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| 1 | CAPS/dCAPS Designer: a web-based high-throughput dCAPS marker design tool显示文摘Dear Editor,An increasing number of single-nucleotide polymorphisms(SNP)have been identified and extensively used in genetics studies with advances in next-generation sequencing(NGS)and SNP arrays.However,due to frequent calling errors,the accuracy of SNPs of interest must usually be validated.In recent years,the single-nucleotide polymorphism genotyping by fluorescent competitive allele-specific polymerase chain reaction(Ni PTag,the commercial technology named KASP),a relatively new and powerful SNP | Lei Li Jiajun Liu Xiang Xue Changcheng Li Zefeng Yang Tao Li | 2018 | Science China(Life Sciences)2018，61，8： | 7 |
| 2 | Down-regulation of CEACAM1 in breast cancer显示文摘(CEACAM1 ) Carcinoembryonic 抗原相关的粘附分子 1 是一种类型属于 CEA 家庭的 1 transmembrane glycoprotein,它当在身体液体的也可溶的形式或房间上的膜界限形式出现,被发现了存在。异常 CEACAM1 表示与肿瘤前进被联系并且在许多人的恶意被发现了。增加的兴趣在乳癌被奉献给 CEACAM1 的表示,但是大多数这些调查结果是矛盾的。这研究的目的是详细地在乳癌调查 CEACAM1 表示。用染色的 immunohistochemical,我们发现那 CEACAM1 表情与 noncancerous 胸纸巾相比在乳癌纸巾被减少或输。另外,可溶的 CEACAM1 在乳癌房间线的文化媒介铺平是比在一个 nontumorigenic 乳房的那些显著地低的上皮的房间线。Immunofluorescence 分析一致地证明乳癌房间线有膜界限 CEACAM1 的相对低的表示。而且, CEACAM1 mRNA 和蛋白质表示层次在分别地用即时反向的 transcriptase 聚合酶链反应和西方的污点分析测量了的乳癌房间线是下面调整的。一起拿,我们的结果在乳癌表明 CEACAM1 的一条系统的下面规定并且建议恢复 CEACAM1 表示的策略可能对乳癌的治疗有用。 | Changcheng Yang Pingqing He Yiwen Liu Yiqing He Cuixia Yang Yan Du Muqing Zhou Wenjuan Wang Guoliang Zhang Man Wu Feng Gao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 5 |
| 3 | Stipa steppes in scantily explored regions of the tibetan Plateau:classification,community characteristics and climatic distribution patterns显示文摘Aims As a unique geographical unit of the earth,the tibetan Plateau is extensively covered by various Stipa communities.However,their vegetation features have not been reported systematically till now,especially in some scantily explored regions.In this study,we endeavor to reveal the community types,quantitative charac-teristics and climatic distribution patterns of Stipa steppes in these areas based on primary relevés obtained from fieldwork.Methods We collected a total of 223 plots in 79 study sites in the Changthang Plateau and the Yarlung Zangbo Valley,ranging from 79°E to 91°E.the categories of Stipa formations were identified according to the classification scheme in Vegetation of China and then verified by Nonmetric Multidimensional Scaling.We performed detrended correspondence analysis and detrended canonical correspondence analysis to hunt for the alteration of Stipa communities along the precipitation gradient.Quantitative characteristics including species richness,coverage,biomass as well as importance values(IV)of dominant species were calcu-lated and visualized,respectively.Important Findings Stipa steppes in scantily explored regions of the tibetan Plateau are classified into 11 formations but major formations are rather limited in number.Formation(form.)Stipa purpurea is the most widespread Stipa assemblages not only in scantily explored regions but also across the whole tibetan Plateau.the characteristics of Stipa com-munities,including coverage,species richness,productivity and IV of dominant species,demonstrate the features of typical alpine steppes on the tibetan Plateau.Precipitation proves to be the prime climatic factor controlling the distribution patterns of Stipa assemblages.Form.Stipa subsessiliflora var.basiplumosa and form.Stipa glareosa normally distribute in arid habitats,but rainfall for the former is of greater variance.Form.Stipa roborowskyi and form.Stipa capillacea favor moderately moist environment.Form.Stipa purpurea and form.Stipa roborowskyi can tolerate a fairly broad range of precipitation. | Haiwei Zhao Ke Guo Yao Yang Changcheng Liu Liqing Zhao Xianguo Qiao Dongjie Hou Chenguang Gao | 2018 | Journal of Plant Ecology2018，11，4： | 4 |
