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| 1 | Expression,deleton and mnutation of ρ16 gene in human gastric cancer显示文摘AIM To investigate the relationship between the expression of p16 gene and the gastric carcinogenesis,depth of invasion and lymph node metastases, and to evaluate the deletion and mutation of exon 2 in p16 gene in gastric carcinoma.METHODS The expression of P16 protein was examined by streptavidin-peroxidase conjugated method (S-P); the deletion and mutation of p16 gene were respectively examined by polymerase chain reaction (PCR) and polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP) in gastric carcinoma.RESULTS Expression of P16 protein was detected in 96.25% (77/80) of the normal gastric mucosa, in 92.00% (45/50) of the dysplastic gastric mucosa and in 47.54% (58/122) of the gastric carcinoma. The positive rate of P16 protein expression in gastric carcinoma was significantly lower than that in normal gastric mucosa and dysplastic gastric mucosa (P<0.05). The positive rate of P16 protein expression in mucoid carcinoma 10.00% (1/ 10) was significantly lower than that in poorly differentiated carcinoma 51.22% ( 21/ 41 ),undifferentiated carcinoma 57.69% (15/26) and signet ring cell carcinoma 62.50% (10/ 16) (P<0.05). The positive rate of p16 protein in 30 cases paired primary and lymph node metastatic gastric carcinoma: There was 46.67% (14/30) in primary gastric carcinoma, 16.67% (5/30) in lymph node metastatic gastric carcinoma. The positive rate of lymph node metastatic carcinoma was significantly lower than that of primary carcinoma (P<0.05). There was of p16 gene mutation in exon 2, but 5 cases displayed deletion of p16 gene in exon 2 in the 25 primary gastric carcinomas.CONCLUSIONS The expression loss of P16 protein related to the gastric carcinogenesis, gastric carcinoma histopathological subtypes and lymph metastasis. The mutation of p16 gene in exon 2 may not be involved in gastric carcinogenesis. But the deletion of p16 gene in exon 2 may be involved in gastric carcinogenesis. | Xiu-Sheng He Qi Su Zhu-Chu Chen Xiu-Tao He Zhi-Feng Long Hui Ling Liang-Run Zhang Oncology Institute,Nanhua University,Hengyang 421001,Hunan Province,ChinaOncology Institute,Center South University,Changsha 410078,Hunan Province,China Department of Gastroenterology,First People’s Hospital of Changde City,Changde 415003,Hunan Province,China | 2001 | World Journal of Gastroenterology2001，7，4： | 40 |
| 2 | Clinicopathological features of gastric glomus tumor显示文摘AIM:To study the clinicopathological features of gastric glomus tumor and review the related Chinese literature published in 1990-2010.METHODS:A case of gastric glomus tumor was re-ported.Clinicopathological findings in 56 cases of gastric glomus tumor were analyzed.RESULTS:Gastric glomus tumor was far more common in women than in men with a female to male ratio of 1.6:1.The median age of the patients was 45 years(range 28-79 years).The patients often complained of epigastric pain and bloody stool.The tumor was located in antrum of the stomach.The greatest diameter of the tumor was 0.8-11cm.Histologically,the tumor was comprised of nests of glomus cells surrounding the capillaries.Glomus cells were small,uniform and round.Vimentin,smooth muscle actin and actin were expressed in the tumor.Other markers,including S-100 protein,CD34,CD117,desmin,CD56,synaptophysin,chromo-granin A,neuron specific enolase and cytokeratin were all negative.CONCLUSION:Gastric glomus tumor is a rare benign mesenchymal neoplasm.Its diagnosis depends on pathologic examination.Differential diagnosis includes gastrointestinal stromal tumor,paraganglioma and carcinoid tumor. | Hui-Qiong Fang,Jing Yang,Fen-Fen Zhang,An-Jia Han,Department of Pathology,First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China Hui-Qiong Fang,Department of Pathology,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,Guangdong Province,China Jing Yang,Department of Pathology,People’s Hospital of Zhu-hai City,Zhuhai 519000,Guangdong Province,China Yi Cui,Department of Gastroenterology,First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China | 2010 | World Journal of Gastroenterology2010，16，36： | 28 |
| 3 | Typical Survey and Research on Returning-home Migrant Workers' Entrepreneurship in Jiangxi Province under Post-financial Crisis显示文摘In order to study the entrepreneurship situation of Jiangxi return migrant workers after the financial crisis,we have conducted a survey on 107 entrepreneurial return migrant workers in 6 counties of Jiangxi Province.The results show that the return of migrant workers is mainly attributed to personal factors,while social factors are also very important.The major difficulties facing return migrant workers are the funding difficulties,complicated formalities to start a business,difficulty in safeguarding their rights and interests,their own low quality and so on.The support needed by the return migrant workers from the government is manifested in five aspects,say,to improve the service and management for the entrepreneurship of migrant workers,to provide financing policy support,to increase the preferential fiscal and taxation policies,to enhance the entrepreneurship training and to provide preference for the return migrant workers to use land. | OUYANG Zhang-sun1,ZHANG Xin-zhi2,WANG Run-qun3,LUO Feng1,SHEN Ai-guo1,WU Xing-lin1 1.Jiangxi Biotech Vocational College,Nanchang 330299,China 2.The Research Center of the Central China’s Economic Development,Nanchang University,Nanchang 330047,China 3.Jizhou Agricultural Bureau,Jizhou District,Ji’an City in Jiangxi Province,Ji’an 343000,China | 2010 | Asian Agricultural Research2010，2，10： | 2 |
