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| 1 | Effect of HCV NS_3 protein on P53 protein expression in hepatocarcinogenesis显示文摘NTRODUCTIONHepatocelularcarcinoma(HCC)isoneofthemostcommonhumancancersintheworld.Recently,theHCVinfectionwasfoundtobeanetiolo... | FENG De Yun, CHEN Rui Xue, PENG Yong, ZHENG Hui and YAN Ya Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 25 |
| 2 | Increase of TNFα-stimulated Osteoarthritic Chondrocytes Apoptosis and Decrease of Matrix Metalloproteinases 9 by NF-κB Inhibition显示文摘Objective To investigate the in vitro effect of caffeic acid phenethyl ester(CAPE),a NF-κB inhibitor,on the apoptosis of osteoarthritic(OA)chondrocytes and on the regulation of the gelatinases matrix metalloproteinase 2(MMP-2)and matrix metalloproteinase 9(MMP-9).Methods Annexin V-FITC/propidium iodide(PI)labeling and western blotting were used to observe and determine the apoptosis in TNFα-stimulated primary cultured osteoarthritic chondrocytes.Also,gelatin zymography was applied to examine MMP-2 and MMP-9 activities in supernatants.Results It was confirmed by both flow cytometry and western blotting that chondrocytes from OA patients have an apoptotic background.Use of CAPE in combination with 10 ng/mL of TNFα for 24 h facilitated the apoptosis.MMP-9 in the supernatant could be autoactivated(from proMMP-9 to active MMP-9),and the physiologic calcium concentration(2.5 mmol/L)could delay the autoactivation of MMP-9.The activities of MMP-2 and MMP-9 in the fresh supernatant increased significantly in response to stimulation by 10 ng/mL of TNFα for 24 h.The stimulatory effect of TNFα just on proMMP-9 was counteracted significantly by CAPE.Conclusion NF-κB could prevent chondrocytes apoptosis though its activation was attributed to the increase of proMMP-9 activity induced by TNFα(a pro-apoptotic factor).Therefore,therapeutic NF-κB inhibitor was a 'double-edged swords' to the apoptosis of chondrocytes and the secretion of MMP-9. | WANG Yan LI De Ling ZHANG Xin Bo DUAN Yuan Hui WU Zhi Hong HAO Dong Sheng CHEN Bao Sheng QIU Gui Xing | 2013 | Biomedical and Environmental Sciences2013，26，4： | 13 |
| 3 | Effects of endotoxin on expression of ras, p53 and bcl-2 oncoprotein in hepatocarcinogenesis induced by thioacetamide in rats显示文摘Efectsofendotoxinonexpressionofras,p53andbcl2oncoproteininhepatocarcinogenesisinducedbythioacetamideinratsYANGJinMing1,HAN... | YANG Jin Ming 1, HAN De Wu 1, LIANG Quan Chen 2, ZHAO Jia Li 2, HAO Su Yuan 1, MA Xue Hui 1 and ZHAO Yuan Chang 1 | 1997 | World Journal of Gastroenterology1997，3，4： | 11 |
| 4 | Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease,2008-2013显示文摘Objective To investigate the serum total IgE(tlgE) and specific IgE(slgE) to common allergens among allergic patients in Guangzhou,China.Methods 7 085 patients were examined for tlgE and slgE to 15 allergens,based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.Results 3 758(53.04%) patients tested positive for tlgE,and 4 640(65.49%) for slgE.Der pteronyssinus,Der farinae,eggs,and cow's milk were the most common allergens leading to higher positive rates of slgE responses.Several peaks of sensitization were:Der pteronyssinus,Der farinae,and Blomia tropicalis at age 10-12;cow's milk at age below 3;eggs at age 4-6.The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens.Sensitization to Der pteronyssinus(OR,1.6;P<0.05),Der farinae(OR,1.5;P<0.05),Blomia tropicalis(OR,1.4;P<0.05),Blattella germanica(OR,1.5;P<0.05),cow's milk(OR,1.3;P<0.05),and soy beans(OR,2.0;P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.Conclusion The major allergens in Guangzhou include Der pteronyssinus,Der farinae,cow's milk,and eggs.Sensitization to these allergens appears to be predictors of allergy-related disorder. | SUN Bao Qing CHEN De Hui ZHENG Pei Yan HUANG Hui Min LUO Wen Ting ZENG Guang Qiao ZHANG Xiao Wen | 2014 | Biomedical and Environmental Sciences2014，27，7： | 11 |