| 4 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.4-Guangdong Province,China,May 4,2022显示文摘On April 29,2022,a flight arrived at Baiyun International Airport,Guangzhou City,Guangdong Province,and departed from Amsterdam Schiphol Airport,Netherlands.After the first test of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid at the Baiyun International Airport,all passengers were admitted to a quarantine hotel for a routine 14-day medical observation.On April 30,one of the passengers(a 20-year-old Chinese female)was reported positive for coronavirus disease 2019(COVID-19),and then a nasopharyngeal swab sample was immediately retested on May 1 and reported positive. | Qianfang Guo Changcheng Wu Aiping Deng Jingtao Liang Xiang Zhao Ruhan A Jiajun Liu Fangzhu Ouyang Jing Xu Shen Huang Yang Song Lirong Zou Xiaoling Deng Kai Nie Baisheng Li | 2022 | China CDC weekly2022，4，40： | 2 |
| 5 | Effect of drought on pigments, osmotic adjustment and antioxidant enzymes in six woody plant species in karst habitats of southwestern China显示文摘 | Changcheng Liu Yuguo Liu Ke Guo Dayong Fan Guoqing Li Yuanrun Zheng Lifei Yu Rui Yang | 2010 | Environmental and Experimental Botany2010，，2： | 2 |
| 6 | Prognostic tumor microenvironment gene and the relationship with immune infiltration characteristics in metastatic breast cancer显示文摘The aim of this study was to reveal genes associated with breast cancer metastasis,to investigate their intrinsic relationship with immune cell infiltration in the tumor microenvironment,and to screen for prognostic biomarkers.Gene expression data of breast cancer patients and their metastases were downloaded from the GEO,TCGA database.R language package was used to screen for differentially expressed genes,enrichment analysis of genes,PPI network construction,and also to elucidate key genes for diagnostic and prognostic survival.Spearman’s r correlation was used to analyze the correlation between key genes and infiltrating immune cells.We screened 25 hub genes,FN1,CLEC5A,ATP8B4,TLR7,LY86,PTGER3 and other genes were differentially expressed in cancer and paraneoplastic tissues.However,patients with higher expression of CD1C,IL-18 breast cancer had a better prognosis in the 10 years survival period,while patients with high expression of FN1,EIF4EBP1 tumors had a worse prognosis.In addition,TP53 and HIF1 genes are closely related to the signaling pathway of breast cancer metastasis.In this study,gene expression of ATP8B4 and CD1C were correlated with cancer tissue infiltration of CD8^(+)T lymphocytes,while GSE43816,GSE62327 and TCGA databases showed that CD8^(+)T lymphocytes were closely associated with breast cancer progression.Functional enrichment analysis of genes based on expression differences yielded key genes of prognostic value in the breast cancer microenvironment. | LU YANG YUN LIU BOKE ZHANG MENGSI YU FEN HUANG YANG WEN JIANGZHENG ZENG YANDA LU CHANGCHENG YANG | 2022 | BIOCELL2022，46，5： | 1 |
| 7 | Large-Scale Spinning Assembly of Neat, Morphology-Defined, Graphene-Based Hollow Fibers显示文摘 | Zhao Yang Jiang Changcheng Hu Chuangang | 2013 | ACS Nano2013，7，3： | 1 |
| 8 | Applying control theoretic approach to mitigate SIP overload显示文摘 | Yang Hong Huang Changcheng Yan James | 2013 | Telecommunication Systems2013，54，4： | 1 |
| 9 | Large-Scale Spinning Assembly of Neat,Morphology-Defined,Graphene-Based Hollow Fibers显示文摘 | Zhao Yang Jiang Changcheng Hu Chuangang | | 0，，03： | 1 |
| 10 | Highly Compression‐Tolerant Supercapacitor Based on Polypyrrole‐mediated Graphene Foam Electrodes显示文摘 | Yang Zhao Jia Liu Yue Hu Huhu Cheng Chuangang Hu Changcheng Jiang Lan Jiang Anyuan Cao Liangti Qu | 2012 | Adv Mater2012，，4： | 1 |
| 11 | Genomic Surveillance for SARS-CoV-2—China,September 26,2022 to January 29,2023显示文摘Introduction:The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has generated 2,431 variants over the course of its global transmission over the past 3 years.To better evaluate the genomic variation of SARS-CoV-2 before and after the optimization of coronavirus disease 2019(COVID-19)prevention and control strategies,we analyzed the genetic evolution branch composition and genomic variation of SARS-CoV-2 in both domestic and imported cases in China(the data from Hong Kong and Macao Special Administrative Regions and Taiwan,China were not included)from September 26,2022 to January 29,2023.Methods:Analysis of the number of genome sequences,sampling time,dynamic changes of evolutionary branches,origin,and clinical typing of SARS-CoV-2 variants submitted by 31 provincial-level administrative divisions(PLADs)and Xinjiang Production and Construction Corps(XPCC)was conducted to assess the accuracy and timeliness of SARS-CoV-2 variant surveillance.Results:From September 26,2022 to January 