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| 1 | A striking local esophageal cytokine expression profile in eosinophilic esophagitis显示文摘 | Carine Blanchard Emily M. Stucke Beatriz Rodriguez-Jimenez Karen Burwinkel Margaret H. Collins Annette Ahrens Eileen S. Alexander Bridget K. Buckmeier Butz Sean C. Jameson Ajay Kaul James P. Franciosi Jonathan P. Kushner Philip E. Putnam J. Pablo Abonia M | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 3 |
| 2 | Juvenile ferric iron prevents microbiota dysbiosis and colitis in adult rodents显示文摘AIM: To assess whether juvenile chronic ferric iron ingestion limit colitis and dysbiosis at adulthood in rats and mice. METHODS: Two sets of experiments were designed. In the first set, recently weaned mice were either orally administered ferrous (Fe2+) iron salt or ferric (Fe3+) microencapsulated iron for 6 wk. The last week of experiments trinitrobenzene sulfonic acid (TNBS) colitis was induced. In the second set, juvenile rats received the microencapsulated ferric iron for 6 wk and were also submitted to TNBS colitis during the last week of experiments. In both sets of experiments, animals were sacrificed 7 d after TNBS instillation. Severity of the inflammation was assessed by scoring macroscopic lesions and quantifying colonic myeloperoxidase (MPO) activity. Alteration of the microflora profile was estimated usingquantitative polymerase chain reaction (qPCR) by measuring the evolution of total caecal microflora, Bacteroidetes, Firmicutes and enterobacteria. RESULTS: Neither ferrous nor ferric iron daily exposures at the juvenile period result in any effect in control animals at adulthood although ferrous iron repeated administration in infancy limited weight gain. Ferrous iron was unable to limit the experimental colitis (1.71 ± 0.27 MPO U/mg proteinvs 2.47 ± 0.22 MPO U/mg protein in colitic mice). In contrast, ferric iron significantly prevented the increase of MPO activity (1.64 ± 0.14 MPO U/mg protein) in TNBS-induced colitis. Moreover, this positive effect was observed at both the doses of ferric iron used (75 and 150 mg/kg per day po - 6 wk). In the study we also compared, in both rats and mice, the consequences of chronic repeated low level exposure to ferric iron (75 mg/kg per day po - 6 wk) on TNBS-induced colitis and its related dysbiosis. We confirmed that ferric iron limited the TNBS-induced increase of MPO activity in both the rodent species. Furthermore, we assessed the ferric iron incidence on TNBS-induced intestinal microbiota dysbiosis. At first, we needed to optimize the isolation and quantify DNA copy numbers using standard curves to perform by qPCR this interspecies comparison. Using this approach, we determined that total microflora was similar in control rats and mice and was mainly composed of Firmicutes and Bacteroidetes at a ratio of 10/1. Ferric juvenile administration did not modify the microflora profile in control animals. Total microflora numbers remained unchanged whichever experimental conditions studied. Following TNBS-induced colitis, the Firmicutes/Bacteroidetes ratio was altered resulting in a decrease of the Firmicutes numbers and an increase of the Bacteroidetes numbers typical of a gut inflammatory reaction. In parallel, the subdominant population, the enterobacteria was also increased. However, ferric iron supplementation for the juvenile period prevented the increase of Bacteroidetes and of enterobacteria numbers consecutive to the colitis in both the studied species at adulthood.CONCLUSION: Rats and mice juvenile chronic ferric iron ingestion prevents colitis and dysbiosis at adulthood as assessed by the first interspecies comparison. | Chourouk Ettreiki Pascale Gadonna-Widehem Irène Mangin Mose Coёffier Carine Delayre-Orthez Pauline M Anton | 2012 | World Journal of Gastroenterology2012，18，21： | 3 |
