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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | J High resolution processing of hybrid strip-map/spotlight mode SAR显示文摘 | Belcher D P Baker C | | 0，，06： | 1 |
| 3 | Struc-tural and microstructural characterization of the growth lines and prismatic microarchitecture in red abalone shell and the microstructures of abalone 'flat pearls”显示文摘 | Su Xiaowei Belcher A M Zaremba C M | | 0，，07： | 1 |
| 4 | Increased physical activity and reduced adiposity in overweight Hispanic adolescents显示文摘 | BYRD-WILLIAMS C E BELCHER B R SPRUIJT-METZ D | 2010 | Med Sci Sports Exe2010，42，3： | 1 |
| 5 | The production of transgenic pigs for potential use in clinical xenotransplantation:microbiological evaluation显示文摘 | Tucker A Belcher C Moloo B | 2002 | Xenotransplantation2002，9，： | 1 |
| 6 | Critical transitions in the biofabrication of abalone shells and flat pearls 显示文摘 | Zaremba C M Belcher A M Fritz M | 1996 | Chem Mater1996，8，： | 1 |
| 7 | High resolution processing of hybrid strip-map/spotlight mode SAR 显示文摘 | Belcher D P Baker C J | 1996 | IEE Proceedings-Radar Sonar and Navigation1996，143，6： | 1 |
| 8 | Theory and simula-tion of ionospheric effects on synthetic aperture radar显示文摘 | BELCHER D P ROGERS N C | 2009 | IET Radar Sonar and Navigation2009，3，5： | 1 |
| 9 | Cell wall defi- cient bacteria as a cause of infections: a review of the clinical signficience 显示文摘 | Onwuamaegbu M E Belcher R A Soare C | 2005 | Int Med Res2005，33，1： | 1 |
| 10 | Cell wall-deficient bacteria as a cause of infections: a review of the clinical significance显示文摘 | Onwuamaegbu ME Belcher RA Soare C | 2005 | J Int Med Res2005，33，1： | 1 |
| 11 | Transforming traditional iris recognition systems to work on non-ideal situations显示文摘 | Z 2]aou Y Du C Belcher | 2009 | 1EEE Trans on Industry Electronics2009，56，8： | 1 |
| 12 | The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies显示文摘 | Drenkow J Kehoe B Gingeras T R McNamara N Lemjabbar H Basbaum C Relman D A | 2000 | Proc Natl Acad Sci USA2000，97，13： | 1 |
| 13 | Limits for Combustion in Low 02 Redefine Paleoatmospheric Predictions for the Mesozoic 显示文摘 | Belcher C M McElwain J C | 2008 | Science2008，321，： | 1 |
| 14 | Single M13 bacteriophage tethering and stretching显示文摘 | Khalil A S Ferrer J M Brau R R Kottmann S T Noren C J Lang M J and Belcher A M | 2007 | PNAS2007，104，48： | 1 |
| 15 | Viral assembly of oriented quantum dot nanowires 显示文摘 | Mao C Flynn C E Hayhurst A Sweeney R Qi J Georgiou G Iverson B and Belcher A M | 2003 | Proceeding of National Academy of Sciences of the USA2003，100，12： | 1 |
| 16 | Cardiovascular effects of treatment of type 2 diabetes with pioglitazone, metformin and gliclazide 显示文摘 | Belcher G Lambert C Goh KL | 2004 | Int J Clin Pract2004，58，9： | 1 |
| 17 | Uncooled monolithic ferroelectric IRFPA technology显示文摘 | BELCHER J F HANSON C M BERATAN H R | 1998 | Proceedings of SPIE1998，3436，： | 1 |
| 18 | Critical transitions in the biofabrication of abalone shells and flat pearls显示文摘 | Zaremba C M Belcher A M Fritz M | 1996 | Chemistry of Materials1996，8，3： | 1 |
| 19 | Cardiovascular effects of treatment of type 2 diabetes with pioglitazone, metformin and gliclazide 显示文摘 | Belcher G Lambert C Goh KL | 2004 | IntJ Clin Pract2004，58，9： | 1 |
| 20 | Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes显示文摘 | Nam K T Kim D W Yoo P J Chiang C Y Meethong N Hammond P T Chiang Y M and Belcher A M | 2006 | Science2006，312，5775： | 1 |
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