29,2023,20,013 valid genome sequences of domestic cases were reported in China,with 72 evolutionary branches.Additionally,1,978 valid genome sequences of imported cases were reported,with 169 evolutionary branches.The prevalence of the Omicron variants of SARS-CoV-2 in both domestic and imported cases was consistent with that of international epidemic variants.Conclusions:This study provides an overview of the prevalence of Omicron variants of SARS-CoV-2 in China.After optimizing COVID-19 prevention and control strategies,no novel Omicron variants of SARSCoV-2 with altered biological characteristics or public health significance have been identified since December 1,2022. | Shiwen Wang Peihua Niu Qiudong Su Xiaozhou He Jing Tang Ji Wang Yenan Feng Cao Chen Xiang Zhao Zhixiao Chen Wenling Wang Zeyuan Yin Yuchao Wu Changcheng Wu Lili Li Aili Cui Yan Zhang Caiyun Long Xiaoyu Yang Zhongxian Zhang Hong Bo Wenbo Xu SARS-CoV-Genome Working Group | 2023 | China CDC weekly2023，5，7： | 1 |
| 12 | Large-Scale Spinning Assembly of Neat, Morphology-Defined, Graphene-Based Hollow Fibers 显示文摘 | Yang Zhao Changcheng Jiang Chuangang Hu | 2013 | ACS Nano2013，7，3： | 1 |
| 13 | Photosynthesis adaption in Korean pine to gap size and position within Populus davidiana forests in Xiaoxing’anling, China显示文摘Forest gaps restrict the restoration of temperate secondary forest to broad-leaved Korean pine forest in zonal climax vegetation by affecting the growth of Korean pine(Pinus koraiensis).However,the photo synthetic adaptability of Korean pine to gap size and position within the gap is unclear.In order to explore the adaptability of young Korean pine(35 years) to different gap sizes in Xiaoxing’anling,photo synthetic capacity and microenvironmental factors(leaf temperature,light transmittance) of Korean pine needles in three positions in the gap(central,transition,and edge areas) were investigated.Three gaps were identified in the secondary Populus davidiana forest:a large 201 m^(2) gap,a middle 112 m^(2) gap,and a small 50 m^(2) gap;12 m^(2) of the understory was sampled as a control.The results show that:(1) maximum net photosynthetic rate(P_(max)) in needles of Korean pine growing in the large gap was higher than in the small gap,and P_(max) in the centre in the same gap was higher than in the transition and edge areas;(2) light saturation point(LSP) and photosynthetic quantum yield(AQY)of needles in the large gap were higher than in the small gap,while the light compensation point(LCP) and chlorophyll contents of needles were lower in the small gap;and,(3)P_(max) had a significant positive correlation with temperature and light transmittance.It is suggested that the larger the gap in secondary Populus davidiana forests,the greater the change in light intensity and temperatures,the stronger the light adaption of Korean pine needles and the higher the photosynthetic capacity.Therefore,in the recovery of broadleaved/Korean pine forests,suitable gaps should be created and gap microhabitats fully utilized to accelerate the restoration process. | Xuannan Li Yahui Wang Zhihui Yang Ting Liu Changcheng Mu | 2022 | Journal of Forestry Research2022，33，5： | 1 |
| 14 | Modeling and analytic optimization of dynamic comfort for wheelchair robots undergoing random roads显示文摘To make a rapid comfort assessment and a reasonable dynamic parameters choice of wheelchair robots,this paper proposes a dynamic comfort coefficientκand analytically optimizes the cushion damping.Firstly,a traveling vibration model of the occupantwheelchair system for wheelchair robots running on random roads was created.Secondly,the analytic formula of the occupant RMS(root mean square)acceleration was deduced.Moreover,the dynamic coefficientκwas proposed and its influence laws were revealed.Finally,the cushion system optimal damping ratio was calculated based onκ.The results show that theκvalue is only determined by the parameters of the occupant-wheelchair system.The smaller theκvalue is,the better the dynamic comfort is for wheelchair robots running on random roads.By minimizingκ,the occupant-wheelchair system can achieve a statistically optimal dynamic comfort effect. | Leilei Zhao Yuewei Yu Changcheng Zhou Xiaohan Li Fuxing Yang | 2018 | International Journal of Modeling, Simulation, and Scientific Computing2018，9，5： | 0 |
