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| 1 | Systemic treatment strategies for triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC) is defined by the lack of immunohistochemical expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2(EGFR2). Most TNBC has a basal-like molecular phenotype by gene expression profiling and shares clinical and pathological features with hereditary BRCA1 related breast cancers. This review evaluates the activity of available chemotherapy and targeted agents in TNBC. A systematic review of PubM ed and conference databases was carried out to identify randomised clinical trials reporting outcomes in women with TNBC treated with chemotherapy and targeted agents. Our review identified TNBC studies of chemotherapy and targeted agents with different mechanisms of action, including induction of synthetic lethality and inhibition of angiogenesis, growth and survival pathways. TNBC is sensitive to taxanes and anthracyclins. Platinum agents are effective in TNBC patients with BRCA1 mutation, either alone or in combination with poly adenosine diphosphate polymerase 1 inhibitors. Combinations of ixabepilone and capecitabine have added to progression-free survival(PFS) without survival benefit in metastatic TNBC. Antiangiogenic agents, tyrosine kinase inhibitors and EGFR inhibitorsin combination with chemotherapy produced only modest gains in PFS and had little impact on survival. TNBC subgroups respond differentially to specific targeted agents. In future, the treatment needs to be tailored for a specific patient, depending on the molecular characteristics of their malignancy. TNBC being a chemosensitive entity, combination with targeted agents have not produced substantial improvements in outcomes. Appropriate patient selection with rationale combinations of targeted agents is needed for success. | Budhi Singh Yadav Suresh C Sharma Priyanka Chanana Swaty Jhamb | 2014 | World Journal of Clinical Oncology2014，5，2： | 18 |
| 2 | Biomarkers in triple negative breast cancer:A review显示文摘Breast cancer is an intrinsically heterogeneous disease. In the world about 1 million cases of breast cancer are diagnosed annually and more than 170000 are triplenegative. Characteristic feature of triple negative breast cancer(TNBC) is that it lacks expression of oestrogen,progesterone and human epidermal growth factor receptor-2/neu receptors. They comprise 15%-20% of all breast cancers. We did a systematic review of Pub Med and conference databases to identify studies published on biomarkers in TNBC. We included studies with biomarkers including: Epidermal growth factor receptor,vascular endothelial growth factor,c-Myc,C-kit and basal cytokeratins,Poly(ADP-ribose) polymerase-1,p53,tyrosinase kinases,m-TOR,heat and shock proteins and TOP-2A in TNBC. We also looked for studies published on synthetic lethality and inhibition of angiogenesis,growth,and survival pathways. TNBC is a complex disease subtype with many subclasses. Majority TNBC have a basal-like molecular phenotype by gene expression profiling. Their clinical and pathologic features overlap with hereditary BRCA1 related breast cancers. Management of these tumours is a challenge to the clinician because of its aggressive behaviour,poor outcome,and absence of targeted therapies. As the complexity of this disease is being simplified over time new targets are also being discovered for the treatment of this disease. There are many biomarkers in TNBC being used in clinical practice. Biomarkers may be useful as prognostic or predictive indicators as well as suggest possible targets for novel therapies. Many targeted agents are being studied for treatment of TNBC. | Budhi S Yadav Priyanka Chanana Swaty Jhamb | 2015 | World Journal of Clinical Oncology2015，6，6： | 13 |
| 3 | Genetic variations in detoxification enzymes and HIF‐1α in Japanese patients with COPD显示文摘 | Andika Chandra Putra Keiji Tanimoto Marina Arifin Budhi Antariksa Keiko Hiyama | 2011 | The Clinical Respiratory Journal2011，，1： | 2 |
| 4 | Changes in microflora and biochemical composition dur- ing the baceman stage of traditional Indonesian kecap ( soy sauce) production显示文摘 | Roling Ling W F M Timotius K H Budhi Prasetyo A | 1994 | Journal of Fermentation and Bioen- gineering1994，77，1： | 1 |
| 5 | Genetic susceptibility for emphysematous changes of the lung in Japanese显示文摘 | Budhi A Hiyama K Isobe T | 2003 | Int J Mol Med2003，11，3： | 1 |
| 6 | Rapid transmission of oxidative and nitrosative stress signals from roots to shoots in Arabidopsis显示文摘 | RICARDO C BUDHI S T ALEX L | 2004 | Plant Physiology and Biochemistry2004，42，5： | 1 |
| 7 | Genetic Susceptibility for emphysematous changes of the lung in Japanese 显示文摘 | Budhi A HiyamA K Isobe T | 2003 | Int J Mol Med2003，11，3： | 1 |
| 8 | Genetic susceptibility for em- physematous changes of the lung in Japanese 显示文摘 | Budhi A Hiyama K Isobe T | 2003 | Int J Mol Med2003，11，3： | 1 |
