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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma: The need for patient-centered research显示文摘Pancreatic ductal adenocarcinoma is an aggressive cancer with high recurrence rates following surgical resection.While adjuvant chemotherapy improves survival,a significant proportion of patients are unable to initiate or complete all intended therapy following pancreatectomy due to postoperative complications or poor performance status.The administration of chemotherapy prior to surgical resection is an alternative strategy that ensures its early and near universal delivery as well as improves margin-negative resection rates and potentially improves long-term survival outcomes.Neoadjuvant therapy is increasingly being recommended to patients with pancreatic ductal adenocarcinoma,however,patient-centered research on its use is lacking.In this review,we highlight opportunities to focus research efforts in the domains of patient preferences,patient-reported outcomes,patient experience,and survivorship.Novel research in these areas may identify relevant barriers and facilitators to the use of neoadjuvant therapy thereby increasing its utilization,improve shareddecision making for patients and providers,and optimize the experience of those undergoing neoadjuvant therapy. | Jordan M Cloyd Allan Tsung John Hays Celia E Wills John FP Bridges | 2020 | World Journal of Gastroenterology2020，26，4： | 2 |
| 3 | A functional relationship between capillary pressure,saturation,and interfacial areas as revealed by a pore-scale network model显示文摘 | Reeves P C Celia M A | 1996 | Water Resources Research1996，32，8： | 1 |
| 4 | Opportunities for low-cost CO2storage demonstration projects in China显示文摘 | Meng K C Williams R H Celia M A | 2007 | Energy Policy2007，35，4： | 1 |
| 5 | A functional relationship between capillary pressure, saturation, and interfacial area as revealed by a pore-scale network model显示文摘 | Reeves P C Celia M A | 1996 | Water Resources Research1996，32，8： | 1 |
| 6 | Non Sedgkm lymphoma of the ureter; a rare disease 显示文摘 | Celia A De Stefani S Bruschi M | 2004 | Arch Ital Urol Androl2004，76，4： | 1 |
| 7 | A human natural killer cell subset provides an innate source of IL-22 fur mucosal immunity 显示文摘 | Celia M Fuchs A Vermi W | 2009 | Nature2009，457，7230： | 1 |
| 8 | Dynamic effect in the cap- illary pressure-saturation relationship and its impacts on un- saturated flow显示文摘 | Hassanizadeh S Celia M Dahle H | 2002 | Vadose Zone Journal2002，，1： | 1 |
| 9 | Large scale nat- ural gradient tracer test in sand and gravel Cape Cod, Massachusetts 3: hydraulic conductivity variability and calculated macrodispersivities显示文摘 | HESS K M WOLF S H CELIA M A | 1992 | Water Resources Re- search1992，28，8： | 1 |
| 10 | Radiation therapy fol- lowing surgery or localized breast cancer:outcome predic- tion by classical prognostic factors and approximated ge- netic subtypes显示文摘 | Pacelli R Conson M Celia L | 2013 | J Radiat Res2013，54，2： | 1 |
| 11 | Benign breast disease,recent alcohol consumption,and risk of breast cancer:a nested case-control study显示文摘 | Rulla M Tamimi Celia Byrne Heather J Baer | 2005 | Breast Cancer Res2005，7，4： | 1 |
| 12 | A general mass-conservative numerical solution for the unsaturated flow equation显示文摘 | Celia M A Bouloutas E T Zarba R L | 1990 | Water Resour Res1990，26，： | 1 |
| 13 | Safe storage of CO2 in deep saline aquifers 显示文摘 | Bruant R G Guswa A J Celia M A | 2002 | Environmental Science & Technology2002，36，11： | 1 |
| 14 | Impaired flexible decision-making in Major Depressive Disorder 显示文摘 | Celia M Dymond S Cooper A | 2010 | J Affect Disord2010，124，12： | 1 |
| 15 | A general mass-conservative numerical solution for the unsaturated flow equation显示文摘 | Celia M A Bouloutas E T Zarba R L | 1990 | Water Resource1990，，26： | 1 |
| 16 | Modeling support of functional relationships between capillary pressure, saturation, interfacial area and common lines 显示文摘 | Held R J Celia M A | 2001 | Advances in Water Resources2001，24，34： | 1 |
| 17 | NK3-specfic natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80 显示文摘 | Celia M Longo A Ferrara GB | 1994 | J Exp Med1994，150，4： | 1 |
| 18 | Prediction of relative permeabilities for unconsolidated soil using pore - scale network models显示文摘 | Rajarama H Ferrand L A Celia M A | 1997 | Water Resources Research1997，33，： | 1 |
| 19 | AHR drives the de- velopment of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch显示文摘 | Lee J S Celia M McDonald K G | 2011 | Nat Immunol2011，13，2： | 1 |
| 20 | Controlled release of the herbicide norflurazon into water from ethylcellulose formulations 显示文摘 | FATIMA S ALEGRIA C CELIA M etal | 2005 | J Agric Food Chem2005，53，9： | 1 |
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