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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure 显示文摘 | Shiroshita-Takeshita A Brundel B J Burstein B | 2007 | Cardiovasc Res2007，74，1： | 1 |
| 3 | Percutaneous pinning using threaded pins as a treatment option for unstable two-and three-part fractures of the proximal humerus:a retrospective study显示文摘 | Fenichel L Oran A Burstein G | 2006 | Int Orthop2006，30，3： | 1 |
| 4 | DAML-S:A Semantic Markup Language for Web Services显示文摘 | Burstein M Hobbs J R | 2002 | IEEE Intelligent Systems Journal2002，，7： | 1 |
| 5 | Phase II study of sunitinib malate, an oral multi-targeted tyrosine kinas inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane 显示文摘 | Burstein H J Elias A D Rugo H S | 2008 | JClin Oncol2008，26，11： | 1 |
| 6 | Fluorescene and the location of tryptophan residues in protein molecules显示文摘 | Burstein E A Vedenkina N S Ivkova M N | | 0，，： | 1 |
| 7 | Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study显示文摘 | Burstein H J Keshaviah A Baron AD | 2007 | Cancer2007，1110，5： | 1 |
| 8 | Sensitization of menin- geal sensory neurons and the origin of headaches 显示文摘 | Strassman A M Raymond S A Burstein R | 1996 | Nature1996，384，6609： | 1 |
| 9 | Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer显示文摘 | Burstein MD Tsimelzon A Poage GM | 2015 | Clin Cancer Res2015，21，7： | 1 |
| 10 | Solid-state synthesis of tungsten carbide from tungsten oxide and carbon,and its catalysis by nickel显示文摘 | Rees E J Brady E D A Burstein G T | 2008 | Materials Letters2008，62，： | 1 |
| 11 | Trade, Production sharing, and the international transmission of business cycles显示文摘 | Burstein A Kurz C J Tesar L | 2008 | Journal of Monetary Economics2008，55，4： | 1 |
| 12 | COMMD proteins, a novel family of structural and functional homologs of MURRI 显示文摘 | Burstein E Hoberg J E Wilkinson A S | 2005 | J Biol Chem2005，280，22： | 1 |
| 13 | Effect of carbon monoxide on the electrooxidation of hydrogen by tungsten carbide 显示文摘 | McIntyre D R Burstein G T Vossen A | 2002 | J Power Sources2002，107，： | 1 |
| 14 | The influence of an experimental immune synovitis on the failure mode and strength of the rabbit anterior cruciate ligament 显示文摘 | Goldberg V M Burstein A Dawson M | 1982 | J Bone Joint Surg Am1982，64，6： | 1 |
| 15 | Percutaneous pinning using threaded pins as a treatment option for unstable two - and three - part fractures of the proximal humerus : a retrospective study 显示文摘 | Fenichel I Oran A Burstein G | 2006 | Int Or- thop2006，3，： | 1 |
| 16 | Fetal echo- genic bowel at 17 weeks' gestational age as the early and only sign of a very long segment of hirschsprung disease 显示文摘 | Bashiri A Burstein E Hershkowitz R | 2008 | J Ultrasound M ed2008，27，7： | 1 |
| 17 | Distribution Costs and Real Exchange Rate Dynamics During Exchange-rate-based Stabilizations 显示文摘 | Burstein A T Neves J C Rebelo S | 2003 | Journal of Monetary Economics2003，，50： | 1 |
| 18 | A phase Ⅱ study of lapatinib monotherapy in chemotherapy - refractory HER2 - positive and HER2 - negative advanced or metastatic breast cancer显示文摘 | BURSTEIN H J STORNIOLO A M FRANCO S | 2008 | Ann Oncology2008，19，6： | 1 |
| 19 | Breast surgery in stage IV breast cancer: impact of staging and patient selection on overall survival 显示文摘 | Bafford A C Burstein H J Barkley C R | 2009 | Breast Cancer Res Treat2009，115，1： | 1 |
| 20 | Effect of carbon monoxide on the electrooxidation of hydrogen by tungsten carbides显示文摘 | Mcintyre D R Burstein G T Vossen A | 2002 | J Power Source2002，107，： | 1 |
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