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| 1 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 2 | Determination of As, Sb, Se, Te and Bi in milk by slurry sampling hydride atomic fluorescence spectrometry 显示文摘 | Patricia C M Luisa C Agustin P | 2004 | Talanta2004，62，1： | 1 |
| 3 | Curvilinear Effects of Consumer LoyaltyDeterminants in Relational Exchanges 显示文摘 | Agustin C Singh J | 2005 | Journal of MarketingResearch2005，42，： | 1 |
| 4 | Manufacture of Cheese Made from CO2-Treated Milk显示文摘 | ANTONIA M MARTA C AGUSTIN O | 1995 | J Dairy Sci1995，，： | 1 |
| 5 | Direct Electrochemical Sensing and Detection of Natural Antioxidants and Antioxidant Capacity in Vitro Systems显示文摘 | Antonio J B Agustin G C Maria C G | 2007 | Electroanalysis2007，19，22： | 1 |
| 6 | Synthesis, characterization and study of the chromogenic properties of the hybrid polyoxo- metalates 3- ( R = Et, ( cn2 )ncn = CH2 ( n -- 0, 1,4 ), CH2CH2SiEh, CH2CH2SiMe2Ph ) 显示文摘 | Agustin D Dallety J Coelho C | 2007 | J Organometallic Chem2007，692，4： | 1 |
| 7 | Adsorptive stripping behavior of mitoxantrone on carbon paste electrodes显示文摘 | Juan C C V Agustin C G Paulino T B | 1993 | Talanta1993，40，3： | 1 |
| 8 | High prevalence of multiple resistance to antibiotics in Salmonella serovars isolated from a poultry slaughterhouse in Spain 显示文摘 | Carraminana J J Rota C Agustin I | 2004 | Vet Microb2004，104，： | 1 |
| 9 | High prevalence of multiple resistance to antibiotics in Salmonella serovars isolated from a poultry slaughterhouse in Spain Veterinary 显示文摘 | Carraminana J J Rota C Agustin I | 2004 | Microbiology2004，104，12： | 1 |
| 10 | Mutation of atranscription factor,TFCP2L3,causes progressive au-tosomal dominant hearing loss,DFNA28显示文摘 | Peters L M Anderson D W Griffith A J Grundfast KM San Agustin T B Madeo A C | 2002 | Hum MolGenet2002，11，： | 1 |
| 11 | Characteristics of post-transcrip-tional gene silencing显示文摘 | Agustin C Giuseppe M | 2001 | EMBO2001，2，： | 1 |
| 12 | Curvilinear Effects of Consumer Loyalty Determinants in Relational Exchanges显示文摘 | C Agustin J Singh | 2005 | Journal of Marketing Research (JMR)2005，42，1： | 1 |
| 13 | New insights into the role of the electronic properties of oxide promoters in Rh-catalyzed selective synthesis of oxygenates from synthesis gas显示文摘 | GONZALO P PATRICLA C AGUSTIN M | 2011 | Journal of Catalysis2011，280，： | 1 |
| 14 | Bcl-2 with loss of apoptosis allowsaccumulation of genetic alterations:A pathway to metastatic progression inhuman breast cancer显示文摘 | Xavier C Agustin E | 2000 | Int J Cancer2000，89，： | 1 |
| 15 | Changes in poly- phenolic content and antioxidant activity after thermal treatments of grape seed extract and grape pomace显示文摘 | Susana C Isabel G Agustin V | 2012 | European Food Research and Technology2012，234，： | 1 |
| 16 | A hardware design of a massive-parallel, modular NN-based vector quantizer for real-time video coding 显示文摘 | AGUSTIN R A RAFAEL G G RICARDO C P | 2007 | Microprocessors and Microsystems2007，32，4： | 1 |
| 17 | Direct measurement of proximal isovelocity surface area by single-beat three-dimensional color Doppler echocardiography in mitralregurgitation:a validation study显示文摘 | de Agustin JA Marcos-Alberca P Fernandez-Golfin C | 2012 | J Am Soc Echocardiogr2012，25，： | 1 |
| 18 | Proximal isovelocitysurface area by single-beat three-dimensional color Dopplerechocardiography applied for tricuspid regurgitation quantification显示文摘 | de Agustin JA Viliani D Vieira C | 2013 | J Am Soc Echocardiogr2013，26，： | 1 |
| 19 | Colorectal Cancer:Epidemiology,Risk Factors,and Health Services显示文摘 | Amersi F Agustin M Ko C Y | 2005 | Clin Colon Rectal Surg2005，18，3： | 1 |
| 20 | Oxobridged bis oxo-vanadium (V) complexes with tridentate Schiff base ligands (VOL)(2)0 (L = SAEI SAMP, SAP): Synthesis, structure and epoxidation catalysis un-der solvent-free conditions 显示文摘 | CORDELLE C AGUSTIN D DARAN J C | 2010 | Inorg Chim Acta2010，364，1： | 1 |
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