| 5 | Transient expression and antigenic characterization of HBsAg of HBV nt551 A to G mutant显示文摘NTRODUCTIONFromthelate80s,therehavebeenincreasingnumberofreportsonhepatitisB(HB)patientswithatypicalHBVserologicalmarkers,so... | FANG De Xing 1, LI Fa Qing 1, TAN Wei Guo 1, CHEN Hua Biao 1, JIN Hui Ying 1, LI Su Qin 1, LIN Hou Ji 2 and ZHOU Zhen Xian 2 | 1999 | World Journal of Gastroenterology1999，5，1： | 10 |
| 6 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 7 | Effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats显示文摘Objective To study the effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats. Methods Rat tail-suspension model was used to simulate the physiological effects of microgravity and changes in pulmonary blood vessel morphology, pulmonary arterial and venous blood pressure, pulmonary vascular resistance, pulmonary vasomotoricity, as well as the regulation of pulmonary circulation by cytokines produced and released by the lung of rats were measured. Results The walls of pulmonary blood vessels of rats were thickened, and the pulmonary artery was reconstructed with increased pulmonary vascular resistance. The pulmonary blood vessels of rats became more prone to dilation as contractions increased. Rat epithelial Adrenomedulin gene transcription and protein expression were upregulated. The level of basic fibroblast growth Factor of rat was also elevated. Conclusion Findings from the present study on rats revealed that the microgravity can affect pulmonary blood vessel structure, pulmonary arterial pressure, and pulmonary blood vessel self-regulation and cytokine production. | LI Tian Zhi YUAN Ming CHEN Zhen Hong GUO Ying Hua KANG Chun Yan WANG Jing Yu LI Zhi Li WANG De Sheng WANG Hui Juan YUAN Min LIU Chang Ting | 2013 | Biomedical and Environmental Sciences2013，26，2： | 6 |
| 8 | Anal cancer in Chinese:human papillomavirus infection and altered expression of p53显示文摘AnalcancerinChinese:humanpapilomavirusinfectionandalteredexpressionofp53LAIMaoDe,LUOMinJie,YAOJianErandCHENPeiHuiSubject... | LAI MaoDe, LUO MinJie, YAO JianEr and CHEN PeiHuiKeywords anus neoplasms papillomavirus infection DNA, viral p53 gene gene expression polymerase chain reaction | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 9 | Complement C3a activates osteoclasts by regulating the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma显示文摘Objective:Myeloma bone disease(MBD)is the most common complication of multiple myeloma(MM).Our previous study showed that the serum levels of C3/C4 in MM patients were significantly positively correlated with the severity of bone disease.However,the mechanism of C3 a/C4 a in osteoclasts MM patients remains unclear.Methods:The formation and function of osteoclasts were analyzed after adding C3 a/C4 a in vitro.RNA-seq analysis was used to screen the potential pathways affecting osteoclasts,and the results were verified by Western blot,q RT-PCR,and pathway inhibitors.Results:The osteoclast area per view induced by 1μg/m L(mean±SD:50.828±12.984%)and 10μg/m L(53.663±12.685%)of C3 a was significantly increased compared to the control group(0μg/m L)(34.635±8.916%)(P<0.001 and P<0.001,respectively).The relative m RNA expressions of genes,OSCAR/TRAP/RANKL/cathepsin K,induced by 1μg/m L(median:5.041,3.726,1.638,and 4.752,respectively)and 10μg/m L(median:5.140,3.702,2.250,and 5.172,respectively)of C3 a was significantly increased compared to the control group(median:3.137,2.004,0.573,and 2.257,respectively)(1μg/m L P=0.001,P=0.003,P<0.001,and P=0.008,respectively;10μg/m L:P<0.001,P=0.019,P<0.001,and P=0.002,respectively).The absorption areas of the osteoclast resorption pits per view induced by 1μg/m