| 15 | Low Temperature Synthesis of Amorphous La0.7Zn0.3MnO3 Films Grown on p+-Si Substrates and Its Resistive Switching Properties显示文摘Amorphous La_(0.7)Zn_(0.3)MnO_3(LZMO) films were deposited on p+-Si substrates by sol-gel method at low temperature of 450 ℃.The Ag/LZMO/p^+-Si device exhibits invertible bipolar resistive switching and the R_(HRS)/R_(LRS) was about 10~4-10~6 at room temperature which can be kept over 10~3 switching cycles.Better endurance characteristics were observed in the Ag/LZMO/p+-Si device,the VSet and the VReset almost remained after 10~3 endurance switching cycles.According to electrical analyses,the conductor mechanism was in low resistor state(LRS) governed by the filament conductor and in the high state(HRS) dominated by the trapscontrolled space-charge-limited current(SCLC) conductor. | 陈齐松 wang hua xu jiwen wei changcheng zhang xiaowen yang ling | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 0 |
| 16 | Detecting SARS-CoV-2 BA.2,BA.4,and BA.5 Variants Utilizing a Robust RT-RPA-CRISPR/Cas12a-Based Method-China,2023显示文摘Introduction:Since 2019,numerous variants of concern for severe acute respiratory syndrome virus 2(SARS-CoV-2)have emerged,leading to significant outbreaks.The development of novel,highly accurate,and rapid detection techniques for these new SARSCoV-2 variants remains a primary focus in the ongoing efforts to control and prevent the coronavirus disease 2019(COVID-19)pandemic.Methods:Reverse transcription-recombinase polymerase amplification combined with the clustered regularly interspaced short palindromic repeatsassociated protein 12a(CRISPR/Cas12a)system was used to validate the detection of the Omicron BA.2,BA.4,and BA.5 variants of SARS-CoV-2.Results:Our results demonstrate that the CRISPR/Cas12a assay is capable of effectively detecting the SARS-CoV-2 BA.2,BA.4,and BA.5 variants with a limit of detection of 10,1,and 10 copies/μL,respectively.Importantly,our assay successfully differentiated the three SARS-CoV-2 Omicron strains from one another.Additionally,we evaluated 46 SARS-CoV-2 positive clinical samples consisting of BA.2(n=20),BA.4(n=6),and BA.5(n=20)variants,and the sensitivity of our assay ranged from 90%to 100%,while the specificity was 100%.Discussion:This research presents a swift and reliable CRISPR-based method that may be employed to track the emergence of novel SARS-CoV-2 variants. | Meihui Luo Yang Pan Yaqing He Ruhan A Changcheng Wu Baoying Huang Roujian Lu Li Zhao Bo Peng Fei Ye Huijuan Wang Yuda Chen Zhen Li Daitao Zhang Wenling Wang Wenjie Tan | 2023 | China CDC weekly2023，5，26： | 0 |
| 17 | STUDY ON THE DECOLORIZATION OF D-RIBOSE ZYMOTIC FLUID BY RESIN ADSORPTION显示文摘In this paper, effects on of six type of resins the decolorization of D-ribosezymotic fluid have been studied for the fist time. The results show that resinNKA-II has the best effect. the decolorization rate of D-ribose zymotic fluid is91% at velocity of 1.0BV/hr and 25℃, the adsorption capacity can reach up to5.7BV. The effects of adsorption conditions as well as conditions of resinregeneration on the resin decolorization capability were also studied. | ZHENG Changcheng GUO Xianzhi DENG Guocai YANG Sihai CHEN Rongti(Department of Chemistry,Nankai University,Tianjin 300071) | 1999 | Chinese Journal of Reactive Polymers1999，8，1： | 0 |
| 18 | Mpox(formerly monkeypox):pathogenesis,prevention,and treatment显示文摘In 2022,a global outbreak of Mpox(formerly monkeypox)occurred in various countries across Europe and America and rapidly spread to more than 100 countries and regions.The World Health Organization declared the outbreak to be a public health emergency of international concern due to the rapid spread of the Mpox virus.Consequently,nations intensified their efforts to explore treatment strategies aimed at combating the infection and its dissemination.Nevertheless,the available therapeutic options for Mpox virus infection remain limited.So far,only a few numbers of antiviral compounds have been approved by regulatory authorities.Given the high mutability of the Mpox virus,certain mutant strains have shown resistance to existing pharmaceutical interventions.This highlights the urgent need to develop novel antiviral drugs that can combat both drug resistance and the potential threat of bioterrorism.Currently,there is a lack of comprehensive literature on