodoro Leonardo dos Reis Silveira Alceu Afonso Jordao | 2015 | The Journal of Nutritional Biochemistry2015，，4： | 1 |
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