L(mean±SD:51.464±11.983%)and 10μg/m L(50.219±12.067%)of C3 a was also significantly increased(33.845±8.331%)(P<0.001 and P<0.001,respectively)compared to the control.There was no difference between the C4 a and control groups.RNA-seq analysis showed that C3 a promoted the proliferation of osteoclasts using the phosphoinositide 3-kinase(PI3 K)signaling pathway.The relative expressions of PIK3 CA/phosphoinositide dependent kinase-1(PDK1)/serum and glucocorticoid inducible protein kinases(SGK3)genes and PI3 K/PDK1/p-SGK3 protein in the C3 a group were significantly higher than in the control group.The activation role of C3 a in osteoclasts of MM patients was reduced by the SGK inhibitor(EMD638683).Conclusions:C3 a activated osteoclasts by regulating the PI3 K/PDK1/SGK3 pathways in MM patients,which was reduced using a SGK inhibitor.Overall,our results identified potential therapeutic targets and strategies for MBD patients。 | Fengjuan Jiang Hui Liu Fengping Peng Zhaoyun Liu Kai Ding Jia Song Lijuan Li Jin Chen Qing Shao Siyang Yan Kim De Veirman Karin Vanderkerken Rong Fu | 2021 | Cancer Biology & Medicine2021，18，3： | 3 |
| 10 | A Bibliometric Analysis of Digital Innovation from 1998 to 2016显示文摘Digital technologies are ubiquitous in our everyday lives.They have been widely embedded into the core processes of services and products,as well as into the operations of many organizations.These digital technologies bring many changes to our work and lifestyles,to the organization of companies,and even to the structures of whole industries.Thus,digital innovation is a research hotspot.This study investigates the development of digital innovation research using a bibliometric method with visual mapping.The status of digital innovation research is analyzed through citation analysis.Influential references,authors,and top-tier journals are identified.The literature’s intellectual structure is mapped through co-word analysis.In addition,co-citation network analysis is used to describe the evolution of digital innovation research,and cluster analysis of the main research stream is conducted.Several research topics addressed by recent papers are also discussed.Finally,cross-country comparisons reveal that the US is currently taking the leading role and that China is a newcomer with potential contributions to make in this research area. | Xi Zhang Yao Meng Hui Chen Jiang Yu Yongqiang Sun Patricia Ordóñez de Pablos Joy Wei He | 2017 | Journal of Management Science and Engineering2017，2，2： | 3 |
| 11 | Synthesis of pillar[7]arene显示文摘支柱的第一合成[7 ] arene 与二个方法被报导。方法 A:有在 CHCl3 的 paraformaldehyde 的 1,4-dimethoxybenzene (1 ) 的催化 FeCl3 的冷凝作用反应给了 dimethoxypillar [7 ] arene (3 ) 。方法 B:p-toluenesulfonic 酸催化在 CH2Cl2 的 -1,4-dimethoxybenzene (2 ) 给了化合物 3 的 2,5 二度(benzyloxymethyl ) 的冷凝作用反应。有 BBr3 的 3 的 Demethylation 给了支柱[7 ] arene (4 ) 。支柱[7 ] arene 可能是在 hostguest 化学的一位观点 macrocyclic 主人。 | Yu Chen Hong Qi Tao Yu Hui Kou Herbert Meier Jian Long Fu De Rong Cao | 2012 | Chinese Chemical Letters2012，23，5： | 3 |
| 12 | Study on Syntheses and Characterizations of Polymethylphenethylsilane, Polymethylcyclohexylsilane and their Copolymers显示文摘The effects of adding cosolvents of diglyme and 15 crown 5 to the reaction mixture of Wurtz type coupling of dichlorosilanes on the yield and relative molecular mass dispersity of polymethylphenethylsilane(PMPES) were discussed. The results show that addition of 10% (volume ratio of diglyme to toluene) diglyme as a cosolvent to the reaction mixture leads to the yield increase of PMPES with a monomodal distribution of relative molecular masses. Adding 10% diglyme to the reaction mixtures, the yields of polymethylcyclohexylsilane(PMCS) and copolymers (polymethylphenethylsilane co methylcyclohexylsilane), (the molar ratios of methylphenethyldichlorosilane to