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| 1 | Cirrhotic patients and older people显示文摘The global population is aging,and so the number of older cirrhotic patients is increasing.Older patients are characterised by a risk of frailty and comorbidities,and age is a risk factor for mortality in cirrhotic patients.The incidence of nonalcoholic fatty liver disease as an aetiology of cirrhosis is increasing,while that of chronic viral hepatitis is decreasing.Also,cirrhosis is frequently idiopathic.The management of portal hypertension in older cirrhotic patients is similar to that in younger patients,despite the greater risk of treatment-related adverse events of the former.The prevalence of hepatocellular carcinoma increases with age,but its treatment is unaffected.Liver transplantation is generally recommended for patients<70 years of age.Despite the increasing prevalence of cirrhosis in older people,little data are available and few recommendations have been proposed.This review suggests that comorbidities have a considerable impact on older cirrhotic patients. | Paul Carrier Marilyne Debette-Gratien Jérémie Jacques Véronique Loustaud-Ratti | 2019 | World Journal of Hepatology2019，11，9： | 6 |
| 2 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 3 | HCV ‐associated B ‐cell non‐ H odgkin lymphomas and new direct antiviral agents显示文摘 | Paul Carrier Arnaud Jaccard Jérémie Jacques Tessa Tabouret Marilyne Debette‐Gratien Julie Abraham Laura Mesturoux Pierre Marquet Sophie Alain Denis Sautereau Marie Essig Véronique Loustaud‐Ratti | 2015 | Liver Int2015，，10： | 2 |
| 4 | Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol csterases显示文摘 | Ali Y B Carriere F Verger R | 2005 | J Lipid Res2005，46，5： | 1 |
| 5 | A GTD-based parametric model for radar scattering显示文摘 | L C Potter Da-Ming Chiang R Carriere M J Gerry | 1995 | IEEE Antennas and Propagation1995，43，10： | 1 |
| 6 | Reproduction of functional smooth muscle tissue and partial bladder replacement显示文摘 | Dahiya R Carrier S | 1997 | Br J Urol1997，79，4： | 1 |
| 7 | The Functional Autonomy Measurement System (SMAF): description and validation of an instrument for the measurement of handicaps显示文摘 | Hebert R Carrier R Bilodeau A | 1988 | Age and ageing1988，17，： | 1 |
| 8 | Nutrition and hormonal requirements of Ginkgo biloba embryo-derived callus and suspension cell culture 显示文摘 | CARRIER D J CONSENTINO G NEUFELD R | 1990 | Plant Cell Reports1990，8，11： | 1 |
| 9 | Nutritional and hormonal requirements of Ginkgo biloba embryo-derived callus and suspension cell culture显示文摘 | Carrier D J Cosentino G Neufeld R | 1990 | Plant Cell Report1990，8，： | 1 |
| 10 | A GTD-based parametric model for radar scattering显示文摘 | POTTER L C CHIANG D M CARRIERE R | 1995 | IEEE Transactions on Antennas and Propagation1995，43，10： | 1 |
| 11 | Effects of material and structure on shielding of electronic devices显示文摘 | Mangeret R Carriere T Beaucour J | 1996 | IEEE Transactions on N uclear Science1996，43，6： | 1 |
| 12 | Double heterozygosity for mutations in the beta-myosin heavy chain and in the cardiac myosin binding protein C genes in a family with hypertrophic cardiomyopathy显示文摘 | Isnard R Carrier L | 1999 | J Med Genet1999，36，7： | 1 |
| 13 | Nutritional and hormonal requirements of Ginkgo biloba embryo-derived callus and suspension cell culture显示文摘 | Carrier D J Consentino G Neufeld R | 1990 | Plant Cell Rep1990，8，11： | 1 |
| 14 | Nutritional and hormonal requirements of Ginkgo biloba embryo-derived callus and suspension cell culture显示文摘 | Carrier D J Cosentino G Neufeld R | 1990 | Plant Cell Reports1990，8，： | 1 |
| 15 | Preparation and prop erties of thermoplastic starch-polyester laminate sheets by coextrusion显示文摘 | Wang L Shogren R L Carriere C | 2000 | Polymer Engineering & Science2000，40，2： | 1 |
| 16 | TP53INPIs and homeodomain-interaeting protein kinase-2(HIPK2) are partners in regulating p53 activity 显示文摘 | Tomasini R Samir AA Carrier A | 2003 | J Biol Chem2003，278，37： | 1 |
| 17 | Health:Endothelin-1 synthesis reduced by red wine显示文摘 | CORDER R DOUTHWAITE J A LEES D M KHAN N Q SANTOS A WOOD E CARRIER M | 2001 | Nature2001，414，： | 1 |
| 18 | Flushing of a Pb(Ⅱ)contaminated soil using HCI, EDTA, and CaCl2显示文摘 | Reed B E Carriere P C Moore R | 1996 | Journal of Environmental Engineering1996，122，1： | 1 |
| 19 | Reproduction of functional smooth tissue and partial bladder replacement 显示文摘 | Probst M Dahiya R Carriers | 1997 | Br J Urol1997，79，： | 1 |
| 20 | Flushing of a Pb (Ⅱ) contaminated soil using HCl,EDTA,and CaCl2显示文摘 | Reed B E Carriere P C Moore R | 1996 | Journal of Environmental Engineering1996，122，1： | 1 |
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