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| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 4 | Natural history of intraductal papillary mucinous neoplasia:How much do we really know?显示文摘Information on the natural history of intraductal papillary mucinous neoplasia(IPMN) is currently inadequate due to a lack of carefully orchestrated long-term followup on a large cohort of patients with asymptomatic disease.Based on the available data,one can draw the conclusions that main duct IPMN is commonly associated with malignancy and an aggressive operative stance should be taken with resection being offered to most patients who are suitable operative candidates.In contrast,the majority of branch type IPMN with a diameter of less than 3 cm can be safely followed with routine surveillance imaging provided they lack the high-risk covariates of age,symptomatology,nodularity or wall thickness. | Chad G Ball Thomas J Howard | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 2 |
| 5 | 显示文摘 | Trewyn Brian G Whitman Chad M Lin Victor S Y | 2004 | Nanoletters2004，11，4： | 1 |
| 6 | Does trade openness affect the speed of output convergence? some empirical evidence 显示文摘 | David G Chad S | 2006 | Empirical Economics2006，31，： | 1 |
| 7 | Effects of specific monoclonal antibodies to dense granular proteins on the inva sion of Toxoplasma gondii in vitro and in vivo 显示文摘 | CHAD Y SONG I K LEE G S | 2001 | Korean J Parasitol2001，39，3： | 1 |
| 8 | Prophylactic antibiotics in clean forefoot surgery, are they necessary? 显示文摘 | CHAD D RICHARD G R WALTER J et aJ | 2002 | Chapter2002，19，4： | 1 |
| 9 | The cumulant theory of cyclostationary time-series,part Ⅱ: development and applications显示文摘 | CHAD M S WILLIAM A G | 1994 | IEEE Trans Signal Processing1994，42，12： | 1 |
| 10 | Complications related to deep venous thrombosis prophyla-xis in trauma:a systematic review of the literature显示文摘 | Indraneel Datta Chad G Ball | 2010 | Journal of Trauma Management & Outcomes2010，4，： | 1 |
| 11 | Canine adenovirus vectors for lung-directed gene transfer:Efficacy,immune response,and duration of transgene expression using helper-dependent vectors显示文摘 | ANNE K CEEL R CHAD G | 2006 | J Virol2006，80，： | 1 |
| 12 | Blobworld:Image segmentation using expectation-maximization and its application to image querying显示文摘 | CHAD C SERGE B HAYIT G | 2002 | IEEE Trans on Pattern Analysis and Machine Intelligence2002，24，8： | 1 |
| 13 | Complications related to deep venous thrombosis prophylaxis in trauma:a systematic review of the Literature显示文摘 | Indraneel Datta Chad G Ball | 2010 | Journal of Trauma Management & Outcomes2010，4，： | 1 |
| 14 | Molecular ecological analysis of the gastrointestinal microbiota显示文摘 | Erwin G Zoetendal Chad T Collier Satoshi Koike | 2004 | A Review J Nutr2004，134，： | 1 |
| 15 | Prophylac- tic antibiotics in clean forefoot surgery are they neces- sary?显示文摘 | CHAD D RICHARD G R WALTER J | 2002 | Chapter2002，19，4： | 1 |
| 16 | Morphological con- trol of room temperature ionic liquid templated mesoporons silica nanoparticals for controlled release of antibacterial agents显示文摘 | Brian G T Chad M W Victor S-Y L | 2004 | Nano Lett2004，4，11： | 1 |
| 17 | Targeted disruption of the matrix mtalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling显示文摘 | Zorina S Chad J Denis G | 2002 | Cir- culation Research2002，91，9： | 1 |
| 18 | The role of epithelial-mesenchymal transition programming in invasion and metastasis:a clinical perspective显示文摘 | CHAD J C DON L G JONATHAN M K | 2013 | Cancer Management and Research2013，5，7： | 1 |
| 19 | A Randomized,Controlled Trial of the Effectiveness of Cognitive-Behavioral Therapy and Sertraline versus a Waitlist Control Group for Anxiety Disorders in Older Adults显示文摘 | Josien Schuurmans Hannie Comijs Paul M G Emmelkamp Chad M Gundy | 2006 | Am J Geriatric Psychiatry2006，14，： | 1 |
| 20 | Blobwodd: Image Segmentation Using Expectation-Maximization and Its Application to Image Querying显示文摘 | Chad C Serge B Hayit G | 2002 | IEEE Transactions on Pattern Analysis and Ma- chine Intelligence2002，24，： | 1 |
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