| 3 | A population-based study of 135 lymphomas after solid organ transplantation: The role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival显示文摘 | Amelie Kinch Eva Baecklund Carin Backlin Tor Ekman Daniel Molin Gunnar Tufveson Pia Fernberg Christer Sundstr? m Karlis Pauksens Gunilla Enblad | 2014 | Acta Oncologica2014，，5： | 2 |
| 4 | Ultra-wideband synthetic-aperture radar for mine-field detection显示文摘 | Geng N McClure M | 1999 | IEEE Antennas and Propagation Magazine1999，41，1： | 1 |
| 5 | Catalytic tar decomposition of biomass pyrolysis gas with a combination of dolomite and silica显示文摘 | CARIN M CHRISTINA H | 2002 | Biomass and Bioenergy2002，，23： | 1 |
| 6 | Endothelial cell responses to hypoxia:initiation of a cascade of cellular interactions显示文摘 | Carine M Thierry A Jose R | 2000 | Biochimica et Biophysica Acta2000，1497，4： | 1 |
| 7 | Uhra-wideband,shortpulse ground-penetrating radar:Simulation and measurement显示文摘 | VITEBSKIY S CARIN L RESSLER M A | 1997 | IEEE Trans Geosei Remote Sens1997，35，3： | 1 |
| 8 | Ultra-wide-band synthetic-aperture radar for mine-field detection显示文摘 | Carin L Geng N MeClure M | 1999 | IEEE Antennas and Propagation Magazine1999，41，1： | 1 |
| 9 | HL-DRBI*03 is a susceptibility gene in patients with Graves' di~a~ with and without ophthal-mopathy 显示文摘 | Yarman S Oguz F Carin M | 2007 | Int J lnununogenet2007，34，： | 1 |
| 10 | Patient safety in nursing education: Contexts, tensions and feeling safe to learn 显示文摘 | Alison S Carin M Pam S | 2014 | Nurse Edu Today2014，34，： | 1 |
| 11 | TIG and A-TIG welding experimental investigations and comparison to simulation: Part 1 : Identification of Marangoni effect 显示文摘 | Berthier A Paillard P Carin M | 2012 | Science and Technology of Welding and Joining2012，，8： | 1 |
| 12 | The osmotic migration of cells in a solute gradient显示文摘 | Jaeger M Carin M Medale M Tryggvason G | 1999 | Biophys J1999，77，： | 1 |
| 13 | Enzymatic acidolysis of sunflower oil with a palmitie-stearic aeid mixture显示文摘 | CARIN M E CRAPISTE G H | 2008 | Journal of Food Engineering2008，84，2： | 1 |
| 14 | The osmotic migration of cells in a solute gradient 显示文摘 | Jaeger M Carin M Medale M | 1999 | Biophys J1999，77，3： | 1 |
| 15 | Distribution of larval krill and zooplankton in association with hydrography in Marguerite Bay,Antarctic Peninsula,in Austral fall and winter 2001 described using the Video Plankton Recorder显示文摘 | Carin J A Cabell S Davis S M | 2008 | Deep-Sea ResearchⅡ2008，55，： | 1 |
| 16 | 3D heat transfer model of hybrid laser Nd: Yag-MAG welding of $355 steel and experimental validation显示文摘 | Le Guen E Carin M Fabbro R | 2011 | International Journal of Heat and Mass Transfer2011，54，7： | 1 |
| 17 | identification of binding media in works of art by gas chromatography massspectrometry显示文摘 | Carine M Marie-Christine P Claude P | 2004 | Journal of Ou]tural Her)rage2004，，5： | 1 |
| 18 | Fast-track hysterectomy: a randomised, controlled study显示文摘 | Ulla-Beth Kroon Michael R?dstr?m Carin Hjelthe Christer Dahlin Lars Kroon | 2010 | European Journal of Obstetrics and Gynecology2010，，2： | 1 |
| 19 | Distribution of larval krill and zooplankton in association with hydrography in Marguerite Bay, Antarctic Peninsula, in austral fall and winter 2001 described using the Video Plankton Recorder 显示文摘 | CARIN J A CABELL S DAVIS S M | 2008 | Deep-Sea Research II2008，，55： | 1 |
| 20 | Kinetic analysis and modelling of combined high pressure temperature inactivation of the yeast Zygosaccharomyces bailii 显示文摘 | Kristien M F A Reyns Carine C F Soontjens Kris Cornelis | 2000 | International Journal of Food Microbiology2000，56，： | 1 |
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