| 4 | Clinicopathogenic studies of acute diarrhea in children显示文摘ClinicopathogenicstudiesofacutediarheainchildrenCAILiMin,ZHANGChang,CHENHe,JIANGWeiPingandMAOWenXiangDepartmentofInfectiou... | CAI Li Min, ZHANG Chang, CHEN He, JIANG Wei Ping and MAO Wen Xiang Department of Infectious Diseases, The First People′s Municipal Hospital of Wenling, Wenling City 317500, Zhejiang Province, China | 1997 | World Journal of Gastroenterology1997，3，3： | 2 |
| 5 | Accumulation of heavy metals in two crop seeds due to soil contamination as determined by neutron activation analysis techniques显示文摘AcumulationofheavymetalsintwocropsedsduetosoilcontaminationasdeterminedbyneutronactivationanalysistechniquesM.F.AbdelSabourS... | M.F.Abdel Sabour Soil and Water Department, Nuclear Research Center, Cairo, Egypt A.S.Abdel Haleem Hot Lab’s Center, Atomic Energy Authority, Cairo, Egypt A.Sroor, N.Abdel Baset Nuclear Physics Lab, Girls Faculty, Ain Shams University, Egypt R.A.Zaghloul Mubarak City for Scientific Research and Technology, Egypt | 1998 | Journal of Environmental Sciences1998，10，2： | 2 |
| 6 | The molecular organization of tight junctions显示文摘 | Citi S | 1993 | J Cell Biol1993，121，3： | 1 |
| 7 | Serum and urine monitoring of fluoride exposed workers in aluminium smelting factory显示文摘Serumandurinemonitoringoffluorideexposedworkersinaluminiumsmeltingfactory￥K.Kono;Y.Yoshisda;M.Watanabe;K.Usuda;H.Nagaie;Y.Tak... | K. Kono Y. Yoshisda M. Watanabe K. Usuda H. Nagaie Y. Takahashi(Department of Hygiene and Public Health , Osaka Medical College, 2- 7 Daigakumachi, Takatsuki City, Osaka, 569, Japan)Sun G(Department of Preventive Medicine, China Medical University ,S | 1996 | Journal of Environmental Sciences1996，8，2： | 1 |
| 8 | COX-2 expression in canine and feline invasive mammary carcinomas:correlation with clinicopathological features and prognostic fmolecular markers显示文摘 | Millanta F Citi S Santa DD | 2006 | Breast Cancer Research and Treatment2006，，98： | 1 |
| 9 | Polarized functions and permeability properties of rat epididymal epithelial cells in vitro 显示文摘 | Byers SW Citi S Anderson JM | 1992 | J Reprod Fertil1992，95，2： | 1 |
| 10 | Cingulin, a new peripheral component of tight junctions 显示文摘 | Citi S Sabanay H Jakes R | 1988 | Nature1988，333，6170： | 1 |
| 11 | Cingulin,a new peripheral compo- nent of tight junctions 显示文摘 | Citi S Sabanay H Jakes R | 1988 | Nature1988，333，6170： | 1 |
| 12 | Obstacles to the Mortgage Financing of Forest Rights and its Countermeasures显示文摘Current status of the mortgage financing of forest rights is introduced.Significance of the development of mortgage financing of rural forest rights is analyzed,indicating that the mortgage financing of rural forest rights is an inevitable trend of rural reform development,Mortgage financing of forest rights in rural China is an effective vector for the farmers' income increase project with financial support,explores the great potential of forest resources,promotes the coordinated development of forestry and financial services.Major obstacles for the mortgage financing of forest rights at present is pointed out,which are the high assessment fees,the complex mortgage valuation,the unsound element market of forestry,and the lack of risk protection mechanism.Countermeasures for the development of mortgage financing of forest rights is out forward.For instance,both government and Forestry Bureau should strengthen the circulation services,establish smooth evaluation mechanism,establish companies for rural assets platform,increase the interest subsidies for forest right mortgage and the risk compensation,strengthen the team construction and improve the service system. | WEI Xin1,GE Jin-chun2 1.Guangxi Economic Management Cadre College,Nanning 530007,China 2.Shabu Town People’s Government of Qinzhou City,Qinzhou 535000,China | 2011 | Asian Agricultural Research2011，3，5： | 1 |
| 13 | A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells显示文摘 | Pulimeno P Paschoud S Citi S | 2011 | J Biol Chem2011，286，16： | 1 |
| 14 | Distinct E-cadherin-based complexes regulate cell behaviour through mi RNA processing or Src and p120 catenin activity显示文摘 | KOURTIDIS A NGOK S P CITI S | 2015 | Nature Cell Biology2015，17，9： | 1 |
| 15 | Cingulin,a new peripheral compo-nent of tight junctions显示文摘 | Citi S Sabanay H Jakes R | 1988 | Nature1988，333，6170： | 1 |
| 16 | Cingulin, a new peripheral component of tight junctions 显示文摘 | Citi S Sabanay H Jakes R | 1988 | Nature1988，333，6170： | 1 |
| 17 | The molecular organization of tight junctions 显示文摘 | | 1993 | J Cell Biol1993，121，3： | 1 |
| 18 | Molecular complexity of vertebrate tight junctions 显示文摘 | D'Atri F Citi S | 2002 | Mol Membr Biol2002，19，： | 1 |
| 19 | Protein kinase inhibitors prevent junctional disassociation induced by low extracellular calcium in MDCK epithelial cells显示文摘 | Citi S | 1992 | J Cell Bid1992，117，： | 1 |
| 20 | The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4 显示文摘 | Guillemot L Spadaro D Citi S | 2013 | PLoS One2013，8，55： | 1 |
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