methylcyclohexyldichlorosilane were 2.0, 1.0 and 0.5, and the copolymers were abbreviated by Copolymers Ⅰ, Ⅱ, Ⅲ, respectively) are 47%, 52%, 54%, 53%, respectively. Their relative molecular masses ( w ) almost reach 10 5. These polysilanes were characterized by 1H NMR, IR and UV absorption spectrum. | HU Hui ping 1,HUANG Ke long 1,PAN Chun yue 1,CHEN De ben 2 (1 College of Chemistry and Chemical Engineering, Central South University of Technology, Changsha 410083, China 2 Department of Chemistry, Sichuan University, Chengdu 610064, China | 2000 | Journal of Central South University2000，12，2： | 2 |
| 13 | miR‐93/Sp7 function loop mediates osteoblast mineralization显示文摘 | Li Yang Peng Cheng Chao Chen Hong‐Bo He Gen‐Qing Xie Hou‐De Zhou Hui Xie Xian‐Ping Wu Xiang‐Hang Luo | 2012 | J Bone Miner Res2012，，7： | 2 |
| 14 | Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China显示文摘Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan Province.Methods We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan Province.Hematological screening was performed,and molecular parameters were assessed.Results The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-thalassemia.The highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),respectively.Fourα-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in China.Furthermore,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,respectively.Conclusion Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan population.The results should facilitate genetic counselling and the prevention of severe thalassemia in this region. | XI Hui LIU Qin XIE Dong Hua ZHOU Xu TANG Wang Lan TANG De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO Xiao Ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG Shu Yuan ZHOU Shu Xiang HE Jun ZHOU Shi Hao ZHOU Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua | 2023 | Biomedical and Environmental Sciences2023，36，2： | 1 |
| 15 | Catalytic performance, structure, surface properties and active oxygen species of the fluoride-containing rare earth (alkaline earth)-based catalysts for the oxidative coupling of methane and oxidative dehydrogenation of light alkanes显示文摘 | Hui Lin Wan Xiao Ping Zhou Wei Zheng Weng Rui Qiang Long Zi Sheng Chao Wei De Zhang Ming Shu Chen Ji Zhong Luo Shui Qin Zhou | 1999 | Catalysis Today1999，，1： | 1 |
| 16 | Changes of mucosal permeability to lipopolysaccharide in the colon of chronic alcoholic rats显示文摘ChangesofmucosalpermeabilitytolipopolysaccharideinthecolonofchronicalcoholicratsCHENXianMing,XURuiLing,MAXueHui,ZHAOYuanC... | CHEN Xian Ming, XU Rui Ling, MA Xue Hui, ZHAO Yuan Chang and HAN De Wu Department of Pathophysiology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China | 1997 | World Journal of Gastroenterology1997，3，3： | 1 |
| 17 | Field study of plastic tube east-in-place concrete pile显示文摘 | CHEN YONG HUI CAO DE HONG WANG XIN QUAN | 2008 | Journal of Central South University of Technology2008，15，2： | 1 |
| 18 | Axial Diffusivity and Tensor Shape as Early Markers to Assess Cerebral White Matter Damage Caused by Brain Tumors Using Quantitative Diffusion Tensor Tractography显示文摘 | Fei Chen Xin Zhang Ming Li Rong Wang Hui‐Ting Wang Feng Zhu De‐Ji Lu Hui Zhao Jing‐Wei Li Yun Xu Bin Zhu Bing Zhang | 2012 | CNS Neurosci Ther2012，，8： | 1 |
| 19 | miR‐148a regulates osteoclastogenesis by targeting V‐maf musculoaponeurotic fibrosarcoma oncogene homolog B显示文摘 | Peng Cheng Chao Chen Hong‐Bo He Rong Hu Hou‐De Zhou Hui Xie Wu Zhu Ru‐Chun Dai Xian‐Ping Wu Er‐Yuan Liao Xiang‐Hang Luo | 2013 | J Bone Miner Res2013，，5： | 1 |
| 20 | MiR‐503 Regulates Osteoclastogenesis via Targeting RANK显示文摘 | Chao Chen Peng Cheng Hui Xie Hou‐De Zhou Xian‐Ping Wu Er‐Yuan Liao Xiang‐Hang Luo | 2014 | J Bone Miner Res2014，，2： | 1 |
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