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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries. | Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho | 2019 | World Journal of Gastroenterology2019，25，26： | 3 |
| 3 | Adenomatous polyposis coli - mediated control of β - catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors 显示文摘 | Razvan LM Marcel K Cathy A J | 2009 | BMC Der Biol2009，9，： | 1 |
| 4 | Evaluation of apparatus designed for the collection of sidestream tobacco smoke显示文摘 | Christopher J Proctor Cathy Martin John L Beven | 1988 | The Analyst1988，113，： | 1 |
| 5 | Calcitonin and insulin in isobutylcyanoacrylate nanocap sules: protection against proteases and effect on intestinal absorption in rats显示文摘 | PHILIP J L CATHY S T | 1994 | J Pharm Pharmacol1994，46，： | 1 |
| 6 | Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glio- blastoma and overrides resistance to temozolomide 显示文摘 | TRISCOTT J CATHY L KAIJI H | 2012 | Oncotar- get2012，3，10： | 1 |
| 7 | Comparing risks of death and recurrent vascular events between lacunar and non-acunar infarction 显示文摘 | Caroline J Cathie S | 2005 | Brain2005，128，11： | 1 |
| 8 | Lane A GIS-based hillslope erosion and sediment delivery model and its application in the Cerro Grande burn area显示文摘 | Cathy J Wilson J William | 2001 | Hydrological Processes2001，15，15： | 1 |
| 9 | Extractive fermentation of aroma with supercritical C02 显示文摘 | Cathy E Fabre Condoret J S Marty A | 1999 | Biotechnology and Bioengineering1999，64，4： | 1 |
| 10 | Harpin, elicitor of the HR produced by the plant pathogen Erwinia amylovora 显示文摘 | WEI Z M RON J L CATHY H Z | 1992 | Science1992，257，： | 1 |
| 11 | Prospective and retrospective studies of recovery in aphasia changes in cerebral flow and language functions显示文摘 | MIMURA M KATO M CATHY J | 1998 | Brain1998，121，： | 1 |
| 12 | The latest on functional imaging studies of aphasic stroke显示文摘 | Cathy J Crinion J | 2005 | Current Opinion Neurology2005，18，4： | 1 |
| 13 | Spatial competition between grasses-rates of mutual invasion between four species and the interaction with grazing显示文摘 | Silvertown J Cathy E M Pam Dale M | 1994 | Journal of Ecology1994，82，： | 1 |
| 14 | Given capsule endoscopy in celiac disease显示文摘 | Rima Petroniene Elena Dubcenco Jeffrey P Baker Ralph E Warren Cathy J Streutker Geoffrey W Gardiner Khursheed N Jeejeebhoy | 2004 | Gastrointestinal Endoscopy Clinics of North Americ2004，，1： | 1 |
| 15 | Testosterone influences renal electrolyte excretion in SHR/Y and wky males显示文摘 | Jonathan T Cathy J Cail D | 2008 | BMC Physiology2008，8，： | 1 |
| 16 | Evaluation of membranes used for electroblotting of proteins for direct automated microsequencing 显示文摘 | Cathy S B Michael J D Magdi H Y | 1991 | Electrophoresis1991，12，： | 1 |
| 17 | Effectiveness of treatments for depression in older people 显示文摘 | Cathy J Frazer Helen Christensen and Kathleen M Griffiths | 2005 | MJA2005，，182： | 1 |
| 18 | A multicenter comparison of intraaortic balloon pump utilization in isolated coronary artery bypass graft surgery显示文摘 | Roger J.F Baskett Gerald T O’Connor Gregory M Hirsch William A Ghali Kathy Sabadosa Jeremy R Morton Cathy S Ross Felix Hernandez William C Nugent Stephen J Lahey Donato A Sisto Lawrence J Dacey John D Klemperer Robert E Helm Andrew Maitland | 2003 | The Annals of Thoracic Surgery2003，，6： | 1 |
| 19 | Hoyer, Planned Versus Impulse Purchase Behavior显示文摘 | Cobb Cathy J Wayne D | 1956 | Journal of Retailing1956，62，： | 1 |
| 20 | A modified data normalization method for GC-MS-based metabolomics to minimize batch variation显示文摘 | Mingjie Chen R Shyama Prasad Rao Yiming Zhang Cathy Xiaoyan Zhong Jay J Thelen | 2014 | SpringerPlus2014，，1： | 1 |
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