the pathophysiology and treatment of Mpox.To address this issue,we conducted a review covering the physiological and pathological processes of Mpox infection,summarizing the latest progress of anti-Mpox drugs.Our analysis encompasses approved drugs currently employed in clinical settings,as well as newly identified small-molecule compounds and antibody drugs displaying potential antiviral efficacy against Mpox.Furthermore,we have gained valuable insights from the process of Mpox drug development,including strategies for repurposing drugs,the discovery of drug targets driven by artificial intelligence,and preclinical drug development.The purpose of this review is to provide readers with a comprehensive overview of the current knowledge on Mpox. | Junjie Lu Hui Xing Chunhua Wang Mengjun Tang Changcheng Wu Fan Ye Lijuan Yin Yang Yang Wenjie Tan Liang Shen | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
| 19 | Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing显示文摘The monkeypox virus(MPXV)has triggered a current outbreak globally.Genome sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and control.It is a significant challenge but necessary to optimize the strategy and application of rapid full-length genome identification and to track variations of MPXV in clinical specimens with low viral loads,as it is one of the DNA viruses with the largest genome and the most AT-biased,and has a significant number of tandem repeats.Here we evaluated the performance of metagenomic and amplicon sequencing techniques,and three sequencing platforms in MPXV genome sequencing based on multiple clinical specimens of five mpox cases in Chinese mainland.We rapidly identified the full-length genome of MPXV with the assembly of accurate tandem repeats in multiple clinical specimens.Amplicon sequencing enables cost-effective and rapid sequencing of clinical specimens to obtain high-quality MPXV genomes.Third-generation sequencing facilitates the assembly of the terminal tandem repeat regions in the monkeypox virus genome and corrects a common misassembly in published sequences.Besides,several intra-host single nucleotide variations were identified in the first imported mpox case.This study offers an evaluation of various strategies aimed at identifying the complete genome of MPXV in clinical specimens.The findings of this study will significantly enhance the surveillance of MPXV. | Changcheng Wu Ruhan A Sheng Ye Fei Ye Weibang Huo Roujian Lu Yue Tang Jianwei Yang Xuehong Meng Yun Tang Shuang Chen Li Zhao Baoying Huang Zhongxian Zhang Yuda Chen Dongfang Li Wenling Wang Ke-jia Shan Jian Lu Wenjie Tan | 2024 | Virologica Sinica2024，39，1： | 0 |
| 20 | Modeling and simulation of twin-tube hydraulic shock absorber thermodynamic characteristics and sensitivity analysis of its influencing factors显示文摘In order to find out the sensitivity of the thermophysical and structural parameters to the thermodynamic characteristics of twin-tube hydraulic shock absorbers,based on the bench test,a method for calculating the time-varying rate of the external work on the shock absorber oil is proposed.And then,a thermodynamic model of the twin-tube hydraulic shock absorber is established by using the basic thermodynamic principles.By analyzing the influence of each parameter on the thermodynamic characteristics of the shock absorber,it can be seen that,the radius of the working cylinder outer wall has the greatest influence on the temperature rise of the shock absorber,followed by the thermal conductivity of the oil,the height of the oil,the heat transfer length of the cylinder barrel,the radius of the oil storage cylinder outer wall,the emissivity of the oil storage cylinder outer wall,the height of the nitrogen,the thermal conductivity of the nitrogen,the specific heat capacity of the oil,the density of the oil,the thermal conductivity of the cylinder,and the mass of the working oil.The kinematic viscosity of the oil has the least influence on the temperature rise of the shock absorber.The research can provide an effective theoretical guidance and reference for the design of the twin-tube hydraulic shock absorber. | Yuewei Yu Leilei Zhao Changcheng Zhou Lin Yang | 2020 | International Journal of Modeling, Simulation, and Scientific Computing2020，11，2： | 0 |
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