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| 1 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 2 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 3 | Acute pancreatitis complicated with splenic rupture: A case report显示文摘Atraumatic splenic rupture is an uncommon complication of acute pancreatitis. This report describes the case of a 30-year-old man with acute pancreatitis and splenic vein thrombosis complicated by splenic rupture. The patient was admitted to the emergency department with pain in the upper abdomen that had been present for six hours and was associated with vomiting and sweating. He was diagnosed with acute pancreatitis of alcoholic etiology. Upon computed tomography(CT) of the abdomen, the pancreatitis was scored as Balthazar C grade, and a suspicious area of necrosis affecting 30% of the pancreas with splenic vein thrombosis was revealed. Seventytwo hours after admission, the patient had significant improvement in symptoms. However, he showed clinical worsening on the sixth day of hospitalization, with increasing abdominal distension and reduced hemoglobin levels. A CT angiography showed a large amount of free fluid in the abdominal cavity, along with a large splenic hematoma and contrast extravasation along the spleen artery. The patient subsequently underwent laparotomy, which showed hemoperitoneum due to rupture of the splenic parenchyma. A splenectomy was then performed, followed by ultrasound-guided percutaneous drainage. | Bruno L Hernani Pedro C Silva Ricardo T Nishio Henrique C Mateus José C Assef Tercio De Campos | 2015 | World Journal of Gastrointestinal Surgery2015，7，9： | 2 |
| 4 | Probiotic yeasts: Anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice显示文摘AIM: To evaluate the in vitro immunomodulation capacity of various non-pathogenic yeast strains and to investigate the ability of some of these food grade yeasts to prevent experimental colitis in mice.METHODS: In vitro immunomodulation was assessed by measuring cytokines [interleukin (IL)-12p70,IL-10,tumor necrosis factor and interferon γ] released by human peripheral blood mononuclear cells after 24 h stimulation with 6 live yeast strains (Saccharomyces ssp.) and with bacterial reference strains.A murine model of acute 2-4-6-trinitrobenzene sulfonic acid (TNBS)-colitis was next used to evaluate the distinct prophylactic protective capacities of three yeast strains compared with the performance of prednisolone treatment.RESULTS: The six yeast strains all showed similar non-discriminating anti-inflammatory potential when tested on immunocompetent cells in vitro .However,although they exhibited similar colonization patterns in vivo ,some yeast strains showed significant anti-inflammatory activities in the TNBS-induced colitis model,whereas others had weaker or no preventive effect at all,as evidenced by colitis markers (body-weight loss,macroscopic and histological scores,myeloperoxidase activities and blood inflammatory markers).CONCLUSION: A careful selection of strains is required among the biodiversity of yeasts for specific clinical studies,including applications in inflammatory bowel disease and other therapeutic uses. | Benot Foligné Jo■lle Dewulf Pascal Vandekerckove Georges Pignède Bruno Pot | 2010 | World Journal of Gastroenterology2010，16，17： | 2 |
| 5 | In vitro antibacterial effects of antilipopolysaccharide DNA aptamer-C1 qrs complexes 显示文摘 | Bruno J G Carrillo M P Phillips T | 2008 | Folia Microbiol(Praha)2008，53，4： | 1 |
| 6 | A Model of Venture Capitalist Investment Activity显示文摘 | T T Tyebjee A V Bruno | 1984 | Managment Science1984，30，9： | 1 |
| 7 | Microstructure of fabrics chemically finished for thermal adaptability 显示文摘 | Goynes W R Vigo T L Bruno J S | 1990 | Textile Res J1990，60，5： | 1 |
| 8 | Thermal properties of insolubilized poly- acetals derived from non-formaldehyde crosslinking agents显示文摘 | Bruno J S Vigo T L | 1994 | Thermochim Acta1994，243，2： | 1 |
| 9 | CYP17 inhibitors for prostatecancer therapy显示文摘 | Vasaitis T S Bruno R D Njar V C | 2011 | Steroid Biochem Mol Biol2011，125，12： | 1 |
| 10 | Rapid Screening of Fluids for Chemical Stability in Organic Rankine Cycle Applications 显示文摘 | Andersen W C Bruno T J | 2005 | Industrial & Engineering Chemistry Research2005，44，15： | 1 |
| 11 | Rapid screening of fluids for chemical stability in organic Rankine cycle applications 显示文摘 | ANDERSEN W C BRUNO T J | 2005 | Industrial and Engineering Chemistry2005，44，15： | 1 |
| 12 | A model of venture capital- ist investment activity 显示文摘 | Tyebjee T T Bruno A V | 1984 | Management Science1984，30，9： | 1 |
| 13 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 14 | A Model of Venture Capitalist Investment Activity显示文摘 | Tyebjee T T Bruno A V | 1984 | Management Science1984，30，9： | 1 |
| 15 | A model of venture capitalist invest- ment activity 显示文摘 | T T TYEBJEE A V BRUNO | 1984 | Management Science1984，30，9： | 1 |
| 16 | Using vanishing points for camera calibratian显示文摘 | Bruno C Vincent T | 1990 | Computer Vision1990，4，2： | 1 |
| 17 | The Novel ATP-Competitive Inhibitor of the MET Hepatocyte Growth Factor Receptor EMD1214063 Displays Inhibitory Activity against Selected MET-Mutated Variants显示文摘 | Michaela Medová Beno?t Pochon Bruno Streit Wieslawa Blank-Liss Paola Francica Deborah Stroka Adrian Keogh Daniel M. Aebersold Andree Blaukat Friedhelm Bladt Yitzhak Zimmer | 2013 | Molecular Cancer Therapeutics2013，，11： | 1 |
| 18 | The pathology of postcurettage intrauterine adhesions 显示文摘 | Foix A Bruno RO Davison T Lema B | 1966 | Am J Obstet Gynecol1966，，96： | 1 |
| 19 | A model of venture capitalist investment activity显示文摘 | Tyebjee T T Bruno A V | 1984 | Management Science1984，，9： | 1 |
| 20 | A model of venture capitalist investment activity显示文摘 | TYEBJEE T T BRUNO A V | 1984 | Management science1984，30，9： | 1 |
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