| 9 | A phase II study of neoadjuvant chemotherapy followed by organ preservation in patients with muscle-invasive bladder cancer显示文摘Objective:Conservative approaches in muscle-invasive bladder cancer(MIBC)have been evolved to avoid aggressive surgery,but are limited to elderly,frail,and patients medically unfit for surgery.Our study aimed to assess the response rate of neoadjuvant chemotherapy(NACT)before radiotherapy(RT)in MIBC patients.Methods:Forty patients with urothelial carcinoma of stage T2-T4a,N0,M0 were enrolled between November 2013 and November 2015,and treated with three cycles of NACT with gemcitabine-cisplatin.Post-NACT response was assessed using Response Evaluation Criteria in Solid Tumors(RECIST)criteria.Patients who achieved complete response(CR)and partial response(PR)>50%were treated with radical RT,and those who had PR<50%,stable disease(SD),and progressive disease(PD)underwent radical cystectomy(RC).Survival analysis was done with Kaplan-Meier method and point-to-time events were analyzed with Cox-proportional hazards regression model.Results:After NACT,35(87.5%)patients achieved either PR>50%or CR,and were treated with RT.Five(12.5%)patients who had PR<50%,SD,or PD underwent RC.All patients who received radiation showed CR after 6 weeks.Median follow-up was 43 months(range:10-66 months)and median overall survival(OS)was not reached.Three-year OS,local control,and disease-free survival were 70.1%,60.9%,50.6%,respectively,and 50%of patients preserved their functioning bladder.Three-year OS rate was 88.9%in patients who achieved CR to NACT,73.1%in patients with PR≥50%and 40%in patients with PR<50%.Conclusion:NACT followed by RT provides a high probability of local response with bladder preservation in CR patients.Appropriate use of this treatment regimen in carefully selected patients may omit the need for morbid surgery. | Chinna Babu Dracham Narendra Kumar Santosh Kumar Arun Elangovan Budhi Singh Yadav Ravimohan S.Mavuduru Anupam Lal Pramod K.Gupta Rakesh Kapoor | 2022 | Asian Journal of Urology2022，9，3： | 1 |
| 10 | Oxidative stress increased respiration and generation of reactive oxygen species, resulting in ATP depletion,opening of mitochondrial permeability transition ,and programmed cell death, plant 显示文摘 | Budhi S Tiwari BB A]ex L | 2002 | Physiol2002，128，： | 1 |
| 11 | 显示文摘 | Budhi A Hiyamai K Isobei T | 2003 | Int J Mol Med2003，11，3： | 1 |
| 12 | Hydrogenated Amorphous Carbon Films from Palmyra Sugar显示文摘A simple,highly reproducible,and environmentally friendly method is a considered approach in generating renewable energy materials.Here,hydrogenated amorphous carbon(a-C)films have been successfully prepared from palmyra liquid sugar,employing spin-coating and spraying methods.Compared with the former method,the latter shows a significance in producing a better homogeneity in particle size and film thickness.The obtained films have a thickness of approximately 1000 to 100 nm and contain an sp^(2) hexagonal structure(~70%)and sp^(3) tetrahedral configuration(~30%)of carbons.The introduction of boron(B)and nitrogen(N)as dopants has created the local structural modification of bonding,inducing a slight change of electrical conductivity,electronic energy bandgap,and optical transparency near-infrared region.The obtained α-C film features a“green”semiconducting material. | Budhi Priyanto Retno Asih Irma Septi Ardiani Anna Zakiyatul Laila Khoirotun Nadiyyah Bima Romadhon Sarayut Tunmee Hideki Nakajima Triwikantoro Yoyok Cahyono Darminto | 2021 | Journal of Renewable Materials2021，9，6： | 0 |
| 13 | N-Doped rGO-Like Carbon Prepared from Coconut Shell:Structure and Specific Capacitance显示文摘An rGO−like carbon compound has been synthesized from biomass,i.e.,old coconut shell,by a carbonization process followed by heating at 400°C for 5 h.The nitrogen doping was achieved by adding the urea(CH4N2O)and stirring at 70°C for 14 h.The morphology and structure of the rGO-like carbon were investigated by electron microscopies and Raman spectroscopy.The presence of C-N functional groups was analyzed by Fourier transform infrared and synchrotron X-ray photoemission spectroscopy,while the particle and the specific capacitance were measured by particle sizer and cyclic voltammetry.The highest specific capacitance of 72.78 F/g is achieved by the sample with 20%urea,having the smallest particles size and the largest surface area.The corresponding sample has shown to be constituted by the appropriate amount of C–N pyrrolic and pyridinic defects. | Imam Khambali Budhi Priyanto Retno Asih Malik Anjelh Baqiya Muhammad Mahyiddin Ramli Nurul Huda Osman Sarayut Tunmee Hideki Nakajima Triwikantoro Mochamad Zainuri Darminto | 2023 | Journal of Renewable Materials2023，11，4： | 0 |
| 14 | High-dose methotrexate and zanubrutinib combination therapy for primary central nervous system lymphoma显示文摘In this editorial I comment on the article,published in the current issue of the World Journal of Clinical Oncology.Primary central nervous system lymphoma(PCNSL)is a disease of elderly and immunocompromised patients.The authors reported clinical results of 19 patients with PCNSL treated with zanubrutinib/high dose methotrexate(HD-MTX)until disease progression.They demonstrated that the combination of zanubrutinib with HD-MTX led to a marked clinical response and tolerability among these patients.They also observed that cerebrospinal fluid liquid biopsy to detect circulating tumor DNA may be a good option for evaluating treatment response and tumor burden in patients with PCNSL.PCNSL is a challenging disease for treatment as these patients present with different neurological states and comorbidities.Treatment has evolved over the years from whole brain radiotherapy to HD-MTX followed by autologous stem cell transplant.Gradually,treatment of patients with PCNSL is going to become individualized. | Budhi Singh Yadav | 2024 | World Journal of Clinical Oncology2024，15，3： | 0 |
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