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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018,39,7: | 31 |
| 2 | 超低碳钢连铸过程中Ti和P对水口结瘤的影响显示文摘浇注含Ti超低碳钢时,浸入式水口内产生结瘤,严重影响生产效率,同时对产品质量造成危害。根据企业生产的经验,随着超低碳钢中Ti和P含量的增加,水口结瘤的问题越来越严重。通过深入分析实际生产过程的试样和实验室研究,阐明浇注超低碳钢时Ti和P对水口结瘤的影响。分析了含Ti含P的超低碳钢水口结瘤物的成分,结果表明结瘤物的主要成分是氧化铝(>90%),Ti含量较少(0.58%~3.58%)。采用脉冲分布解析原子发射光谱法(OES-PDA)测得氧化夹杂物的大小随Ti含量的增加而变小。采用液滴法测定了溶质Ti和P对钢液/Al2O3体系的润湿性影响,结果表明Ti和P使体系接触角和钢液表面张力降低,其中Ti能够降低体系的接触角只是在其具有反应湿润性的情况下。研究表明Ti和P对产生结瘤的作用有显著区别:只要形成的表层界面具有润湿性,Ti就可以降低Al2O3夹杂物的大小,而氧化铝夹杂物颗粒越小,越容易结瘤。为了不产生结瘤就必须控制好Al脱氧的时间和Ti的加入时间。P可以增加Fe-Ti-P三元体系的润湿性是因为P可以增加Ti的活度,降低钢液的粘度。与Ti相比,P对产生结瘤的影响较小。 | C Bernhard A Karasangabo M Egger A Pissenberger 贾洪海(译) | 2012 | 世界钢铁2012,12,5: | 17 |
| 3 | Method development for the determination of cadmium in fertilizer samples using high-resolution continuum source graphite furnace atomic absorption spectrometry and slurry sampling显示文摘 | Aline R. Borges Emilene M. Becker Céline Lequeux Maria Goreti R. Vale Sergio L.C. Ferreira Bernhard Welz | 2011 | Spectrochimica Acta Part B: Atomic Spectroscopy2011,,7: | 3 |
| 4 | Experimentally optimal v in support vector regression for different noise models and parameter settings显示文摘 | ATHANASSIA C BERNHARD S ALEX J S | 2004 | Neural Networks2004,17,: | 1 |
| 5 | Austenite Grain Size in the Continuous Casting Proeess显示文摘 | Reiter J Bernhard C Presslinger H | 2008 | Metallographic Methods and Evaluation Materials Characterization2008,59,6: | 1 |
| 6 | Relay-based deployment concepts for wireless and mobile broadband radio显示文摘 | PABST R BERNHARD W H DANIEL S C | 2004 | IEEE Communication Magazine2004,42,9: | 1 |
| 7 | Comprehensive Identification of Proteins from MALDI Imaging显示文摘 | Stefan K. Maier Hannes Hahne Amin Moghaddas Gholami Benjamin Balluff Stephan Meding Cédrik Schoene Axel K. Walch Bernhard Kuster | 2013 | Molecular & Cellular Proteomics2013,,10: | 1 |
| 8 | Identification of defect prone peritectic steel grades by analyzing high- temperature phase transformations显示文摘 | PRESOLY P PIERER R BERNHARD C | 2013 | Metallurgical andMaterials Transactions A2013,44,12: | 1 |
| 9 | No evidence of increased oxida- tive degradation of urate to allantoin in the CSF and serum of pa- tients with multiple sclerosis显示文摘 | Stefan K Bernd C Bernhard F | 2005 | J Neurol2005,252,5: | 1 |
| 10 | Dynamic modelling of a shapememory alloy adaptive tuned vibration absorber 显示文摘 | Williams K A Chiu G T C Bernhard R J | 2005 | Journal of Sound and Vibration2005,280,: | 1 |
| 11 | Fermentation of raw sludge on an industrial scale and applications for elutriating its dissolved products and non-sedimentable solids 显示文摘 | Moser-Engeler R Kuhni M Bernhard C | 1999 | Water Research1999,33,16: | 1 |
| 12 | Comparing support vector machines with Gaussian kernels to radial basis function classifiers 显示文摘 | BERNHARD S SUNG K K BURGES C | 1997 | IEEE Transactions on Signal Proces- sing1997,45,11: | 1 |
| 13 | MRA of the lower extremities in patients with pulmonary embolism using a blood pool contrast agent:initial experience显示文摘 | Hoffmann U Loewe C Bernhard C | 2002 | Magn Reson Imaging2002,15,: | 1 |
| 14 | Factors affecting baseline quality of life in two international adjuvant breast cancer trials显示文摘 | Bernhard J Hurny C Coates AS | 1998 | Br J Cancer1998,78,5: | 1 |
| 15 | Estimating the support of a high-dimensional distribution显示文摘 | Scholkopf Bernhard Platt John C Shawe-Taylor John | 2001 | Neural Computation2001,13,7: | 1 |
| 16 | The sub- classification of papillary renal cell carcinoma does not affect oncological outcomes after nephron sparing surgery显示文摘 | BIGOT P BERNHARD J C GILL I | 2015 | Eur Urol Suppl2015,14,2: | 1 |
| 17 | Chro- mium supplementation alters both glucose and lipid metabolism in feedlot cattle during the receiving period 显示文摘 | BERNHARD B C BURDICK N C RATHMANN R J | 2012 | J Anita Sci2012,90,13: | 1 |
| 18 | Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum显示文摘 | Haubold Bernhard Williams Jeff T | 2000 | Molecular Biology and Evolution2000,17,10: | 1 |
| 19 | Development of a pilot scale process for the anti-Alzheimer drug (-)-galanthamine using large-scale phenolic oxidative coupling and crystallisation-induced chiral conversion 显示文摘 | Bernhard K Laszlo C Johannes F Ulrich J | 1999 | Organic Process Research & Development1999,3,6: | 1 |
| 20 | Early feeding of fortified breast milk and in-hospital-growth in very pre mature infants: a retrospective cohort analysis显示文摘 | Maas C Wiechers C Bernhard W | 2013 | BMC Pediatr2013,13,1: | 1 |