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| 1 | G2/M inhibitors as pharmacotherapeutic opportunities for glioblastoma:the old,the new,and the future显示文摘Glioblastoma(GBM) is one of the deadliest tumors and has a median survival of 3 months if left untreated. Despite advances in rationally targeted pharmacological approaches, the clinical care of GBM remains palliative in intent. Since the majority of altered signaling cascades involved in cancer establishment and progression eventually affect cell cycle progression, an alternative approach for cancer therapy is to develop innovative compounds that block the activity of crucial molecules needed by tumor cells to complete cell division. In this context, we review promising ongoing and future strategies for GBM therapeutics aimed towards G2/M inhibition such as anti-microtubule agents and targeted therapy against G2/M regulators like cyclin-dependent kinases,Aurora inhibitors, PLK1, BUB, 1, and BUBR1, and survivin. Moreover, we also include investigational agents in the preclinical and early clinical settings. Although several drugs were shown to be gliotoxic, most of them have not yet entered therapeutic trials. The use of either single exposure or a combination with novel compounds may lead to treatment alternatives for GBM patients in the near future. | Angel Mauricio Castro-Gamero Julia Alejandra Pezuk Maria Sol Brassesco Luiz Gonzaga Tone | 2018 | Cancer Biology & Medicine2018，15，4： | 3 |
| 2 | Polynomial affined algorithm for linear programming显示文摘 | Gonzaga C C | 1990 | Mathematical Programming1990，49，： | 1 |
| 3 | Comparison of root-system efficiency and arsenic up- take of two fern Species 显示文摘 | SILVA GONZAGA M I SANTOS J A G COMERFORD N B | 2007 | Communications in Soil Science and Plant Analysis2007，38，： | 1 |
| 4 | To treat or not to treat? A meta-analysis of the use of cholinesterase inhibitors in mild cognitive impairment for delaying progression to Alzheimer's disease显示文摘 | Diniz B S Pinto J A Jr Gonzaga M L | 2009 | Eur Arch Psychiatry Clin Neurosci2009，259，： | 1 |
| 5 | ANN-based soft sensor for real-time process monitoring and control of an industrial polymerization process 显示文摘 | Gonzaga J Meleiro L Kiang C | 2009 | Com户uters & Chemical Engineering2009，33，1： | 1 |
| 6 | Obstructive sleep apnea:the most common secondary cause of hypertension associated with resistant hypertension显示文摘 | Pedrosa R P Drager L F Gonzaga C C | | 0，，05： | 1 |
| 7 | A global convergent filter method for nonlinear programming显示文摘 | Gonzaga C Karas E Vanti M | 2003 | SIAM Journal on Optimization2003，14，3： | 1 |
| 8 | Phenolic compounds and antioxidant activity of seed and skin extracts of red grape显示文摘 | Ismael Ivan Rockenbach Luciano Valdemiro Gonzaga Viviane Maria Rizelio | 2011 | Food Research International2011，44，4： | 1 |
| 9 | Resistant Hypertension and Hyperaldosteronism显示文摘 | Gonzaga CC Calhoun DA | 2008 | Curr Hyperten Rep2008，10，6： | 1 |
| 10 | ANN-based soft-sensor for real-time process monitoring and control of an industrial polymerization process显示文摘 | Gonzaga J C B Meleiro L A C Kiang C | 2009 | Computers and Chemical Engineering2009，33，1： | 1 |
| 11 | A globally convergent filter method for nonlinear program-ming显示文摘 | GONZAGA C C KARAS E VANTI M | 2003 | SIAM Journal on Optimization2003，14，3： | 1 |
| 12 | Optimization of extraction of high-ester pectin from passion fruit peel (Pasiflora edulits flavicarpa) with citric acid by using response surface methodology显示文摘 | Pinheiro E R Silva I M D A Gonzaga L V | 2008 | Bioresource Tech- nolo2008，99，： | 1 |
| 13 | Both psoriasis and benign migratory glossitis are associated with HLA- Cw6显示文摘 | Gonzaga HF Torres EA Alchome MM | 1996 | Br J Dermatol1996，135，3： | 1 |
| 14 | The largest step path following algorithm for monotone linear complementarity problems显示文摘 | Clovis C. Gonzaga | 1997 | Mathematical Programming1997，，2： | 1 |
| 15 | Friedel-Crafts acylaiton of anisole with acetic anhydride over silica-supported hetempolyphostungstic acid (HPW/SiO2 )显示文摘 | CARDOSO L A M ALVES W It GONZAGA A R E AGUIAR L M G ANDRADE H M C | 2004 | J Mol Catal A2004，209，12： | 1 |
| 16 | Isolation and characterization of polysaccharides from Agaricus blazei Murill显示文摘 | GONZAGA M L C RICARDO N M P S HEATLEY F | 2005 | Carbohydrate Polymers2005，60，1： | 1 |
| 17 | ANN-based soft-sensor for real-time process monitoring and control of an industrial polymerization process 显示文摘 | Gonzaga J C B Meleiro L A C Kiang C | 2009 | Computers & Chemical Engineering2009，33，1： | 1 |
| 18 | Effect of ion exchange on hardness and fracture toughness of dental porcelains 显示文摘 | Cesar PF Gonzaga CC Miranda WG Jr | 2007 | J Biomed Mater Res B Appl Biomater2007，83，2： | 1 |
| 19 | Analysis of the genetic diversity in Metopolophium dirhodum (Walker) (Hemiptera,Aphididae) by RAPD markers显示文摘 | LOPES-DA-SILV A Marcelo GONZAGA ESTEVES VIEIRA Luiz | 2007 | Sociedade Brasileira de Entomologia2007，51，： | 1 |
| 20 | Optimization of extraction of high-ester pectin from passion fruit peel (Passiflora edulis flavicarpa) with citric acid by using response surface methodology显示文摘 | Pinheiro E Silva I M D A Gonzaga L V | 2008 | Bioresource Technology2008，99，13： | 1 |
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