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| 1 | Statin use and cognitive function in middle-aged adults with type 1 diabetes显示文摘AIM To test associations between statin use and cognitive impairment in adults with childhood-onset type 1 diabetes(T1D).METHODS In 2010-13, n = 108 middle-aged participants from ongoing observational Pittsburgh Epidemiology of Diabetes Complications Study underwent neurocognitive assessment(mean age and T1 D duration of 49 and 41 years, respectively). All were diagnosed with childhoodonset(i.e., prior to age 18) T1 D between 1950 and 1980 and were seen within one year of diagnosis at Children's Hospital of Pittsburgh. Self-reported statin use(yes/no and if yes, name of statin) was collected biennially from parent study baseline(1986-1988) to time of neurocognitive testing. Logistic regression models tested associations between statin use groups and cognitive impairment(defined as having two or more cognitive test scores 1.5SD or worse than published norms) while linear regression models tested associations between statin use groups and cognitive domain z-scores(domains: Verbal IQ, memory, executive function, psychomotor speed, and visuo-construction). All models controlled for education and age. To address confounding by indication, models were repeated using a propensity score for statin use.RESULTS Of the 108 participants, 51 reported never using statins. Median duration of statin use among the 57 ever users was 6 years. These 57 ever statin users were split to create two groups(≤ or > median years of statin use): 1-6 years(n = 25), and 7-12 years(n = 32). Compared with never users, using statins 1-6 years tripled the odds of cognitive impairment(OR = 3.16; 95%CI: 0.93-10.72; P = 0.06) and using statins 7-12 years almost quintupled the odds of cognitive impairment(OR = 4.84; 95%CI: 1.63-14.44; P = 0.005). Compared with never users, using statins 1-6 or 7-12 years was related to worse performance in the memory domain(β =-0.52; P = 0.003, and-0.39; P = 0.014, respectively). Adjusting for coronary artery disease, low density lipoprotein cholesterol, and Apo E4 status did not substantially alter results, and none of these covariates were significantly related to cognitive outcomes(all P > 0.05). Propensity score analyses support that associations between poor cognitive outcomes and statin use were not due merely to confounding by indication. CONCLUSION Statin use was associated with cognitive impairment, particularly affecting memory, in these middle-aged adults with childhood-onset T1 D, whom at this age, should not yet manifest age-related memory deficits. | Karen A Nunley Trevor J Orchard Christopher M Ryan Rachel Miller Tina Costacou Caterina Rosano | 2017 | World Journal of Diabetes2017，8，6： | 2 |
| 2 | THE VANILLOID RECEPTOR: A Molecular Gateway to the Pain Pathway显示文摘 | Michael J Caterina David Julius | 2001 | Annual Review of Neuroscience2001，，： | 2 |
| 3 | TRPV1 shows dynamic ionic selectivity during agonist stimulation 显示文摘 | Man-Kyo Chung Ali D Giiler Michael J Caterina | 2008 | Nature Neurosci2008，11，： | 1 |
| 4 | The capsaicinreceptor:Aheat-acfivateclion channel in the pain pathway显示文摘 | CATERINA M J SCHUMACHER M A TOMINAGA M | 1997 | Nature1997，389，： | 1 |
| 5 | Development of a multiplex PCR for detection of avian adeno virus , avian reovirus , infectious bursal , disease virus and chicken anemia virus 显示文摘 | Caterina K M Frasea S J R Girshick | 2004 | Molecular Cellular Probes2004，18，： | 1 |
| 6 | MT1 -MMP- deficient mice develop dwarfism, osteopenia, arthritis, and con- nective tissue disease due to inadequate collagen turn over 显示文摘 | HOLMBECK K BIANCO P CATERINA J | 1999 | Cell1999，99，1： | 1 |
| 7 | Impaired nociception and pain sensation in mice lacking the capsaicin receptor显示文摘 | Caterina M J Leffler A Malmberg AB | | 0，，03： | 1 |
| 8 | Transient receptor potential ion channels as partici- pants in thermosensation and thermoregulation 显示文摘 | Caterina M J | 2007 | Am J Physiol Regul Integr Comp Physiol2007，292，： | 1 |
| 9 | The capsaicin receptor: a heat-activated ion channel in the pain pathway 显示文摘 | Caterina M J Schumacher MA Tominaga M | 1997 | Nature1997，389，6653： | 1 |
| 10 | Shear stress regulates aquaporin-5 and airway epithelial barrier function显示文摘 | SIDHAYE V K SCHWEITZER K S CATERINA M J | | 0，，： | 1 |
| 11 | The capsaicin receptor: a heat-activated ion channel in the pain pathway显示文摘 | Caterina M J Schumacher M A Tominaga M | 1997 | Nature1997，398，6653： | 1 |
| 12 | 2012 focused update of the ESC Guidelines for the management of atrial fibrilla- tion: an update of the 2010 ESC Guidelines for the manage- ment of atrial fibrillation--developed with the special contri- bution of the European Heart Rhythm Association 显示文摘 | Camm A J Lip G Y De Caterina R etal | 2012 | Europace2012，14，10： | 1 |
| 13 | The capsaicin receptor: a heat-activated ion channel in the pain pathway 显示文摘 | Caterina M J Schumacher MA Tominaga M | 1997 | Nature1997，389，： | 1 |
| 14 | The capsaicin receptor:a heat-activated ion channel in the pain pathway 显示文摘 | Caterina M J Schumacher M A Tominaga M | 1997 | Nature1997，398，： | 1 |
| 15 | Nitrates and other nitric oxide donors in cardiology: Current positioning and perspectives显示文摘 | Iaehini Bellisarii F Radico F Muscente F Horowitz J De Caterina R | 2012 | Cardiovasc Drugs Ther2012，26，： | 1 |
| 16 | Impaired nociception and pain sensation in mice lacking the capsaicin reeeptor显示文摘 | Caterina M J Leffler A Malmberg A B | 2000 | Science2000，288，5464： | 1 |
| 17 | The capsaicin receptor: a heat-activated ion channel in the pain pathway显示文摘 | Caterina M J Schumacher M A Tominaga M Rosen T A Levine J D Julius D | 1997 | Nature1997，389，： | 1 |
| 18 | The capsaiein receptor: a heat-activated ion channel in the pain pathway显示文摘 | Caterina M J Schumacher M A Tominaga M Rosen T A Levine J D Julius D | 1997 | Nature1997，389，： | 1 |
| 19 | Multiple element in human β - globin locus eontrol region 5'HS 2 are involved in enhaneer aetivity and position-- independent transgene expression 显示文摘 | John J Caterina Dominie J Ciavatta | 1994 | Nueleic Acids Research1994，22，6： | 1 |
| 20 | The capsaicin receptor:a heat-activated ion channel in the pain pathway显示文摘 | Caterina M J Schumacher M A Tominaga M Rosen T A Levine J D Julius D | | 0，，： | 1 |
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