|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine显示文摘AIM: To investigate the reduction in hepatitis B virus(HBV) covalently closed-circular DNA(ccc DNA) with entecavir(ETV) or lamivudine(LAM). METHODS: This analysis included patients who had participated in the randomized Phase Ⅲ study ETV-022 comparing ETV vs LAM in nucleos(t)ide-naive, HBe Agpositive patients. Patients received ETV(0.5 mg daily) or LAM(100 mg daily) for a minimum of 52 wk. Patients were eligible to participate in this sub-study if they had paired biopsies at baseline and week 48 with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA. The main objective was to compare changes in hepatic HBV ccc DNA and total hepatic HBV DNA at week 48 of ETV or LAM treatment, which was a secondary endpoint of study ETV-022. Additional post hoc analyses included linear regression analyses to assess associations of baseline levels and on-treatment changes of ccc DNA with other baseline factors [sex,age, serum HBV DNA, alanine aminotransferase(ALT), Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBV genotype], or ontreatment factors(changes from baseline at week 48 in serum HBV DNA, ALT, Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBe Ag loss at week 48).RESULTS: Overall, 305 patients(ETV = 159; LAM = 146) of ETV-022 had paired baseline and week 48 liver biopsies with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA, and were included in this analysis. Baseline demographics and disease characteristics were comparable between the two arms. After 48 wk, ETV resulted in significantly greater reductions in hepatic HBV ccc DNA [-0.9 log10 copies/human genome equivalent(HGEq) vs-0.7 log10 copies/HGEq; P = 0.0033] and total hepatic DNA levels(-2.1 log10 copies/HGEq vs-1.6 log10 copies/HGEq; P < 0.0001) than LAM. Virologic, biochemical, and histologic response rates at week 48 were also greater with ETV than with LAM. Baseline HBV ccc DNA levels were positively associated with baseline levels of serum HBV DNA and total hepatic HBV DNA, and negatively associated with HBV genotype F. On-treatment changes in HBV ccc DNA levels were negatively associated with baseline levels of serum HBV DNA and baseline ALT, and were positively associated with on-treatment changes in the levels of serum HBV DNA, total hepatic HBV DNA levels, and ALT, change in Knodell necroinflammatory score, and HBe Ag loss.CONCLUSION: Forty-eight weeks of ETV resulted in greater reductions in ccc DNA and total hepatic HBV DNA than LAM, but long-term therapy may be needed for ccc DNA elimination. | Scott Bowden Stephen Locarnini Ting-Tsung Chang You-Chen Chao Kwang-Hyub Han Robert G Gish Robert A de Man Miao Yu Cyril Llamoso Hong Tang | 2015 | World Journal of Gastroenterology2015，21，15： | 11 |
| 2 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 3 | New mineralnames显示文摘 | FLEISCHER M CHAO G Y MANDARINO J A | 1979 | Am Mineral1979，64，56： | 2 |
| 4 | VIP-man:An image-based whole-body adult male model constructed from color photographs of the visible human project for multi-particle Monte Carlo calculations显示文摘 | Chao T C Bozkurt A | 2000 | Health Phys2000，78，5： | 1 |
| 5 | Systematic functional pandemic - strain - specific genes, three genomic islands, two T3SSs in food- borne and clinical vibrio parahaemolyticus isolates in China显示文摘 | Chao G Jiao X Zhou X | 2009 | Food- borne Pathog Dis2009，6，6： | 1 |
| 6 | Integrated approaches toimprove birth outcomes: perinatal periods of risk,infant mortal-ity review,and the Los Angeles Mommy and Baby Project 显示文摘 | Chao SM Donatoni G?Bemis C | 2010 | Matern Child Health2010，14，6： | 1 |
| 7 | Specific absorbed fractions from the image-based VIP-man body model and EGS4-VLSI Monte Carlo code:Internal electron emitters显示文摘 | Xu X G | 2001 | Phys Med Biol2001，46，： | 1 |
| 8 | Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer显示文摘 | Chao KS Ozyigit G Tran BN | 2003 | 1nt J Radiat Oncol Biol Phys2003，55，2： | 1 |
| 9 | On tracking the source location of voltage sags and utility shunt capacitor switching transients显示文摘 | Chang G W Chao Jupeng Huang H M | 2008 | IEEE Trans on Power Delivery2008，23，4： | 1 |
| 10 | VIP-man: An image-based whole-body adult male model constructed from color photographs of the visible human project for multi-particle Monte Carlo calculations 显示文摘 | Xu X G Chao T C Bozkurt A | 2000 | Health Phys2000，78，5： | 1 |
| 11 | On chromatic equivalence of graphs 显示文摘 | Chao C Y Whitehead E G | 1978 | Theory and Applications of Graphs Lecture Notes in Math1978，642，： | 1 |
| 12 | Theoretical design and advanced microstructure in super high strength steels显示文摘 | ABALLERO F G SANTOFIMIA M J CHAO J | 2009 | Materials and Design2009，30，16： | 1 |
| 13 | Preparation and Char- acterization of Bismaleimide-triazine/Epoxy Interpenetra- ting Polymer Networks显示文摘 | Wu G L Kou K C Chao M | 2012 | Thermochim Acta2012，537，： | 1 |
| 14 | A Long Intrudingly Investigation of New Comer Expectations, Early Socialization out Comes, and Than Overrating Effects Froe Development factors 显示文摘 | Major D A Kozlowski S W J Chao G | 1995 | Journal of Applied Psychology1995，80，3： | 1 |
| 15 | Expression of P2X purinoceptnrs during rat brain development and their inhihitory role on motor axon outgrowth in neural tube explant cultures 显示文摘 | Cheung K K Chao W Y Burnstoek G | 2005 | Neuroscience2005，133，4： | 1 |
| 16 | Simplification of fuzzy-neural systems using similarity analysis 显示文摘 | CHEN Y G TENG C C | 1996 | IEEE Trans on Systems Man and Cybernetics-Part B: Cybernetics1996，26，2： | 1 |
| 17 | Fluence-to-dose conversion coefficients from monoenergetic neutron beams below 20 MeV based on the VIP-man anatomical model显示文摘 | Chao T C Xu X G | 2000 | Phys Med Biol2000，45，： | 1 |
| 18 | Acute inflammatory reaction following experimental intracerebral hemorrhage in rats 显示文摘 | CHAO G JULIAN T H KEEP R F | 2000 | Brain Res2000，871，1： | 1 |
| 19 | TanIdentification and fine-mapping of a major QTL conferring resistance against head smut in maize显示文摘 | Chen Y S Chao Q Guo G | 2008 | Theoretical and Applied Genetics2008，，8： | 1 |
| 20 | Formal and informal mentorships: a comparison on mentoring functions and contrast with nonmentored counter parts显示文摘 | Chao G Walz P Gardner P | 1992 | Personnel Psychology1992，45，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员